Publications by authors named "Byoung-Mog Kwon"

100Publications

8-Epi-xanthatin induces the apoptosis of DU145 prostate carcinoma cells through signal transducer and activator of transcription 3 inhibition and reactive oxygen species generation.

Phytother Res 2020 Nov 8. Epub 2020 Nov 8.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

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http://dx.doi.org/10.1002/ptr.6918DOI Listing
November 2020

Jaceosidin Ameliorates Insulin Resistance and Kidney Dysfunction by Enhancing Insulin Receptor Signaling and the Antioxidant Defense System in Type 2 Diabetic Mice.

J Med Food 2020 Oct 11;23(10):1083-1092. Epub 2020 Aug 11.

Department of Home Economics Education, College of Education, Chung-Ang University, Seoul, Korea.

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http://dx.doi.org/10.1089/jmf.2020.4739DOI Listing
October 2020

Ethacrynic acid inhibits STAT3 activity through the modulation of SHP2 and PTP1B tyrosine phosphatases in DU145 prostate carcinoma cells.

Biochem Pharmacol 2020 05 19;175:113920. Epub 2020 Mar 19.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 34141, Republic of Korea; University of Science and Technology in Korea, 217 Gajeongro, Daejeon 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2020.113920DOI Listing
May 2020

Pimozide suppresses cancer cell migration and tumor metastasis through binding to ARPC2, a subunit of the Arp2/3 complex.

Cancer Sci 2019 Dec 15;110(12):3788-3801. Epub 2019 Nov 15.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.14205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890432PMC
December 2019

Benproperine, an ARPC2 inhibitor, suppresses cancer cell migration and tumor metastasis.

Biochem Pharmacol 2019 05 30;163:46-59. Epub 2019 Jan 30.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 34141, Republic of Korea; Korea University of Science and Technology in Korea, Daejeon, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952193002
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http://dx.doi.org/10.1016/j.bcp.2019.01.017DOI Listing
May 2019

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation.

Pharmacol Res 2019 01 22;139:325-336. Epub 2018 Nov 22.

Biotherapeutics Translational Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; Department of Biomolecular Science, University of Science & Technology (UST), Daejeon, Republic of Korea. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10436618183073
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http://dx.doi.org/10.1016/j.phrs.2018.11.027DOI Listing
January 2019

2'-Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation.

Cancer Sci 2019 Jan 20;110(1):366-378. Epub 2018 Nov 20.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.13852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317917PMC
January 2019

Up-regulation of Bone Morphogenetic Protein 7 by 2-Hydroxycinnamaldehyde Attenuates HNSCC Cell Invasion.

Anticancer Res 2018 Oct;38(10):5747-5757

Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.12
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http://dx.doi.org/10.21873/anticanres.12913DOI Listing
October 2018

2'-hydroxycinnamaldehyde inhibits cancer cell proliferation and tumor growth by targeting the pyruvate kinase M2.

Cancer Lett 2018 10 18;434:42-55. Epub 2018 Jul 18.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon, 34141, Republic of Korea; Korea University of Science and Technology in Korea, Daejeon, 34113, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.07.015DOI Listing
October 2018

Piperlongumine derivative, CG-06, inhibits STAT3 activity by direct binding to STAT3 and regulating the reactive oxygen species in DU145 prostate carcinoma cells.

Bioorg Med Chem Lett 2018 08 14;28(14):2566-2572. Epub 2018 May 14.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.05.025DOI Listing
August 2018

KRIBB53 binds to OCT4 and enhances its degradation through the proteasome, causing apoptotic cell death of OCT4-positive testicular germ cell tumors.

Carcinogenesis 2018 05;39(6):838-849

Personalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Yuseong-gu, Daejeon, Korea.

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http://dx.doi.org/10.1093/carcin/bgy054DOI Listing
May 2018

Methyllucidone inhibits STAT3 activity by regulating the expression of the protein tyrosine phosphatase MEG2 in DU145 prostate carcinoma cells.

Bioorg Med Chem Lett 2018 03 8;28(5):853-857. Epub 2018 Feb 8.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.02.012DOI Listing
March 2018

Ginkgetin induces cell death in breast cancer cells via downregulation of the estrogen receptor.

