Bruno Vellas

Bruno Vellas

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Bruno Vellas

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Prospective association of white matter hyperintensity volume and frailty in older adults.

Exp Gerontol 2019 Apr 10;118:51-54. Epub 2019 Jan 10.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, 37 allée Jules Guesdes, 31000 Toulouse, France; UMR INSERM, 1027 University of Toulouse III, Faculté de médecine, 37 allées Jules Guesde, 31000 Toulouse, France.

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http://dx.doi.org/10.1016/j.exger.2019.01.007DOI Listing
April 2019

Potentially modifiable factors associated with agitation and aggression in Alzheimer's disease: results of the ICTUS study.

Int Psychogeriatr 2019 Feb 4:1-8. Epub 2019 Feb 4.

Alzheimer's Disease Research and Clinical Center, Gérontopôle,Toulouse University Hospital,Toulouse,France.

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http://dx.doi.org/10.1017/S1041610218001990DOI Listing
February 2019

Association between brain -amyloid and frailty in older adults.

J Gerontol A Biol Sci Med Sci 2019 Jan 9. Epub 2019 Jan 9.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.

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https://academic.oup.com/biomedgerontology/advance-article/d
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http://dx.doi.org/10.1093/gerona/glz009DOI Listing
January 2019

Cognitive changes of older adults with an equivocal amyloid load.

J Neurol 2019 Jan 28. Epub 2019 Jan 28.

Gérontopôle de Toulouse, Centre Hospitalo-Universitaire de Toulouse (CHU Toulouse), Toulouse, France.

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http://dx.doi.org/10.1007/s00415-019-09203-5DOI Listing
January 2019

Benzodiazepines and frail elderly people: how prescribing can be optimized?

Geriatr Psychol Neuropsychiatr Vieil 2018 Dec;16(4):359-366

Pôle pharmacie, CHU de Toulouse, France.

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http://dx.doi.org/10.1684/pnv.2018.0755DOI Listing
December 2018

Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis.

JAMA Intern Med 2018 Dec 28. Epub 2018 Dec 28.

Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU Toulouse), Toulouse, France.

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http://archinte.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamainternmed.2018.5406DOI Listing
December 2018

Evidence for the Domains Supporting the Construct of Intrinsic Capacity.

J Gerontol A Biol Sci Med Sci 2018 Nov;73(12):1653-1660

Department of Ageing and Life Course, World Health Organization, Geneva, Switzerland.

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http://dx.doi.org/10.1093/gerona/gly011DOI Listing
November 2018

Associations of Multidomain Lifestyle Intervention with Frailty: Secondary Analysis of a Randomized Controlled Trial.

Am J Med 2018 Nov 1;131(11):1382.e7-1382.e13. Epub 2018 Jul 1.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France; Unité Mixte de Recherche (UMR) Institut National de la Santé et de la recherche médicale (INSERM) 1027, University of Toulouse III, France.

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http://dx.doi.org/10.1016/j.amjmed.2018.06.002DOI Listing
November 2018

Effect of Relocation on Neuropsychiatric Symptoms in Elderly Adults Living in Long-Term Care.

J Am Geriatr Soc 2018 Nov 8;66(11):2183-2187. Epub 2018 Oct 8.

Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France.

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http://doi.wiley.com/10.1111/jgs.15612
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http://dx.doi.org/10.1111/jgs.15612DOI Listing
November 2018

Exercise Training for Preventing Dementia, Mild Cognitive Impairment, and Clinically Meaningful Cognitive Decline: A Systematic Review and Meta-analysis.

J Gerontol A Biol Sci Med Sci 2018 Oct;73(11):1504-1511

Gerontopole of Toulouse, Institute on Aging, Toulouse University Hospital (CHU Toulouse), France.

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http://dx.doi.org/10.1093/gerona/glx234DOI Listing
October 2018

Relationship Between Brain Amyloid Deposition and Instrumental Activities of Daily Living in Older Adults: A Longitudinal Study from the Multidomain Alzheimer Prevention Trial.

J Am Geriatr Soc 2018 Oct 12;66(10):1940-1947. Epub 2018 Sep 12.

Department of Internal Medicine and Geriatrics, Gérontopôle, University of Toulouse, Toulouse, France.

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http://dx.doi.org/10.1111/jgs.15497DOI Listing
October 2018

Effect of Exercise on Behavioral Symptoms and Pain in Patients With Dementia Living in Nursing Homes.

Am J Alzheimers Dis Other Demen 2018 Oct 3:1533317518803773. Epub 2018 Oct 3.

1 Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.

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http://journals.sagepub.com/doi/10.1177/1533317518803773
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http://dx.doi.org/10.1177/1533317518803773DOI Listing
October 2018

Ready-meal consumption in older people: association with obesity and dietary intake.

Aging Clin Exp Res 2018 Oct 23. Epub 2018 Oct 23.

Institut du Vieillissement, Gérontopôle, Université Toulouse III Paul Sabatier, 37, Allées Jules Guesde, 31000, Toulouse, France.

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http://link.springer.com/10.1007/s40520-018-1043-5
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http://dx.doi.org/10.1007/s40520-018-1043-5DOI Listing
October 2018

Determinants of time to institutionalisation and related healthcare and societal costs in a community-based cohort of patients with Alzheimer's disease dementia.

Eur J Health Econ 2018 Sep 3. Epub 2018 Sep 3.

Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s10198-018-1001-3DOI Listing
September 2018

Red blood cell membrane omega-3 fatty acid levels and physical performance: Cross-sectional data from the MAPT study.

Clin Nutr 2018 Aug 12;37(4):1141-1144. Epub 2017 Apr 12.

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.clnu.2017.04.005DOI Listing
August 2018

Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study.

Int Psychogeriatr 2018 Aug 30;30(8):1109-1117. Epub 2018 Jan 30.

The Center of Gerontology and Geriatrics,West China Medical School/West China Hospital,Sichuan University,Chengdu,Sichuan,China.

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http://dx.doi.org/10.1017/S1041610217002460DOI Listing
August 2018

Stability of graph theoretical measures in structural brain networks in Alzheimer's disease.

Sci Rep 2018 Aug 2;8(1):11592. Epub 2018 Aug 2.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/s41598-018-29927-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072788PMC
August 2018

Memory Complaints and Cognitive Decline: Data from the GUIDAGE Study1.

J Alzheimers Dis 2017 ;60(4):1567-1578

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.3233/JAD-170229DOI Listing
July 2018

Chronically raised C-reactive protein is inversely associated with cortical β-amyloid in older adults with subjective memory complaints.

Exp Gerontol 2018 07 25;108:226-230. Epub 2018 Apr 25.

Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France; UMR1027 INSERM, Université de Toulouse III Paul Sabatier, Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2018.04.014DOI Listing
July 2018

Six-month observational follow-up on activities of daily living in people with dementia living in nursing homes after a 6-month group based on either exercise or social activities.

Aging Clin Exp Res 2018 Jun 7. Epub 2018 Jun 7.

Gérontopôle de Toulouse, Institut du Vieillissement, Bâtiment B, Centre Hospitalo-Universitaire de Toulouse, 37 Allée Jules Guesdes, 31000, Toulouse, France.

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http://dx.doi.org/10.1007/s40520-018-0984-zDOI Listing
June 2018

Frailty Screening (FRAIL-NH) and Mortality in French Nursing Homes: Results From the Incidence of Pneumonia and Related Consequences in Nursing Home Residents Study.

J Am Med Dir Assoc 2018 May;19(5):411-414

Aged and Extended Care Services, The Queen Elizabeth Hospital, Central Adelaide Local Health Network, Adelaide, South Australia, Australia; National Health and Medical Research Council Center of Research Excellence in Frailty and Healthy Aging, Australia; Adelaide Geriatric Training and Research with Aged Care (GTRAC) Centre, School of medicine, The University of Adelaide, Adelaide, South Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2017.12.101DOI Listing
May 2018

Heterogeneous patterns of brain atrophy in Alzheimer's disease.

Neurobiol Aging 2018 05 31;65:98-108. Epub 2018 Jan 31.

Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.01.009DOI Listing
May 2018

Randomized Trial of Verubecestat for Mild-to-Moderate Alzheimer's Disease.

N Engl J Med 2018 05;378(18):1691-1703

From Merck Research Laboratories, Merck, Kenilworth, NJ (M.F.E., J.K., C.S., Y. Mukai, T.V., C.F., E.M., L.H.M., Y. Mo, D.M.); Banner Alzheimer's Institute, Phoenix, AZ (P.N.T.); University of Southern California, San Diego (P.S.A.); Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas (J.L.C.); Gerontopole, INSERM Unité 1027, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France (B.V.); and Leuven Institute of Neuroscience and Disease, Alzheimer Research Center, and the Laboratory for Cognitive Neurology, Department of Neurosciences, Katholieke Universiteit Leuven, and Neurology, University Hospitals - both in Leuven, Belgium (R.V.).

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http://dx.doi.org/10.1056/NEJMoa1706441DOI Listing
May 2018

Burden of Frailty in Post-Disaster Low-Income Countries: An Example From Nepal.

Disaster Med Public Health Prep 2018 May 30. Epub 2018 May 30.

1Gérontopôle,Department of Geriatrics,University Hospital of Toulouse,Toulouse,France.

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http://dx.doi.org/10.1017/dmp.2018.50DOI Listing
May 2018

Optimization of drug therapy in elderly individuals admitted to a geriatric unit.

Clin Interv Aging 2017 11;12:1691-1696. Epub 2017 Oct 11.

Gérontopôle, Centre Hospitalier Universitaire Toulouse, Toulouse, France.

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http://dx.doi.org/10.2147/CIA.S132309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644527PMC
April 2018

Prospective associations between white matter hyperintensities and lower extremity function.

Neurology 2018 Apr 9;90(15):e1291-e1297. Epub 2018 Mar 9.

From Gerontopole of Toulouse (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.) and Department of Epidemiology and Public Health (S.A.), University Hospital of Toulouse (CHU-Toulouse); UMR INSERM 1027 (S.Y.M., P.d.S.B., Y.R., S.A., M.C., B.V.), University of Toulouse III, France; Department of Neurology (S.Y.M.), Ajou University School of Medicine, Kyungki-do, Republic of Korea; UPMC Univ Paris 06 (M.C.), UMR S 1127, ICM, Sorbonne Universités; Inserm (M.C.), U1127; CNRS (M.C.), UMR 7225; ICM (M.C.); Inria Paris-Rocquencourt (M.C.), Paris; UNATI (J.F.M.), Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette; and CATI Multicenter Neuroimaging Platform (A.B., L.F., J.F.M., M.C.), cati-neuroimaging.com, France.

