Burkhard Kleuser

Burkhard Kleuser

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Burkhard Kleuser

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Mechanisms of GLP-1 receptor-independent renoprotective effects of the dipeptidyl peptidase type 4 inhibitor linagliptin in GLP-1 receptor knockout mice with 5/6 nephrectomy.

Kidney Int 2019 Jun 27;95(6):1373-1388. Epub 2019 Feb 27.

Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany; LADR GmbH Neuruppin MVZ, Neuruppin, Germany; Department of Basic Medicine, Medical college of Hunan Normal University, Changsha, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00852538193005
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http://dx.doi.org/10.1016/j.kint.2019.01.010DOI Listing
June 2019

Qualifying X-ray and Stimulated Raman Spectromicroscopy for Mapping Cutaneous Drug Penetration.

Anal Chem 2019 May 15. Epub 2019 May 15.

Institute of Pharmacy (Pharmacology and Toxicology) , Freie Universität Berlin , Königin-Luise-Strasse 2 + 4 , 14195 Berlin , Germany.

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http://dx.doi.org/10.1021/acs.analchem.9b00519DOI Listing
May 2019

Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin.

J Control Release 2019 Apr 21;299:138-148. Epub 2019 Feb 21.

Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité-Universitaetsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.02.028DOI Listing
April 2019

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging.

Mol Metab 2019 Apr 4. Epub 2019 Apr 4.

Department of Adipocyte Development and Nutrition, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; German Center for Diabetes Research (DZD), München, Neuherberg, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Nuthetal, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183119
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http://dx.doi.org/10.1016/j.molmet.2019.03.011DOI Listing
April 2019

Methionine restriction prevents onset of type 2 diabetes in NZO mice.

FASEB J 2019 Mar 6:fj201900150R. Epub 2019 Mar 6.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

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http://dx.doi.org/10.1096/fj.201900150RDOI Listing
March 2019

Fatal gastric distension in a gold thioglucose mouse model of obesity.

Lab Anim 2019 Feb 5;53(1):89-94. Epub 2018 Oct 5.

3 German Institute of Human Nutrition, Germany.

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http://journals.sagepub.com/doi/10.1177/0023677218803384
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http://dx.doi.org/10.1177/0023677218803384DOI Listing
February 2019

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery.

Nanoscale 2018 Sep;10(35):16848-16856

Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.

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http://dx.doi.org/10.1039/c8nr05536jDOI Listing
September 2018

The Enigma of Sphingolipids in Health and Disease.

Authors:
Burkhard Kleuser

Int J Mol Sci 2018 10 12;19(10). Epub 2018 Oct 12.

Department of Toxicology, Institute of Nutritional Science, Faculty of Mathematics and Natural Science, University of Potsdam, Arthur-Scheunert Allee 114-116, 14558 Nuthetal, Germany.

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http://dx.doi.org/10.3390/ijms19103126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213595PMC
October 2018

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Crit Care 2018 Oct 29;22(1):282. Epub 2018 Oct 29.

Division of Pulmonary Inflammation, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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https://ccforum.biomedcentral.com/articles/10.1186/s13054-01
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http://dx.doi.org/10.1186/s13054-018-2213-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206919PMC
October 2018

Synthesis of poly(lactide-co-glycerol) as a biodegradable and biocompatible polymer with high loading capacity for dermal drug delivery.

Nanoscale 2018 Sep;10(35):16848-16856

Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.

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http://dx.doi.org/10.1039/c8nr05536jDOI Listing
September 2018

Nuclear Translocation of SGPP-1 and Decrease of SGPL-1 Activity Contribute to Sphingolipid Rheostat Regulation of Inflammatory Dendritic Cells.

Mediators Inflamm 2017 11;2017:5187368. Epub 2017 Dec 11.

Institute of General Pharmacology and Toxicology, pharmazentrum frankfurt/ZAFES, Hospital of the Goethe University, Frankfurt, Germany.

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https://www.hindawi.com/journals/mi/2017/5187368/
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http://dx.doi.org/10.1155/2017/5187368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5742514PMC
August 2018

Sphingolipids as targets for inhalation treatment of cystic fibrosis.

