Bruno Stieger

Bruno Stieger

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Bruno Stieger

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Structure of the human lipid exporter ABCB4 in a lipid environment.

Nat Struct Mol Biol 2020 Jan 23;27(1):62-70. Epub 2019 Dec 23.

Department of Biology, ETH Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.1038/s41594-019-0354-3DOI Listing
January 2020

microRNA-206 modulates the hepatic expression of the organic anion-transporting polypeptide 1B1.

Liver Int 2019 Dec 3;39(12):2350-2359. Epub 2019 Sep 3.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zürich, Switzerland.

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http://dx.doi.org/10.1111/liv.14212DOI Listing
December 2019

A rare cause of a cholestatic jaundice in a North African teenager.

Liver Int 2019 Nov 24;39(11):2036-2041. Epub 2019 Jul 24.

Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/liv.14122DOI Listing
November 2019

Human MRP2 exports MC-LR but not the glutathione conjugate.

Chem Biol Interact 2019 Sep 23;311:108761. Epub 2019 Jul 23.

Human and Environmental Toxicology, University of Konstanz, 78457, Konstanz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cbi.2019.108761DOI Listing
September 2019

Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications.

Mol Pharm 2019 03 25;16(3):1406-1411. Epub 2019 Jan 25.

Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy , University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467649PMC
March 2019

Imaging techniques to study drug transporter function in vivo.

Pharmacol Ther 2018 09 22;189:104-122. Epub 2018 Apr 22.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria; Biomedical Systems, Center for Health & Bioresources, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2018.04.006DOI Listing
September 2018

Age-dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers.

Hepatol Commun 2018 Jun 6;2(6):693-702. Epub 2018 Apr 6.

Institute of Experimental and Clinical Research, Laboratory of Pediatric Hepatology and Cell Therapy Université Catholique de Louvain Brussels Belgium.

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http://dx.doi.org/10.1002/hep4.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983131PMC
June 2018

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

Pharm Res 2017 Nov 21;34(11):2336-2348. Epub 2017 Aug 21.

Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, O&N2, Herestraat 49 - box 921, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11095-017-2241-0DOI Listing
November 2017

Model Systems for Studying the Role of Canalicular Efflux Transporters in Drug-Induced Cholestatic Liver Disease.

J Pharm Sci 2017 09 3;106(9):2295-2301. Epub 2017 Apr 3.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.xphs.2017.03.023DOI Listing
September 2017

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin.

PLoS One 2017 18;12(1):e0169480. Epub 2017 Jan 18.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, Rennes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169480PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5242521PMC
August 2017

β2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine.

Eur J Pharm Sci 2017 Aug 8;106:302-312. Epub 2017 Jun 8.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 Rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.06.010DOI Listing
August 2017

Proteomic Analysis of the Rat Canalicular Membrane Reveals Expression of a Complex System of P4-ATPases in Liver.

PLoS One 2016 27;11(6):e0158033. Epub 2016 Jun 27.

Department of Clinical Pharmacology and Toxicology, University Hospital Zürich, Zürich, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158033PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4922570PMC
July 2017

Inhibition of SLC drug transporter activities by environmental bisphenols.

Toxicol In Vitro 2017 Apr 15;40:34-44. Epub 2016 Dec 15.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2016.12.009DOI Listing
April 2017

Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression.

Int J Mol Sci 2017 Apr 4;18(4). Epub 2017 Apr 4.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.3390/ijms18040764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412348PMC
April 2017

Impact of Organic Cation Transporters (OCT-SLC22A) on Differential Diagnosis of Intrahepatic Lesions.

Drug Metab Dispos 2017 02 30;45(2):166-173. Epub 2016 Nov 30.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Switzerland (M.V., C.H., L.H., G.A. K.-U., B.S.); Department of Surgery, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (B.V.v.R., M.B., T.M.v.G.); Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (R.J.B.); Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (S.S.K.S.P.); Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands (J.V.); Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Germany (H.K.); and Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan (I.T.)

