Bruno Lomonte

Bruno Lomonte

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Bruno Lomonte

Bruno Lomonte

Publications by authors named "Bruno Lomonte"

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Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms.

Toxins (Basel) 2020 Feb 20;12(2). Epub 2020 Feb 20.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501-2060, Costa Rica.

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http://dx.doi.org/10.3390/toxins12020131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076770PMC
February 2020

Potent virucidal activity against Flaviviridae of a group IIA phospholipase A isolated from the venom of Bothrops asper.

Biologicals 2020 Jan 12;63:48-52. Epub 2019 Dec 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.biologicals.2019.12.002DOI Listing
January 2020

Proteogenomic analysis of the Clostridium difficile exoproteome reveals a correlation between phylogenetic distribution and virulence potential.

Anaerobe 2020 Jan 13;62:102151. Epub 2020 Jan 13.

Centro de Investigación en Enfermedades Tropicales and Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.anaerobe.2020.102151DOI Listing
January 2020

Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus coral snake venoms: Phylogenetic relationships and characterization of Clarkitoxin-I-Mdum.

Toxicon 2019 Dec 23;170:85-93. Epub 2019 Sep 23.

Programa de Ofidismo y Escorpionismo, Universidad de Antioquia, Calle 62 #52-59, Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Calle 70 No. 52-21, Medellín, Colombia.

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http://dx.doi.org/10.1016/j.toxicon.2019.09.017DOI Listing
December 2019

Enzymatic labelling of snake venom phospholipase A toxins.

Toxicon 2019 Dec 26;170:99-107. Epub 2019 Sep 26.

Istituto di Neuroscienze, CNR, Viale G. Colombo, 3, 35121, Padova, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2019.09.019DOI Listing
December 2019

Venom characterization of the bark scorpion Centruroides edwardsii (Gervais 1843): Composition, biochemical activities and in vivo toxicity for potential prey.

Toxicon 2019 Dec 1;171:7-19. Epub 2019 Oct 1.

Instituto Clodomiro Picado, Facultad de Microbiología, San José, Costa Rica; Escuela de Biología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.toxicon.2019.09.021DOI Listing
December 2019

Structural basis for phospholipase A-like toxin inhibition by the synthetic compound Varespladib (LY315920).

Sci Rep 2019 Nov 20;9(1):17203. Epub 2019 Nov 20.

Departamento de Física e Biofísica, Instituto de Biociências, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.

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http://dx.doi.org/10.1038/s41598-019-53755-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868273PMC
November 2019

Isolation of two basic phospholipases A from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants.

Toxicon 2019 Oct 18;168:113-121. Epub 2019 Jul 18.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2019.07.004DOI Listing
October 2019

Three-finger toxins from the venom of Micrurus tschudii tschudii (desert coral snake): Isolation and characterization of tschuditoxin-I.

Toxicon 2019 Sep 15;167:144-151. Epub 2019 Jun 15.

Departamento Académico de Ciencias Celulares y Moleculares, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 31, Peru.

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http://dx.doi.org/10.1016/j.toxicon.2019.06.023DOI Listing
September 2019

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species.

Nat Commun 2019 08 13;10(1):3642. Epub 2019 Aug 13.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México - UNAM, Apartado Postal 510-3, Cuernavaca Morelos, 61500, Mexico.

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http://dx.doi.org/10.1038/s41467-019-11639-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6692343PMC
August 2019

Proteomic profiling, functional characterization, and immunoneutralization of the venom of Porthidium porrasi, a pitviper endemic to Costa Rica.

Acta Trop 2019 May 1;193:113-123. Epub 2019 Mar 1.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San Jose, 11501, Costa Rica. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X193010
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http://dx.doi.org/10.1016/j.actatropica.2019.02.030DOI Listing
May 2019

New insights into the phylogeographic distribution of the 3FTx/PLA venom dichotomy across genus Micrurus in South America.

J Proteomics 2019 May 1;200:90-101. Epub 2019 Apr 1.

Evolutionary and Translational Venomics Laboratory, CSIC, Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2019.03.014DOI Listing
May 2019

First look into the venom of Roatan Island's critically endangered coral snake Micrurus ruatanus: Proteomic characterization, toxicity, immunorecognition and neutralization by an antivenom.

