Publications by authors named "Burhan Dadaş"

40 Publications

Levels of reactive oxygen species in rat tympanic membranes after incisional versus radiofrequency myringotomy.

Int J Pediatr Otorhinolaryngol 2013 May 9;77(5):792-5. Epub 2013 Mar 9.

Sisli Etfal Training and Research Hospital, Department of Otorhinolaryngology, Istanbul, Turkey.

Objective: A close relationship between reactive oxygen species (ROS) and myringosclerosis, which is a common complication of myringotomy, was recently reported. The objective of this study was to measure ROS levels directly in rat tympanic membranes using luminol-aided chemiluminescence (CL) in order to compare the levels of ROS after incisional and radiofrequency (RF) myringotomy.

Methods: Fifteen Sprague-Dawley rats were separated into three groups of five animals each. Bilateral myringotomies were made using an appropriate myringotomy lancet in Group 1 and RF in Group 2. Group 3 served as the control group with no myringotomy. Twenty-four hours after the procedure, all tympanic membranes were inspected with an otomicroscope and then excised for the measurement of ROS using luminol-aided CL.

Results: The mean ROS level in Group 1 was significantly higher than that in Groups 2 and 3 (p<0.05 for both). The difference in mean ROS level between Groups 2 and 3 was not significant (p>0.05). Otomicroscopy revealed increased vascularity and vessel dilation in all tympanic membranes that underwent myringotomy. Vascular dilation was observed in the annular region in the vessels that passed along the long arm of the malleus, in addition to the vessels feeding the anterior and posterior tympanomalleolar folds.

Conclusions: Although the relationship between ROS and the development of myringosclerosis after myringotomy has been demonstrated, the present study is the first to compare incisional and RF myringotomy based on the measurement of ROS levels. Our results indicate that the increase in ROS due to myringotomy was greater following incisional myringotomy than RF myringotomy.
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http://dx.doi.org/10.1016/j.ijporl.2013.02.013DOI Listing
May 2013

Does lack of glottic closure affect quality of life as a cause of constipation in laryngectomized patients?

Eur Arch Otorhinolaryngol 2013 Feb 25;270(2):629-34. Epub 2012 Sep 25.

Otorhinolaryngology Department, Derince Training and Research Hospital, Kocaeli, Turkey.

The permanent disappearance of glottic closure eventually causes inadequate defecatory propulsion resulting in functional constipation. The aim of this study is to reveal functional constipation probably induced by lack of glottic closure in laryngectomized patients. The study was conducted in a prospective, tertiary care center. Forty patients who had undergone total laryngectomy (study group) and 30 who had undergone microlaryngoscopic surgery (control group) were evaluated. Based on the European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaires C30, the presence of functional constipation was investigated using the Rome II diagnostic criteria and was confirmed by measurement of colonic transit time using a radiopaque marker test. Functional constipation and colonic transit time were found to be increased and statistically significant in laryngectomized patients (70 %) compared with the control group (26 %) (p < 0.01). Functional constipation is more prevalent among laryngectomized patients. When evaluating quality of life of patients undergoing laryngectomy, colorectal functions must be taken into consideration.
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http://dx.doi.org/10.1007/s00405-012-2176-3DOI Listing
February 2013

Is the tragal cartilage necessary for type 1 tympanoplasties?

J Craniofac Surg 2012 Jul;23(4):e280-3

Department of Otolaryngology-Head and Neck Surgery, Şişli Etfal Training and Research Hospital, Istanbul, Turkey.

The use of cartilage grafts in tympanoplasties is recommended in cases with a higher probability of failure. Many grafting techniques have been reported, including palisade, cartilage island, and cartilage shield grafts. Cartilage minimizes the inflammatory tissue reaction, ensures resistance against infection during the recovery process, and provides good support against the retraction by virtue of its rigidity.This study compared the anatomic and functional results of conchal cartilage, tragal cartilage, and temporal muscle fascia grafts in primary type 1 tympanoplasty. Between January 2007 and January 2011, 79 patients with subtotal dry tympanic membrane perforation and an intact ossicular chain underwent primary type 1 tympanoplasty in our clinic. The postoperative perforation closure ratios, air and bone pure tone averages, and mean air-bone gap (ABG) in the 3 groups were compared with the preoperative values. The improvement in the mean ABG was assessed.The perforation closure ratio was 80.6%, 100%, and 88.5% in the muscle fascia, conchal cartilage, and tragal cartilage groups, respectively, and the mean increase in the ABG was 5.7, 8.9, and 9.7 dB, respectively.The island graft with cartilage perichondrium, which has recently become popular, can be also used in type 1 tympanoplasty. Because it does not require a second incision, conchal cartilage can be used routinely in tympanoplasties performed via a postauricular approach.
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http://dx.doi.org/10.1097/SCS.0b013e31824f6666DOI Listing
July 2012

