Bryan R Lajoie

Bryan R Lajoie

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Bryan R Lajoie

Bryan R Lajoie

Publications by authors named "Bryan R Lajoie"

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38Publications

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Highly structured homolog pairing reflects functional organization of the Drosophila genome.

Nat Commun 2019 Oct 3;10(1):4485. Epub 2019 Oct 3.

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41467-019-12208-3DOI Listing
October 2019

Publisher Correction: Heterochromatin drives compartmentalization of inverted and conventional nuclei.

Nature 2019 Aug;572(7771):E22

Institute for Medical Engineering and Science, and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1454-2DOI Listing
August 2019

Heterochromatin drives compartmentalization of inverted and conventional nuclei.

Nature 2019 Jun 5;570(7761):395-399. Epub 2019 Jun 5.

Institute for Medical Engineering and Science, and Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1275-3DOI Listing
June 2019

Higher-Order Organization Principles of Pre-translational mRNPs.

Mol Cell 2018 11 8;72(4):715-726.e3. Epub 2018 Nov 8.

RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239896PMC
November 2018

RUNX1 contributes to higher-order chromatin organization and gene regulation in breast cancer cells.

Biochim Biophys Acta 2016 11 9;1859(11):1389-1397. Epub 2016 Aug 9.

Department of Cell and Developmental Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA; Department of Biochemistry, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA. Electronic address:

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5071180PMC
http://dx.doi.org/10.1016/j.bbagrm.2016.08.003DOI Listing
November 2016

SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.

Genome Res 2016 09 19;26(9):1188-201. Epub 2016 Jul 19.

Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA;

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http://dx.doi.org/10.1101/gr.201624.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052043PMC
September 2016

Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus.

Am J Hum Genet 2016 Jan;98(1):185-201

Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA, 01605-0103, USA; Howard Hughes Medical Institute. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2015.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716690PMC
January 2016

The Conformation of Yeast Chromosome III Is Mating Type Dependent and Controlled by the Recombination Enhancer.

Cell Rep 2015 Dec 19;13(9):1855-67. Epub 2015 Nov 19.

Howard Hughes Medical Institute, Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4681004PMC
December 2015

Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells.

Genome Biol 2015 Sep 28;16:214. Epub 2015 Sep 28.

Department of Biochemistry and University of Vermont Cancer Center, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, 05405, USA.

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http://dx.doi.org/10.1186/s13059-015-0768-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587679PMC
September 2015

Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis.

Genes Dev 2015 Aug;29(15):1661-75

Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA;

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http://dx.doi.org/10.1101/gad.265876.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536313PMC
August 2015

Condensin-driven remodelling of X chromosome topology during dosage compensation.

Nature 2015 Jul 1;523(7559):240-4. Epub 2015 Jun 1.

Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California-Berkeley, Berkeley, California 94720-3204, USA.

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http://dx.doi.org/10.1038/nature14450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498965PMC
July 2015

The Hitchhiker's guide to Hi-C analysis: practical guidelines.

Methods 2015 Jan 6;72:65-75. Epub 2014 Nov 6.

Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605-0103, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.10.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347522PMC
January 2015

Organization of the mitotic chromosome.

Science 2013 Nov 7;342(6161):948-53. Epub 2013 Nov 7.

Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School (UMMS), 368 Plantation Street, Worcester, MA 01605-0103, USA.

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http://mirnylab.mit.edu/publications/pdf/Naumova_2013_Scienc
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http://www.sciencemag.org/cgi/doi/10.1126/science.1236083
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http://dx.doi.org/10.1126/science.1236083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040465PMC
November 2013

Iterative correction of Hi-C data reveals hallmarks of chromosome organization.

Nat Methods 2012 Oct 2;9(10):999-1003. Epub 2012 Sep 2.

Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nmeth.2148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816492PMC
October 2012

The long-range interaction landscape of gene promoters.

Nature 2012 Sep;489(7414):109-13

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-0103, USA.

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http://dx.doi.org/10.1038/nature11279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3555147PMC
September 2012

An encyclopedia of mouse DNA elements (Mouse ENCODE).

August 2012

MORC family ATPases required for heterochromatin condensation and gene silencing.

Science 2012 Jun 3;336(6087):1448-51. Epub 2012 May 3.

Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, Terasaki Life Sciences Building, 610 Charles Young Drive East, Los Angeles, CA 90095-723905, USA.

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http://dx.doi.org/10.1126/science.1221472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376212PMC
June 2012

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.

Cell 2012 Mar 16;148(5):908-21. Epub 2012 Feb 16.

Howard Hughes Medical Institute, Children's Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320767PMC
March 2012

A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.

Nature 2011 Apr 20;472(7341):120-4. Epub 2011 Mar 20.

Howard Hughes Medical Institute, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/nature09819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670758PMC
April 2011

The three-dimensional folding of the α-globin gene domain reveals formation of chromatin globules.

Nat Struct Mol Biol 2011 Jan 5;18(1):107-14. Epub 2010 Dec 5.

Structural Genomics Unit, Bioinformatics and Genomics Department, Centro de Investigación Príncipe Felipe, Valencia, Spain.

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http://dx.doi.org/10.1038/nsmb.1936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056208PMC
January 2011