Oncol Lett 2017 Oct 10;14(4):5027-5033. Epub 2017 Aug 10.

Division of Radiation Cancer Research, Korea Institute of Radiological and Medical Sciences, Nowon, Seoul, Gyeonggi 01812, Republic of Korea.

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http://dx.doi.org/10.3892/ol.2017.6742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649541PMC
October 2017

Ginkgetin induces G2-phase arrest in HCT116 colon cancer cells through the modulation of b‑Myb and miRNA34a expression.

Int J Oncol 2017 Oct 5;51(4):1331-1342. Epub 2017 Sep 5.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2017.4116DOI Listing
October 2017

Inhibitory effect of obovatol from Magnolia obovata on the Salmonella type III secretion system.

J Antibiot (Tokyo) 2017 Nov 6;70(11):1065-1069. Epub 2017 Sep 6.

Department of Nano Science and Technology, Graduate School, Kyungpook National University, Daegu, Korea.

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http://dx.doi.org/10.1038/ja.2017.98DOI Listing
November 2017

Geranylnaringenin (CG902) inhibits constitutive and inducible STAT3 activation through the activation of SHP-2 tyrosine phosphatase.

Biochem Pharmacol 2017 10 28;142:46-57. Epub 2017 Jun 28.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Republic of Korea; Korea University of Science and Technology, Daejeon, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.06.131DOI Listing
October 2017

PPARγ agonists induce adipocyte differentiation by modulating the expression of Lipin-1, which acts as a PPARγ phosphatase.

Int J Biochem Cell Biol 2016 12 22;81(Pt A):57-66. Epub 2016 Oct 22.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea; University of Science and Technology in Korea, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.10.018DOI Listing
December 2016

Cinnamaldehydes in Cancer Chemotherapy.

Phytother Res 2016 May 18;30(5):754-67. Epub 2016 Feb 18.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon, 305-806, Korea.

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http://dx.doi.org/10.1002/ptr.5592DOI Listing
May 2016

Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents.

ACS Appl Mater Interfaces 2016 Mar 26;8(9):5887-97. Epub 2016 Feb 26.

Department of BIN Convergence Technology, Chonbuk National University , Jeonju, Chonbuk 561-756, Republic of Korea.

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http://dx.doi.org/10.1021/acsami.5b12523DOI Listing
March 2016

Artocarpus altilis CG-901 alters critical nodes in the JH1-kinase domain of Janus kinase 2 affecting upstream JAK/STAT3 signaling.

J Mol Model 2015 Nov 7;21(11):280. Epub 2015 Oct 7.

Center for Genomics Research and Innovation, National Biotechnology Development Agency, Abuja, Nigeria.

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http://dx.doi.org/10.1007/s00894-015-2821-zDOI Listing
November 2015

Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.

Biochem Pharmacol 2015 Sep 23;97(1):38-50. Epub 2015 Jul 23.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology 125Gwahakro Yoosunggu, Daejeon 305-806, Republic of Korea; Biomolecular Science, University of Science and Technology in Korea, 125 Gwahakro Yoosunggu, Daejeon 305-806, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.06.033DOI Listing
September 2015

Tanshinone IIA exerts antitumor activity against vestibular schwannoma cells by inhibiting the expression of hypoxia-inducible factor-1α.

Mol Med Rep 2015 Sep 15;12(3):4604-4609. Epub 2015 Jun 15.

Department of Otorhinolaryngology ‑ Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon‑si, Gyeonggi‑do 420‑767, Republic of Korea.

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https://www.spandidos-publications.com/10.3892/mmr.2015.3932
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http://dx.doi.org/10.3892/mmr.2015.3932DOI Listing
September 2015

Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.

Carcinogenesis 2015 Jun 3;36(6):696-706. Epub 2015 Apr 3.

Genomics Structure Research Center, Korea Research Institute of Bioscience and Biotechnology and Department of BioMolecular Science, University of Science and Technology in Korea and

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http://dx.doi.org/10.1093/carcin/bgv045DOI Listing
June 2015

Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells.

