Burgess Freeman

Burgess Freeman

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Burgess Freeman

Burgess Freeman

Publications by authors named "Burgess Freeman"

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Practical approaches to evaluating and optimizing brain exposure in early drug discovery.

Eur J Med Chem 2019 Aug 23;182:111643. Epub 2019 Aug 23.

Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2019.111643DOI Listing
August 2019

Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses.

Cancer Cell 2018 09 23;34(3):411-426.e19. Epub 2018 Aug 23.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 323, Memphis, TN 38105-3678, USA; Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, TN 38105, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158019PMC
September 2018

Simvastatin Hydroxy Acid Fails to Attain Sufficient Central Nervous System Tumor Exposure to Achieve a Cytotoxic Effect: Results of a Preclinical Cerebral Microdialysis Study.

Drug Metab Dispos 2016 Apr 22;44(4):591-4. Epub 2016 Jan 22.

Departments of Pharmaceutical Sciences (Y.T.P., M.O.J., A.D.D., D.C.T. C.F.S.), Hematology (N.B.), and Developmental Neurobiology (R.J.G.), Preclinical Pharmacokinetic Shared Resource (P.K.V., B.B.F.), St. Jude Children's Research Hospital, Memphis, Tennessee; Merck, Rahway, New Jersey (D.C.T.); and Cambridge Cancer Centre, Cambridge, United Kingdom (R.J.G.)

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http://dx.doi.org/10.1124/dmd.115.068445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810761PMC
April 2016

Preclinical studies of 5-fluoro-2'-deoxycytidine and tetrahydrouridine in pediatric brain tumors.

J Neurooncol 2016 Jan 30;126(2):225-34. Epub 2015 Oct 30.

Department of Tumor Cell Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1007/s11060-015-1965-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718940PMC
January 2016

Population pharmacokinetics of bevacizumab in children with osteosarcoma: implications for dosing.

Clin Cancer Res 2014 May 17;20(10):2783-92. Epub 2014 Mar 17.

Authors' Affiliations: Departments of Pharmaceutical Sciences, Oncology, Biostatistics, and Surgery; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital; Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee; Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas; Department of Pediatrics, Stanford School of Medicine, Palo Alto, California; and Department of Oncology, Division of Pediatric Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024352PMC
May 2014

Optimization of antitumor modulators of pre-mRNA splicing.

J Med Chem 2013 Dec 11;56(24):10033-44. Epub 2013 Dec 11.

Department of Chemical Biology and Therapeutics, ‡Preclinical PK Shared Resource, St. Jude Children's Research Hospital , 262 Danny Thomas Place, Memphis, Tennessee 38105-2794, United States.

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http://dx.doi.org/10.1021/jm401370hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932738PMC
December 2013

Development of an oral form of azacytidine: 2'3'5'triacetyl-5-azacytidine.

Chemother Res Pract 2011 18;2011:965826. Epub 2011 Dec 18.

Nevada Cancer Institute, One Breakthough Way, Las Vegas, NV 89135, USA.

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http://dx.doi.org/10.1155/2011/965826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263612PMC
August 2012

A phase I trial of PTK787/ZK222584 in combination with pemetrexed and cisplatin in patients with advanced solid tumors.

Invest New Drugs 2009 Feb 19;27(1):63-5. Epub 2008 Jul 19.

Nevada Cancer Institute, 1, Breakthrough Way, Las Vegas, NV, 89144, USA.

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http://dx.doi.org/10.1007/s10637-008-9157-9DOI Listing
February 2009

Population pharmacokinetic analysis of topotecan in pediatric cancer patients.

Clin Cancer Res 2007 Nov;13(22 Pt 1):6703-11

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-07-1376DOI Listing
November 2007

Phase I clinical trial of oxaliplatin in children and adolescents with refractory solid tumors.

J Clin Oncol 2007 Jun;25(16):2274-80

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.

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http://dx.doi.org/10.1200/JCO.2006.08.2388DOI Listing
June 2007

Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer.

Pediatr Blood Cancer 2006 Oct;47(5):572-9

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1002/pbc.20685DOI Listing
October 2006

Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

Cancer Invest 2006 Apr-May;24(3):310-7

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

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http://dx.doi.org/10.1080/07357900600632058DOI Listing
August 2006

Using plasma topotecan pharmacokinetics to estimate topotecan exposure in cerebrospinal fluid of children with medulloblastoma.

Neuro Oncol 2006 Apr 3;8(2):89-95. Epub 2006 Feb 3.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 North Lauderdale, Memphis TN 38105-2794, USA.

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http://dx.doi.org/10.1215/15228517-2005-004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1871944PMC
April 2006

Determination of lapatinib (GW572016) in human plasma by liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS).

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Feb 20;831(1-2):169-75. Epub 2005 Dec 20.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1016/j.jchromb.2005.11.044DOI Listing
February 2006

Development of a pharmacokinetic limited sampling model for temozolomide and its active metabolite MTIC.

Cancer Chemother Pharmacol 2005 May 26;55(5):433-8. Epub 2005 Jan 26.

Department of Pharmaceutical Sciences, St Jude Children's Research Hospital, 332 N. Lauderdale, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1007/s00280-004-0896-9DOI Listing
May 2005

Combining quinupristin/dalfopristin with other agents for resistant infections.

Ann Pharmacother 2004 Apr 27;38(4):677-85. Epub 2004 Feb 27.

Department of Infectious Disease and Pharmacy, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756-0001, USA.

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http://dx.doi.org/10.1345/aph.1D323DOI Listing
April 2004