Adv Drug Deliv Rev 2018 Aug 24;133:66-75. Epub 2018 Apr 24.

Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany; Department of Surgery, University of Cincinnati, 231 Albert Sabin Way, ML 0558, Cincinnati, OH 45229, USA. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2018.04.015DOI Listing
August 2018

Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes.

Diabetologia 2018 06 17;61(6):1459-1469. Epub 2018 Mar 17.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

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http://dx.doi.org/10.1007/s00125-018-4595-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449005PMC
June 2018

Crosstalk between core-multishell nanocarriers for cutaneous drug delivery and antigen-presenting cells of the skin.

Biomaterials 2018 04 3;162:60-70. Epub 2018 Feb 3.

Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.01.058DOI Listing
April 2018

Fetal Serum Metabolites Are Independently Associated with Gestational Diabetes Mellitus.

Cell Physiol Biochem 2018 29;45(2):625-638. Epub 2018 Jan 29.

Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Germany.

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http://dx.doi.org/10.1159/000487119DOI Listing
March 2018

Divergent Role of Sphingosine 1-Phosphate in Liver Health and Disease.

Authors:
Burkhard Kleuser

Int J Mol Sci 2018 Mar 3;19(3). Epub 2018 Mar 3.

Department of Toxicology, Institute of Nutritional Science, Faculty of Mathematics and Natural Science, University of Potsdam, Arthur-Scheunert Allee 114-116, 14558 Nuthetal, Germany.

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http://www.mdpi.com/1422-0067/19/3/722
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http://dx.doi.org/10.3390/ijms19030722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877583PMC
March 2018

How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis?

J Invest Dermatol 2018 02 22;138(2):455-458. Epub 2017 Sep 22.

Institute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.019DOI Listing
February 2018

Selenium increases hepatic DNA methylation and modulates one-carbon metabolism in the liver of mice.

J Nutr Biochem 2017 10 9;48:112-119. Epub 2017 Jul 9.

Institute of Nutrition, Department of Molecular Nutrition Physiology, Friedrich Schiller University Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jnutbio.2017.07.002DOI Listing
October 2017

Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity.

Cell Physiol Biochem 2017 1;43(2):445-456. Epub 2017 Sep 1.

Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany.

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http://dx.doi.org/10.1159/000480470DOI Listing
October 2017

The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro.

J Lipid Res 2017 08 6;58(8):1648-1660. Epub 2017 Jun 6.

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, 14558 Nuthetal, Germany

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http://dx.doi.org/10.1194/jlr.M076562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5538286PMC
August 2017

Poly[acrylonitrile-co-(N-vinyl pyrrolidone)] nanoparticles - Composition-dependent skin penetration enhancement of a dye probe and biocompatibility.

Eur J Pharm Biopharm 2017 Jul 27;116:66-75. Epub 2016 Oct 27.

Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany; Helmholtz Virtual Institute Multifunctional Biomaterials for Medicine, Helmholtz-Zentrum Geesthacht, Teltow, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2016.10.019DOI Listing
July 2017

Specific uptake mechanisms of well-tolerated thermoresponsive polyglycerol-based nanogels in antigen-presenting cells of the skin.

Eur J Pharm Biopharm 2017 Jul 24;116:155-163. Epub 2016 Dec 24.

Institute of Nutritional Science, University of Potsdam, Potsdam, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2016.12.016DOI Listing
July 2017

Formulation and ex vivo evaluation of polymeric nanoparticles for controlled delivery of corticosteroids to the skin and the corneal epithelium.

Eur J Pharm Biopharm 2017 Jun 9;115:122-130. Epub 2017 Feb 9.

College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, 12169 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.02.001DOI Listing
June 2017

Acid sphingomyelinase mediates murine acute lung injury following transfusion of aged platelets.

Am J Physiol Lung Cell Mol Physiol 2017 05 10;312(5):L625-L637. Epub 2017 Mar 10.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada;

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http://dx.doi.org/10.1152/ajplung.00317.2016DOI Listing
May 2017

Inflammatory cells, ceramides, and expression of proteases in perivascular adipose tissue adjacent to human abdominal aortic aneurysms.