Phytother Res 2015 May 13;29(5):749-56. Epub 2015 Feb 13.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 125 Gwahakro Yoosunggu, Daejeon, 305-600, Republic of Korea.

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http://doi.wiley.com/10.1002/ptr.5311
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http://dx.doi.org/10.1002/ptr.5311DOI Listing
May 2015

Ginkgetin inhibits the growth of DU-145 prostate cancer cells through inhibition of signal transducer and activator of transcription 3 activity.

Cancer Sci 2015 Apr 20;106(4):413-20. Epub 2015 Feb 20.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea; Korea University of Science and Technology, Daejeon, Korea.

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http://dx.doi.org/10.1111/cas.12608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409885PMC
April 2015

Dual pH-sensitive oxidative stress generating micellar nanoparticles as a novel anticancer therapeutic agent.

J Control Release 2014 Dec 30;196:19-27. Epub 2014 Sep 30.

Department of BIN Fusion Technology, Chonbuk National University, Baekje-daero 567, Jeonju, Chonbuk, 561-756, Republic of Korea; Polymer Fusion Research Center, Department of Polymer Nano Science and Technology, Chonbuk National University, Baekje-daero 567,Jeonju, Chonbuk, 561-756, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.09.017DOI Listing
December 2014

LRP1-dependent pepsin clearance induced by 2'-hydroxycinnamaldehyde attenuates breast cancer cell invasion.

Int J Biochem Cell Biol 2014 Aug 4;53:15-23. Epub 2014 May 4.

Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu 700-412, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.04.021DOI Listing
August 2014

EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer.

Cancer Lett 2014 Jul 1;349(1):35-44. Epub 2014 Apr 1.

Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu 700-412, South Korea. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.03.025DOI Listing
July 2014

Inhibition of STAT3 activation by KT-18618 via the disruption of the interaction between JAK3 and STAT3.

Biochem Pharmacol 2014 May 4;89(1):62-73. Epub 2014 Mar 4.

Laboratory of Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Daejeon 305-806, Republic of Korea; University of Science and Technology in Korea, 125 Gwahakro, Daejeon 305-806, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.02.017DOI Listing
May 2014

Inhibitory effects of obovatol on osteoclast differentiation and bone resorption.

Eur J Pharmacol 2014 Jan 24;723:473-80. Epub 2013 Oct 24.

Skeletal Diseases Genome Research Center, Kyungpook National University and Hospital, Daegu 700-412, Republic of Korea; Department of Orthopedic Surgery, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2013.10.027DOI Listing
January 2014

Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.

Bioorg Med Chem Lett 2013 Jul 9;23(13):3769-74. Epub 2013 May 9.

Laboratory of Chemical Genomics and Biology, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 125 Gwahakro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2013.04.092DOI Listing
July 2013

Activation of AMP-Activated Protein Kinase α and Extracelluar Signal-Regulated Kinase Mediates CB-PIC-Induced Apoptosis in Hypoxic SW620 Colorectal Cancer Cells.

Evid Based Complement Alternat Med 2013 26;2013:974313. Epub 2013 Mar 26.

College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.

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http://dx.doi.org/10.1155/2013/974313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622407PMC
April 2013

In vitro metabolism of obovatol and its effect on cytochrome P450 enzyme activities in human liver microsomes.

Biopharm Drug Dispos 2013 May 26;34(4):195-202. Epub 2013 Mar 26.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Korea.

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http://dx.doi.org/10.1002/bdd.1837DOI Listing
May 2013

2-Hydroxycinnamaldehyde inhibits the epithelial-mesenchymal transition in breast cancer cells.

Breast Cancer Res Treat 2013 Feb 3;137(3):697-708. Epub 2013 Jan 3.

Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.

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http://dx.doi.org/10.1007/s10549-012-2388-7DOI Listing
February 2013

Early growth response protein 1 upregulation and nuclear translocation by 2'-benzoyloxycinnamaldehyde induces prostate cancer cell death.

Cancer Lett 2013 Feb 23;329(2):217-27. Epub 2012 Nov 23.

Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu 700-412, South Korea.

