Bruno Sarmento

Bruno Sarmento

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Bruno Sarmento

Bruno Sarmento

Publications by authors named "Bruno Sarmento"

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Novel amphiphilic chitosan micelles as carriers for hydrophobic anticancer drugs.

Mater Sci Eng C Mater Biol Appl 2020 Jul 3;112:110920. Epub 2020 Apr 3.

i3S - Institute for Research and Innovation in Health/INEB -Institute of Biomedical Engineering (INEB), University of Porto, Portugal; CESPU, IINFACTS - Institute for Research and Advanced Training in Health Sciences and Technologies, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.msec.2020.110920DOI Listing
July 2020

The solid progress of nanomedicine.

Drug Deliv Transl Res 2020 Jun;10(3):726-729

Drug Research Program, Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, FI-00014, Helsinki, Finland.

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http://dx.doi.org/10.1007/s13346-020-00743-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228908PMC
June 2020

Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol.

Drug Deliv Transl Res 2020 Jun;10(3):826-837

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1007/s13346-020-00738-zDOI Listing
June 2020

In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair.

J Control Release 2020 Jun 31;322:375-389. Epub 2020 Mar 31.

Shanghai Key Laboratory of Embryo Original Diseases, The International Peace Maternal and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 910 Hengshan Road, Shanghai 200030, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.03.030DOI Listing
June 2020

Lipid nanocapsules to enhance drug bioavailability to the central nervous system.

J Control Release 2020 Jun 2;322:390-400. Epub 2020 Apr 2.

I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.03.042DOI Listing
June 2020

Fundamentals of nanomedicines towards clinical translation.

Drug Deliv Transl Res 2020 Jun;10(3):571

Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, USA.

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http://dx.doi.org/10.1007/s13346-020-00762-zDOI Listing
June 2020

Evaluation of lipid nanoparticles for topical delivery of protocatechuic acid and ethyl protocatechuate as a new photoprotection strategy.

Int J Pharm 2020 May 15;582:119336. Epub 2020 Apr 15.

i3S - Institute for Research and Innovation in Health, University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Institute of Biomedical Engineering, University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU, IINFACTS - Institute for Research and Advanced Training in Health Sciences and Technologies, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2020.119336DOI Listing
May 2020

SARS-CoV-2 and Diabetes: New Challenges for the Disease.

Diabetes Res Clin Pract 2020 May 21:108228. Epub 2020 May 21.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.diabres.2020.108228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242186PMC
May 2020

Guidelines of the Brazilian Society of Oncologic Surgery for pelvic exenteration in the treatment of cervical cancer.

J Surg Oncol 2020 Apr 27;121(5):718-729. Epub 2019 Nov 27.

Brazilian Society of Surgical Oncology, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1002/jso.25759DOI Listing
April 2020

Colorectal cancer triple co-culture spheroid model to assess the biocompatibility and anticancer properties of polymeric nanoparticles.

J Control Release 2020 Apr 19;323:398-411. Epub 2020 Apr 19.

Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; Instituto de Engenharia Biomédica (INEB), University of Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central da Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2020.04.025DOI Listing
April 2020

Vaginal multipurpose prevention technologies: promising approaches for enhancing women's sexual and reproductive health.

Expert Opin Drug Deliv 2020 Mar 17;17(3):379-393. Epub 2020 Feb 17.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1080/17425247.2020.1728251DOI Listing
March 2020

Oral nanoparticles based on gellan gum/pectin for colon-targeted delivery of resveratrol.

Drug Dev Ind Pharm 2020 Feb 23;46(2):236-245. Epub 2020 Jan 23.

School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, SP, Brazil.

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http://dx.doi.org/10.1080/03639045.2020.1716374DOI Listing
February 2020

Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption.

Foods 2020 Feb 17;9(2). Epub 2020 Feb 17.

Cardiovascular Research Laboratory, Department of Surgery, Medical, Molecular, and Critical Area Pathology, University of Pisa, via Paradisa 2, 56100 Pisa, Italy.

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http://dx.doi.org/10.3390/foods9020207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074069PMC
February 2020

Microfluidic Manufacturing of Multitargeted PLGA/PEG Nanoparticles for Delivery of Taxane Chemotherapeutics.