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http://dx.doi.org/10.1212/WNL.0000000000005289DOI Listing
April 2018

Chronic inflammation and sarcopenia: A regenerative cell therapy perspective.

Exp Gerontol 2018 03 10;103:115-123. Epub 2018 Jan 10.

Gérontopôle, Department of Geriatrics, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; INSERM, UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France; Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Università di Milano, Milan, Italy.

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https://linkinghub.elsevier.com/retrieve/pii/S05315565173082
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http://dx.doi.org/10.1016/j.exger.2017.12.023DOI Listing
March 2018

Resource Use and Cost of Alzheimer's Disease in France: 18-Month Results from the GERAS Observational Study.

Value Health 2018 03 11;21(3):295-303. Epub 2017 Nov 11.

Gerontopole, INSERM UMR1027, Toulouse University Hospital, Toulouse, France.

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http://dx.doi.org/10.1016/j.jval.2017.09.019DOI Listing
March 2018

Cognitive Event-Related Potential, an Early Diagnosis Biomarker in Frail Elderly Subjects: The ERP-MAPT-PLUS Ancillary Study.

J Alzheimers Dis 2017 ;58(1):87-97

Memory Research and Resource Center for Alzheimer's Disease, Department of Neurology, University Hospital of Montpellier, Montpellier, France.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JAD-161012DOI Listing
February 2018

Redox Systems, Antioxidants and Sarcopenia.

Curr Protein Pept Sci 2018 ;19(7):643-648

Gerontopole, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.2174/1389203718666170317120040DOI Listing
January 2018

Physical activity domains and cognitive function over three years in older adults with subjective memory complaints: Secondary analysis from the MAPT trial.

J Sci Med Sport 2018 Jan 26;21(1):52-57. Epub 2017 Jul 26.

University Hospital of Toulouse (CHU-Toulouse), Gérontopôle, Institute on Aging, France; University of Toulouse III, Inserm/UPS UMR1027, France.

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http://dx.doi.org/10.1016/j.jsams.2017.07.019DOI Listing
January 2018

Physical status and frailty index in nursing home residents: Results from the INCUR study.

Arch Gerontol Geriatr 2018 Jan 12;74:72-76. Epub 2017 Oct 12.

Gérontopôle CHU de Toulouse, France; UMR 1027 INSERM, Université Toulouse 3, France. Electronic address:

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http://dx.doi.org/10.1016/j.archger.2017.10.005DOI Listing
January 2018

Costs of Care of Agitation Associated With Dementia in 8 European Countries: Results From the RightTimePlaceCare Study.

J Am Med Dir Assoc 2018 Jan;19(1):95.e1-95.e10

UMR1027, University of Toulouse, UPS, Inserm, Toulouse, France; Gerontopole, Alzheimer's Disease Research and Clinical Center, University Hospital of Toulouse, Toulouse, France.

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https://linkinghub.elsevier.com/retrieve/pii/S15258610173058
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http://dx.doi.org/10.1016/j.jamda.2017.10.013DOI Listing
January 2018

Trial of Solanezumab for Mild Dementia Due to Alzheimer's Disease.

N Engl J Med 2018 01;378(4):321-330

From the Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York (L.S.H.); Gérontopôle, Centre Hospitalier Universitaire Toulouse, Unité Mixte de Recherche INSERM Unité 1027 Université Toulouse III-Paul Sabatier, Toulouse, France (B.V.); Austin Health Continuing Care Clinical Service Unit, Heidelberg, and the University of Melbourne, Melbourne, VIC - both in Australia (M.W.); Fundació ACE, Alzheimer Research Center and Memory Clinic, Institut Català de Neurociències Aplicades, Barcelona (M. Boada); Kingshill Research Centre, Victoria Hospital, Swindon, United Kingdom (R.B.); the Division of Geriatric Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada (M. Borrie); Clinic for Medicine of the Elderly, Diakovere Henriettenstift, Hannover, Germany (K.H.); Karolinska Institutet Alzheimer's Disease Research Center and Clinical Trial Unit, Geriatric Clinic, Karolinska University Hospital, Huddinge, Sweden (N.A.); the Department of Pathophysiology and Transplantation, Neurology Unit, Dino Ferrari Center, University of Milan, Fondazione Ca' Granda, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Policlinico, Milan (E. Scarpini); Eli Lilly (H.L.-S., M.C., A.H., K.S., V.P.H., C.C., R.K., M.M., R.D., K.J.S., E. Siemers) and the Department of Pathology and Laboratory Medicine, Indiana University School of Medicine (R.A.D.) - both in Indianapolis; and Avid Radiopharmaceuticals, Philadelphia (M.M.).

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http://dx.doi.org/10.1056/NEJMoa1705971DOI Listing
January 2018

Untangling the overlap between frailty and low lean mass: Data from Toulouse frailty day hospital.

Arch Gerontol Geriatr 2018 Mar - Apr;75:209-213. Epub 2017 Dec 29.

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.

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https://linkinghub.elsevier.com/retrieve/pii/S01674943173035
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http://dx.doi.org/10.1016/j.archger.2017.12.013DOI Listing
December 2017

Association Between Frailty and Cognitive Impairment: Cross-Sectional Data From Toulouse Frailty Day Hospital.

J Am Med Dir Assoc 2017 Nov 7;18(11):990.e1-990.e5. Epub 2017 Aug 7.

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.