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http://dx.doi.org/10.1016/j.canlet.2012.11.006DOI Listing
February 2013

2'-Benzoyloxycinnamaldehyde inhibits nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells via regulation of AP-1 pathway.

Eur J Pharmacol 2012 Dec 1;696(1-3):179-86. Epub 2012 Oct 1.

Department of Biochemistry, Dongguk University College of Oriental Medicine, 707 Seokjang-dong, Gyeongju-si, Gyeongsangbuk-do 780-714, Korea.

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http://dx.doi.org/10.1016/j.ejphar.2012.09.027DOI Listing
December 2012

Cryptotanshinone and tanshinone IIA enhance IL-15-induced natural killer cell differentiation.

Biochem Biophys Res Commun 2012 Aug 26;425(2):340-7. Epub 2012 Jul 26.

Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2012.07.093DOI Listing
August 2012

2'-Benzoyloxycinnamaldehyde-mediated DJ-1 upregulation protects MCF-7 cells from mitochondrial damage.

Biol Pharm Bull 2012 ;35(6):895-902

Department of Oral Microbiology, School of Dentistry, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.1248/bpb.35.895DOI Listing
October 2012

Natural flavone jaceosidin is a neuroinflammation inhibitor.

Phytother Res 2013 Mar 23;27(3):404-11. Epub 2012 May 23.

Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Korea.

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http://dx.doi.org/10.1002/ptr.4737DOI Listing
March 2013

Obovatol improves cognitive functions in animal models for Alzheimer's disease.

J Neurochem 2012 Mar 10;120(6):1048-59. Epub 2012 Feb 10.

College of Pharmacy and MRC, Chungbuk National University, Heungduk-gu, Cheongju, Chungbuk, South Korea.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07642.xDOI Listing
March 2012

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity.

Bioorg Med Chem Lett 2012 Jan 9;22(1):323-6. Epub 2011 Nov 9.

Laboratory of Chemical Genomics and Biology, Korea Research Institute of Bioscience and Biotechnology, 1125 Gwahakro, Yoosunggu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.008DOI Listing
January 2012

Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells.

Int J Cancer 2012 Aug 11;131(3):E190-203. Epub 2012 Jan 11.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Yuseonggu, Daejon, Republic of Korea.

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http://dx.doi.org/10.1002/ijc.27381DOI Listing
August 2012

Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell.

Bioorg Med Chem 2011 Dec 17;19(24):7582-9. Epub 2011 Oct 17.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahakro, Yoosung, Daejeon 305-806, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S096808961100833
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http://dx.doi.org/10.1016/j.bmc.2011.10.025DOI Listing
December 2011

The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.

Laryngoscope 2012 Jan 4;122(1):162-6. Epub 2011 Nov 4.

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.

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http://dx.doi.org/10.1002/lary.21781DOI Listing
January 2012

Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression.

Bioorg Med Chem Lett 2011 Dec 13;21(24):7363-6. Epub 2011 Oct 13.

Laboratory of Chemical Genomics, Pharmacology Research Center, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2011.10.020DOI Listing
December 2011

Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage.

J Neuroimmune Pharmacol 2012 Mar 28;7(1):173-86. Epub 2011 Jul 28.

Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.

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http://link.springer.com/content/pdf/10.1007/s11481-011-9300
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http://link.springer.com/10.1007/s11481-011-9300-9
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http://dx.doi.org/10.1007/s11481-011-9300-9DOI Listing
March 2012

Antiplatelet activity of obovatol, a biphenolic component of Magnolia Obovata, in rat arterial thrombosis and rabbit platelet aggregation.

J Atheroscler Thromb 2011 21;18(8):659-69. Epub 2011 Apr 21.

College of Pharmacy, Chungbuk National University, Cheongju, Republic of Korea.

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http://dx.doi.org/10.5551/jat.7427DOI Listing
January 2012

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor.

Bioorg Med Chem Lett 2011 Feb 13;21(3):977-9. Epub 2010 Dec 13.

Bio-Therapeutics Research Institute, KRIBB, Ochang, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2010.12.044DOI Listing
February 2011

2-Hydroxycurcuminoid induces apoptosis of human tumor cells through the reactive oxygen species-mitochondria pathway.