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http://dx.doi.org/10.1124/dmd.116.072371DOI Listing
February 2017

Intestinal and Hepatocellular Transporters: Therapeutic Effects and Drug Interactions of Herbal Supplements.

Annu Rev Pharmacol Toxicol 2017 01 14;57:399-416. Epub 2016 Sep 14.

Division of Clinical Pharmacy and Diagnostics, Department of Pharmaceutical Chemistry, University of Vienna, A-1090 Vienna, Austria; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010716-105010DOI Listing
January 2017

Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal Inflammation.

Inflamm Bowel Dis 2016 10;22(10):2382-9

*Division of Hepatology, Department of Medicine II, University Hospital Würzburg, Würzburg, Germany; †Department of Clinical Pharmacology and Toxicology, USZ, Zurich, Switzerland; ‡Laboratory of Experimental Hepatology and Drug Targeting (HEVEFARM), IBSAL, CIBERehd, University of Salamanca, Salamanca, Spain; and §Division of Gastroenterology and Hepatology, USZ, Zurich, Switzerland.

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http://dx.doi.org/10.1097/MIB.0000000000000879DOI Listing
October 2016

Recent advances in understanding hepatic drug transport.

F1000Res 2016 6;5:2465. Epub 2016 Oct 6.

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS, 66160, USA.

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http://dx.doi.org/10.12688/f1000research.9466.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054808PMC
October 2016

Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis.

Mol Pharmacol 2016 07 25;90(1):23-34. Epub 2016 Apr 25.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, University of Zurich, Zurich, Switzerland (Z.M.M., U.S.-H., A.Y., B.S.); and Institute of Molecular Biology and Biophysics, ETH Zurich, Zurich, Switzerland (K.P.L.)

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http://dx.doi.org/10.1124/mol.116.103390DOI Listing
July 2016

Alteration of human hepatic drug transporter activity and expression by cigarette smoke condensate.

Toxicology 2016 07 19;363-364:58-71. Epub 2016 Jul 19.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2016.07.011DOI Listing
July 2016

Efflux and uptake transporters involved in the disposition of bazedoxifene.

Eur J Drug Metab Pharmacokinet 2016 Jun 29;41(3):251-7. Epub 2015 Jan 29.

Department of Biopharmacy and Pharmacokinetics, Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, 1000, Ljubljana, Slovenia.

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http://dx.doi.org/10.1007/s13318-015-0256-7DOI Listing
June 2016

Regulation of human hepatic drug transporter activity and expression by diesel exhaust particle extract.

PLoS One 2015 24;10(3):e0121232. Epub 2015 Mar 24.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121232PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372591PMC
April 2016

Inconsistencies in the red blood cell membrane proteome analysis: generation of a database for research and diagnostic applications.

Database (Oxford) 2015 14;2015:bav056. Epub 2015 Jun 14.

MTA-SE Molecular Biophysics Research Group, Hungarian Academy of Sciences, Tűzoltó u. 37-47, H-1094 Budapest, Hungary, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary, Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary and Functional Genomics Center Zurich, University of Zurich, ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland MTA-SE Molecular Biophysics Research Group, Hungarian Academy of Sciences, Tűzoltó u. 37-47, H-1094 Budapest, Hungary, Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó u. 37-47, H-1094 Budapest, Hungary, Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Raemistrasse 100, CH-8091 Zurich, Switzerland, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary and Functional Genomics Center Zurich, University of Zurich, ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

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http://dx.doi.org/10.1093/database/bav056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480073PMC
March 2016

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

J Pharm Sci 2016 Feb 11;105(2):854-863. Epub 2016 Jan 11.

Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1002/jps.24564DOI Listing
February 2016

Flagging Drugs That Inhibit the Bile Salt Export Pump.

Mol Pharm 2016 Jan 21;13(1):163-71. Epub 2015 Dec 21.