J Vasc Surg 2017 04 6;65(4):1171-1179.e1. Epub 2016 Mar 6.

Division of Drug Research, Department of Medical and Health Sciences, Linköping University, Linköping, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jvs.2015.12.056DOI Listing
April 2017

TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents.

Sci Rep 2017 04 4;7(1):774. Epub 2017 Apr 4.

Institute for Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1038/s41598-017-00670-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5428778PMC
April 2017

Maternal PCaaC38:6 is Associated With Preterm Birth - a Risk Factor for Early and Late Adverse Outcome of the Offspring.

Kidney Blood Press Res 2016 22;41(3):250-7. Epub 2016 Apr 22.

Department of Clinical Medicine, Medical college of Hunan Normal University, Changsha 410006, China.

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http://dx.doi.org/10.1159/000443428DOI Listing
March 2017

Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease.

Cell Physiol Biochem 2016 23;40(6):1637-1645. Epub 2016 Dec 23.

Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany.

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http://dx.doi.org/10.1159/000453213DOI Listing
February 2017

Formulation and comparative in vitro evaluation of various dexamethasone-loaded pH-sensitive polymeric nanoparticles intended for dermal applications.

Int J Pharm 2017 Jan 11;516(1-2):21-31. Epub 2016 Nov 11.

College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, D-12169, Berlin, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03785173163108
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http://dx.doi.org/10.1016/j.ijpharm.2016.11.029DOI Listing
January 2017

Acid Sphingomyelinase Inhibition in Stored Erythrocytes Reduces Transfusion-Associated Lung Inflammation.

Ann Surg 2017 01;265(1):218-226

*Department of Surgery and Institute for Military Medicine, University of Cincinnati, Cincinnati, OH †Department of Toxicology, Institute of Nutritional Science, University of Potsdam, Germany ‡Department of Molecular Biology, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1097/SLA.0000000000001648DOI Listing
January 2017

Caenorhabditis elegans as a model system to study post-translational modifications of human transthyretin.

Sci Rep 2016 11 21;6:37346. Epub 2016 Nov 21.

Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.

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http://dx.doi.org/10.1038/srep37346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116746PMC
November 2016

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+ Conventional versus Foxp3+ Regulatory T Cells.

J Immunol 2016 10 16;197(8):3130-3141. Epub 2016 Sep 16.

Institute for Virology and Immunobiology, University of Würzburg, D-97078 Würzburg, Germany;

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http://dx.doi.org/10.4049/jimmunol.1600691DOI Listing
October 2016

Comparison of different methods to study effects of silver nanoparticles on the pro- and antioxidant status of human keratinocytes and fibroblasts.

Methods 2016 10 20;109:55-63. Epub 2016 May 20.

Department of Dermatology, Venerology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2016.05.015DOI Listing
October 2016

A Highly Photostable Hyperbranched Polyglycerol-Based NIR Fluorescence Nanoplatform for Mitochondria-Specific Cell Imaging.

Adv Healthc Mater 2016 09 2;5(17):2214-26. Epub 2016 Jun 2.

Institut of Chemie and Biochemie, Freie Universität Berlin, Takustr. 3, 14195, Berlin, Germany.

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http://dx.doi.org/10.1002/adhm.201600212DOI Listing
September 2016

Formulation and in vitro evaluation of polymeric enteric nanoparticles as dermal carriers with pH-dependent targeting potential.

Eur J Pharm Sci 2016 Sep 5;92:98-109. Epub 2016 Jul 5.

College of Pharmacy, Freie Universität Berlin, Kelchstr. 31, D-12169 Berlin, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.07.004DOI Listing
September 2016

A sphingolipid mechanism for behavioral extinction.

J Neurochem 2016 05 15;137(4):589-603. Epub 2016 Mar 15.

Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.

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http://dx.doi.org/10.1111/jnc.13537DOI Listing
May 2016

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate.

J Hepatol 2016 Jan 5;64(1):60-8. Epub 2015 Aug 5.