J Proteomics 2019 Apr 17;198:177-185. Epub 2019 Jan 17.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2019.01.007DOI Listing
April 2019

Biochemical characterization of the venom of Central American scorpion Didymocentrus krausi Francke, 1978 (Diplocentridae) and its toxic effects in vivo and in vitro.

Comp Biochem Physiol C Toxicol Pharmacol 2019 Mar 2;217:54-67. Epub 2018 Dec 2.

Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.cbpc.2018.11.021DOI Listing
March 2019

Venom characterization of the three species of Ophryacus and proteomic profiling of O. sphenophrys unveils Sphenotoxin, a novel Crotoxin-like heterodimeric β-neurotoxin.

J Proteomics 2019 02 8;192:196-207. Epub 2018 Sep 8.

Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, México. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18743919183034
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http://dx.doi.org/10.1016/j.jprot.2018.09.002DOI Listing
February 2019

Cloning, purification and characterization of nigrelysin, a novel actinoporin from the sea anemone Anthopleura nigrescens.

Biochimie 2019 Jan 21;156:206-223. Epub 2018 Jul 21.

Centro de Estudio de Proteínas, Facultad de Biología, Universidad de La Habana, Cuba. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2018.07.013DOI Listing
January 2019

Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A.

Toxicon 2019 Jan 14;157:1-7. Epub 2018 Nov 14.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, 11501, Costa Rica. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183101
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http://dx.doi.org/10.1016/j.toxicon.2018.11.292DOI Listing
January 2019

Innovative Immunization Strategies for Antivenom Development.

Toxins (Basel) 2018 11 2;10(11). Epub 2018 Nov 2.

Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kongens Lyngby, Denmark.

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http://www.mdpi.com/2072-6651/10/11/452
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http://dx.doi.org/10.3390/toxins10110452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265855PMC
November 2018

A novel pentameric phospholipase A myotoxin (PophPLA) from the venom of the pit viper Porthidium ophryomegas.

Int J Biol Macromol 2018 Oct 7;118(Pt A):1-8. Epub 2018 Jun 7.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2018.06.028DOI Listing
October 2018

Delayed Oral LY333013 Rescues Mice from Highly Neurotoxic, Lethal Doses of Papuan Taipan (Oxyuranus scutellatus) Venom.

Toxins (Basel) 2018 09 20;10(10). Epub 2018 Sep 20.

Department of Pharmacology and Therapeutics, Australian Venom Research Unit, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.3390/toxins10100380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215158PMC
September 2018

Proteomic and toxinological characterization of the venom of the South African Ringhals cobra Hemachatus haemachatus.

J Proteomics 2018 06 12;181:104-117. Epub 2018 Apr 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2018.04.007DOI Listing
June 2018

Unresolved issues in the understanding of the pathogenesis of local tissue damage induced by snake venoms.

Toxicon 2018 Jun 23;148:123-131. Epub 2018 Apr 23.

School of Medicine, University of Virginia, Charlottesville, VA 22959, USA.

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http://dx.doi.org/10.1016/j.toxicon.2018.04.016DOI Listing
June 2018

A myotoxic Lys49 phospholipase A-homologue is the major component of the venom of Bothrops cotiara from Misiones, Argentina.

Toxicon 2018 Jun 27;148:143-148. Epub 2018 Apr 27.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00410101183016
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http://dx.doi.org/10.1016/j.toxicon.2018.04.026DOI Listing
June 2018

MipLAAO, a new L-amino acid oxidase from the redtail coral snake .

PeerJ 2018 8;6:e4924. Epub 2018 Jun 8.

Programa de Ofidismo y Escorpionismo, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín, Colombia.

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http://dx.doi.org/10.7717/peerj.4924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995095PMC
June 2018

Biological and Proteolytic Variation in the Venom of Crotalus scutulatus scutulatus from Mexico.

Toxins (Basel) 2018 01 8;10(1). Epub 2018 Jan 8.

Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Av. Artículo 123 s/n. Fracc. Filadelfia, Apartado Postal No. 51, C.P. 35010 Gómez Palacio, Dgo., Mexico.

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http://dx.doi.org/10.3390/toxins10010035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793122PMC
January 2018

From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy.

Curr Pharm Des 2016 ;22(34):5270-5293

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.2174/1381612822666160623073438DOI Listing
December 2017

High-density peptide microarray exploration of the antibody response in a rabbit immunized with a neurotoxic venom fraction.

Toxicon 2017 Nov 1;138:151-158. Epub 2017 Sep 1.

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kgs. Lyngby, Denmark.

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http://dx.doi.org/10.1016/j.toxicon.2017.08.028DOI Listing
November 2017

Comparison of biochemical and cytotoxic activities of extracts obtained from dorsal spines and caudal fin of adult and juvenile non-native Caribbean lionfish (Pterois volitans/miles).

Toxicon 2017 Oct 5;137:158-167. Epub 2017 Aug 5.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica; Departamento de Bioquímica, Escuela de Medicina, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2017.08.004DOI Listing
October 2017

Primary structures and partial toxicological characterization of two phospholipases A from Micrurus mipartitus and Micrurus dumerilii coral snake venoms.

Biochimie 2017 Jun 14;137:88-98. Epub 2017 Mar 14.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biochi.2017.03.008DOI Listing
June 2017

Strategies in 'snake venomics' aiming at an integrative view of compositional, functional, and immunological characteristics of venoms.

J Venom Anim Toxins Incl Trop Dis 2017 28;23:26. Epub 2017 Apr 28.

Structural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain.

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http://dx.doi.org/10.1186/s40409-017-0117-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408369PMC
April 2017

Protein-species quantitative venomics: looking through a crystal ball.

J Venom Anim Toxins Incl Trop Dis 2017 28;23:27. Epub 2017 Apr 28.

Department of Physical and Analytical Chemistry, University of Oviedo, Oviedo, Spain.

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http://dx.doi.org/10.1186/s40409-017-0116-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408492PMC
April 2017

Pitfalls to avoid when using phage display for snake toxins.

Toxicon 2017 Feb 23;126:79-89. Epub 2016 Dec 23.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00410101163063
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http://dx.doi.org/10.1016/j.toxicon.2016.12.010DOI Listing
February 2017

Crystal structure of a phospholipase A from Bothrops asper venom: Insights into a new putative "myotoxic cluster".

Biochimie 2017 Feb 27;133:95-102. Epub 2016 Dec 27.

Departamento de Física e Biofísica, Instituto de Biociências, UNESP - Univ. Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2016.12.015DOI Listing
February 2017

Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach.

J Proteomics 2017 01 20;151:204-213. Epub 2016 May 20.

Laboratório de Toxinologia, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Ciência e Tecnologia em Toxinas, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.05.020DOI Listing
January 2017

Exploring the venom of the forest cobra snake: Toxicovenomics and antivenom profiling of Naja melanoleuca.

J Proteomics 2017 01 1;150:98-108. Epub 2016 Sep 1.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.08.024DOI Listing
January 2017

Proteomic analysis of venom variability and ontogeny across the arboreal palm-pitvipers (genus Bothriechis).

J Proteomics 2017 01 21;152:1-12. Epub 2016 Oct 21.

Structural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.10.006DOI Listing
January 2017

Divergent functional profiles of acidic and basic phospholipases A2 in the venom of the snake Porthidium lansbergii lansbergii.

Toxicon 2016 Sep 2;119:289-98. Epub 2016 Jul 2.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2016.07.006DOI Listing
September 2016

Lemnitoxin, the major component of Micrurus lemniscatus coral snake venom, is a myotoxic and pro-inflammatory phospholipase A2.

Toxicol Lett 2016 Aug 7;257:60-71. Epub 2016 Jun 7.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.toxlet.2016.06.005DOI Listing
August 2016

Characterization of a novel snake venom component: Kazal-type inhibitor-like protein from the arboreal pitviper Bothriechis schlegelii.

Biochimie 2016 Jun 10;125:83-90. Epub 2016 Mar 10.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.biochi.2016.03.004DOI Listing
June 2016

N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils.