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https://linkinghub.elsevier.com/retrieve/pii/S15258610173036
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http://dx.doi.org/10.1016/j.jamda.2017.06.024DOI Listing
November 2017

Cross-sectional Associations of Fatigue with Cerebral β-Amyloid in Older Adults at Risk of Dementia.

Front Med (Lausanne) 2017 6;4:173. Epub 2017 Nov 6.

Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.

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http://dx.doi.org/10.3389/fmed.2017.00173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681742PMC
November 2017

Effectiveness of a Standardized and Specific Follow-Up in Memory Centers in Patients with Alzheimer's Disease.

Curr Alzheimer Res 2017 ;14(3):255-267

Epidemiology and Public Health Research Unit, INSERM 1027, 37, Allées Jules Guesde, 31000 Toulouse, France.

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http://dx.doi.org/10.2174/1567205013666161108114850DOI Listing
October 2017

Sarcopenia Screened by the SARC-F Questionnaire and Physical Performances of Elderly Women: A Cross-Sectional Study.

J Am Med Dir Assoc 2017 Oct 16;18(10):848-852. Epub 2017 Jun 16.

Gérontopôle, Department of Internal Medicine and Geriatrics, Toulouse University Hospital, Toulouse, France; INSERM U1027, University of Toulouse III, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2017.05.010DOI Listing
October 2017

How clinical practitioners assess frailty in their daily practice: an international survey.

Aging Clin Exp Res 2017 Oct 2;29(5):905-912. Epub 2017 Aug 2.

Gérontopôle de Toulouse, Département de Médecine Interne et Gérontologie Clinique, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.1007/s40520-017-0806-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589778PMC
October 2017

Motoric Cognitive Risk Syndrome: Predictor of Dementia and Age-Related Negative Outcomes.

Front Med (Lausanne) 2017 25;4:166. Epub 2017 Oct 25.

Gérontopôle, Department of Geriatrics, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.3389/fmed.2017.00166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660976PMC
October 2017

Exercise or Social Intervention for Nursing Home Residents with Dementia: A Pilot Randomized, Controlled Trial.

J Am Geriatr Soc 2017 Sep 19;65(9):E123-E129. Epub 2017 May 19.

Gérontopôle de Toulouse, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, Toulouse, France.

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http://dx.doi.org/10.1111/jgs.14947DOI Listing
September 2017