Department of Pharmaceutical Chemistry, University of Vienna , Althanstrasse 14, 1090 Vienna, Austria.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00594DOI Listing
January 2016

Influence of 24-Nor-Ursodeoxycholic Acid on Hepatic Disposition of [(18)F]Ciprofloxacin, a Positron Emission Tomography Study in Mice.

J Pharm Sci 2016 Jan 13;105(1):106-12. Epub 2016 Jan 13.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223549150012
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http://dx.doi.org/10.1016/j.xphs.2015.11.014DOI Listing
January 2016

Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate.

Biochem Pharmacol 2015 Dec 28;98(4):649-58. Epub 2015 Sep 28.

Momentum Membrane Protein Research Group, Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok krt. 2, H-1117 Budapest, Hungary. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952150062
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http://dx.doi.org/10.1016/j.bcp.2015.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959548PMC
December 2015

Protein kinase C-dependent regulation of human hepatic drug transporter expression.

Biochem Pharmacol 2015 Dec 14;98(4):703-17. Epub 2015 Oct 14.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 Rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2015.10.007DOI Listing
December 2015

Octreotide inhibits the bilirubin carriers organic anion transporting polypeptides 1B1 and 1B3 and the multidrug resistance-associated protein 2.

J Pharmacol Exp Ther 2015 Nov 1;355(2):145-51. Epub 2015 Sep 1.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland (M.V., B.S., G.A.K.-U.); and Discovery and Investigative Safety, Novartis Institutes for BioMedical Research, Basel, Switzerland (M.M., G.A.K.-U.)

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http://dx.doi.org/10.1124/jpet.115.227546DOI Listing
November 2015

ATP-binding cassette transporters in liver.

Biofactors 2014 Mar-Apr;40(2):188-98. Epub 2013 Sep 16.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://doi.wiley.com/10.1002/biof.1136
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http://dx.doi.org/10.1002/biof.1136DOI Listing
August 2015

Polarized location of SLC and ABC drug transporters in monolayer-cultured human hepatocytes.

Toxicol In Vitro 2015 Aug 7;29(5):938-46. Epub 2015 Apr 7.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.tiv.2015.03.019DOI Listing
August 2015

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes.

Toxicol Sci 2015 May 17;145(1):157-68. Epub 2015 Feb 17.

*Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland *Inserm UMR991, Foie, Métabolismes et Cancer, Rennes, France; Université de Rennes 1, Rennes, France, Université Libanaise, EDST-PRASE and EDST-AZM-center-LBA3B, Beirut, Lebanon, Biopredic International, Saint Grégoire, France, ImPACcell, SFR Biosit, Université de Rennes 1, Rennes, France and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfv041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833040PMC
May 2015

Drug transporters in the central nervous system.

Clin Pharmacokinet 2015 Mar;54(3):225-42

Department of Clinical Pharmacology and Toxicology, University Hospital, Rämistrasse 100, Zurich, 8091, Switzerland,

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http://link.springer.com/10.1007/s40262-015-0241-y
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http://dx.doi.org/10.1007/s40262-015-0241-yDOI Listing
March 2015

The effect of organic anion-transporting polypeptides 1B1, 1B3 and 2B1 on the antitumor activity of flavopiridol in breast cancer cells.

Int J Oncol 2015 Jan 24;46(1):324-32. Epub 2014 Oct 24.

Department of Clinical Pharmacy and Diagnostics, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.3892/ijo.2014.2731DOI Listing
January 2015

Role of (drug) transporters in imaging in health and disease.

Drug Metab Dispos 2014 Dec 23;42(12):2007-15. Epub 2014 Sep 23.

Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland (B.S.); Department of Pharmaceutics, University of Washington, Seattle, Washington (J.D.U., B.P.); Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria and Health and Environment Department, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria (O.L.); and the Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (H.G.).