An incidental middle-ear mass: Jacobson's nerve schwannoma.

Otol Neurotol 2012 Jul;33(5):e37-8

Department of Otolaryngology-Head and Neck Surgery, Sişli Etfal Training and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1097/MAO.0b013e3182338984DOI Listing
July 2012

Does the open rhinoplasty incision decrease nasal projection?

Eur Arch Otorhinolaryngol 2012 Mar 17;269(3):867-70. Epub 2011 Sep 17.

II Ear Nose Throat Head and Neck Surgery, Sisli Etfal Training and Education Hospital, Adnan Saygun Caddesi Kelaynak Sokak, Kibele Sitesi 10. Blok Daire:1, Ulus, Istanbul, 34340, Turkey.

To evaluate the effects of open rhinoplasty incisions on tip projection using digitized photographs. Thirty-one patients, who underwent open technique rhinoplasty were prospectively included in the study. The lateral aspect photographs were taken before the operations. Following midcolumellar incision septal elevation was done until septal cartilage was shown. After replacing the skin totally back and suturing midcolumellar incision, the intraoperative photographs were taken. The projection indexes were measured by Goode method from the photographs and the measurements were compared. A statistically significant decline of the nasal projection was established after open technique approach. Open rhinoplasty approach led to the decrease of the nasal tip projection. This result was thought to be the effect of ligamentous disruption.
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http://dx.doi.org/10.1007/s00405-011-1765-xDOI Listing
March 2012

Effect of the use of dry (rigid) or wet (soft) temporal fascia graft on tympanoplasty.

J Otolaryngol Head Neck Surg 2009 Feb;38(1):126-32

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Training and Research Hospital, Istanbul, Turkey.

Objective: The aim of this study was to research the advantages and disadvantages of using a wet or dry temporalis fascia graft in myringoplasty surgery.

Study Design: Randomized prospective study.

Setting: Teaching and research hospital.

Methods: Dry graft was used in 210 cases, and wet graft was used in 174 cases in 384 patients who underwent tympanoplasty.

Outcomes Measures: (1) Rate of primary closure of perforation, (2) rate of recurrent and residual perforation, (3) difference in hearing improvement between the two groups, (4) total operation time and graft placement time, and (5) histologic properties of wet and dry fascia grafts.

Results: The success rate was 91.4% (159 of 174) in the wet graft group and 88.6% (186 of 210) in the dry graft group. There were no differences between groups regarding recurrent disease, residual disease, and postoperative hearing results (p > .05). The mean operation time and graft placement time were shorter in group 2 (wet graft), and this difference was found to be statistically significant (p < .01). Histologically, the number of fibroblast nuclei was higher in group 2 (wet graft), and this was statistically significant (p < .01).

Conclusion: The temporal fascia graft has a high success rate regardless of its use, either wet or dry. Using wet grafts can shorten the operation time and result in a high number of fibroblast nuclei histologically.
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February 2009

Transient vocal cord paralysis following ultrasound-guided fine-needle aspiration biopsy for a thyroid nodule.

J Otolaryngol Head Neck Surg 2009 Feb;38(1):E14-5

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey.

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February 2009

Coexistence of laryngeal mucormycosis with retropharyngeal abscess causing acute upper airway obstruction.

J Otolaryngol Head Neck Surg 2008 Jun;37(3):E73-5

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey.

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June 2008

Assessment of long- and short-term neurotoxic effects of glass ionomer bone cement by electromyography and histopathologic examination: experimental study.

J Otolaryngol Head Neck Surg 2008 Dec;37(6):844-50

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, and Department of Neurology, Istanbul University Medicine Faculty, Istanbul, Turkey.