Methods Mol Biol 2020 ;2059:213-224

I3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1007/978-1-4939-9798-5_11DOI Listing
January 2020

Design and characterization of an organogel system containing ascorbic acid microparticles produced with propolis by-product.

Pharm Dev Technol 2020 Jan 3;25(1):54-67. Epub 2019 Oct 3.

Department of Pharmacy, Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, State University of Maringa, Maringa, Brazil.

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http://dx.doi.org/10.1080/10837450.2019.1669643DOI Listing
January 2020

The effect of freeze-drying on mucoadhesion and transport of acrylated chitosan nanoparticles.

Int J Pharm 2020 Jan 6;573:118739. Epub 2019 Nov 6.

The Russell Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel; Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118739DOI Listing
January 2020

Mucoadhesive buccal films based on a graft co-polymer - A mucin-retentive hydrogel scaffold.

Eur J Pharm Sci 2020 Jan 7;142:105142. Epub 2019 Nov 7.

Department of Pharmacy, University of Oslo, Norway. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105142DOI Listing
January 2020

and assessment of buccal permeation of drugs from delivery systems.

Expert Opin Drug Deliv 2020 Jan 3;17(1):33-48. Epub 2019 Dec 3.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.

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http://dx.doi.org/10.1080/17425247.2020.1699913DOI Listing
January 2020

Establishment of a multilayered 3D cellular model of the retinal-blood barrier.

Int J Pharm 2019 Dec 31;572:118811. Epub 2019 Oct 31.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118811DOI Listing
December 2019

Recent advance of erythrocyte-mimicking nanovehicles: From bench to bedside.

J Control Release 2019 11 20;314:81-91. Epub 2019 Oct 20.

Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.10.032DOI Listing
November 2019

Zein-casein-lysine multicomposite nanoparticles are effective in modulate the intestinal permeability of ferulic acid.

Int J Biol Macromol 2019 Oct 4;138:244-251. Epub 2019 Jul 4.

INEB - National Institute of Biomedical Engineering, University of Porto, Porto, Portugal; i3S - Institute for Research and Innovation in Health, University of Porto, Porto, Portugal; CESPU - Institute for Research and Advanced Training in Health Sciences and Technologies, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.07.030DOI Listing
October 2019

Glycoengineered nanoparticles enhance the delivery of 5-fluoroucil and paclitaxel to gastric cancer cells of high metastatic potential.

Int J Pharm 2019 Oct 26;570:118646. Epub 2019 Aug 26.

Experimental Pathology and Therapeutics Group, Portuguese Institute of Oncology, 4200-162 Porto, Portugal; Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, 4050-013 Porto, Portugal; Porto Comprehensive Cancer Centre (P.ccc), 4200-162 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118646DOI Listing
October 2019

Nanoparticles for the regulation of intestinal inflammation: opportunities and challenges.

Nanomedicine (Lond) 2019 10 15;14(19):2631-2644. Epub 2019 Oct 15.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

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http://dx.doi.org/10.2217/nnm-2019-0191DOI Listing
October 2019

Impact of CEA-targeting Nanoparticles for Drug Delivery in Colorectal Cancer.

J Pharmacol Exp Ther 2019 09 22;370(3):657-670. Epub 2019 Jan 22.

Instituto de Investigação e Inovação em Saúde (A.R.S., M.J.O., B.S.), Instituto de Engenharia Biomédica (A.R.S., M.J.O., B.S.), Instituto de Ciências Biomédicas Abel Salazar (A.R.S., M.J.O.), and Faculdade de Medicina da (M.J.O.), Universidade do Porto, Porto, Portugal; Instituto Português de Oncologia do Porto, Porto, Portugal (A.R.S.); and Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal (B.S.)

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http://dx.doi.org/10.1124/jpet.118.254441DOI Listing
September 2019

Film-nanoparticle composite for enhanced oral delivery of alpha-casozepine.

Colloids Surf B Biointerfaces 2019 Sep 18;181:149-157. Epub 2019 May 18.

CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2019.05.029DOI Listing
September 2019

Colorectal distribution and retention of polymeric nanoparticles following incorporation into a thermosensitive enema.

Biomater Sci 2019 Sep 25;7(9):3801-3811. Epub 2019 Jun 25.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. and INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal and CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal.