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http://dx.doi.org/10.1124/dmd.114.059873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611776PMC
December 2014

Organic anion-transporting polypeptides.

Curr Top Membr 2014 ;73:205-32

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas, USA.

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http://dx.doi.org/10.1016/B978-0-12-800223-0.00005-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996503PMC
November 2014

Uninephrectomy augments the effects of high fat diet induced obesity on gene expression in mouse kidney.

Biochim Biophys Acta 2014 Sep 10;1842(9):1870-8. Epub 2014 Jul 10.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Switzerland; Zurich Centre for Integrative Human Physiology, University of Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.07.001DOI Listing
September 2014

Rivaroxaban postmarketing risk of liver injury.

J Hepatol 2014 Aug 28;61(2):293-300. Epub 2014 Mar 28.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland; Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2014.03.026DOI Listing
August 2014

Chronic cholestatic liver diseases: clues from histopathology for pathogenesis.

Mol Aspects Med 2014 Jun 17;37:35-56. Epub 2013 Oct 17.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2013.10.001DOI Listing
June 2014

Molecular pathogenesis of chronic cholestatic liver disease: impact on novel therapeutic approaches.

Mol Aspects Med 2014 Jun 25;37:1-2. Epub 2013 Nov 25.

University Hospital, Rämistrasse 100, 8091 Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.mam.2013.11.001DOI Listing
June 2014

Confocal imaging with a fluorescent bile acid analogue closely mimicking hepatic taurocholate disposition.

J Pharm Sci 2014 Jun 20;103(6):1872-81. Epub 2014 Mar 20.

Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, O&N2, Leuven, 3000, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153054
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http://dx.doi.org/10.1002/jps.23933DOI Listing
June 2014

Differential effects of membrane cholesterol content on the transport activity of multidrug resistance-associated protein 2 (ABCC2) and of the bile salt export pump (ABCB11).

Mol Pharmacol 2014 Jun 7;85(6):909-20. Epub 2014 Apr 7.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
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http://dx.doi.org/10.1124/mol.114.092262DOI Listing
June 2014

Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1.

Genome Med 2013 11;5(1). Epub 2013 Jan 11.

Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, 70376 Stuttgart, Germany, and University of Tübingen.

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http://dx.doi.org/10.1186/gm405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706890PMC
May 2014

The role of organic anion transporters in diagnosing liver diseases by magnetic resonance imaging.

Drug Metab Dispos 2014 Apr 7;42(4):675-84. Epub 2014 Jan 7.

Laboratoire de Physiopathologie Hépatique et Imagerie Moléculaire, Hôpitaux Universitaires de Genève, Switzerland, and U1149 INSERM-Université Paris Diderot, Sorbonne Paris Cité, Paris, France (C.M.P.); Swiss HPB and Department of Gastroenterology and Hepatology, University Hospital, Zurich, Switzerland (B.M.); and Department of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland (B.S.).

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http://dx.doi.org/10.1124/dmd.113.055707DOI Listing
April 2014

Transport of estradiol-17β-glucuronide, estrone-3-sulfate and taurocholate across the endoplasmic reticulum membrane: evidence for different transport systems.

Biochem Pharmacol 2014 Mar 7;88(1):106-18. Epub 2014 Jan 7.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952130081
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http://dx.doi.org/10.1016/j.bcp.2013.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969151PMC
March 2014

Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters.

Pflugers Arch 2014 Jan 3;466(1):77-89. Epub 2013 Oct 3.

Department of Biomedical Sciences, Cummings School of Veterinary Medicine, Tufts University, 200 Westboro Road, North Grafton, MA, 01536, USA,

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http://link.springer.com/content/pdf/10.1007/s00424-013-1367
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http://link.springer.com/10.1007/s00424-013-1367-0
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http://dx.doi.org/10.1007/s00424-013-1367-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877701PMC
January 2014

The SLCO (former SLC21) superfamily of transporters.

