Byoung S Kwon

Byoung S Kwon

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Delayed IL-21 treatment preferentially expands peptide-specific CD8 T cells by reducing bystander activation of T cells.

Immunotherapy 2019 04 14;11(6):497-513. Epub 2019 Feb 14.

Biomedicine Production Branch, National Cancer Center, Goyang, 10408 Korea.

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http://dx.doi.org/10.2217/imt-2018-0095DOI Listing
April 2019

The hyaluronic acid-rich node and duct system is a structure organized for innate immunity and mediates the local inflammation.

Cytokine 2019 01 12;113:74-82. Epub 2018 Jun 12.

Eutilex, Co., Ltd., Suite# 1401, Daeryung Technotown 17 Gasan digital 1-ro 25, Geumcheon-gu, Seoul 08594, Republic of Korea; Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183025
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http://dx.doi.org/10.1016/j.cyto.2018.06.011DOI Listing
January 2019

RELT negatively regulates the early phase of the T-cell response in mice.

Eur J Immunol 2018 10 2;48(10):1739-1749. Epub 2018 Sep 2.

Eutilex, Co., Ltd., Seoul, Korea.

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http://dx.doi.org/10.1002/eji.201847633DOI Listing
October 2018

Harnessing immune checkpoints for cancer therapy.

Immunotherapy 2018 10;10(14):1265-1284

Section of Clinical Immunology, Allergy & Rheumatology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.

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https://www.futuremedicine.com/doi/10.2217/imt-2017-0168
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http://dx.doi.org/10.2217/imt-2017-0168DOI Listing
October 2018

Cancer immunotherapy using tumor antigen-reactive T cells.

Immunotherapy 2018 03;10(3):235-245

Eutilex, Suite 1401 Daeryung Technotown 17, Gasan Digital 1-ro 25, Geumcheon-gu, Seoul, Korea 08594.

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http://dx.doi.org/10.2217/imt-2017-0130DOI Listing
March 2018

Chimeric antigen receptor T-cell therapy for cancer: a basic research-oriented perspective.

Immunotherapy 2018 03;10(3):221-234

Immunotherapeutics Branch, Division of Convergence Technology Research Institute, National Cancer Center, Goyang 10408, Korea.

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http://dx.doi.org/10.2217/imt-2017-0133DOI Listing
March 2018

Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.

Cancer Res 2017 11 18;77(21):5989-6000. Epub 2017 Sep 18.

School of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-0610DOI Listing
November 2017

4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8 T cell proliferation.

Cell Mol Immunol 2017 Sep 14;14(9):748-757. Epub 2016 Mar 14.

Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi 10408, Korea.

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http://dx.doi.org/10.1038/cmi.2016.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5596242PMC
September 2017

The repopulating cancer cells in melanoma are characterized by increased mitochondrial membrane potential.

Cancer Lett 2016 11 5;382(2):186-194. Epub 2016 Sep 5.

T Cell Therapy Unit, Eutilex Research Institute of Biomedicine, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea; Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.08.027DOI Listing
November 2016

Therapeutic potential of anti-CD137 (4-1BB) monoclonal antibodies.

Expert Opin Ther Targets 2016 1;20(3):361-73. Epub 2015 Oct 1.

a 1 Tulane University, Section of Clinical Immunology, Allergy and Rheumatology, Department of Medicine , New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1517/14728222.2016.1091448DOI Listing
September 2016

Immunophenotyping of Stage III Melanoma Reveals Parameters Associated with Patient Prognosis.

J Invest Dermatol 2016 05 29;136(5):994-1001. Epub 2016 Jan 29.

INSERM U1015, Gustave Roussy Cancer Center, Villejuif, France; University Paris Saclay, Kremlin Bicêtre, France; Gustave Roussy Cancer Center, Villejuif, France; CIC Biothérapie IGR Curie CIC1428, Gustave Roussy Cancer Center, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2015.12.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156792PMC
May 2016

Phase I Clinical Trial of 4-1BB-based Adoptive T-Cell Therapy for Epstein-Barr Virus (EBV)-positive Tumors.