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http://dx.doi.org/10.1039/c9bm00759hDOI Listing
September 2019

Nanotechnology-based siRNA delivery strategies for metastatic colorectal cancer therapy.

Int J Pharm 2019 Sep 16;568:118530. Epub 2019 Jul 16.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118530DOI Listing
September 2019

Multicomponent self nano emulsifying delivery systems of resveratrol with enhanced pharmacokinetics profile.

Eur J Pharm Sci 2019 Sep 19;137:105011. Epub 2019 Jul 19.

INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2019.105011DOI Listing
September 2019

Enhanced anti-angiogenic effects of bevacizumab in glioblastoma treatment upon intranasal administration in polymeric nanoparticles.

J Control Release 2019 09 22;309:37-47. Epub 2019 Jul 22.

Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2019.07.033DOI Listing
September 2019

Anti-Inflammatory Effect of Cherry Extract Loaded in Polymeric Nanoparticles: Relevance of Particle Internalization in Endothelial Cells.

Pharmaceutics 2019 Sep 29;11(10). Epub 2019 Sep 29.

Cardiovascular Research Laboratory, Department of Surgery, Medical, Molecular, and Critical Area Pathology, University of Pisa, via Paradisa 2, 56100 Pisa, Italy.

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http://dx.doi.org/10.3390/pharmaceutics11100500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6835553PMC
September 2019

Mannosylated solid lipid nanoparticles for the selective delivery of rifampicin to macrophages.

Artif Cells Nanomed Biotechnol 2018 12;46(sup1):653-663. Epub 2018 Feb 12.

a UCIBIO, REQUIMTE, Departamento de Ciências Químicas , Faculdade de Farmácia, Universidade do Porto , Porto , Portugal.

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https://www.tandfonline.com/doi/full/10.1080/21691401.2018.1
Publisher Site
http://dx.doi.org/10.1080/21691401.2018.1434186DOI Listing
August 2019

Therapeutic Monoclonal Antibodies Delivery for the Glioblastoma Treatment.

Adv Protein Chem Struct Biol 2018 30;112:61-80. Epub 2018 Mar 30.

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB-Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU-Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/bs.apcsb.2018.03.001DOI Listing
August 2019

Have nanomedicines progressed as much as we'd hoped for in drug discovery and development?

Authors:
Bruno Sarmento

Expert Opin Drug Discov 2019 08 4;14(8):723-725. Epub 2019 Jun 4.

a I3S - Instituto de Investigação e Inovação em Saúde , Universidade do Porto , Porto , Portugal.

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http://dx.doi.org/10.1080/17460441.2019.1621286DOI Listing
August 2019

pH-responsive chitosan based hydrogels affect the release of dapsone: Design, set-up, and physicochemical characterization.

Int J Biol Macromol 2019 Jul 26;133:1268-1279. Epub 2019 Apr 26.

Department of Pharmacy, University of Chieti - Pescara "G. d'Annuzio", 66100 Chieti, Italy; Department of Nanomedicine, Houston Methodist Research Institute, 77030 Houston, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.178DOI Listing
July 2019

Delivering amoxicillin at the infection site - a rational design through lipid nanoparticles.

Int J Nanomedicine 2019 23;14:2781-2795. Epub 2019 Apr 23.

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal,

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http://dx.doi.org/10.2147/IJN.S193992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488159PMC
July 2019

Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid.

Artif Cells Nanomed Biotechnol 2018 29;46(sup2):993-1002. Epub 2018 May 29.

a Department of Pharmacy, Laboratory of Pharmaceutical Nanotechnology , Universidade Estadual do Centro-Oeste/UNICENTRO , Guarapuava , Brazil.

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http://dx.doi.org/10.1080/21691401.2018.1477788DOI Listing
June 2019

Antimicrobial properties of rosin acids-loaded nanoparticles against antibiotic-sensitive and antibiotic-resistant foodborne pathogens.

Artif Cells Nanomed Biotechnol 2018 7;46(sup3):S414-S422. Epub 2018 Dec 7.

a Institute of Sciences of Food Production , National Research Council (ISPA-CNR) , Bari , Italy.

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http://dx.doi.org/10.1080/21691401.2018.1496924DOI Listing
June 2019

Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 06 18;91:235-247. Epub 2019 Apr 18.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123 Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing
June 2019

Using microfluidic platforms to develop CNS-targeted polymeric nanoparticles for HIV therapy.