Mol Aspects Med 2013 Apr-Jun;34(2-3):396-412

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.mam.2012.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602805PMC
September 2013

Polarized expression of drug transporters in differentiated human hepatoma HepaRG cells.

Toxicol In Vitro 2013 Sep 12;27(6):1979-86. Epub 2013 Jul 12.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.1016/j.tiv.2013.07.003DOI Listing
September 2013

Hepatocellular organic anion-transporting polypeptides (OATPs) and multidrug resistance-associated protein 2 (MRP2) are inhibited by silibinin.

Drug Metab Dispos 2013 Aug 21;41(8):1522-8. Epub 2013 May 21.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1124/dmd.113.051037DOI Listing
August 2013

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Arch Toxicol 2013 Aug 23;87(8):1315-530. Epub 2013 Aug 23.

Leibniz Research Centre for Working Environment and Human Factors (IFADO), 44139, Dortmund, Germany.

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http://dx.doi.org/10.1007/s00204-013-1078-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753504PMC
August 2013

Structure-based identification of OATP1B1/3 inhibitors.

Mol Pharmacol 2013 Jun 9;83(6):1257-67. Epub 2013 Apr 9.

Drug Delivery and Disposition, KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Leuven, Belgium.

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http://dx.doi.org/10.1124/mol.112.084152DOI Listing
June 2013

Functional expression and regulation of drug transporters in monolayer- and sandwich-cultured mouse hepatocytes.

Eur J Pharm Sci 2013 Apr 6;49(1):39-50. Epub 2013 Feb 6.

Institut de Recherches en Santé, Environnement et Travail (IRSET), UMR INSERM U1085, Faculté de Pharmacie, 2 Avenue du Pr Léon Bernard, 35043 Rennes, France; Pôle Biologie, Centre Hospitalier Universitaire, 2 rue Henri Le Guilloux, 35033 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2013.01.013DOI Listing
April 2013

Differential regulation of drug transporter expression by all-trans retinoic acid in hepatoma HepaRG cells and human hepatocytes.

Eur J Pharm Sci 2013 Mar 23;48(4-5):767-74. Epub 2013 Jan 23.

Institut de Recherche sur la Santé, l'Environnement et le Travail/INSERM U1085, University of Rennes 1, 2 Avenue du Professeur Léon Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.1016/j.ejps.2013.01.005DOI Listing
March 2013

Genetic variations in bile acid homeostasis are not overrepresented in alcoholic cirrhosis compared to patients with heavy alcohol abuse and absent liver disease.

Mutagenesis 2012 Sep 19;27(5):567-72. Epub 2012 Apr 19.

Department of Gastroenterology and Hepatology, University Hospital Zurich (USZ), CH-8091 Zurich, Switzerland.

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http://dx.doi.org/10.1093/mutage/ges020DOI Listing
September 2012

Serotonin protects mouse liver from cholestatic injury by decreasing bile salt pool after bile duct ligation.

Hepatology 2012 Jul 5;56(1):209-18. Epub 2012 Jun 5.

Swiss HPB (Hepato-Pancreato-Biliary) Center, Department of Surgery,University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1002/hep.25626DOI Listing
July 2012

An Arabidopsis T-DNA insertion mutant for galactokinase (AtGALK, At3g06580) hyperaccumulates free galactose and is insensitive to exogenous galactose.

Plant Cell Physiol 2012 May 21;53(5):921-9. Epub 2012 Mar 21.

Institute of Plant Biology, Molecular Plant Physiology, University of Zürich, Zollikerstrasse 107, CH-8008 Zürich, Switzerland.

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https://academic.oup.com/pcp/article-lookup/doi/10.1093/pcp/
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http://dx.doi.org/10.1093/pcp/pcs036DOI Listing
May 2012

Diverse functional properties of Wilson disease ATP7B variants.

Gastroenterology 2012 Apr 10;142(4):947-956.e5. Epub 2012 Jan 10.