J Immunother 2016 Apr;39(3):140-8

*Hematologic Oncology Clinic, Center for Specific Organs Cancer, National Cancer Center, Korea †Center for Clinical Trial, National Cancer Center, Korea ‡Cancer Immunology Branch, Division of Cancer Biology §Immune Cell Production Unit, Program for Immunotherapeutic Research, Research Institute and Hospital, National Cancer Center, Ilsandong-gu, Goyang, Gyeonggi ∥Department of Hematology-Oncology, Chonnam National University Medical School, Gwangju, Korea ¶Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA.

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http://dx.doi.org/10.1097/CJI.0000000000000113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834812PMC
April 2016

Depletion of Alloreactive T-Cells by Anti-CD137-Saporin Immunotoxin.

Cell Transplant 2015 3;24(6):1167-81. Epub 2014 Mar 3.

Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Republic of Korea.

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http://dx.doi.org/10.3727/096368914X679327DOI Listing
March 2016

4-1BB Signaling Enhances Primary and Secondary Population Expansion of CD8+ T Cells by Maximizing Autocrine IL-2/IL-2 Receptor Signaling.

PLoS One 2015 11;10(5):e0126765. Epub 2015 May 11.

Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Ilsan, Goyang, Gyeonggi, Korea; Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126765PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427336PMC
February 2016

Immune evasion in cancer: Mechanistic basis and therapeutic strategies.

Semin Cancer Biol 2015 Dec 25;35 Suppl:S185-S198. Epub 2015 Mar 25.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, United States; Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2015.03.004DOI Listing
December 2015

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted.

J Immunol 2015 Nov 30;195(10):4721-9. Epub 2015 Sep 30.

Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Gyeonggi, 410-769, Republic of Korea; Program for Immunotherapeutic Research, National Cancer Center, Gyeonggi, 410-769, Republic of Korea; and Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112

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http://dx.doi.org/10.4049/jimmunol.1403076DOI Listing
November 2015

A Hyaluronic Acid-Rich Node and Duct System in Which Pluripotent Adult Stem Cells Circulate.

Stem Cells Dev 2015 Oct 10;24(19):2243-58. Epub 2015 Aug 10.

1 Cancer Immunology Branch, National Cancer Center , Ilsan, Gyeonggi, Korea.

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https://www.liebertpub.com/doi/10.1089/scd.2015.0024
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http://dx.doi.org/10.1089/scd.2015.0024DOI Listing
October 2015

Glucocorticoid-induced tumor necrosis factor receptor-related protein co-stimulation facilitates tumor regression by inducing IL-9-producing helper T cells.

Nat Med 2015 Sep 17;21(9):1010-7. Epub 2015 Aug 17.

Laboratory of Immunology, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

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http://dx.doi.org/10.1038/nm.3922DOI Listing
September 2015

In vivo 4-1BB deficiency in myeloid cells enhances peripheral T cell proliferation by increasing IL-15.

J Immunol 2015 Feb 19;194(4):1580-90. Epub 2015 Jan 19.

Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Gyeonggi 410-769, Republic of Korea; Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1303439
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http://dx.doi.org/10.4049/jimmunol.1303439DOI Listing
February 2015

Adult stem cells from the hyaluronic acid-rich node and duct system differentiate into neuronal cells and repair brain injury.

Stem Cells Dev 2014 Dec 18;23(23):2831-40. Epub 2014 Aug 18.

1 Cancer Immunology Branch, National Cancer Center , Ilsan, Gyeonggi, Korea.

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http://dx.doi.org/10.1089/scd.2014.0142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235983PMC
December 2014

Nonmarrow hematopoiesis occurs in a hyaluronic-acid-rich node and duct system in mice.

Stem Cells Dev 2014 Nov 14;23(21):2661-71. Epub 2014 Jul 14.