Department of Surgery, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278150053
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http://dx.doi.org/10.1016/j.jhep.2015.07.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843792PMC
January 2016

In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.

J Biol Chem 2016 Jan 5;291(1):58-71. Epub 2015 Nov 5.

From the Institute of Pharmacy, Freie Universität Berlin, Königin-Luise-Str. 2/4, 14195 Berlin,

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http://dx.doi.org/10.1074/jbc.M115.685610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697188PMC
January 2016

Hypermethylation of ITGA4, TFPI2 and VIMENTIN promoters is increased in inflamed colon tissue: putative risk markers for colitis-associated cancer.

J Cancer Res Clin Oncol 2015 Dec 23;141(12):2097-107. Epub 2015 Apr 23.

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.

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http://dx.doi.org/10.1007/s00432-015-1972-8DOI Listing
December 2015

Alterations of plasma glycerophospholipid and sphingolipid species in male alcohol-dependent patients.

Biochim Biophys Acta 2015 Nov 17;1851(11):1501-10. Epub 2015 Aug 17.

Department of Psychiatry and Psychotherapy, University Hospital, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2015.08.005DOI Listing
November 2015

Highly sensitive isotope-dilution liquid-chromatography-electrospray ionization-tandem-mass spectrometry approach to study the drug-mediated modulation of dopamine and serotonin levels in Caenorhabditis elegans.

Talanta 2015 Nov 28;144:71-9. Epub 2015 May 28.

Department of Food Chemistry, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.talanta.2015.05.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600537PMC
November 2015

Decreased plasma levels of the endothelial protective sphingosine-1-phosphate are associated with dengue-induced plasma leakage.

J Infect 2015 Oct 14;71(4):480-7. Epub 2015 Jul 14.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.jinf.2015.06.014DOI Listing
October 2015

Sphingosine 1-phosphate counteracts insulin signaling in pancreatic β-cells via the sphingosine 1-phosphate receptor subtype 2.

FASEB J 2015 Aug 24;29(8):3357-69. Epub 2015 Apr 24.

*Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany; German Institute of Human Nutrition, Max Rubner Laboratory, Nuthetal, Germany; and Lpath Incorporated, San Diego, California, USA

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http://dx.doi.org/10.1096/fj.14-263194DOI Listing
August 2015

Internal threshold of toxicological concern values: enabling route-to-route extrapolation.

Arch Toxicol 2015 Jun 12;89(6):941-8. Epub 2014 Jun 12.

Institute for Clinical Pharmacology and Toxicology, Charité - Universitätsmedizin, Berlin, Germany.

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http://dx.doi.org/10.1007/s00204-014-1287-6DOI Listing
June 2015

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans.

Metallomics 2015 May 13;7(5):847-56. Epub 2015 Mar 13.

Neuroscience Graduate Program, Vanderbilt University Medical Center, Nashville, TN, USA.

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http://dx.doi.org/10.1039/c5mt00052aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431931PMC
May 2015

Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo.

Cell Physiol Biochem 2014 16;34(1):27-44. Epub 2014 Jun 16.

Pharmazentrum Frankfurt/ZAFES, Clinic of the Goethe University, Frankfurt, Germany.

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http://dx.doi.org/10.1159/000362982DOI Listing
February 2015

Divergent role of sphingosine 1-phosphate on insulin resistance.

Cell Physiol Biochem 2014 16;34(1):134-47. Epub 2014 Jun 16.

Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany.

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http://dx.doi.org/10.1159/000362990DOI Listing
February 2015

Enhanced thyroid hormone breakdown in hepatocytes by mutual induction of the constitutive androstane receptor (CAR, NR1I3) and arylhydrocarbon receptor by benzo[a]pyrene and phenobarbital.

Toxicology 2015 Feb 6;328:21-8. Epub 2014 Dec 6.

University of Potsdam, Institute of Nutritional Science, Department of Nutritional Biochemistry, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.12.004DOI Listing
February 2015

Analysis of genomic DNA methylation levels in human placenta using liquid chromatography-electrospray ionization tandem mass spectrometry.

Cell Physiol Biochem 2014 31;33(4):945-52. Epub 2014 Mar 31.

