Buhm Han

Buhm Han

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Buhm Han

Buhm Han

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Effects of smoking on the association of HLA with ulcerative colitis.

J Gastroenterol Hepatol 2019 Apr 30. Epub 2019 Apr 30.

Department of Gastroenterology and Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.14695
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http://dx.doi.org/10.1111/jgh.14695DOI Listing
April 2019

An Association Mapping Framework To Account for Potential Sex Difference in Genetic Architectures.

Genetics 2018 07 11;209(3):685-698. Epub 2018 May 11.

Department of Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

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http://dx.doi.org/10.1534/genetics.117.300501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028251PMC
July 2018

Association of CDKN2A/CDKN2B with inflammatory bowel disease in Koreans.

J Gastroenterol Hepatol 2018 Apr 5;33(4):887-893. Epub 2018 Feb 5.

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/jgh.14031DOI Listing
April 2018

FOLD: a method to optimize power in meta-analysis of genetic association studies with overlapping subjects.

Bioinformatics 2017 Dec;33(24):3947-3954

Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Korea.

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http://dx.doi.org/10.1093/bioinformatics/btx463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860085PMC
December 2017

MergeReference: A Tool for Merging Reference Panels for HLA Imputation.

Genomics Inform 2017 Sep 28;15(3):108-111. Epub 2017 Sep 28.

Department of Convergence Medicine, University of Ulsan College of Medicine and Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.

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http://dx.doi.org/10.5808/GI.2017.15.3.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637342PMC
September 2017

X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans.

J Crohns Colitis 2017 Jul;11(7):820-830

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1093/ecco-jcc/jjx023DOI Listing
July 2017

Identification of Loci at 1q21 and 16q23 That Affect Susceptibility to Inflammatory Bowel Disease in Koreans.

Gastroenterology 2016 Dec 26;151(6):1096-1099.e4. Epub 2016 Aug 26.

Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.08.025DOI Listing
December 2016

Comparison of Two Meta-Analysis Methods: Inverse-Variance-Weighted Average and Weighted Sum of Z-Scores.

Genomics Inform 2016 Dec 30;14(4):173-180. Epub 2016 Dec 30.

Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Korea.; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul 05505, Korea.

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http://dx.doi.org/10.5808/GI.2016.14.4.173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287121PMC
December 2016

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis.

G3 (Bethesda) 2016 07 7;6(7):1793-8. Epub 2016 Jul 7.

Department of Computer Science, University of California, Los Angeles, California 90095 Department of Human Genetics, University of California, Los Angeles, California 90095

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http://dx.doi.org/10.1534/g3.116.029439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938634PMC
July 2016

Imputing Phenotypes for Genome-wide Association Studies.

Am J Hum Genet 2016 Jul 9;99(1):89-103. Epub 2016 Jun 9.

Department of Computer Science, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297163013
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http://dx.doi.org/10.1016/j.ajhg.2016.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005435PMC
July 2016

Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.

J Am Heart Assoc 2016 07 14;5(7). Epub 2016 Jul 14.

Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

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http://dx.doi.org/10.1161/JAHA.115.002603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015357PMC
July 2016

Using genomic annotations increases statistical power to detect eGenes.

Bioinformatics 2016 06;32(12):i156-i163

Department of Computer Science Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908356PMC
June 2016

A general framework for meta-analyzing dependent studies with overlapping subjects in association mapping.

Hum Mol Genet 2016 05 21;25(9):1857-66. Epub 2016 Feb 21.

Division of Genetics, Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Partners Center for Personalized Genetic Medicine, Boston, MA 02115, USA and Faculty of Medical and Human Sciences, University of Manchester, Manchester M13 9PL, UK.

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http://dx.doi.org/10.1093/hmg/ddw049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4986332PMC
May 2016

Multiple testing correction in linear mixed models.

Genome Biol 2016 Apr 1;17:62. Epub 2016 Apr 1.

Computer Science Department, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s13059-016-0903-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818520PMC
April 2016

Association of HLA Genotype and Fulminant Type 1 Diabetes in Koreans.

Genomics Inform 2015 Dec 31;13(4):126-31. Epub 2015 Dec 31.

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Korea.

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http://dx.doi.org/10.5808/GI.2015.13.4.126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742322PMC
December 2015

Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.

Nat Genet 2015 Aug 13;47(8):898-905. Epub 2015 Jul 13.

1] Department of Medicine, Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital, Division of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Partners Center for Personalized Genetic Medicine, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. [5] Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/ng.3353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930791PMC
August 2015

Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.

Am J Hum Genet 2015 Jul;97(1):139-52

Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02446, USA; Partners Center for Personalized Genetic Medicine, Boston, MA 02446, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4572568PMC
July 2015

Accurate and fast multiple-testing correction in eQTL studies.

Am J Hum Genet 2015 Jun 28;96(6):857-68. Epub 2015 May 28.

Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea; Department of Medicine, University of Ulsan College of Medicine, Seoul 138-736, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457958PMC
June 2015

Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response.

JAMA 2015 Apr;313(16):1645-56

Arthritis Research UK Centre for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, England2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manches.

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http://dx.doi.org/10.1001/jama.2015.3435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928097PMC
April 2015

A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk.

Ann Rheum Dis 2015 Jan 3;74(1):170-6. Epub 2013 Oct 3.

Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, The University of Manchester, Manchester, UK.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2013-20413
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http://dx.doi.org/10.1136/annrheumdis-2013-204133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283663PMC
January 2015

Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.

Hum Mol Genet 2014 Dec 28;23(25):6916-26. Epub 2014 Jul 28.

Division of Rheumatology, Immunology, and Allergy and Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA NIHR Manchester Musculoskeletal Biomedical, Research Unit, Central Manchester NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, UK

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http://dx.doi.org/10.1093/hmg/ddu387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245039PMC
December 2014

Variation at HLA-DRB1 is associated with resistance to enteric fever.

Nat Genet 2014 Dec 10;46(12):1333-6. Epub 2014 Nov 10.

1] Genome Institute of Singapore, Singapore. [2] Singapore Eye Research Institute, Singapore. [3] Saw Swee Hock School of Public Health, National University of Singapore, Singapore. [4] Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [5] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099079PMC
December 2014

The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.

Nat Commun 2014 Dec 23;5:5902. Epub 2014 Dec 23.

Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul 133-792, Republic of Korea.

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http://dx.doi.org/10.1038/ncomms6902DOI Listing
December 2014

Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes.

Am J Hum Genet 2014 Aug 31;95(2):162-72. Epub 2014 Jul 31.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, USA; Arthritis Research UK Epidemiology Unit, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, University of Manchester, Manchester M13 9PT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129407PMC
August 2014

Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity.

Am J Hum Genet 2014 Apr 20;94(4):522-32. Epub 2014 Mar 20.

Division of Genetics, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, MA 02115, USA; Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Arthritis Research UK Epidemiology Unit, Musculoskeletal Research Group, University of Manchester, Manchester Academic Health Sciences Centre, Manchester M13 9PT, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297140007
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http://dx.doi.org/10.1016/j.ajhg.2014.02.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980428PMC
April 2014

Imputing amino acid polymorphisms in human leukocyte antigens.

PLoS One 2013 6;8(6):e64683. Epub 2013 Jun 6.

Harvard-MIT (Massachusetts Institute of Technology) Division of Health Sciences and Technology, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064683PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675122PMC
January 2014

Fast pairwise IBD association testing in genome-wide association studies.

Bioinformatics 2014 Jan 24;30(2):206-13. Epub 2013 Oct 24.

Division of Genetics, Brigham and Women's Hospital and Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA, Partners Center for Personalized Genetic Medicine, Boston, MA 02115, USA, Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA, Computer Science Department, University of California, Los Angeles, CA 90095, USA, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands and Department of Human Genetics, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892684PMC
January 2014

Meta-analysis identifies gene-by-environment interactions as demonstrated in a study of 4,965 mice.

PLoS Genet 2014 Jan 9;10(1):e1004022. Epub 2014 Jan 9.

Department of Computer Science, University of California, Los Angeles, Los Angeles, California, United States of America ; Department of Human Genetics, University of California, Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3886926PMC
January 2014

Application of user-guided automated cytometric data analysis to large-scale immunoprofiling of invariant natural killer T cells.

Proc Natl Acad Sci U S A 2013 Nov 4;110(47):19030-5. Epub 2013 Nov 4.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1318322110
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http://dx.doi.org/10.1073/pnas.1318322110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3839720PMC
November 2013

Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches.

PLoS Genet 2013 Jun 13;9(6):e1003491. Epub 2013 Jun 13.

Computer Science Department, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681686PMC
June 2013

Chromatin marks identify critical cell types for fine mapping complex trait variants.

Nat Genet 2013 Feb 23;45(2):124-30. Epub 2012 Dec 23.

Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.2504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826950PMC
February 2013

Hap-seq: an optimal algorithm for haplotype phasing with imputation using sequencing data.

J Comput Biol 2013 Feb;20(2):80-92

IBM T.J. Watson Research, Yorktown Heights, NY 10598, USA.

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http://dx.doi.org/10.1089/cmb.2012.0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576919PMC
February 2013

Interpreting meta-analyses of genome-wide association studies.

PLoS Genet 2012 1;8(3):e1002555. Epub 2012 Mar 1.

Department of Computer Science, University of California Los Angeles, Los Angeles, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1002555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291559PMC
September 2012

Incorporating prior information into association studies.

Bioinformatics 2012 Jun;28(12):i147-53

Department of Computer Science, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1093/bioinformatics/bts235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371867PMC
June 2012

Increasing power of groupwise association test with likelihood ratio test.

J Comput Biol 2011 Nov 15;18(11):1611-24. Epub 2011 Sep 15.

Department of Computer Science, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1089/cmb.2011.0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3216097PMC
November 2011

An optimal weighted aggregated association test for identification of rare variants involved in common diseases.

Genetics 2011 May 2;188(1):181-8. Epub 2011 Mar 2.

Computer Science Department, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1534/genetics.110.125070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120154PMC
May 2011

Postassociation cleaning using linkage disequilibrium information.

Genet Epidemiol 2011 Jan;35(1):1-10

Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1002/gepi.20544DOI Listing
January 2011

Rapid and accurate multiple testing correction and power estimation for millions of correlated markers.

PLoS Genet 2009 Apr 17;5(4):e1000456. Epub 2009 Apr 17.

Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1371/journal.pgen.1000456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663787PMC
April 2009

Structural alignment of pseudoknotted RNA.

J Comput Biol 2008 Jun;15(5):489-504

Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1089/cmb.2007.0214DOI Listing
June 2008