Objective: The objective of this study was to investigate the possible neurotoxic effects of bone cement on the peripheral nerves.

Study Design: Experimental study.

Setting: Teaching and research hospital.

Methods: Twenty New Zealand rabbits were included in this study. The sciatic nerves of both legs of the 10 rabbits were exposed surgically under general anesthesia and closed primarily without any intervention and constituted the control group (group 1). Following surgical exploration, glass ionomer cement (GIC) was applied to the left sciatic nerves of the 10 rabbits for 10 seconds and then aspirated (group 2). GIC material was also applied to the right sciatic nerves of these rabbits but without aspiration (group 3).

Outcome Measures: All rabbits were sacrificed at the end of 8 weeks postoperatively following electromyographic investigation. The sections were stained with hematoxylin-eosin and Immune Olig 2 staining technique for histopathologic examination under light microscopy.

Results: There was no statistically significant difference in distal latency, which indicates the conduction speed of the nerve, between all groups by electromyography. Histopathologic examination of all specimens revealed no demyelinization or axonal degeneration, and all had an intact myelin structure. There was no statistically significant difference in inflammation of the specimens between groups. (p>.05).

Conclusion: GIC has no neurotoxic effects on the nerves in short- and long-term applications.
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December 2008

Bilateral lateral saccular cyst.

J Otolaryngol Head Neck Surg 2008 Oct;37(5):E135-7

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey.

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October 2008

Thyroid dysfunction after combined therapy for laryngeal cancer: a prospective study.

Otolaryngol Head Neck Surg 2008 Dec;139(6):787-91

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey.

Objective: The purpose of this study was to assess the incidence of the thyroid dysfunction in a group of patients treated with laryngectomy and radiotherapy for larynx cancer and to analyze the risk factors related to the development of hypothyroidism.

Study Design: This was a prospective study conducted in a tertiary center hospital.

Subjects And Methods: Thyroid function tests have been applied to 75 patients treated with surgery and radiotherapy preoperatively, before radiotherapy, and postoperatively. Risk factors have been analyzed by carrying out a multivariate analysis.

Results: All the patients were men with the mean age of 59.4 and an average follow-up of 28.6 months. The incidence of hypothyroidism was 49.3 percent. The average time to detection of hypothyroidism was 6 months after the completion of treatment. Radiotherapy dose, type of laryngectomy, extent of neck dissection, implementation of thyroid lobectomy, and presence of thyroiditis in specimens were risk factors for thyroid dysfunction.

Conclusions: It is important to check the thyroid function periodically in these patients especially with risk factor to obtain early diagnosis and appropriate treatment.
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http://dx.doi.org/10.1016/j.otohns.2008.09.011DOI Listing
December 2008

Papillary thyroid carcinoma in a 3-year-old child: case report.

Int J Pediatr Otorhinolaryngol 2008 Feb 3;72(2):275-7. Epub 2007 Dec 3.

M.D., Sişli Etfal Teaching and Research Hospital, Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul, Turkey.

Thyroid cancers account for 0.5-3.0% of all childhood malignancies. These cancers are exceedingly rare at ages younger than 5 years. Although the disease is biologically more aggressive in children when compared with adults, the prognosis is better. There are only few case reports in the literature describing papillary thyroid carcinoma under age 5. In this case report, a 3-year-old child with bilateral multiple masses on the neck that were present for 6 months and who was diagnosed with thyroid papillary carcinoma is presented, and the diagnosis and therapy of the disease is discussed.
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http://dx.doi.org/10.1016/j.ijporl.2007.10.014DOI Listing
February 2008

Transsellar transsphenoidal rhino-oral encephalocele.

Turk Neurosurg 2007 Oct;17(4):264-8

Sişli Etfal Education and Research Hospital, Neurosurgery Clinic, Istanbul, Turkey.