1 Cancer Biology and Immunotherapy, National Cancer Center , Goyang, Korea.

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http://dx.doi.org/10.1089/scd.2014.0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201297PMC
November 2014

4-1BB-based isolation and expansion of CD8+ T cells specific for self-tumor and non-self-tumor antigens for adoptive T-cell therapy.

J Immunother 2014 May;37(4):225-36

*Immune & Cell Therapy Branch, Division of Cancer Biology ‡Biomedicine Production Branch §Center for Gastric Cancer, National Cancer Center, Goyang †Personalized Medicine System R&D Center, Bio-Support Co., Ltd, Gwanyang, Dongan, Anyang, Gyeonggi ∥Department of Surgery, Kosin University College of Medicine, Busan, Korea ¶T Cell Technologies Inc., Nagoya, Aichi, Japan #Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA.

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http://dx.doi.org/10.1097/CJI.0000000000000027DOI Listing
May 2014

4-1BB (CD137), an inducible costimulatory receptor, as a specific target for cancer therapy.

BMB Rep 2014 Mar;47(3):122-9

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA70112, USA; Cell and Immunobiology, and R & D Center for Cancer Therapeutics, National Cancer Center, Goyang 410-769, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163883PMC
http://dx.doi.org/10.5483/bmbrep.2014.47.3.283DOI Listing
March 2014

TLR2 signaling in tubular epithelial cells regulates NK cell recruitment in kidney ischemia-reperfusion injury.

J Immunol 2013 Sep 31;191(5):2657-64. Epub 2013 Jul 31.

Biomedical Research Center, Ulsan University Hospital, School of Medicine, University of Ulsan, Ulsan 682-714, Korea.

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http://dx.doi.org/10.4049/jimmunol.1300358DOI Listing
September 2013

4-1BB signal stimulates the activation, expansion, and effector functions of γδ T cells in mice and humans.

Eur J Immunol 2013 Jul 12;43(7):1839-48. Epub 2013 Jun 12.

Immune & Cell Therapy Branch, National Cancer Center, Ilsan, Gyeonggi-do, Korea.

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http://dx.doi.org/10.1002/eji.201242842DOI Listing
July 2013

Exposure of a distinct PDCA-1+ (CD317) B cell population to agonistic anti-4-1BB (CD137) inhibits T and B cell responses both in vitro and in vivo.

PLoS One 2012 21;7(11):e50272. Epub 2012 Nov 21.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3503989PMC
May 2013

CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.

Eur J Immunol 2013 Mar 31;43(3):667-78. Epub 2013 Jan 31.

Cancer Immunology Branch, Division of Cancer Biology, National Cancer Center, Goyang, Korea.

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http://dx.doi.org/10.1002/eji.201242997DOI Listing
March 2013

Microscopic nodes and ducts inside lymphatics and on the surface of internal organs are rich in granulocytes and secretory granules.

Cytokine 2012 Nov 10;60(2):587-92. Epub 2012 Aug 10.

Cancer Biology and Immunotherapy, National Cancer Center, Ilsan, Kyunggi-do, Republic of Korea.

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http://dx.doi.org/10.1016/j.cyto.2012.07.016DOI Listing
November 2012

Immunotherapy of cancer with 4-1BB.

Mol Cancer Ther 2012 May 24;11(5):1062-70. Epub 2012 Apr 24.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-11-0677DOI Listing
May 2012

Targeting TNF superfamily members for therapeutic intervention in rheumatoid arthritis.

Cytokine 2012 Mar 30;57(3):305-12. Epub 2011 Dec 30.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1016/j.cyto.2011.12.005DOI Listing
March 2012

Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation.

Proc Natl Acad Sci U S A 2012 Jan 12;109(1):E13-22. Epub 2011 Dec 12.

School of Biological Sciences, Department of Internal Medicine, University of Ulsan, Ulsan 680-749, Korea.

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http://dx.doi.org/10.1073/pnas.1112256109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252952PMC
January 2012

Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo.

Cytokine 2011 Sep 22;55(3):420-8. Epub 2011 Jun 22.

