Publications by authors named "Bum-Rak Choi"

55Publications

Human Cardiac Fibroblast Number and Activation State Modulate Electromechanical Function of hiPSC-Cardiomyocytes in Engineered Myocardium.

Stem Cells Int 2020 16;2020:9363809. Epub 2020 Jul 16.

Center for Biomedical Engineering, School of Engineering and Division of Biology and Medicine, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1155/2020/9363809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7381987PMC
July 2020

Impact of I Voltage and Ca/Mg-Dependent Rectification on Cardiac Repolarization.

Biophys J 2020 Aug 27;119(3):690-704. Epub 2020 Jun 27.

Cardiovascular Research Center, Rhode Island Hospital, Department of Medicine, The Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2020.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7399499PMC
August 2020

Late I blocker GS967 Suppress Polymorphic VT in a Transgenic Rabbit Model of Long QT Type 2.

Circ Arrhythm Electrophysiol 2020 Jul 6. Epub 2020 Jul 6.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI.

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http://dx.doi.org/10.1161/CIRCEP.118.006875DOI Listing
July 2020

Short-Long Heart Rate Variation Increases Dispersion of Action Potential Duration in Long QT Type 2 Transgenic Rabbit Model.

Sci Rep 2019 10 16;9(1):14849. Epub 2019 Oct 16.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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http://www.nature.com/articles/s41598-019-51230-9
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http://dx.doi.org/10.1038/s41598-019-51230-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795902PMC
October 2019

LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase.

Circ Genom Precis Med 2019 09 28;12(9):407-420. Epub 2019 Aug 28.

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence (K.S.M., K.R., A.Y.K., N.N.T., A.X., T.Y.K., Y.L., W.L., D.T., B.-R.C., G.K.).

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http://dx.doi.org/10.1161/CIRCGEN.119.002641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750970PMC
September 2019

PKA phosphorylation underlies functional recruitment of sarcolemmal SK2 channels in ventricular myocytes from hypertrophic hearts.

J Physiol 2020 Jul 20;598(14):2847-2873. Epub 2019 Mar 20.

Department of Medicine, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Cardiovascular Research Center, Providence, RI, USA.

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http://dx.doi.org/10.1113/JP277618DOI Listing
July 2020

NCX-Mediated Subcellular Ca Dynamics Underlying Early Afterdepolarizations in LQT2 Cardiomyocytes.

Biophys J 2018 09 9;115(6):1019-1032. Epub 2018 Aug 9.

Physics Department and Center for Interdisciplinary Research in Complex Systems, Northeastern University, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140381PMC
September 2018

Transient Outward K Current (I) Underlies the Right Ventricular Initiation of Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long-QT Syndrome Type 1.

Circ Arrhythm Electrophysiol 2018 06;11(6):e005414

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence (B.-R.C., W.L., D.T., A.Y.K., R.T., T.Y.K., G.K.).

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http://dx.doi.org/10.1161/CIRCEP.117.005414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081959PMC
June 2018

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts.

PLoS One 2018 1;13(5):e0196714. Epub 2018 May 1.

Cardiovascular Research Center, Cardiovascular Institute, Rhode Island Hospital and Alpert Medical School of Brown University, Providence, RI, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196714PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929561PMC
July 2018

HuR-mediated SCN5A messenger RNA stability reduces arrhythmic risk in heart failure.

Heart Rhythm 2018 07 16;15(7):1072-1080. Epub 2018 Feb 16.

Department of Cardiology, The Warren Alpert Medical School of Brown University, Providence, Rhode Island; The Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2018.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026071PMC
July 2018

Mechanisms linking T-wave alternans to spontaneous initiation of ventricular arrhythmias in rabbit models of long QT syndrome.

J Physiol 2018 04 2;596(8):1341-1355. Epub 2018 Mar 2.

Department of Medicine, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1113/JP275492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5899976PMC
April 2018

Laser-Etched Designs for Molding Hydrogel-Based Engineered Tissues.

Tissue Eng Part C Methods 2017 05;23(5):311-321

1 School of Engineering, Brown University , Providence, Rhode Island.

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http://dx.doi.org/10.1089/ten.TEC.2017.0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444510PMC
May 2017

SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.

Cardiovasc Res 2017 03;113(3):343-353

Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, 1 Hoppin Street, Providence, RI, 02903-4141, USA.

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http://dx.doi.org/10.1093/cvr/cvx005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852621PMC
March 2017

Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.

Am J Physiol Heart Circ Physiol 2016 12 7;311(6):H1470-H1484. Epub 2016 Oct 7.

Department of Medicine (Cardiology), David Geffen School of Medicine, University of California, Los Angeles, California;

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http://dx.doi.org/10.1152/ajpheart.00500.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5206347PMC
December 2016

RAGE siRNA-mediated gene silencing provides cardioprotection against ventricular arrhythmias in acute ischemia and reperfusion.