Bioorg Med Chem Lett 2011 Jan 28;21(2):747-51. Epub 2010 Nov 28.

Laboratory of Chemical Biology and Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yoosung, Daejeon 305-806, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2010.11.114DOI Listing
January 2011

Inhibitory activities of anthraquinones from Rubia akane on phosphatase regenerating liver-3.

Arch Pharm Res 2010 Nov 30;33(11):1747-51. Epub 2010 Nov 30.

Woosuk University, Samrye, Korea.

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http://dx.doi.org/10.1007/s12272-010-1106-4DOI Listing
November 2010

Differential antiproliferation effect of 2'-benzoyloxycinnamaldehyde in K-ras-transformed cells via downregulation of thiol antioxidants.

Cancer Sci 2011 Jan 22;102(1):212-8. Epub 2010 Nov 22.

Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01781.xDOI Listing
January 2011

2'-Hydroxycinnamaldehyde targets low-density lipoprotein receptor-related protein-1 to inhibit lipopolysaccharide-induced microglial activation.

J Neuroimmunol 2011 Jan 8;230(1-2):52-64. Epub 2010 Oct 8.

Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, Daegu, Republic of Korea.

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http://dx.doi.org/10.1016/j.jneuroim.2010.08.021DOI Listing
January 2011

Obovatol attenuates microglia-mediated neuroinflammation by modulating redox regulation.

Br J Pharmacol 2010 Apr;159(8):1646-62

Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925488PMC
http://dx.doi.org/10.1111/j.1476-5381.2010.00659.xDOI Listing
April 2010

2'-Hydroxycinnamaldehyde shows antitumor activity against oral cancer in vitro and in vivo in a rat tumor model.

Anticancer Res 2010 Feb;30(2):489-94

Department of Biochemistry, Dongguk University College of Oriental Medicine, Gyeongju 780-714, South Korea.

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February 2010

Obovatol from Magnolia obovata inhibits vascular smooth muscle cell proliferation and intimal hyperplasia by inducing p21Cip1.

Atherosclerosis 2010 Jun 29;210(2):372-80. Epub 2009 Nov 29.

Research Institute of Veterinary Medicine, Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.

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http://dx.doi.org/10.1016/j.atherosclerosis.2009.11.037DOI Listing
June 2010

A novel benzimidazole analogue inhibits the hypoxia-inducible factor (HIF)-1 pathway.

Biochem Biophys Res Commun 2009 Jul 9;385(1):16-21. Epub 2009 May 9.

Medical Genome Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, South Korea.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.022DOI Listing
July 2009

Farnesyl protein transferase inhibitory components of Polygonum multiflorum.

Arch Pharm Res 2009 Apr 29;32(4):495-9. Epub 2009 Apr 29.

Korea Research Institute of Bioscience and Biotechnology, KIST, Daejeon, 305-333, Korea.

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http://dx.doi.org/10.1007/s12272-009-1403-yDOI Listing
April 2009

Obovatol isolated from Magnolia obovata enhances pentobarbital-induced sleeping time: Possible involvement of GABAA receptors/chloride channel activation.

Phytomedicine 2009 Apr 6;16(4):308-13. Epub 2009 Feb 6.

College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea.

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http://dx.doi.org/10.1016/j.phymed.2008.12.007DOI Listing
April 2009

Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells.

Cancer Res 2009 Jan;69(1):193-202

Laboratory of Chemical Biology and Chemical Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Daejeon, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2575DOI Listing
January 2009

Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis.

Bioorg Med Chem 2008 Sep 19;16(18):8397-402. Epub 2008 Aug 19.

Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, 52 Uendong, Yuseonggu, Daejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2008.08.033DOI Listing
September 2008

Isolation of Sorangium cellulosum carrying epothilone gene clusters.

J Microbiol Biotechnol 2008 Aug;18(8):1416-22

Myxobacteria Bank, Department of Biotechnology, Hoseo University, Asan 336-795, Korea.

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August 2008

Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity.

Eur J Pharmacol 2008 Jun 18;588(1):106-13. Epub 2008 Apr 18.