Eur J Pharm Biopharm 2019 May 31;138:111-124. Epub 2018 Jan 31.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.01.014DOI Listing
May 2019

Composite films for vaginal delivery of tenofovir disoproxil fumarate and emtricitabine.

Eur J Pharm Biopharm 2019 May 2;138:3-10. Epub 2018 Feb 2.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.02.001DOI Listing
May 2019

Alginate-Based Delivery Systems for Bevacizumab Local Therapy: In Vitro Structural Features and Release Properties.

J Pharm Sci 2019 04 1;108(4):1559-1568. Epub 2018 Dec 1.

Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista (UNESP), Araraquara, Rodovia Araraquara-Jaú, km 1, 14.801-902 Araraquara, SP, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183078
Publisher Site
http://dx.doi.org/10.1016/j.xphs.2018.11.038DOI Listing
April 2019

Cherry Extract from L. to Improve the Resistance of Endothelial Cells to Oxidative Stress: Mucoadhesive Chitosan vs. Poly(lactic--glycolic acid) Nanoparticles.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen 208, 4200-153 Porto, Portugal.

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http://dx.doi.org/10.3390/ijms20071759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480209PMC
April 2019

3D Model Replicating the Intestinal Function to Evaluate Drug Permeability.

Methods Mol Biol 2018 ;1817:107-113

I3S - Instituto de Investigação e Inovação na Saúde, University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1007/978-1-4939-8600-2_11DOI Listing
March 2019

Photoimmunoconjugates: novel synthetic strategies to target and treat cancer by photodynamic therapy.

Org Biomol Chem 2019 03;17(10):2579-2593

CQE, Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

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http://xlink.rsc.org/?DOI=C8OB02902D
Publisher Site
http://dx.doi.org/10.1039/c8ob02902dDOI Listing
March 2019

Adhesive nanoparticles with inflammation regulation for promoting skin flap regeneration.

J Control Release 2019 03 25;297:91-101. Epub 2019 Jan 25.

Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, PR China.. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659193005
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2019.01.031DOI Listing
March 2019

Blood-brain barrier receptors and transporters: an insight on their function and how to exploit them through nanotechnology.

Expert Opin Drug Deliv 2019 03 26;16(3):271-285. Epub 2019 Feb 26.

a CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Gandra , Portugal.

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http://dx.doi.org/10.1080/17425247.2019.1583205DOI Listing
March 2019

Pharmaceutical Vehicles for Vaginal and Rectal Administration of Anti-HIV Microbicide Nanosystems.

Pharmaceutics 2019 Mar 26;11(3). Epub 2019 Mar 26.

i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.

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http://dx.doi.org/10.3390/pharmaceutics11030145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472048PMC
March 2019

Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug.

Int J Pharm 2019 Feb 20;557:36-42. Epub 2018 Dec 20.

Department of Pharmacokinetics and Pharmaceutical Technology, Miguel Hernandez University, San Juan de Alicante, 03550 Alicante, Spain.

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http://dx.doi.org/10.1016/j.ijpharm.2018.12.038DOI Listing
February 2019

Development and Characterization of Chitosan Microparticles-in-Films for Buccal Delivery of Bioactive Peptides.

Pharmaceuticals (Basel) 2019 Feb 20;12(1). Epub 2019 Feb 20.

Escola Superior de Biotecnologia, Centro de Biotecnologia e Química Fina, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal.

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http://dx.doi.org/10.3390/ph12010032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469171PMC
February 2019

Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution.

Cancer Lett 2019 01 9;440-441:64-81. Epub 2018 Oct 9.

CESPU, Instituto de Investigação e Formação Avançada Em Ciências e Tecnologias da Saúde, Instituto Universitário de Ciências da Saúde, Gandra PRD, Portugal; Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR/CIMAR), Universidade Do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.10.005DOI Listing
January 2019

Gene Silencing via PDA/ERK2-siRNA-Mediated Electrospun Fibers for Peritendinous Antiadhesion.

Adv Sci (Weinh) 2019 Jan 20;6(2):1801217. Epub 2018 Nov 20.

Department of Orthopaedics Shanghai Jiao Tong University Affiliated Sixth People's Hospital 600 Yishan Road Shanghai 200233 China.