Department of Medicine, Dermatology and Neurology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany.

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http://dx.doi.org/10.1053/j.gastro.2011.12.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3461965PMC
April 2012

Complement factor C5 deficiency significantly delays the progression of biliary fibrosis in bile duct-ligated mice.

Biochem Biophys Res Commun 2012 Feb 18;418(3):445-50. Epub 2012 Jan 18.

Division for Gastroenterology and Hepatology, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.bbrc.2012.01.036DOI Listing
February 2012

The emerging role of transport systems in liver function tests.

Eur J Pharmacol 2012 Jan 6;675(1-3):1-5. Epub 2011 Dec 6.

Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ejphar.2011.11.048DOI Listing
January 2012

Interaction of bile salts with rat canalicular membrane vesicles: evidence for bile salt resistant microdomains.

J Hepatol 2011 Dec 19;55(6):1368-76. Epub 2011 May 19.

Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.jhep.2011.04.014DOI Listing
December 2011

Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

J Pharm Sci 2011 Nov 11;100(11):5018-30. Epub 2011 Aug 11.

Department of Pharmaceutical Sciences, Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1002/jps.22694DOI Listing
November 2011

Expression of organic anion-transporting polypeptides 1B1 and 1B3 in ovarian cancer cells: relevance for paclitaxel transport.

Biomed Pharmacother 2011 Sep 12;65(6):417-26. Epub 2011 Jun 12.

Department of Pathophysiology, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.biopha.2011.04.031DOI Listing
September 2011

Regulation of drug transporter expression by oncostatin M in human hepatocytes.

Biochem Pharmacol 2011 Aug 6;82(3):304-11. Epub 2011 May 6.

EA 4427 SeRAIC, Institut de Recherches Santé, Environnement et Travail, Université de Rennes 1, Département HITC, Hôpital Pontchaillou, CHU, 2 Avenue du Pr L. Bernard, 35043 Rennes, France.

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http://dx.doi.org/10.1016/j.bcp.2011.04.017DOI Listing
August 2011

The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target.

Curr Drug Targets 2011 May;12(5):661-70

Division of Clinical Pharmacology and Toxicology, University Hospital, Zurich, Switzerland.

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http://dx.doi.org/10.2174/138945011795378496DOI Listing
May 2011

Pharmacogenetics of drug transporters in the enterohepatic circulation.

Pharmacogenomics 2011 May;12(5):611-31

Division of Clinical Pharmacology & Toxicology, University Hospital, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.2217/pgs.11.53DOI Listing
May 2011

Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green.

J Hepatol 2011 Apr 1;54(4):738-45. Epub 2010 Oct 1.

Department of Experimental Surgery, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jhep.2010.07.047DOI Listing
April 2011

Genetic variations of bile salt transporters as predisposing factors for drug-induced cholestasis, intrahepatic cholestasis of pregnancy and therapeutic response of viral hepatitis.

Expert Opin Drug Metab Toxicol 2011 Apr 15;7(4):411-25. Epub 2011 Feb 15.

University Hospital Zurich, Division of Clinical Pharmacology and Toxicology, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1517/17425255.2011.557067DOI Listing
April 2011

How organic anions accumulate in hepatocytes lacking Mrp2: evidence in rat liver.

J Pharmacol Exp Ther 2011 Mar 2;336(3):624-32. Epub 2010 Dec 2.

Unite´ de Neurophysiologie et Neuroimagerie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.

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http://dx.doi.org/10.1124/jpet.110.175406DOI Listing
March 2011

The human organic anion transporter genes OAT5 and OAT7 are transactivated by hepatocyte nuclear factor-1α (HNF-1α).

Mol Pharmacol 2010 Dec 9;78(6):1079-87. Epub 2010 Sep 9.

Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, Zurich, Switzerland.