Transsphenoidal encephaloceles are rare and the transsellar variety is the least common. We present a 1-year-old male patient with transsellar transsphenoidal encephalocele which herniated into the oral cavity through the congenital split palate. The patient was operated on using a combined transcranial and transpalatal approach without mortality or permanent morbidity. Clinical findings, imaging reviews, surgical repair techniques and postoperative morbidity are discussed with the relevant literature. We conclude that repair of a transsphenoidal encephalocele should be coordinated between a team of neurosurgeons and otorhinolaryngologists. Our surgical outcome supports a transcranial approach for the treatment of these difficult lesions, with transpalatal dissection and exposure.
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October 2007

The efficacy of N-2-butyl cyanoacrylate in the fixation of nasal septum to the anterior nasal spine in rabbits: experimental study.

Eur Arch Otorhinolaryngol 2007 Dec 4;264(12):1425-30. Epub 2007 Aug 4.

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Istanbul, Turkey.

In nasal septal surgery, fixing the caudal portion of the nasal septum to the anterior nasal spine is difficult with the present techniques. N-2-butyl cyanoacrylate is a form of cyanoacrylate which is bioabsorbable and biocompatible. The feasibility and efficacy of the compound, which is easy to apply to the tissues, for the above purpose is investigated in this experimental study. Fourteen New Zealand rabbits were included in the study. The nasal septum was exposed with the open approach (transcolumellar). In the study group (n=10), the septum was detached from the nasal floor and attached to a point 3 mm lateral to the nasal spine on the right side, using 2-butyl cyanoacrylate. In control group (n=4) it was deviated 3 mm to the right side and left for spontaneous healing without using any fixation method. Beginning on the third postoperative week, one animal was sacrificed under general anesthesia, every week in the study group and every third week in the control group, and the septum was analysed. Foreign body reaction, histotoxicity, and the structure of the regenerative tissue in the junction of bone and cartilage were analysed with histopathology. The success of stabilization in the study group, where the septum was attached with N-2-butyl cyanoacrylate, was significantly superior to the control group where no fixation method was used (P<0.05). Histopathologically, there were no differences between the two groups with respect to foreign body reaction, histotoxicity, and the tissue that formed between the bone and cartilage (P>0.05). This study demonstrated that N-2-Butyl cyanoacrylate was successful in the fixation of the caudal edge of the nasal septum to the anterior nasal spine. No serious infections, foreign body reaction, necrosis or histotoxicity were observed.
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http://dx.doi.org/10.1007/s00405-007-0407-9DOI Listing
December 2007

Histopathological and radiological investigations of the influence of botulinum toxin on the submandibular gland of the rat.

Eur Arch Otorhinolaryngol 2007 Jul 7;264(7):783-7. Epub 2007 Feb 7.

Department of Otorhinolaryngology, Sisli Etfal Training and Education Hospital, Istanbul, Turkey.

The aim of the study was to correlate the sonographic features of Botox A injection in rat submandibular gland with the histopathological changes. Fifteen Wistar albino rats were randomly assigned to 2 groups. Group 1 (control group) consisted of 5 animals not given any substance. Group 2 was divided as "a" and "b" each consisting of 5 animals. A median cervical incision has been performed to the rats in group 2 and 2.5 U Botulinum toxin A reconstituted 0.1 ml physiologic saline was injected into the right gland. Sonograms were obtained before the application, at the first day of the Botox A application, in addition to group 2a on the 14th day, and on 28th day to group 2b. Gland size was lower in group 2a and 2b comparing to control group. The gland size of group 2b was lower than group 2a. There was no change in vascularization. There was no other histopathological change except lymphocytic infiltration in group 2. It was observed that Botox A injection does not have a direct effect on the cells in submandibular gland but it causes a homogenic shrinking in gland size without atrophy.
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http://dx.doi.org/10.1007/s00405-007-0254-8DOI Listing
July 2007

Treatment of tripod fracture of zygomatic bone by N-2-butyl cyanoacrylate glue fixation, and its effects on the tissues.

Eur Arch Otorhinolaryngol 2007 May 4;264(5):539-44. Epub 2007 Jan 4.

Department of Otorhinolaryngology and Head and Neck Surgery, Sişli Etfal Teaching and Research Hospital, Fatih, Istanbul, Turkey.