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Authors:
Rebecca Sims Sven J van der Lee Adam C Naj Céline Bellenguez Nandini Badarinarayan Johanna Jakobsdottir Brian W Kunkle Anne Boland Rachel Raybould Joshua C Bis Eden R Martin Benjamin Grenier-Boley Stefanie Heilmann-Heimbach Vincent Chouraki Amanda B Kuzma Kristel Sleegers Maria Vronskaya Agustin Ruiz Robert R Graham Robert Olaso Per Hoffmann Megan L Grove Badri N Vardarajan Mikko Hiltunen Markus M Nöthen Charles C White Kara L Hamilton-Nelson Jacques Epelbaum Wolfgang Maier Seung-Hoan Choi Gary W Beecham Cécile Dulary Stefan Herms Albert V Smith Cory C Funk Céline Derbois Andreas J Forstner Shahzad Ahmad Hongdong Li Delphine Bacq Denise Harold Claudia L Satizabal Otto Valladares Alessio Squassina Rhodri Thomas Jennifer A Brody Liming Qu Pascual Sánchez-Juan Taniesha Morgan Frank J Wolters Yi Zhao Florentino Sanchez Garcia Nicola Denning Myriam Fornage John Malamon Maria Candida Deniz Naranjo Elisa Majounie Thomas H Mosley Beth Dombroski David Wallon Michelle K Lupton Josée Dupuis Patrice Whitehead Laura Fratiglioni Christopher Medway Xueqiu Jian Shubhabrata Mukherjee Lina Keller Kristelle Brown Honghuang Lin Laura B Cantwell Francesco Panza Bernadette McGuinness Sonia Moreno-Grau Jeremy D Burgess Vincenzo Solfrizzi Petra Proitsi Hieab H Adams Mariet Allen Davide Seripa Pau Pastor L Adrienne Cupples Nathan D Price Didier Hannequin Ana Frank-García Daniel Levy Paramita Chakrabarty Paolo Caffarra Ina Giegling Alexa S Beiser Vilmantas Giedraitis Harald Hampel Melissa E Garcia Xue Wang Lars Lannfelt Patrizia Mecocci Gudny Eiriksdottir Paul K Crane Florence Pasquier Virginia Boccardi Isabel Henández Robert C Barber Martin Scherer Lluis Tarraga Perrie M Adams Markus Leber Yuning Chen Marilyn S Albert Steffi Riedel-Heller Valur Emilsson Duane Beekly Anne Braae Reinhold Schmidt Deborah Blacker Carlo Masullo Helena Schmidt Rachelle S Doody Gianfranco Spalletta W T Longstreth Thomas J Fairchild Paola Bossù Oscar L Lopez Matthew P Frosch Eleonora Sacchinelli Bernardino Ghetti Qiong Yang Ryan M Huebinger Frank Jessen Shuo Li M Ilyas Kamboh John Morris Oscar Sotolongo-Grau Mindy J Katz Chris Corcoran Melanie Dunstan Amy Braddel Charlene Thomas Alun Meggy Rachel Marshall Amy Gerrish Jade Chapman Miquel Aguilar Sarah Taylor Matt Hill Mònica Díez Fairén Angela Hodges Bruno Vellas Hilkka Soininen Iwona Kloszewska Makrina Daniilidou James Uphill Yogen Patel Joseph T Hughes Jenny Lord James Turton Annette M Hartmann Roberta Cecchetti Chiara Fenoglio Maria Serpente Marina Arcaro Carlo Caltagirone Maria Donata Orfei Antonio Ciaramella Sabrina Pichler Manuel Mayhaus Wei Gu Alberto Lleó Juan Fortea Rafael Blesa Imelda S Barber Keeley Brookes Chiara Cupidi Raffaele Giovanni Maletta David Carrell Sandro Sorbi Susanne Moebus Maria Urbano Alberto Pilotto Johannes Kornhuber Paolo Bosco Stephen Todd David Craig Janet Johnston Michael Gill Brian Lawlor Aoibhinn Lynch Nick C Fox John Hardy Roger L Albin Liana G Apostolova Steven E Arnold Sanjay Asthana Craig S Atwood Clinton T Baldwin Lisa L Barnes Sandra Barral Thomas G Beach James T Becker Eileen H Bigio Thomas D Bird Bradley F Boeve James D Bowen Adam Boxer James R Burke Jeffrey M Burns Joseph D Buxbaum Nigel J Cairns Chuanhai Cao Chris S Carlson Cynthia M Carlsson Regina M Carney Minerva M Carrasquillo Steven L Carroll Carolina Ceballos Diaz Helena C Chui David G Clark David H Cribbs Elizabeth A Crocco Charles DeCarli Malcolm Dick Ranjan Duara Denis A Evans Kelley M Faber Kenneth B Fallon David W Fardo Martin R Farlow Steven Ferris Tatiana M Foroud Douglas R Galasko Marla Gearing Daniel H Geschwind John R Gilbert Neill R Graff-Radford Robert C Green John H Growdon Ronald L Hamilton Lindy E Harrell Lawrence S Honig Matthew J Huentelman Christine M Hulette Bradley T Hyman Gail P Jarvik Erin Abner Lee-Way Jin Gyungah Jun Anna Karydas Jeffrey A Kaye Ronald Kim Neil W Kowall Joel H Kramer Frank M LaFerla James J Lah James B Leverenz Allan I Levey Ge Li Andrew P Lieberman Kathryn L Lunetta Constantine G Lyketsos Daniel C Marson Frank Martiniuk Deborah C Mash Eliezer Masliah Wayne C McCormick Susan M McCurry Andrew N McDavid Ann C McKee Marsel Mesulam Bruce L Miller Carol A Miller Joshua W Miller John C Morris Jill R Murrell Amanda J Myers Sid O'Bryant John M Olichney Vernon S Pankratz Joseph E Parisi Henry L Paulson William Perry Elaine Peskind Aimee Pierce Wayne W Poon Huntington Potter Joseph F Quinn Ashok Raj Murray Raskind Barry Reisberg Christiane Reitz John M Ringman Erik D Roberson Ekaterina Rogaeva Howard J Rosen Roger N Rosenberg Mark A Sager Andrew J Saykin Julie A Schneider Lon S Schneider William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Rudolph E Tanzi Tricia A Thornton-Wells John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Fabienne Garzia Feroze Golamaully Gislain Septier Sebastien Engelborghs Rik Vandenberghe Peter P De Deyn Carmen Muñoz Fernadez Yoland Aladro Benito Hakan Thonberg Charlotte Forsell Lena Lilius Anne Kinhult-Stählbom Lena Kilander RoseMarie Brundin Letizia Concari Seppo Helisalmi Anne Maria Koivisto Annakaisa Haapasalo Vincent Dermecourt Nathalie Fievet Olivier Hanon Carole Dufouil Alexis Brice Karen Ritchie Bruno Dubois Jayanadra J Himali C Dirk Keene JoAnn Tschanz Annette L Fitzpatrick Walter A Kukull Maria Norton Thor Aspelund Eric B Larson Ron Munger Jerome I Rotter Richard B Lipton María J Bullido Albert Hofman Thomas J Montine Eliecer Coto Eric Boerwinkle Ronald C Petersen Victoria Alvarez Fernando Rivadeneira Eric M Reiman Maura Gallo Christopher J O'Donnell Joan S Reisch Amalia Cecilia Bruni Donald R Royall Martin Dichgans Mary Sano Daniela Galimberti Peter St George-Hyslop Elio Scarpini Debby W Tsuang Michelangelo Mancuso Ubaldo Bonuccelli Ashley R Winslow Antonio Daniele Chuang-Kuo Wu Oliver Peters Benedetta Nacmias Matthias Riemenschneider Reinhard Heun Carol Brayne David C Rubinsztein Jose Bras Rita Guerreiro Ammar Al-Chalabi Christopher E Shaw John Collinge David Mann Magda Tsolaki Jordi Clarimón Rebecca Sussams Simon Lovestone Michael C O'Donovan Michael J Owen Timothy W Behrens Simon Mead Alison M Goate Andre G Uitterlinden Clive Holmes Carlos Cruchaga Martin Ingelsson David A Bennett John Powell Todd E Golde Caroline Graff Philip L De Jager Kevin Morgan Nilufer Ertekin-Taner Onofre Combarros Bruce M Psaty Peter Passmore Steven G Younkin Claudine Berr Vilmundur Gudnason Dan Rujescu Dennis W Dickson Jean-François Dartigues Anita L DeStefano Sara Ortega-Cubero Hakon Hakonarson Dominique Campion Merce Boada John Keoni Kauwe Lindsay A Farrer Christine Van Broeckhoven M Arfan Ikram Lesley Jones Jonathan L Haines Christophe Tzourio Lenore J Launer Valentina Escott-Price Richard Mayeux Jean-François Deleuze Najaf Amin Peter A Holmans Margaret A Pericak-Vance Philippe Amouyel Cornelia M van Duijn Alfredo Ramirez Li-San Wang Jean-Charles Lambert Sudha Seshadri Julie Williams Gerard D Schellenberg

Nat Genet 2017 09 17;49(9):1373-1384. Epub 2017 Jul 17.

Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1038/ng.3916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669039PMC
September 2017

Lower brain and blood nutrient status in Alzheimer's disease: Results from meta-analyses.

Alzheimers Dement (N Y) 2017 Sep 24;3(3):416-431. Epub 2017 Jun 24.

Nutricia Research, Nutricia Advanced Medical Nutrition, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.trci.2017.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651428PMC
September 2017

Cross-sectional associations of cortical β-amyloid with erythrocyte membrane long-chain polyunsaturated fatty acids in older adults with subjective memory complaints.

J Neurochem 2017 08 29;142(4):589-596. Epub 2017 May 29.

Gérontopôle, Department of Geriatrics, CHU Toulouse, Purpan University Hospital, Toulouse, France.

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http://dx.doi.org/10.1111/jnc.14062DOI Listing
August 2017

Cognitive Frailty: Mechanisms, Tools to Measure, Prevention and Controversy.

Clin Geriatr Med 2017 08 13;33(3):339-355. Epub 2017 May 13.

Ge´rontopoˆ le, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Universite´ de Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.cger.2017.03.001DOI Listing
August 2017

Associations between white matter hyperintensities and cognitive decline over three years in non-dementia older adults with memory complaints.

J Neurol Sci 2017 Aug 20;379:266-270. Epub 2017 Jun 20.

Gérontopôle of Toulouse, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France; UMR INSERM 1027, University of Toulouse III, Toulouse, France.

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http://dx.doi.org/10.1016/j.jns.2017.06.031DOI Listing
August 2017

Patient-Centered (P4) Medicine and the Older Person.

J Am Med Dir Assoc 2017 Jun;18(6):455-459

Gérontopôle, CHU Toulouse University Hospital and INSERM U1027, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2017.04.001DOI Listing
June 2017

Integrated Care: Enhancing the Role of the Primary Health Care Professional in Preventing Functional Decline: A Systematic Review.

J Am Med Dir Assoc 2017 Jun;18(6):489-494

Department of Medicine & Therapeutics, and the Jockey Club Institute of Aging, The Chinese University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1016/j.jamda.2017.03.015DOI Listing
June 2017

Additional Cost Because of Pneumonia in Nursing Home Residents: Results From the Incidence of Pneumonia and Related Consequences in Nursing Home Resident Study.

J Am Med Dir Assoc 2017 May;18(5):453.e7-453.e12

Gérontopôle, University Hospital of Toulouse, Toulouse, France; University of Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2017.01.021DOI Listing
May 2017

Physical Activity and Incident Chronic Diseases: A Longitudinal Observational Study in 16 European Countries.

Am J Prev Med 2017 Mar 13;52(3):373-378. Epub 2016 Oct 13.

Gerontopole of Toulouse, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France;; UMR INSERM 1027, University of Toulouse III, Toulouse, France.

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http://dx.doi.org/10.1016/j.amepre.2016.08.028DOI Listing
March 2017

Effects of Diabetes Mellitus on Cognitive Decline in Patients with Alzheimer Disease: A Systematic Review.

Can J Diabetes 2017 Feb 7;41(1):114-119. Epub 2016 Sep 7.

Institut du Vieillissement, Gérontopôle, Université Toulouse III-Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.jcjd.2016.07.003DOI Listing
February 2017

Cross-Sectional and Prospective Associations Between β-Amyloid in the Brain and Chair Rise Performance in Nondementia Older Adults With Spontaneous Memory Complaints.

J Gerontol A Biol Sci Med Sci 2017 02 30;72(2):278-283. Epub 2016 Sep 30.

Gerontopole of Toulouse, University Hospital of Toulouse (CHU Toulouse), France.

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http://dx.doi.org/10.1093/gerona/glw195DOI Listing
February 2017

Potentially inappropriate prescribing in a population of frail elderly people.

Int J Clin Pharm 2017 Feb 10;39(1):113-119. Epub 2016 Dec 10.

Department of Pharmacy, Centre Hospitalier Universitaire de Toulouse, Cité de la Santé, 20 Rue du Pont Saint-Pierre, TSA 60033, 31059, Toulouse Cedex 9, France.

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http://dx.doi.org/10.1007/s11096-016-0406-2DOI Listing
February 2017

General Practitioners' Clinical Impression in the Screening for Frailty: Data From the FAP Study Pilot.

J Am Med Dir Assoc 2017 Feb;18(2):193.e1-193.e5

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2016.11.008DOI Listing
February 2017

The need of operational paradigms for frailty in older persons: the SPRINTT project.

Aging Clin Exp Res 2017 Feb 2;29(1):3-10. Epub 2017 Feb 2.

Geriatrics and Geriatric Emergency Care, IRCCS-INRCA, Ancona, Italy.