J Control Release 2015 Nov 14;217:315-26. Epub 2015 Sep 14.

Division of Cardiology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul 120-752, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2015.09.006DOI Listing
November 2015

Alpha B-crystallin prevents ventricular arrhythmia by attenuating inflammation and oxidative stress in rat with autoimmune myocarditis.

Int J Cardiol 2015 Mar 30;182:399-402. Epub 2014 Dec 30.

Division of Cardiology, Yonsei University College of Medicine, Seoul, Republic of Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University, Seoul, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2014.12.152DOI Listing
March 2015

Complex excitation dynamics underlie polymorphic ventricular tachycardia in a transgenic rabbit model of long QT syndrome type 1.

Heart Rhythm 2015 Jan 5;12(1):220-8. Epub 2014 Oct 5.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15475271140113
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http://dx.doi.org/10.1016/j.hrthm.2014.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277941PMC
January 2015

RING finger protein RNF207, a novel regulator of cardiac excitation.

J Biol Chem 2014 Dec 3;289(49):33730-40. Epub 2014 Oct 3.

From the Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903,

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http://dx.doi.org/10.1074/jbc.M114.592295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256309PMC
December 2014

Progesterone modulates SERCA2a expression and function in rabbit cardiomyocytes.

Am J Physiol Cell Physiol 2014 Dec 24;307(11):C1050-7. Epub 2014 Sep 24.

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island

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http://dx.doi.org/10.1152/ajpcell.00127.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254949PMC
December 2014

Hyperphosphorylation of RyRs underlies triggered activity in transgenic rabbit model of LQT2 syndrome.

Circ Res 2014 Nov 23;115(11):919-28. Epub 2014 Sep 23.

From the Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Rhode Island Hospital, Alpert Medical School of Brown University, Providence (D.T., W.L., L.L.C., H.K.J., Y.L., R.T., J.D., K.B., B.-R.C., G.K.); Physics Department, Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, MA (C.M.R., A.K.); Department of Comparative Medicine, Pennsylvania State University College of Medicine, Hershey (X.P.); and Department of Cardiology and Angiology I, Heart Center Freiburg University, Freiburg, Germany (K.E.O.).

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http://circres.ahajournals.org/content/early/2014/09/23/CIRC
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http://circres.ahajournals.org/cgi/doi/10.1161/CIRCRESAHA.11
Publisher Site
http://dx.doi.org/10.1161/CIRCRESAHA.115.305146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406222PMC
November 2014

Calcium measurements from whole heart using Rhod-2.

Authors:
Bum-Rak Choi

Methods Mol Biol 2013 ;937:217-28

Cardiovascular Research Center, Rhode Island Hospital and Brown Medical School, Providence, RI, USA.

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http://dx.doi.org/10.1007/978-1-62703-086-1_13DOI Listing
February 2013

A novel, minimally invasive, segmental myocardial infarction with a clear healed infarct borderzone in rabbits.

Am J Physiol Heart Circ Physiol 2012 Jun 23;302(11):H2321-30. Epub 2012 Mar 23.

Cardiovascular Research Center, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, USA.

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http://dx.doi.org/10.1152/ajpheart.00031.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774205PMC
June 2012

Electromechanical and structural alterations in the aging rabbit heart and aorta.

Am J Physiol Heart Circ Physiol 2012 Apr 3;302(8):H1625-35. Epub 2012 Feb 3.

Cardiovascular Research Center, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

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http://dx.doi.org/10.1152/ajpheart.00960.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4747897PMC
April 2012

Differential conditions for early after-depolarizations and triggered activity in cardiomyocytes derived from transgenic LQT1 and LQT2 rabbits.

J Physiol 2012 Mar 19;590(5):1171-80. Epub 2011 Dec 19.

Cardiovascular Research Centre, Division of Cardiology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

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http://dx.doi.org/10.1113/jphysiol.2011.218164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381823PMC
March 2012

Electrophysiological studies of transgenic long QT type 1 and type 2 rabbits reveal genotype-specific differences in ventricular refractoriness and His conduction.

Am J Physiol Heart Circ Physiol 2010 Sep 25;299(3):H643-55. Epub 2010 Jun 25.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

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http://dx.doi.org/10.1152/ajpheart.00074.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944497PMC
September 2010

Origin of complex behaviour of spatially discordant alternans in a transgenic rabbit model of type 2 long QT syndrome.

J Physiol 2009 Oct 12;587(Pt 19):4661-80. Epub 2009 Aug 12.

Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

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http://doi.wiley.com/10.1113/jphysiol.2009.175018
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http://dx.doi.org/10.1113/jphysiol.2009.175018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768020PMC
October 2009

Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution.

Heart Rhythm 2009 May 31;6(5):696-706. Epub 2009 Jan 31.

Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, UK.