The standard treatment of zygomatic bone fractures is fixation by microplates or miniplates and screws today. It is very difficult to place plates and screws into thin bones or small bone fragments especially in the facial bones and bones adjacent to important structures. Cyanoacrylate is used as a hemostatic agent, an embolic agent, in retinal tears, in corneal ulcers, in fixation of mandibular osteotomies and in craniofacial surgery. N-2-Butyl cyanoacrylate is a form of cyanoacrylate which is bioabsorbable and biocompatible. It is easily applied to the tissues. We aimed to determine the effect of N-2-butyl cyanoacrylate in the fixation of displaced zygomatic bone fractures. We examined the histotoxicity and the effects on healing and foreign body reaction of N-2-butyl cyanoacrylate. Eight New Zealand white rabbits underwent zygomatic osteotomies bilaterally. The fractures on left sides of the rabbits were determined as study site and right sides as control site. Knight and North classification of zygomatic bone fractures were used and group 4 fractures were made bilaterally. Open reduction of fractures was performed bilaterally and N-2-butyl cyanoacrylate was applied only on left sides. No fixation was made on right sides representing the control group. Postoperatively in the first, second, third and fourth weeks, two rabbits were sacrificed and the fracture sites were examined macroscopically and histopathologically. In the glued study group, fixation was obtained in all cases whereas in the control group, all the fractures were seen to be displaced. Tissue reaction was similar in the study and the control groups.
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http://dx.doi.org/10.1007/s00405-006-0227-3DOI Listing
May 2007

The effects of the incision types in myringoplasty operations on cosmesis.

Eur Arch Otorhinolaryngol 2006 Sep 11;263(9):820-2. Epub 2006 Jul 11.

Department of Otorhinolaryngology, Sisli Etfal Teaching and Training Hospital, Istanbul, Turkey.

There is no study based on objective measurements about the cosmetic results of myringoplasty operation in medical literature. This study aims to show the differences in the auriculomastoid angle between the operations which were done with postauricular and endaural incisions. The auriculomastoid angle of 20 patients having had postauricular myringoplasty operation were measured both preoperative and postoperative periods. The auriculomastoid angles of 17 patients having had endaural myringoplasty operation were also measured in both preoperative and postoperative periods. Also, the patients were asked whether there was a change in the shape of their ears. It was observed that the increase of the auriculomastoid angles of the patients who had myringoplasty by postauricular incision was statistically significant when compared to the ones having had the operation by endaural incision. Also, the patients who had myringoplasty operation by postauricular incision realized the change in their ears significantly when compared to the other group. In this study, esthetically better results were observed in the myringoplasty operations done by endaural incision than the ones done by postauricular incision. When deciding on the incision type, this should be considered.
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http://dx.doi.org/10.1007/s00405-006-0069-zDOI Listing
September 2006

Blood gas changes in patients undergoing laryngeal microsurgery.

Auris Nasus Larynx 2006 Sep 10;33(3):299-302. Epub 2006 Mar 10.

Department of Anesthesiology, Sisli Etfal Training Hospital, Istanbul, Turkey.

Background: The aim of this prospective, single-blind study was to assess the variations in the blood levels of PaO(2), PaO(2)/FiO(2), PaCO(2), and acid-base balance of patients undergoing laryngeal microsurgery under general anesthesia using small-bore endotracheal tubes.

Methods: 25 male patients were intubated with endotracheal tubes of 5.5-mm-inner diameter and fifteen female patients were intubated with endotracheal tubes of 5-mm-inner diameter during surgery. PaO(2)/FiO(2), PaO(2), PaCO(2), percentage saturation of O(2) and HCO(3), and pH levels were monitored before surgery and at 15-min intervals during laryngeal microsurgery. Respiratory function's values (dead space, peak inspiratory pressure (PIP) and dynamic compliance) were recorded every 15 min throughout laryngeal microsurgery.

Results: No significant differences were observed between the pre- and intra-operative values of percentage saturation of O(2), PaO(2)/FiO(2) and HCO(3) until 120th min. There was no significant difference in respiratory function's values intraoperatively. Under anesthesia, PaO(2) levels significantly increased when compared with preoperative values. Another significant increase was observed in PaCO(2) levels after the 60th min. However, compared with preoperative values, pH levels significantly decreased under anesthesia at the 105th and 120th min.

Conclusion: Laryngeal microsurgery under general anesthesia can be performed using small-bore endotracheal tubes. This is not likely to have any adverse effects on a patient's blood gases and acid-base balance unless the operation lasts longer than 105 min.
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http://dx.doi.org/10.1016/j.anl.2006.01.005DOI Listing
September 2006

Inverted papilloma with new bone formation in ethmoidofrontal region.