Immune and Cell Therapy Branch, Division of Cancer Biology, R&D Center for Cancer Therapeutics, National Cancer Center, 809 Madu, Ilsan, Goyang, Kyeonggi-do 411-769, Republic of Korea.

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https://linkinghub.elsevier.com/retrieve/pii/S10434666110016
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http://dx.doi.org/10.1016/j.cyto.2011.05.015DOI Listing
September 2011

4-1BB triggering ameliorates experimental autoimmune encephalomyelitis by modulating the balance between Th17 and regulatory T cells.

J Immunol 2011 Aug 29;187(3):1120-8. Epub 2011 Jun 29.

Immune and Cell Therapy Branch, Division of Cancer Biology, National Cancer Center, Goyang-si, Gyeongi-do 410-769, Korea.

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http://www.jimmunol.org/content/187/3/1120.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1002681
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1002681DOI Listing
August 2011

4-1BB signaling beyond T cells.

Cell Mol Immunol 2011 Jul 10;8(4):281-4. Epub 2011 Jan 10.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1038/cmi.2010.82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002439PMC
July 2011

Regulation of mouse 4-1BB expression: multiple promoter usages and a splice variant.

Mol Cells 2011 Feb 11;31(2):141-9. Epub 2011 Jan 11.

Biomedical Research Center, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.

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http://dx.doi.org/10.1007/s10059-011-0018-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932682PMC
February 2011

Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells.

Exp Mol Med 2010 Dec;42(12):805-10

Department of Biological Science and the Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015154PMC
http://dx.doi.org/10.3858/emm.2010.42.12.083DOI Listing
December 2010

CD11c+CD8+ T cells: two-faced adaptive immune regulators.

Cell Immunol 2010 27;264(1):18-22. Epub 2010 May 27.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1016/j.cellimm.2010.05.010DOI Listing
September 2010

Peripheral 4-1BB signaling negatively regulates NK cell development through IFN-gamma.

J Immunol 2010 Aug 7;185(3):1404-11. Epub 2010 Jul 7.

Division of Cell and Immunobiology, National Cancer Center, 809 Madu, Ilsan, Goyang, Kyounggi-do 411-769, Korea.

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http://dx.doi.org/10.4049/jimmunol.1000850DOI Listing
August 2010

CD137 is required for M cell functional maturation but not lineage commitment.

Am J Pathol 2010 Aug 8;177(2):666-76. Epub 2010 Jul 8.

Division of Biomedical Sciences, University of California, Riverside, Riverside, CA 92521, USA.

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http://dx.doi.org/10.2353/ajpath.2010.090811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913358PMC
August 2010

CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice.

Circulation 2010 Mar 22;121(9):1124-33. Epub 2010 Feb 22.

Division of Life and Pharmaceutical Science, Ewha Womans University, Seoul, Korea.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.109.882704DOI Listing
March 2010

PDCA expression by B lymphocytes reveals important functional attributes.

J Immunol 2010 Jan 16;184(2):807-15. Epub 2009 Dec 16.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.4049/jimmunol.0902528DOI Listing
January 2010

Expression of 4-1BB and 4-1BBL in thymocytes during thymus regeneration.

Exp Mol Med 2009 Dec;41(12):896-911

Department of Pediatrics, Pusan National University School of Medicine, Yangsan 626-870, Korea.

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http://dx.doi.org/10.3858/emm.2009.41.12.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802685PMC
December 2009

In vitro development of a hemangioblast from a human embryonic stem cell, SNUhES#3.

Life Sci 2009 Jul 3;85(1-2):39-45. Epub 2009 May 3.

IRC, Department of Biological Sciences, University of Ulsan, Ulsan, Republic of Korea.

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http://dx.doi.org/10.1016/j.lfs.2009.04.008DOI Listing
July 2009

Origins and functional basis of regulatory CD11c+CD8+ T cells.

Eur J Immunol 2009 Jun;39(6):1552-63

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1002/eji.200839057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748059PMC
June 2009

IFN-gamma-indoleamine-2,3 dioxygenase acts as a major suppressive factor in 4-1BB-mediated immune suppression in vivo.