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http://dx.doi.org/10.1016/j.hrthm.2009.01.035DOI Listing
May 2009

Imaging ventricular fibrillation.

J Electrocardiol 2007 Nov-Dec;40(6 Suppl):S56-61

Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1016/j.jelectrocard.2007.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175033PMC
January 2008

Dual-dye optical mapping after myocardial infarction: does the site of ventricular stimulation alter the properties of electrical propagation?

J Cardiovasc Electrophysiol 2008 Feb 24;19(2):197-202. Epub 2007 Oct 24.

Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

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http://doi.wiley.com/10.1111/j.1540-8167.2007.00998.x
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http://dx.doi.org/10.1111/j.1540-8167.2007.00998.xDOI Listing
February 2008

Calcium transients modulate action potential repolarizations in ventricular fibrillation.

Conf Proc IEEE Eng Med Biol Soc 2006;2006:2264-7

University of Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1109/IEMBS.2006.260059DOI Listing
March 2008

Monte Carlo simulation of 3D mapping of cardiac electrical activity with spinning slit confocal optics.

Conf Proc IEEE Eng Med Biol Soc 2006;2006:1093-7

Department of Cell Biology & Physiology, School of Medicine, University of Pittsburgh, 3500 Terrace Street, Pittsburgh, PA 15261, USA.

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http://ieeexplore.ieee.org/document/4461946/
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http://dx.doi.org/10.1109/IEMBS.2006.259837DOI Listing
March 2008

Spatially discordant voltage alternans cause wavebreaks in ventricular fibrillation.

Heart Rhythm 2007 Aug 12;4(8):1057-68. Epub 2007 Jun 12.

Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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http://dx.doi.org/10.1016/j.hrthm.2007.03.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137164PMC
August 2007

Autonomic nerve stimulation reverses ventricular repolarization sequence in rabbit hearts.

Circ Res 2007 Apr 15;100(7):e72-80. Epub 2007 Mar 15.

Department of Cardiovascular Sciences, Cardiology Group, University of Leicester, UK.

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http://dx.doi.org/10.1161/01.RES.0000264101.06417.33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3021455PMC
April 2007

Low osmolarity transforms ventricular fibrillation from complex to highly organized, with a dominant high-frequency source.

Heart Rhythm 2006 Oct 8;3(10):1210-20. Epub 2006 Jul 8.

Department of Biomedical Engineering, Tulane University, New Orleans, Louisiana, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S154752710601722
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http://dx.doi.org/10.1016/j.hrthm.2006.06.026DOI Listing
October 2006

Sex modulates the arrhythmogenic substrate in prepubertal rabbit hearts with Long QT 2.

J Cardiovasc Electrophysiol 2005 May;16(5):516-24

Department of Cell Biology and Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://dx.doi.org/10.1046/j.1540-8167.2005.40622.xDOI Listing
May 2005

Adaptation of cardiac action potential durations to stimulation history with random diastolic intervals.

J Cardiovasc Electrophysiol 2004 Oct;15(10):1188-97

Department of Cell Biology and Physiology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, USA.

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http://doi.wiley.com/10.1046/j.1540-8167.2004.04070.x
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http://dx.doi.org/10.1046/j.1540-8167.2004.04070.xDOI Listing
October 2004

Effects of mechanical uncouplers, diacetyl monoxime, and cytochalasin-D on the electrophysiology of perfused mouse hearts.

Am J Physiol Heart Circ Physiol 2004 Oct 10;287(4):H1771-9. Epub 2004 Jun 10.

Dept. of Cell Biology and Physiology, S314 Biomedical Science Tower, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA.

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http://dx.doi.org/10.1152/ajpheart.00234.2004DOI Listing
October 2004

Calcium-dependent arrhythmias in transgenic mice with heart failure.

Am J Physiol Heart Circ Physiol 2003 Feb 17;284(2):H431-41. Epub 2002 Oct 17.

Cardiovascular Institute, University of Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1152/ajpheart.00431.2002DOI Listing
February 2003

Cytosolic Ca2+ triggers early afterdepolarizations and Torsade de Pointes in rabbit hearts with type 2 long QT syndrome.

J Physiol 2002 Sep;543(Pt 2):615-31

University of Pittsburgh, School of Medicine, Department of Cell Biology and Physiology, Pittsburgh, PA 15261, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290501PMC
http://dx.doi.org/10.1113/jphysiol.2002.024570DOI Listing
September 2002

Life span of ventricular fibrillation frequencies.

Circ Res 2002 Aug;91(4):339-45

Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pa 15261, USA.

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http://dx.doi.org/10.1161/01.res.0000031801.84308.f4DOI Listing
August 2002

Images of Action Potential Propagation in Heart.

News Physiol Sci 2000 Feb;15:33-41

Department of Cell Biology and Physiology at the University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261.

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http://dx.doi.org/10.1152/physiologyonline.2000.15.1.33DOI Listing
February 2000