Otolaryngol Head Neck Surg 2006 Feb;134(2):343-4

Otorhinolaryngology-Head and Neck Surgery Clinics, Sisli Etfal Teaching and Research Hospital, Kagithane/Istanbul Turkey.

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http://dx.doi.org/10.1016/j.otohns.2005.02.011DOI Listing
February 2006

Changes occurring in the nasal mucociliary transport in patients with one-sided septum deviation.

Rhinology 2005 Dec;43(4):257-60

Department of Otolaryngology, Istanbul Teaching and Research Hospital, Istanbul, Turkey.

Septum deviation is the most commonly seen nasal pathology. Mucociliar activity can be affected by septum deviation that can be detected in many nasal pathologies. This study was aimed to compare the changes occurring in the mucociliary activities in both the nasal cavities of 20 patients with one-sided septal deviation and 20 healthy young individuals without septal deviation. The mucociliary activity of the right nasal cavity in healthy human beings and the mucociliary activity of the concave and convex sides of nasal cavities in patients with septal deviation were measured. Mucociliary clearance was measured by means of the rhinoscintigraphy technique. The mucociliary transport speed on the concave side was found to be significantly increased compared to the convex side and the control group. As a result, the mucociliary activity was within normal limits in patients with septum deviation who didn't have a nasal mucosal disease. Furthermore, the mucociliary activity was found to be increased on the concave side where the airflow was higher.
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December 2005

Radiology quiz case 3. Hydatid cyst of the neck.

Arch Otolaryngol Head Neck Surg 2005 Nov;131(11):1025, 1029

Sisli Etfal Teaching and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1001/archotol.131.11.1025DOI Listing
November 2005

Isolated maxillary sinus Ewing's sarcoma.

Rhinology 2005 Sep;43(3):225-8

Sisli Etfal Training and Research Hospital, Otolaryngology Department, Istanbul, Turkey.

Extraskeletal Ewing's sarcoma is rarely found arising in the head and neck region. Only six cases of extraskeletal Ewing's sarcoma invading the nasal cavity or paranasal sinuses have been reported in the literature. The first described case of that Ewing's sarcoma located in isolated maxillary sinus extending into the orbita without involving the nose is presented. A 16-year-old woman presented with swelling in her right cheek. The nasal examination was normal. A computed tomography (CT) and magnetic resonance imaging (MRI) of the sinuses revealed a large mass in the right maxillary sinus with extension to the orbita. Under general anesthesia biopsies were taken. Based on histopathological analysis, a diagnosis of extraskeletal Ewing's sarcoma was made. The patient did not accept the surgical therapy. The patient was treated with combined chemotherapy and radiotherapy. The patient has done without evidence of recurrence or metastasis for one year.
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September 2005

Basaloid squamous cell carcinoma of the larynx.

Auris Nasus Larynx 2006 Mar 26;33(1):71-4. Epub 2005 Sep 26.

Department of Otorhinolaryngology and Head & Neck Surgery, Sisli Etfal Training and Research Hospital, Dikilitaş Emirhan cad. No: 8/1, Avarsaray apt. D. 7, 34349 Beşiktaş, TR-Istanbul, Turkey.

Basaloid squamous cell carcinoma (BSCC) is a rare tumor with distinct morphological and biological features that differentiate it from the common form of squamous cell carcinoma (SCC) in the head and neck region. It is mostly seen in the supraglottic larynx, hypopharynx and a base of the tongue. We present two cases of BSCC of the larynx; both being transglottic tumors. Both of the patients underwent primary surgery including bilateral neck dissections. None of the patients had cervical metastases at histopathological examination. Both patients received radiotherapy after surgery. They were alive and free of disease at 24 and 27 months, respectively.
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http://dx.doi.org/10.1016/j.anl.2005.07.017DOI Listing
March 2006

Giant concha bullosa: a case report.

Kulak Burun Bogaz Ihtis Derg 2004 ;13(3-4):77-9

Department of Otolaryngology, Sişli Etfal Training and Research Hospital, Istanbul, Turkey.