Institute of Nutritional Science, Department of Experimental Nutritional Medicine, University of Potsdam, Potsdam, Germany.

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https://www.karger.com/Article/FullText/358666
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http://dx.doi.org/10.1159/000358666DOI Listing
January 2015

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice.

Neuropharmacology 2014 Oct 23;85:314-27. Epub 2014 May 23.

Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010 Bern, Switzerland; Pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe University Frankfurt am Main, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2014.05.012DOI Listing
October 2014

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.

EMBO Mol Med 2014 Sep;6(9):1205-14

Department of Molecular Biology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany Department of Surgery, University of Cincinnati, Cincinnati, OH, USA

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http://dx.doi.org/10.15252/emmm.201404075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197866PMC
September 2014

Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry.

Anal Chem 2014 Sep 3;86(18):9065-73. Epub 2014 Sep 3.

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam , Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.

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http://dx.doi.org/10.1021/ac501677yDOI Listing
September 2014

The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion.

Liver Int 2014 Aug 20;34(7):e271-89. Epub 2013 Nov 20.

Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain; Departamento de Patologia e Medicina Legal, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1111/liv.12348DOI Listing
August 2014

Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis.

Allergo J Int 2014;23(2):54-59. Epub 2014 Mar 19.

Toxicology, Faculty of Mathematics and Natural Science, University of Potsdam, Potsdam, Germany ; Department of Toxicology Faculty of Mathematics and Natural Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.

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http://link.springer.com/10.1007/s40629-014-0008-2
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http://dx.doi.org/10.1007/s40629-014-0008-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479432PMC
March 2014

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype.

Diabetologia 2014 Feb 29;57(2):373-82. Epub 2013 Nov 29.

Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Arthur-Scheunert Allee 114-116, 14558, Nuthetal, Potsdam, Germany.

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http://dx.doi.org/10.1007/s00125-013-3123-6DOI Listing
February 2014

Aspirin inhibits release of platelet-derived sphingosine-1-phosphate in acute myocardial infarction.

Int J Cardiol 2013 Dec 16;170(2):e23-4. Epub 2013 Oct 16.

Universitätsklinikum Düsseldorf, Klinik für Kardiologie, Pneumologie und Angiologie, Universitätsstraße 1, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.1016/j.ijcard.2013.10.050DOI Listing
December 2013

Ultrasensitive detection of unknown colon cancer-initiating mutations using the example of the Adenomatous polyposis coli gene.

Cancer Prev Res (Phila) 2013 Sep;6(9):898-907

Department of Nutritional Toxicology, Institute of Nutritional Science, University of Potsdam, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.

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http://dx.doi.org/10.1158/1940-6207.CAPR-13-0145DOI Listing
September 2013

Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells.

Cardiovasc Res 2013 Aug 7;99(3):505-13. Epub 2013 May 7.

Institut für Pharmakologie, Abteilung Allgemeine Pharmakologie, Universitätsmedizin Greifswald, Felix-Hausdorff-Str. 3, Greifswald, Germany.

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http://dx.doi.org/10.1093/cvr/cvt112DOI Listing
August 2013

Sphingolipids and inflammatory diseases of the skin.

Handb Exp Pharmacol 2013 (216):355-72

Department of Toxicology, University of Potsdam, Nuthetal, Potsdam, Germany.

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http://dx.doi.org/10.1007/978-3-7091-1511-4_18DOI Listing
July 2013

Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis.

J Dermatol Sci 2013 Jul 6;71(1):29-36. Epub 2013 Apr 6.

Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

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http://dx.doi.org/10.1016/j.jdermsci.2013.03.006DOI Listing
July 2013

Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype.

PLoS One 2012 8;7(11):e49427. Epub 2012 Nov 8.

Faculty of Mathematics and Natural Science, Department of Toxicology, Institute of Nutritional Science, University of Potsdam, Potsdam, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493526PMC
June 2013

Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues.

Bioorg Med Chem 2013 Feb 21;21(4):874-82. Epub 2012 Dec 21.