Department of Pharmacology, Brain Science and Engineering Institute, CMRI, Kyungpook National University School of Medicine, 101 Dong-In, Joong-gu, Daegu, 700-422, Republic of Korea.

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http://linkinghub.elsevier.com/retrieve/pii/S001429990800455
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http://dx.doi.org/10.1016/j.ejphar.2008.04.035DOI Listing
June 2008

Biphenyl versus phenylpyridazine derivatives: the role of the heterocycle in a series of acyl-CoA:cholesterol acyl transferase inhibitors.

J Med Chem 2008 Mar 20;51(5):1474-7. Epub 2008 Feb 20.

Istituto di Chimica Farmaceutica e Tossicologica, Universita di Milano, Milano, Italy.

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http://pubs.acs.org/doi/abs/10.1021/jm701474c
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http://dx.doi.org/10.1021/jm701474cDOI Listing
March 2008

Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity.

Int Immunopharmacol 2008 Mar 16;8(3):484-94. Epub 2008 Jan 16.

Department of Pharmacology, School of Medicine, Brain Science and Engineering Institute, CMRI, Kyungpook National University, Daegu, Republic of Korea.

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http://dx.doi.org/10.1016/j.intimp.2007.12.012DOI Listing
March 2008

KRIBB3, a novel microtubule inhibitor, induces mitotic arrest and apoptosis in human cancer cells.

Biochem Pharmacol 2008 Jan 30;75(2):383-94. Epub 2007 Aug 30.

Molecular Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong Yuseong-gu, Daejeon 305-806, Republic of Korea.

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http://dx.doi.org/10.1016/j.bcp.2007.08.027DOI Listing
January 2008

Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents.

Bioorg Med Chem Lett 2007 Oct 25;17(19):5423-7. Epub 2007 Jul 25.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Daejeon 305-333, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmcl.2007.07.033DOI Listing
October 2007

Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells.

Biochem Pharmacol 2007 Aug 24;74(4):557-65. Epub 2007 May 24.

Department of Dental Microbiology, School of Dentistry, Kyungpook National University, Daegu 700-412, Republic of Korea.

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http://dx.doi.org/10.1016/j.bcp.2007.05.016DOI Listing
August 2007

Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

Nat Prod Res 2007 May;21(6):487-93

Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology in Korea, Yoosung-Gu, Daejeon, Republic of Korea.

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http://dx.doi.org/10.1080/14786410601012265DOI Listing
May 2007

Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines.

Arch Pharm Res 2007 Apr;30(4):402-7

Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon, Korea.

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http://dx.doi.org/10.1007/BF02980211DOI Listing
April 2007

Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2.

Bioorg Med Chem 2007 Jun 30;15(12):4085-90. Epub 2007 Mar 30.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2007.03.081DOI Listing
June 2007

Inhibition of chitin synthases and antifungal activities by 2'-benzoyloxycinnamaldehyde from Pleuropterus ciliinervis and its derivatives.

Biol Pharm Bull 2007 Mar;30(3):598-602

Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

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http://dx.doi.org/10.1248/bpb.30.598DOI Listing
March 2007

Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of Ixeris dentata forma albiflora.

Arch Pharm Res 2006 Nov;29(11):937-41

Department of Herbal Food Science, Daegu Haany University, Gyeongsan, 712-715, Korea.

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http://dx.doi.org/10.1007/BF02969274DOI Listing
November 2006

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).

Nat Prod Res 2006 Apr;20(4):341-6

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1080/14786410500463312DOI Listing
April 2006

Acyl-CoA: cholesterol acyltransferase inhibitors from Ilex macropoda.

Arch Pharm Res 2006 Mar;29(3):191-4

College of Pharmacy, Woosuk University, Samrye, Korea.

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http://dx.doi.org/10.1007/BF02969391DOI Listing
March 2006

Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase.

Arch Pharm Res 2006 Jan;29(1):64-6

College of Pharmacy, Woosuk University, Samrye 565-701, Korea.

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January 2006

Delayed occurrence of H-ras12V-induced hepatocellular carcinoma with long-term treatment with cinnamaldehydes.