Concha bullosa is a relatively common anatomic variant that is in fact an enlarged pneumatized middle turbinate. We report a case of giant concha bullosa in a 21-year-old woman who had a history of nasal obstruction. Anterior nasal examination of the nasal cavity revealed bilateral nasal masses which were covered with normal mucosa. Nasal endoscopy of both nasal cavities was impossible because of total occlusion. Computed tomography showed a bilateral giant concha bullosa. Under general anesthesia, resection of lateral half of the concha bullosa was performed bilaterally by a transnasal endoscopic technique to achieve nasal airway patency.
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September 2005

Arteriovenous malformation of the nasopharynx: a case report.

Int J Pediatr Otorhinolaryngol 2005 Sep;69(9):1287-90

Sisli Etfal Teaching and Training Hospital, Otorhinolaryngology Department, Istanbul, Turkey.

Arteriovenous malformation (AVM) of the head and neck is a rare vascular anomaly but when present is persistent and progressive in nature and can represent itself truly as a lethal benign disease. We present here an unusual case of an AVM with the size of 1.5 cm x 0.8 cm at the adenoid tissue found in an 8-year-old boy, which is not previously reported in the literature where we treated the patient with surgery alone. Although bleeding is a common presentation with vascular malformations, we have not seen any bleeding in our case. After the surgery, paranasal sinus and neck CT were undertaken. They showed no other AVM.
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http://dx.doi.org/10.1016/j.ijporl.2005.03.050DOI Listing
September 2005

Lymphoepithelial carcinoma of the larynx.

Auris Nasus Larynx 2005 Jun;32(2):189-93

Department of Otolaryngology, Sisli Etfal Training and Research Hospital, Adnan Saygun Cad. Kelaynak Sok., Kibele Sitesi 10/1 Ulus 34340, Istanbul, Turkey.

Lymphoepithelial carcinoma (LEC) of the larynx is a rare neoplasm; with a review of the literature having disclosed only 34 documented cases. This neoplasm seems to behave in a fashion reminiscent of nasopharyngeal carcinoma. In contrast to nasopharyngeal carcinoma, most cases have not been associated with Epstein-Barr virus (EBV). The diagnosis often requires immunohistochemistry or electron microscopy for confirmation. We describe a case of this tumor involving the supraglottis. The patient was treated with supraglottic laryngectomy and bilateral modified neck dissection. The histopathological study of the surgical specimen revealed an undifferentiated carcinoma with aspects of lymphoeptihelioma. The patient underwent radiotherapy and his 2-year follow-up showed no evidence of local or distant metastasis.
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http://dx.doi.org/10.1016/j.anl.2004.11.014DOI Listing
June 2005

Comparison of diced cartilage graft wrapped in surgicell and diced cartilage graft wrapped in fascia: an experimental study.

Laryngoscope 2005 Apr;115(4):668-71

Department of Otorhinolaryngology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Hypothesis: This study was conducted to compare diced cartilage grafts wrapped in fascia and diced cartilage grafts wrapped in surgicell with respect to their resorption.

Study Design: Experimental study.

Methods: Eight male Wistar Albino rats were used. After general anesthesia, two different subcutaneous pockets (upper and lower pocket) were prepared in the rat's abdomen. Surgicell-wrapped homograft that was taken from the ear was placed into the upper subcutaneous pocket. Fascia-wrapped homograft which was taken from the ear was placed into the lower subcutaneous pocket. All the rats were killed at the end of 2 months, and the samples were collected to be examined histopathologically. Cartilage mass, foreign body reaction, fibrosis, chronic inflammation, and vascularization were researched.

Results: Diced cartilage wrapped surgicell stained negative for glial fibrillary acidic protein (GFAP). Diced cartilage wrapped in fascia stained positive for GFAP. There was a significant difference between two groups with respect to fibrosis, chronic inflammation, and cartilage mass. There was no significant difference between the two groups regarding vascularization.

Conclusions: This study suggests that diced cartilage graft wrapped in surgicell was absorbed, whereas diced cartilage graft wrapped in fascia was not.
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http://dx.doi.org/10.1097/01.mlg.0000161356.35697.f6DOI Listing
April 2005

Cavernous lymphangioma in the laryngeal ventricle in an adult patient.