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http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.110.06
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http://dx.doi.org/10.1124/mol.110.065201DOI Listing
December 2010

Garlic extract induces intestinal P-glycoprotein, but exhibits no effect on intestinal and hepatic CYP3A4 in humans.

Eur J Pharm Sci 2010 Dec 7;41(5):729-35. Epub 2010 Oct 7.

Division of Clinical Pharmacology and Toxicology, University Hospital Zürich, Switzerland.

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http://dx.doi.org/10.1016/j.ejps.2010.09.016DOI Listing
December 2010

Relapsing features of bile salt export pump deficiency after liver transplantation in two patients with progressive familial intrahepatic cholestasis type 2.

J Hepatol 2010 Nov 29;53(5):981-6. Epub 2010 Jul 29.

Department of Pediatrics, Division of Gastroenterology and Hepatology, University Hospital Santa Chiara, Pisa, Italy.

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http://dx.doi.org/10.1016/j.jhep.2010.05.025DOI Listing
November 2010

Functional identification of Arabidopsis ATSIP2 (At3g57520) as an alkaline α-galactosidase with a substrate specificity for raffinose and an apparent sink-specific expression pattern.

Plant Cell Physiol 2010 Oct 24;51(10):1815-9. Epub 2010 Aug 24.

Institute of Plant Biology, University of Zürich, Zollikerstrasse 107, 8008 Zürich, Switzerland.

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http://dx.doi.org/10.1093/pcp/pcq127DOI Listing
October 2010

Role of the bile salt export pump, BSEP, in acquired forms of cholestasis.

Authors:
Bruno Stieger

Drug Metab Rev 2010 Aug;42(3):437-45

Department of Medicine, University Hospital Zurich, Switzerland.

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http://dx.doi.org/10.3109/03602530903492004DOI Listing
August 2010

Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein.

J Pharmacol Exp Ther 2010 Jul 13;334(1):78-86. Epub 2010 Apr 13.

Liver Center, Academic Medical Center, Amsterdam, The Netherlands.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.110.16699
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http://dx.doi.org/10.1124/jpet.110.166991DOI Listing
July 2010

The plasma carnitine concentration regulates renal OCTN2 expression and carnitine transport in rats.

Eur J Pharmacol 2010 Jun 19;635(1-3):171-6. Epub 2010 Mar 19.

Division of Clinical Pharmacology and Toxicology, University Hospital and University of Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ejphar.2010.02.045DOI Listing
June 2010

Differential regulation of drug transporter expression by hepatocyte growth factor in primary human hepatocytes.

Drug Metab Dispos 2009 Nov 6;37(11):2228-35. Epub 2009 Aug 6.

Equipe d'Accueil 4427, SeRAIC/Institut National de la Santé et de la Recherche Médicale U620, Institut Fédératif de Recherches 140, University of Rennes 1, Rennes, France.

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http://dmd.aspetjournals.org/cgi/doi/10.1124/dmd.109.028035
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http://dx.doi.org/10.1124/dmd.109.028035DOI Listing
November 2009

Vitamin D3 and its nuclear receptor increase the expression and activity of the human proton-coupled folate transporter.

Mol Pharmacol 2009 Nov 7;76(5):1062-71. Epub 2009 Aug 7.

Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1124/mol.109.055392DOI Listing
November 2009

Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers.

Eur J Clin Pharmacol 2009 Oct 27;65(10):999-1006. Epub 2009 Jun 27.

Division of Clinical Pharmacology and Toxicology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland.

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http://dx.doi.org/10.1007/s00228-009-0683-yDOI Listing
October 2009

Recent insights into the function and regulation of the bile salt export pump (ABCB11).

Authors:
Bruno Stieger

Curr Opin Lipidol 2009 Jun;20(3):176-81

Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, Zurich, Switzerland.

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https://insights.ovid.com/crossref?an=00041433-200906000-000
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http://dx.doi.org/10.1097/MOL.0b013e32832b677cDOI Listing
June 2009