J Leukoc Biol 2009 May 13;85(5):817-25. Epub 2009 Feb 13.

Division of Cell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, Kyonggi-do, Korea.

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http://dx.doi.org/10.1189/jlb.0408246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669405PMC
May 2009

TNF superfamily: costimulation and clinical applications.

Cell Biol Int 2009 Apr 20;33(4):453-65. Epub 2009 Feb 20.

Section of Clinical Immunology, Allergy, and Rheumatology, Department of Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

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http://dx.doi.org/10.1016/j.cellbi.2009.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712666PMC
April 2009

4-1BB functions as a survival factor in dendritic cells.

J Immunol 2009 Apr;182(7):4107-15

R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Korea.

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http://dx.doi.org/10.4049/jimmunol.0800459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681223PMC
April 2009

Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy.

Mol Cancer Ther 2009 Feb 3;8(2):469-78. Epub 2009 Feb 3.

Division of Cell and Immunobiology, and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Goyang, Kyounggi-do, Korea.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0993DOI Listing
February 2009

Combination therapy with cisplatin and anti-4-1BB: synergistic anticancer effects and amelioration of cisplatin-induced nephrotoxicity.

Cancer Res 2008 Sep;68(18):7264-9

Division of Cell and Immunobiology, and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan, Goyang, Kyeonggi-do, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551756PMC
September 2008

Comparative analysis of the expression patterns of various TNFSF/TNFRSF in atherosclerotic plaques.

Immunol Invest 2008 ;37(4):359-73

Department of Genetic Engineering, School of Life Sciences and Biotechnology School of Medicine, Kyungpook National University, Daegu, Korea.

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http://dx.doi.org/10.1080/08820130802123139DOI Listing
August 2008

Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.

Nat Immunol 2008 Aug 6;9(8):917-26. Epub 2008 Jul 6.

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA.

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http://www.nature.com/articles/ni.1632
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http://dx.doi.org/10.1038/ni.1632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561255PMC
August 2008

MCP-1 derived from stromal keratocyte induces corneal infiltration of CD4+ T cells in herpetic stromal keratitis.

Mol Cells 2008 Jul 2;26(1):67-73. Epub 2008 Jul 2.

The Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.

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July 2008

Regulation of the murine TR2/HVEM gene expression by IRF.

Biochem Biophys Res Commun 2008 Mar 26;367(2):277-83. Epub 2007 Dec 26.

Department of Biological Science and the Immunomodulation Research Center, University of Ulsan, San29 Mugeo-Dong, Nam-Gu, Ulsan 680-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2007.12.071DOI Listing
March 2008

Potent costimulation of human CD8 T cells by anti-4-1BB and anti-CD28 on synthetic artificial antigen presenting cells.

Cancer Immunol Immunother 2008 Feb 27;57(2):175-83. Epub 2007 Jul 27.

Department of Immunology, Institute for Cell Biology, University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

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http://link.springer.com/10.1007/s00262-007-0360-x
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http://dx.doi.org/10.1007/s00262-007-0360-xDOI Listing
February 2008

4-1BB engagement costimulates NKT cell activation and exacerbates NKT cell ligand-induced airway hyperresponsiveness and inflammation.

J Immunol 2008 Feb;180(4):2062-8

Laboratory of Immunology and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Shillim-9-dong, Kwanak-gu, Seoul, Republic of Korea.

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http://dx.doi.org/10.4049/jimmunol.180.4.2062DOI Listing
February 2008

Reverse signaling initiated from GITRL induces NF-kappaB activation through ERK in the inflammatory activation of macrophages.

Mol Immunol 2008 Jan 28;45(2):523-33. Epub 2007 Jun 28.

Department of Genetic Engineering, School of Life Sciences and Biotechology, Kyungpook National University, Taegu 702-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.molimm.2007.05.013DOI Listing
January 2008

Role of endogenous 4-1BB in the development of systemic lupus erythematosus.