Kulak Burun Bogaz Ihtis Derg 2003 Oct;11(4):117-20

Department of 'Otolaryngology, Sişli Etfal Training Hospital, Istanbul, Turkey.

Lymphangiomas of the larynx are quite rare and even rarer in adults. Isolated cavernous lymphangioma in the laryngeal ventricle was diagnosed in a 47-year-old woman. The patient presented with hoarseness with a history of three months. Direct laryngoscopy performed under general anesthesia showed a large, smooth, gray-reddish tumor above the right vocal fold, originating from the right ventricle. The tumor was removed through a micro-laryngoscopic procedure with cold instruments. Histopathologic diagnosis was cavernous lymphangioma. There was no local recurrence a year after the operation.
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October 2003

Efficacy of anti-adhesive barriers in secondary thyroidectomy: an experimental study.

Laryngoscope 2004 Sep;114(9):1668-73

Department of Otorhinolaryngology, Head and Neck Surgery, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Hypothesis: This study was conducted to compare the effectiveness of two anti-adhesive barriers (Seprafilm and Interceed) for reducing adhesions after thyroidectomy in a rat model. The anti-adhesive barriers are suggested for use in repeated surgeries in general and the gynecologic fields in particular.

Study Design: Controlled, randomized study.

Methods: Twenty-eight male Wistar Albino rats that underwent right subtotal thyroidectomy were randomly assigned to three groups. One group received Seprafilm (n = 10), and the other received Interceed (n = 10) as anti-adhesive barriers. The third group was the control group (n = 8). At postoperative day 14, the rats were killed under general anesthesia, and the surgical fields were evaluated for the adhesion formation. The extent of the adhesion formation is scored from 0 (no adhesions) to 2 (fibrous adhesions that required sharp dissection). Histopathologically, chronic inflammation, histiocyte, fibroblast, fibrosis, collagen, vascularization, granuloma, giant cell, and fat necrosis were examined.

Results: All the subjects in the control group, 7 of 10 in the Interceed group, and 4 of 10 in the Seprafilm group needed to be dissected bluntly or sharply. There was significant difference between the Seprafilm and the control group (P < .05) whereas there was no significant difference between the Interceed group and the control group (P > .05). When examined histopathologically, the criteria showing adhesion, such as fibrosis, fibroblast, and collagen were higher in the control group compared with the Seprafilm and Interceed groups. There was no significant difference between the Seprafilm and Interceed groups, whereas a significant difference was found between these two groups and the control group.

Conclusion: This study suggests that both Seprafilm and Interceed decrease the incidence of posthyroidectomy adhesions in a rat model. Both agents showed no foreign body reaction.
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http://dx.doi.org/10.1097/00005537-200409000-00031DOI Listing
September 2004

Short-term evaluation of over-under myringoplasty technique.

Eur Arch Otorhinolaryngol 2005 May 11;262(5):400-3. Epub 2004 Sep 11.

Department of Otorhinolaryngology and Head and Neck Surgery, Sisli Etfal Teaching and Research Hospital, Istanbul, Turkey.

Over-under tympanoplasty is a technique aimed at eliminating the disadvantages of the two classical techniques of overlay and underlay myringoplasty, which are employed in repairing the tympanic membrane. In this retrospective study, a total of 104 patients underwent myringoplasty, which was performed by means of the underlay technique in 46 patients and over-under technique in 58 patients. The mean follow-up period was 11 months. In the first group of patients, the underlay technique was performed; the grafted membrane was placed medial to the remaining drum and the manubrium of the malleus. In the second group, the over-under technique was performed; the grafted membrane was placed under the remaining drum and over the malleus. The rate of success in the first group of 46 patients was 91.5%, and that of atelectasis was 19.5%. The rate of success in the second group of 58 patients was 94.9% and 12%, respectively. Lateralization of the graft was not observed in either of the groups. In the patients operated on by means of the underlay technique, the air-bone gap decreased by 16.55 dB this rate was 16.96 dB in those operated on by the over-under technique. The authors consider over-under tympanoplasty to be superior to the other two classical methods not only because of its effectiveness, but also because of the results achieved by this technique.
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http://dx.doi.org/10.1007/s00405-004-0834-9DOI Listing
May 2005