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http://dx.doi.org/10.1002/advs.201801217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343062PMC
January 2019

Hierarchical structured and programmed vehicles deliver drugs locally to inflamed sites of intestine.

Biomaterials 2018 12 19;185:322-332. Epub 2018 Sep 19.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 00014, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki 00014, Finland. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2018.09.024DOI Listing
December 2018

Targeted Reinforcement of Macrophage Reprogramming Toward M2 Polarization by IL-4-Loaded Hyaluronic Acid Particles.

ACS Omega 2018 Dec 27;3(12):18444-18455. Epub 2018 Dec 27.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy and Helsinki Institute of Life Science (HiLIFE), University of Helsinki,Helsinki FI-00014, Finland.

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http://dx.doi.org/10.1021/acsomega.8b03182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711357PMC
December 2018

Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6.

Acta Biomater 2018 11 27;81:208-218. Epub 2018 Sep 27.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.09.043DOI Listing
November 2018

PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor.

ACS Appl Mater Interfaces 2018 Nov 9;10(46):39557-39569. Epub 2018 Nov 9.

CIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences , University of Porto , 4169-007 Porto , Portugal.

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http://pubs.acs.org/doi/10.1021/acsami.8b17224
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http://dx.doi.org/10.1021/acsami.8b17224DOI Listing
November 2018

Carcinoembryonic antigen-targeted nanoparticles potentiate the delivery of anticancer drugs to colorectal cancer cells.

Int J Pharm 2018 Oct 12;549(1-2):397-403. Epub 2018 Aug 12.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, Gandra, Portugal; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2018.08.016DOI Listing
October 2018

Biophysical, photochemical and biochemical characterization of a protease from Aspergillus tamarii URM4634.

Int J Biol Macromol 2018 Oct 4;118(Pt B):1655-1666. Epub 2018 Jul 4.

Northeast Biotechnology Network, Federal Rural University of Pernambuco, Rua Manuel de Medeiros, s/n - Dois Irmãos, Recife, Pernambuco 52171-900, Brazil; Federal Rural University of Pernambuco, Academic Unity of Garanhuns, Avenida Bom Pastor, s/n - Boa Vista, Garanhuns, Pernambuco 55292-270, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2018.07.004DOI Listing
October 2018

Noncovalent PEG Coating of Nanoparticle Drug Carriers Improves the Local Pharmacokinetics of Rectal Anti-HIV Microbicides.

ACS Appl Mater Interfaces 2018 Oct 4;10(41):34942-34953. Epub 2018 Oct 4.

CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde , Gandra 4585-116 , Portugal.

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http://pubs.acs.org/doi/10.1021/acsami.8b12214
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http://dx.doi.org/10.1021/acsami.8b12214DOI Listing
October 2018

Lipid nanocarriers loaded with natural compounds: Potential new therapies for age related neurodegenerative diseases?

Prog Neurobiol 2018 09 8;168:21-41. Epub 2018 Apr 8.

CF-UM-UP (Centre of Physics of University of Minho and Porto), Department of Physics, University of Minho, Campus of Gualtar, 4710-057 Braga, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2018.04.004DOI Listing
September 2018

Surface modification with polyethylene glycol enhances colorectal distribution and retention of nanoparticles.

Eur J Pharm Biopharm 2018 Sep 28;130:200-206. Epub 2018 Jun 28.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.06.029DOI Listing
September 2018

Nanoparticles provide long-term stability of bevacizumab preserving its antiangiogenic activity.

Acta Biomater 2018 09 21;78:285-295. Epub 2018 Jul 21.

I3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.07.040DOI Listing
September 2018

Combination of PLGA nanoparticles with mucoadhesive guar-gum films for buccal delivery of antihypertensive peptide.

Int J Pharm 2018 Aug 22;547(1-2):593-601. Epub 2018 May 22.

CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183036
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http://dx.doi.org/10.1016/j.ijpharm.2018.05.051DOI Listing
August 2018

Incorporation of beads into oral films for buccal and oral delivery of bioactive molecules.

Carbohydr Polym 2018 Aug 9;194:411-421. Epub 2018 Apr 9.

CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01448617183041
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http://dx.doi.org/10.1016/j.carbpol.2018.04.032DOI Listing
August 2018

Metronidazole within phosphatidylcholine lipid membranes: New insights to improve the design of imidazole derivatives.

Eur J Pharm Biopharm 2018 Aug 30;129:204-214. Epub 2018 May 30.

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.05.036DOI Listing
August 2018

iPSC-Derived Enterocyte-like Cells for Drug Absorption and Metabolism Studies.

Trends Mol Med 2018 08 26;24(8):696-708. Epub 2018 Jun 26.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde e Instituto Universitário de Ciências da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2018.06.001DOI Listing
August 2018

Development of a microparticulate system containing Brazilian propolis by-product and gelatine for ascorbic acid delivery: evaluation of intestinal cell viability and radical scavenging activity.

Food Funct 2018 Aug;9(8):4194-4206

Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringá, 87020-900 Maringá, Brazil.

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http://dx.doi.org/10.1039/c8fo00863aDOI Listing
August 2018

Engineered Multifunctional Albumin-Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin.

Small 2018 07 31;14(27):e1800462. Epub 2018 May 31.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.

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http://dx.doi.org/10.1002/smll.201800462DOI Listing
July 2018

Nanosystems as modulators of intestinal dapsone and clofazimine delivery.

Biomed Pharmacother 2018 Jul 7;103:1392-1396. Epub 2018 May 7.

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.biopha.2018.04.195DOI Listing
July 2018

Impact of surfactants on the target recognition of Fab-conjugated PLGA nanoparticles.

Eur J Pharm Biopharm 2018 Jun 13;127:366-370. Epub 2018 Mar 13.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde & Instituto Universitário de Ciências da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2018.03.005DOI Listing
June 2018

Stem cells as vehicles and targets of nanoparticles.

Drug Discov Today 2018 05 11;23(5):1071-1078. Epub 2018 Jan 11.

CNC - Center of Neurosciences and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Azinhaga de Santa Combra, 3000-354 Coimbra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.01.030DOI Listing
May 2018

Development of a PEGylated-Based Platform for Efficient Delivery of Dietary Antioxidants Across the Blood-Brain Barrier.

Bioconjug Chem 2018 05 19;29(5):1677-1689. Epub 2018 Apr 19.

CIQUP, Centro de Investigação em Química, Departmento de Química e Bioquímica, Faculdade de Ciências , Universidade do Porto , 4169-007 , Porto , Portugal.

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http://dx.doi.org/10.1021/acs.bioconjchem.8b00151DOI Listing
May 2018

Development, characterization, antioxidant and hepatoprotective properties of poly(Ɛ-caprolactone) nanoparticles loaded with a neuroprotective fraction of Hypericum perforatum.

Int J Biol Macromol 2018 Apr 14;110:185-196. Epub 2017 Nov 14.

Centre for the Research and Technology of Agro-Environment and Biological Sciences (CITAB-UM), AgroBioPlant Group, Department of Biology, University of Minho, 4710-057 Braga, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2017.10.103DOI Listing
April 2018

Mannose-functionalized solid lipid nanoparticles are effective in targeting alveolar macrophages.

Eur J Pharm Sci 2018 Mar 8;114:103-113. Epub 2017 Dec 8.

CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal.

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http://dx.doi.org/10.1016/j.ejps.2017.12.006DOI Listing
March 2018

PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.

Eur J Pharm Sci 2018 Mar 14;115:119-125. Epub 2017 Dec 14.

i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; INEB-Instituto de Engenharia Biomédica, University of Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central da Gandra 1317, 4585-116 Gandra, Portugal.

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http://dx.doi.org/10.1016/j.ejps.2017.12.009DOI Listing
March 2018

Development and characterization of lipid-polymeric nanoparticles for oral insulin delivery.

Expert Opin Drug Deliv 2018 03 27;15(3):213-222. Epub 2017 Dec 27.

a Centro de Ciências Médicas e Farmacêuticas , Universidade Estadual do Oeste do Paraná , Cascavel/PR , Brazil.

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https://www.tandfonline.com/doi/full/10.1080/17425247.2018.1
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http://dx.doi.org/10.1080/17425247.2018.1420050DOI Listing
March 2018

Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides.

Peptides 2018 03 9;101:112-123. Epub 2018 Jan 9.