Humboldt Universität zu Berlin, Institute for Chemistry, Brook-Taylor-Str. 2, 12489 Berlin, Germany.

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http://dx.doi.org/10.1016/j.bmc.2012.12.014DOI Listing
February 2013

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation.

J Clin Invest 2013 Feb 16;123(2):666-81. Epub 2013 Jan 16.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI64840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561821PMC
February 2013

Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃.

Mol Cell Biochem 2012 Dec 17;371(1-2):165-76. Epub 2012 Aug 17.

Institute of Nutritional Science, Toxicology, Faculty of Mathematics and Natural Science, University of Potsdam, Arthur-Scheunert-Allee, 114-116, 14558 Nuthetal, Germany.

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http://dx.doi.org/10.1007/s11010-012-1433-5DOI Listing
December 2012

Novel methods for the quantification of (2E)-hexadecenal by liquid chromatography with detection by either ESI QTOF tandem mass spectrometry or fluorescence measurement.

Anal Chim Acta 2012 Apr 13;722:70-9. Epub 2012 Feb 13.

University of Potsdam, Institute of Nutritional Science, Dept. Nutritional Toxicology, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal (Bergholz-Rehbrücke), Germany.

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http://dx.doi.org/10.1016/j.aca.2012.01.063DOI Listing
April 2012

Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₁ and S1P₃ and Smad-signalling.

Cytoskeleton (Hoboken) 2010 Dec 10;67(12):773-83. Epub 2010 Nov 10.

Institute of Pharmacy, Free University of Berlin and Physics Department, Phillips University of Marburg, Germany.

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http://dx.doi.org/10.1002/cm.20486DOI Listing
December 2010

Phosphorylation of the immunomodulator FTY720 inhibits programmed cell death of fibroblasts via the S1P3 receptor subtype and Bcl-2 activation.

Cell Physiol Biochem 2010 18;26(1):67-78. Epub 2010 May 18.

Faculty of Mathematics and Natural Science, Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.

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https://www.karger.com/Article/FullText/315107
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http://dx.doi.org/10.1159/000315107DOI Listing
September 2010

Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis.

Am J Respir Cell Mol Biol 2010 Jun 27;42(6):716-24. Epub 2009 Jul 27.

Professor and Chair, Department of Molecular Biology, University of Duisburg-Essen, Hufelandstrasse 55, D-45122 Essen, Germany.

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http://dx.doi.org/10.1165/rcmb.2009-0174OCDOI Listing
June 2010

Dexamethasone protects human fibroblasts from apoptosis via an S1P3-receptor subtype dependent activation of PKB/Akt and Bcl XL.

Pharmacol Res 2010 May 18;61(5):449-59. Epub 2009 Dec 18.

Institute of Pharmacy, Pharmacology and Toxicology, Freie Universität Berlin, Germany.

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http://dx.doi.org/10.1016/j.phrs.2009.12.005DOI Listing
May 2010

The role of sphingosine-1-phosphate receptor modulators in the prevention of transplant rejection and autoimmune diseases.

Curr Opin Investig Drugs 2009 Nov;10(11):1183-94

Freie Universität Berlin, Institute of Pharmacy, Pharmacology and Toxicology, Königin-Luise-Strause 2+4, D-14195 Berlin, Germany.

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November 2009

Influences of opioids and nanoparticles on in vitro wound healing models.

Eur J Pharm Biopharm 2009 Sep 1;73(1):34-42. Epub 2009 Apr 1.

Institut für Pharmazie, Freie Universität Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.ejpb.2009.03.009DOI Listing
September 2009

Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.

J Invest Dermatol 2009 Aug 5;129(8):1954-62. Epub 2009 Feb 5.

Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany.

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http://dx.doi.org/10.1038/jid.2008.454DOI Listing
August 2009

Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease.

Biol Chem 2008 Nov;389(11):1381-90

Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik mit Schwerpunkt Nephrologie, Hindenburgdamm 30, D-12203 Berlin, Germany.

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https://www.degruyter.com/view/j/bchm.2008.389.issue-11/bc.2
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http://dx.doi.org/10.1515/BC.2008.165DOI Listing
November 2008