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http://dx.doi.org/10.1007/s40520-016-0712-5DOI Listing
February 2017

Rationale for a preliminary operational definition of physical frailty and sarcopenia in the SPRINTT trial.

Aging Clin Exp Res 2017 Feb 10;29(1):81-88. Epub 2017 Feb 10.

Department of Geriatrics, Neurosciences and Orthopedics, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.

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http://dx.doi.org/10.1007/s40520-016-0716-1DOI Listing
February 2017

Implementing Assessment of Cognitive Function and Frailty Into Primary Care: Data From Frailty and Alzheimer disease prevention into Primary care (FAP) Study Pilot.

J Am Med Dir Assoc 2017 01 16;18(1):47-52. Epub 2016 Sep 16.

Gérontopôle, Centre Hospitalier Universitaire de Toulouse, Toulouse, France; Inserm UMR1027, Université de Toulouse III Paul Sabatier, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2016.08.003DOI Listing
January 2017

[Role of the nurse in the prevention of dependence].

Soins Gerontol 2016 Sep-Oct;21(121):39-41

Gérontopôle, CHU Toulouse, Cité de la Santé, 20-24 rue du Pont-Saint-Pierre, 31052 Toulouse, France. Electronic address:

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http://dx.doi.org/10.1016/j.sger.2016.07.011DOI Listing
January 2017

Novel genetic loci associated with hippocampal volume.

Authors:
Derrek P Hibar Hieab H H Adams Neda Jahanshad Ganesh Chauhan Jason L Stein Edith Hofer Miguel E Renteria Joshua C Bis Alejandro Arias-Vasquez M Kamran Ikram Sylvane Desrivières Meike W Vernooij Lucija Abramovic Saud Alhusaini Najaf Amin Micael Andersson Konstantinos Arfanakis Benjamin S Aribisala Nicola J Armstrong Lavinia Athanasiu Tomas Axelsson Ashley H Beecham Alexa Beiser Manon Bernard Susan H Blanton Marc M Bohlken Marco P Boks Janita Bralten Adam M Brickman Owen Carmichael M Mallar Chakravarty Qiang Chen Christopher R K Ching Vincent Chouraki Gabriel Cuellar-Partida Fabrice Crivello Anouk Den Braber Nhat Trung Doan Stefan Ehrlich Sudheer Giddaluru Aaron L Goldman Rebecca F Gottesman Oliver Grimm Michael E Griswold Tulio Guadalupe Boris A Gutman Johanna Hass Unn K Haukvik David Hoehn Avram J Holmes Martine Hoogman Deborah Janowitz Tianye Jia Kjetil N Jørgensen Nazanin Karbalai Dalia Kasperaviciute Sungeun Kim Marieke Klein Bernd Kraemer Phil H Lee David C M Liewald Lorna M Lopez Michelle Luciano Christine Macare Andre F Marquand Mar Matarin Karen A Mather Manuel Mattheisen David R McKay Yuri Milaneschi Susana Muñoz Maniega Kwangsik Nho Allison C Nugent Paul Nyquist Loes M Olde Loohuis Jaap Oosterlaan Martina Papmeyer Lukas Pirpamer Benno Pütz Adaikalavan Ramasamy Jennifer S Richards Shannon L Risacher Roberto Roiz-Santiañez Nanda Rommelse Stefan Ropele Emma J Rose Natalie A Royle Tatjana Rundek Philipp G Sämann Arvin Saremi Claudia L Satizabal Lianne Schmaal Andrew J Schork Li Shen Jean Shin Elena Shumskaya Albert V Smith Emma Sprooten Lachlan T Strike Alexander Teumer Diana Tordesillas-Gutierrez Roberto Toro Daniah Trabzuni Stella Trompet Dhananjay Vaidya Jeroen Van der Grond Sven J Van der Lee Dennis Van der Meer Marjolein M J Van Donkelaar Kristel R Van Eijk Theo G M Van Erp Daan Van Rooij Esther Walton Lars T Westlye Christopher D Whelan Beverly G Windham Anderson M Winkler Katharina Wittfeld Girma Woldehawariat Christiane Wolf Thomas Wolfers Lisa R Yanek Jingyun Yang Alex Zijdenbos Marcel P Zwiers Ingrid Agartz Laura Almasy David Ames Philippe Amouyel Ole A Andreassen Sampath Arepalli Amelia A Assareh Sandra Barral Mark E Bastin Diane M Becker James T Becker David A Bennett John Blangero Hans van Bokhoven Dorret I Boomsma Henry Brodaty Rachel M Brouwer Han G Brunner Randy L Buckner Jan K Buitelaar Kazima B Bulayeva Wiepke Cahn Vince D Calhoun Dara M Cannon Gianpiero L Cavalleri Ching-Yu Cheng Sven Cichon Mark R Cookson Aiden Corvin Benedicto Crespo-Facorro Joanne E Curran Michael Czisch Anders M Dale Gareth E Davies Anton J M De Craen Eco J C De Geus Philip L De Jager Greig I De Zubicaray Ian J Deary Stéphanie Debette Charles DeCarli Norman Delanty Chantal Depondt Anita DeStefano Allissa Dillman Srdjan Djurovic Gary Donohoe Wayne C Drevets Ravi Duggirala Thomas D Dyer Christian Enzinger Susanne Erk Thomas Espeseth Iryna O Fedko Guillén Fernández Luigi Ferrucci Simon E Fisher Debra A Fleischman Ian Ford Myriam Fornage Tatiana M Foroud Peter T Fox Clyde Francks Masaki Fukunaga J Raphael Gibbs David C Glahn Randy L Gollub Harald H H Göring Robert C Green Oliver Gruber Vilmundur Gudnason Sebastian Guelfi Asta K Håberg Narelle K Hansell John Hardy Catharina A Hartman Ryota Hashimoto Katrin Hegenscheid Andreas Heinz Stephanie Le Hellard Dena G Hernandez Dirk J Heslenfeld Beng-Choon Ho Pieter J Hoekstra Wolfgang Hoffmann Albert Hofman Florian Holsboer Georg Homuth Norbert Hosten Jouke-Jan Hottenga Matthew Huentelman Hilleke E Hulshoff Pol Masashi Ikeda Clifford R Jack Mark Jenkinson Robert Johnson Erik G Jönsson J Wouter Jukema René S Kahn Ryota Kanai Iwona Kloszewska David S Knopman Peter Kochunov John B Kwok Stephen M Lawrie Hervé Lemaître Xinmin Liu Dan L Longo Oscar L Lopez Simon Lovestone Oliver Martinez Jean-Luc Martinot Venkata S Mattay Colm McDonald Andrew M McIntosh Francis J McMahon Katie L McMahon Patrizia Mecocci Ingrid Melle Andreas Meyer-Lindenberg Sebastian Mohnke Grant W Montgomery Derek W Morris Thomas H Mosley Thomas W Mühleisen Bertram Müller-Myhsok Michael A Nalls Matthias Nauck Thomas E Nichols Wiro J Niessen Markus M Nöthen Lars Nyberg Kazutaka Ohi Rene L Olvera Roel A Ophoff Massimo Pandolfo Tomas Paus Zdenka Pausova Brenda W J H Penninx G Bruce Pike Steven G Potkin Bruce M Psaty Simone Reppermund Marcella Rietschel Joshua L Roffman Nina Romanczuk-Seiferth Jerome I Rotter Mina Ryten Ralph L Sacco Perminder S Sachdev Andrew J Saykin Reinhold Schmidt Helena Schmidt Peter R Schofield Sigurdur Sigursson Andrew Simmons Andrew Singleton Sanjay M Sisodiya Colin Smith Jordan W Smoller Hilkka Soininen Vidar M Steen David J Stott Jessika E Sussmann Anbupalam Thalamuthu Arthur W Toga Bryan J Traynor Juan Troncoso Magda Tsolaki Christophe Tzourio Andre G Uitterlinden Maria C Valdés Hernández Marcel Van der Brug Aad van der Lugt Nic J A van der Wee Neeltje E M Van Haren Dennis van 't Ent Marie-Jose Van Tol Badri N Vardarajan Bruno Vellas Dick J Veltman Henry Völzke Henrik Walter Joanna M Wardlaw Thomas H Wassink Michael E Weale Daniel R Weinberger Michael W Weiner Wei Wen Eric Westman Tonya White Tien Y Wong Clinton B Wright Ronald H Zielke Alan B Zonderman Nicholas G Martin Cornelia M Van Duijn Margaret J Wright W T Longstreth Gunter Schumann Hans J Grabe Barbara Franke Lenore J Launer Sarah E Medland Sudha Seshadri Paul M Thompson M Arfan Ikram