Eur J Pharmacol 2006 Jan;530(3):270-5

Department of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Oun-Dong, Yusong-Gu, Taejeon 305-806, Korea.

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http://dx.doi.org/10.1016/j.ejphar.2005.11.053DOI Listing
January 2006

Synthesis and biological evaluation of dimeric cinnamaldehydes as potent antitumor agents.

Bioorg Med Chem 2006 Apr 15;14(8):2498-506. Epub 2005 Dec 15.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Taejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2005.11.028DOI Listing
April 2006

Confirmation of a linkage between H-Ras and MMP-13 expression as well as MMP-9 by chemical genomic approach.

Int J Cancer 2006 May;118(9):2172-81

Korea Research Institute of Bioscience and Biotechnology, Yoosunggu, Taejon 305-600, Korea.

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http://dx.doi.org/10.1002/ijc.21610DOI Listing
May 2006

Cyclic diarylheptanoids inhibit cell-mediated low-density lipoprotein oxidation.

Nat Prod Res 2006 Feb;20(2):139-43

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1080/14786410500045895DOI Listing
February 2006

Mono- or diphenylpyridazines connected to N-(2,4-difluorophenyl)-N'-heptylurea as acyl-CoA:cholesterol acyltransferase inhibitors.

J Med Chem 2005 Dec;48(24):7708-13

Istituto di Chimica Farmaceutica e Tossicologica, Università di Milano, Viale Abruzzi 42, 20131 Milano, Italy.

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http://dx.doi.org/10.1021/jm050703xDOI Listing
December 2005

Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen.

Life Sci 2006 Apr 9;78(19):2204-12. Epub 2005 Nov 9.

Korea Research Institute of Bioscience and Biotechnology, Taejeon, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2005.09.029DOI Listing
April 2006

Cyclic diarylheptanoids inhibit cell mediated low-density lipoprotein oxidation.

Nat Prod Res 2006 Jan;20(1):37-41

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

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http://dx.doi.org/10.1080/14786410500081494DOI Listing
January 2006

Blocking tumor cell migration and invasion with biphenyl isoxazole derivative KRIBB3, a synthetic molecule that inhibits Hsp27 phosphorylation.

J Biol Chem 2005 Dec 18;280(50):41439-48. Epub 2005 Oct 18.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Daejeon 305-600, Korea.

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http://dx.doi.org/10.1074/jbc.M507209200DOI Listing
December 2005

Inhibition of Shc/Grb2 protein-protein interaction suppresses growth of B104-1-1 tumors xenografted in nude mice.

Life Sci 2005 Dec 16;78(3):321-8. Epub 2005 Sep 16.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yusung Taejon, 305-333, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2005.04.067DOI Listing
December 2005

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.

Life Sci 2006 Jan 19;78(6):607-13. Epub 2005 Aug 19.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2005.05.066DOI Listing
January 2006

Protein binding characteristics of 2'-benzoyloxycinnamaldehyde.

Drug Dev Ind Pharm 2005 Jul;31(6):545-9

College of Pharmacy, Pusan National University, Pusan, Korea.

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http://dx.doi.org/10.1080/03639040500215651DOI Listing
July 2005

Cyclopentenediones, inhibitors of farnesyl protein transferase and anti-tumor compounds, isolated from the fruit of Lindera erythrocarpa Makino.

Bioorg Med Chem 2005 Nov 1;13(22):6182-7. Epub 2005 Aug 1.

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosung, Taejeon 305-600, Republic of Korea.

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http://dx.doi.org/10.1016/j.bmc.2005.06.029DOI Listing
November 2005

Triterpenoids from the flower of Campsis grandiflora K. Schum. as human acyl-CoA: cholesterol acyltransferase inhibitors.

Arch Pharm Res 2005 May;28(5):550-6

Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 449-701, Korea.

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http://dx.doi.org/10.1007/BF02977757DOI Listing
May 2005

Ergosterol peroxide from flowers of Erigeron annuus L. as an anti-atherosclerosis agent.

Arch Pharm Res 2005 May;28(5):541-5

Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 449-701, Korea.

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http://dx.doi.org/10.1007/BF02977755DOI Listing
May 2005