CBQF, Centro de Biotecnologia e Química Fina, Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua Arquiteto Lobão Vital, 172, 4200-374 Porto, Portugal; INEB, Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01969781183000
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http://dx.doi.org/10.1016/j.peptides.2018.01.002DOI Listing
March 2018

Evaluation of radical scavenging activity, intestinal cell viability and antifungal activity of Brazilian propolis by-product.

Food Res Int 2018 03 21;105:537-547. Epub 2017 Nov 21.

LAQV/REQUIMTE, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira n. °280, 4050-313 Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.foodres.2017.11.046DOI Listing
March 2018

Measuring the emulsification dynamics and stability of self-emulsifying drug delivery systems.

Eur J Pharm Biopharm 2018 Feb 10;123:1-8. Epub 2017 Nov 10.

INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde and Instituto Universitário de Ciências da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal; School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejpb.2017.11.003DOI Listing
February 2018

Synthesis and characterization of Locust Bean Gum derivatives and their application in the production of nanoparticles.

Carbohydr Polym 2018 Feb 16;181:974-985. Epub 2017 Nov 16.

CIQA - Centre of Research in Chemistry of Algarve, Faculty of Sciences and Technology, Campus de Gambelas, 8005-139 Faro, Portugal; Department of Chemistry and Pharmacy, Faculty of Science and Technology, University of Algarve, Campus de Gambelas, 8005-139 Faro, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.carbpol.2017.11.052DOI Listing
February 2018

Overcoming clofazimine intrinsic toxicity: statistical modelling and characterization of solid lipid nanoparticles.

J R Soc Interface 2018 02;15(139)

LAQV, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal

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http://dx.doi.org/10.1098/rsif.2017.0932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832736PMC
February 2018

Mucoadhesive nanostructured polyelectrolytes complexes modulate the intestinal permeability of methotrexate.

Eur J Pharm Sci 2018 Jan 28;111:73-82. Epub 2017 Sep 28.

UNESP - São Paulo State University, School of Pharmaceutical Sciences, Rod. Araraquara-Jaú, Km 01, CEP: 14801-902 Araraquara, Brazil.

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http://dx.doi.org/10.1016/j.ejps.2017.09.042DOI Listing
January 2018

Chemical modification of drug molecules as strategy to reduce interactions with mucus.

Adv Drug Deliv Rev 2018 01 28;124:98-106. Epub 2017 Sep 28.

INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393 Porto, Portugal; CESPU - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Rua Central de Gandra 1317, 4585-116 Gandra, Portugal.

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http://dx.doi.org/10.1016/j.addr.2017.09.020DOI Listing
January 2018

In vivo evaluation of cetuximab-conjugated poly(γ-glutamic acid)-docetaxel nanomedicines in EGFR-overexpressing gastric cancer xenografts.

Int J Nanomedicine 2017 30;12:7165-7182. Epub 2017 Sep 30.

Department of Biomedical Science, BK21 PLUS Center for Creative Biomedical Scientists, Chonnam National University Medical School, Gwangju, Republic of Korea.

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http://dx.doi.org/10.2147/IJN.S143529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628680PMC
January 2018

Development of PLGA nanoparticles loaded with clofazimine for oral delivery: Assessment of formulation variables and intestinal permeability.

Eur J Pharm Sci 2018 Jan 6;112:28-37. Epub 2017 Nov 6.

UCIBIO, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2017.11.004DOI Listing
January 2018

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications.

Adv Healthc Mater 2018 01 24;7(1). Epub 2017 Nov 24.

I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-393, Porto, Portugal.

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http://dx.doi.org/10.1002/adhm.201701035DOI Listing
January 2018

Mucoadhesive chitosan-coated solid lipid nanoparticles for better management of tuberculosis.

Int J Pharm 2018 Jan 2;536(1):478-485. Epub 2017 Dec 2.

UCIBIO, REQUIMTE, Departamento de Ciências Químicas, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2017.11.071DOI Listing
January 2018

Technological strategies to overcome the mucus barrier in mucosal drug delivery.

Adv Drug Deliv Rev 2018 01;124:1-2

i3S - Instituto de Investigação e Inovação em Saúde & INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; CESPU, Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Gandra, Portugal. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2018.01.014DOI Listing
January 2018