Nat Commun 2017 01 18;8:13624. Epub 2017 Jan 18.

Department of Epidemiology, Erasmus University Medical Center, 3015 CE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms13624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253632PMC
January 2017

How useful is the EQ-5D in assessing the impact of caring for people with Alzheimer's disease?

Health Qual Life Outcomes 2017 Jan 21;15(1):16. Epub 2017 Jan 21.

Parc Sanitari Sant Joan de Déu, CIBERSAM, Universitat de Barcelona, Barcelona, Spain.

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http://dx.doi.org/10.1186/s12955-017-0591-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251250PMC
January 2017

Physical Activity and Cognitive Function in Middle-Aged and Older Adults: An Analysis of 104,909 People From 20 Countries.

Mayo Clin Proc 2016 Nov 6;91(11):1515-1524. Epub 2016 Oct 6.

Gerontopole of Toulouse, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France; UMR INSERM 1027, University of Toulouse III, Toulouse, France.

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http://dx.doi.org/10.1016/j.mayocp.2016.06.032DOI Listing
November 2016

Muscle Strength and Body Weight Mediate the Relationship Between Physical Activity and Usual Gait Speed.

J Am Med Dir Assoc 2016 11 21;17(11):1031-1036. Epub 2016 Aug 21.

Groupe de Recherche en Activité Physique Adaptée, Université du Québec à Montréal, Montréal, Canada; Centre de Recherche de l'Institut Universitaire de Gériatrie de Montréal, Montréal, Canada; Département des sciences de l'activité physique, Université du Québec à Montréal, Montréal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jamda.2016.06.026DOI Listing
November 2016

Refining Mild-to-Moderate Alzheimer Disease Screening: A Tool for Clinicians.

J Am Med Dir Assoc 2016 10;17(10):913-20

Gérontopôle, Institute of Ageing, Toulouse University Hospital, Toulouse, France; INSERM UMR 1027, Paul Sabatier University of Toulouse, Toulouse, France.

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http://dx.doi.org/10.1016/j.jamda.2016.06.005DOI Listing
October 2016