Immunology 2007 Nov 29;122(3):394-400. Epub 2007 Jun 29.

LSU Eye Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA, USA.

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http://dx.doi.org/10.1111/j.1365-2567.2007.02653.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2266025PMC
November 2007

HVEM signaling in monocytes is mediated by intracellular calcium mobilization.

J Immunol 2007 Nov;179(9):6305-10

Department of Biomedicine, Immunomodulation Research Center, University of Ulsan, Ulsan, South Korea.

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http://dx.doi.org/10.4049/jimmunol.179.9.6305DOI Listing
November 2007

Absence of 4 1BB gene function exacerbates lacrimal gland inflammation in autoimmune-prone MRL-Faslpr mice.

Invest Ophthalmol Vis Sci 2007 Oct;48(10):4608-15

LSU Eye Center, LSU Health Sciences Center School of Medicine, New Orleans, Louisiana, USA.

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http://dx.doi.org/10.1167/iovs.07-0153DOI Listing
October 2007

Mechanisms involved in synergistic anticancer immunity of anti-4-1BB and anti-CD4 therapy.

Cancer Res 2007 Sep;67(18):8891-9

The Immunomodulation Research Center, University of Ulsan, Ulsan, Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1056DOI Listing
September 2007

CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent.

J Immunol 2007 Aug;179(4):2203-14

Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.4049/jimmunol.179.4.2203DOI Listing
August 2007

Marked expansion of CD11c+CD8+ T-cells in melanoma-bearing mice induced by anti-4-1BB monoclonal antibody.

Mol Cells 2007 Aug;24(1):132-8

Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.

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August 2007

4-1BB triggers IL-13 production from T cells to limit the polarized, Th1-mediated inflammation.

J Leukoc Biol 2007 Jun 27;81(6):1455-65. Epub 2007 Mar 27.

The Immunomodulation Research Center, University of Ulsan, San29, Mukeo-Dong, Nam-Ku, Ulsan, Korea 680-749.

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http://dx.doi.org/10.1189/jlb.1006619DOI Listing
June 2007

Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.

Nat Immunol 2007 Jun 13;8(6):601-9. Epub 2007 May 13.

Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1038/ni1471DOI Listing
June 2007

Promoter analysis of human CC chemokine CCL23 gene in U937 monocytoid cells.

Biochim Biophys Acta 2007 Mar 7;1769(3):204-8. Epub 2007 Feb 7.

Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449-701, Korea.

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http://dx.doi.org/10.1016/j.bbaexp.2007.01.012DOI Listing
March 2007

Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis.

J Leukoc Biol 2006 Oct 1;80(4):922-8. Epub 2006 Aug 1.

Department of Genetic Engineering, Kyungpook National University, Taegu 702-701, Korea.

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http://dx.doi.org/10.1189/jlb.0306160DOI Listing
October 2006

Functional dichotomy between OX40 and 4-1BB in modulating effector CD8 T cell responses.

J Immunol 2006 Oct;177(7):4464-72

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA.

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http://www.jimmunol.org/content/177/7/4464.full.pdf
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October 2006

Amelioration of mercury-induced autoimmunity by 4-1BB.

J Immunol 2006 Oct;177(8):5708-17

Louisiana State University Eye Center, Louisiana State University Health Science Center School of Medicine, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.4049/jimmunol.177.8.5708DOI Listing
October 2006

Dual immunoregulatory pathways of 4-1BB signaling.

J Mol Med (Berl) 2006 Sep 5;84(9):726-36. Epub 2006 Aug 5.

LSU Eye Center, Louisiana State University Health Sciences Center School of Medicine, Suite B, 2020 Gravier Street, New Orleans, LA 70112, USA.

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http://dx.doi.org/10.1007/s00109-006-0072-2DOI Listing
September 2006

4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms.

Cytokine 2006 Jun 8;34(5-6):233-42. Epub 2006 Aug 8.

The Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.cyto.2006.04.008DOI Listing
June 2006

A signal through 4-1BB ligand inhibits receptor for activation of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis by increasing interferon (IFN)-beta production.

FEBS Lett 2006 Mar 9;580(6):1601-6. Epub 2006 Feb 9.

Department of Biological Sciences and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.febslet.2006.01.091DOI Listing
March 2006

LIGHT enhances the bactericidal activity of human monocytes and neutrophils via HVEM.

J Leukoc Biol 2006 Feb 7;79(2):330-8. Epub 2005 Nov 7.

University of Ulsan, San 29, Mookeo-dong, Nam-ku, Ulsan, Republic of Korea.

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http://dx.doi.org/10.1189/jlb.1104694DOI Listing
February 2006

Combined CD137 (4-1BB) and adjuvant therapy generates a developing pool of peptide-specific CD8 memory T cells.

Int Immunol 2006 Feb 22;18(2):325-33. Epub 2005 Dec 22.

Department of Immunology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.

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http://dx.doi.org/10.1093/intimm/dxh371DOI Listing
February 2006

Human CC chemokine CCL23 enhances expression of matrix metalloproteinase-2 and invasion of vascular endothelial cells.

Biochem Biophys Res Commun 2006 Feb 19;340(2):498-504. Epub 2005 Dec 19.

Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449-701, Republic of Korea.

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http://dx.doi.org/10.1016/j.bbrc.2005.12.037DOI Listing
February 2006

Immunotherapy targeting 4-1BB and its ligand.

Int J Hematol 2006 Jan;83(1):23-8

Department of Ophthalmology, LSU Eye Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans, USA.

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http://dx.doi.org/10.1532/IJH97.05125DOI Listing
January 2006

Transcriptional regulation of human CC chemokine CCL15 gene by NF-kappaB and AP-1 elements in PMA-stimulated U937 monocytoid cells.

Biochim Biophys Acta 2005 Dec 1;1732(1-3):38-42. Epub 2005 Dec 1.

Graduate School of Biotechnology and Institute of Life Sciences and Resources, Kyung Hee University, Yongin 449-701, Korea.

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http://dx.doi.org/10.1016/j.bbaexp.2005.11.001DOI Listing
December 2005

CKbeta8-1 alters expression of cyclin E in colony forming units-granulocyte macrophage (CFU-GM) lineage from human cord blood CD34+ cells.

Exp Mol Med 2005 Dec;37(6):619-23

Immunomodulation Research Center, Department of Biological Science, University of Ulsan, Ulsan 680-749, Korea.

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http://dx.doi.org/10.1038/emm.2005.75DOI Listing
December 2005

4-1BB costimulation enhances HSV-1-specific CD8+ T cell responses by the induction of CD11c+CD8+ T cells.

Cell Immunol 2005 Dec 9;238(2):76-86. Epub 2006 Mar 9.

The Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellimm.2006.01.004DOI Listing
December 2005

4-1BB (CD137) is required for rapid clearance of Listeria monocytogenes infection.

Infect Immun 2005 Aug;73(8):5144-51

Immunomodulation Research Center, University of Ulsan, San 29, Mukeo-dong, Nam-ku, Ulsan, Republic of Korea, 680-749.

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http://dx.doi.org/10.1128/IAI.73.8.5144-5151.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1201223PMC
August 2005

The therapeutic potential of 4-1BB (CD137) in cancer.

Curr Cancer Drug Targets 2005 Aug;5(5):357-63

Department of Pharmacology, School of Dentistry, Kyung Hee University, Seoul 130-701, Korea.

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http://dx.doi.org/10.2174/1568009054629681DOI Listing
August 2005

Characterization of monoclonal antibody specific to the Z39Ig protein, a member of immunoglobulin superfamily.

Immunol Lett 2005 Jul 25;99(2):153-61. Epub 2005 Mar 25.

Immunomodulation Research Center, University of Ulsan, South Korea.

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http://dx.doi.org/10.1016/j.imlet.2005.02.012DOI Listing
July 2005