Infect Immun 2016 06 24;84(6):1712-21. Epub 2016 May 24.

Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Heredia, Costa Rica Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica

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http://dx.doi.org/10.1128/IAI.00137-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907143PMC
June 2016

Venomic Analysis of the Poorly Studied Desert Coral Snake, Micrurus tschudii tschudii, Supports the 3FTx/PLA₂ Dichotomy across Micrurus Venoms.

Toxins (Basel) 2016 06 7;8(6). Epub 2016 Jun 7.

Laboratorio de Venómica Estructural y Funcional, Instituto de Biomedicina de Valencia, CSIC, Jaime Roig 11, Valencia 46010, Spain.

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http://dx.doi.org/10.3390/toxins8060178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926144PMC
June 2016

Venom of the Coral Snake Micrurus clarki: Proteomic Profile, Toxicity, Immunological Cross-Neutralization, and Characterization of a Three-Finger Toxin.

Toxins (Basel) 2016 05 5;8(5). Epub 2016 May 5.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.

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http://dx.doi.org/10.3390/toxins8050138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885053PMC
May 2016

Toxicovenomics and antivenom profiling of the Eastern green mamba snake (Dendroaspis angusticeps).

J Proteomics 2016 Mar 12;136:248-61. Epub 2016 Feb 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2016.02.003DOI Listing
March 2016

Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom.

J Proteomics 2016 Mar 12;136:262-73. Epub 2016 Feb 12.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica.

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http://dx.doi.org/10.1016/j.jprot.2016.02.006DOI Listing
March 2016

Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis.

Toxicon 2015 Dec 11;107(Pt B):187-96. Epub 2015 Jul 11.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.07.008DOI Listing
December 2015

Snake venomics of Micrurus alleni and Micrurus mosquitensis from the Caribbean region of Costa Rica reveals two divergent compositional patterns in New World elapids.

Toxicon 2015 Dec 29;107(Pt B):217-33. Epub 2015 Aug 29.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.08.016DOI Listing
December 2015

A bright future for integrative venomics.

Toxicon 2015 Dec 2;107(Pt B):159-62. Epub 2015 Nov 2.

Instituto Clodomiro Picado, Universidad de Costa Rica, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.10.024DOI Listing
December 2015

A constant area monolayer method to assess optimal lipid packing for lipolysis tested with several secreted phospholipase A2.

Biochim Biophys Acta 2015 Oct 4;1848(10 Pt A):2216-24. Epub 2015 Jun 4.

Centro de Investigaciones en Química Biológica de Córdoba, CIQUIBIC, Departamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.bbamem.2015.06.003DOI Listing
October 2015

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score.

Toxicon 2015 Sep 31;104:43-5. Epub 2015 Jul 31.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.07.334DOI Listing
September 2015

Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.

Toxicon 2015 Jun 11;99:23-35. Epub 2015 Mar 11.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.03.001DOI Listing
June 2015

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development.

J Proteomics 2015 Apr 14;119:126-42. Epub 2015 Feb 14.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.02.002DOI Listing
April 2015

Proteomic and functional analyses of the venom of Porthidium lansbergii lansbergii (Lansberg's hognose viper) from the Atlantic Department of Colombia.

J Proteomics 2015 Jan 8;114:287-99. Epub 2014 Dec 8.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.11.016DOI Listing
January 2015

A structure-based proposal for a comprehensive myotoxic mechanism of phospholipase A2-like proteins from viperid snake venoms.

Biochim Biophys Acta 2014 Dec 30;1844(12):2265-76. Epub 2014 Sep 30.

Depto. de Física e Biofísica, Instituto de Biociências, Universidade Estadual Paulista-UNESP, Botucatu, SP, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2014.09.015DOI Listing
December 2014

Omics meets biology: application to the design and preclinical assessment of antivenoms.

Toxins (Basel) 2014 Dec 15;6(12):3388-405. Epub 2014 Dec 15.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.

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http://dx.doi.org/10.3390/toxins6123388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280540PMC
December 2014

Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: identification of directly hemolytic phospholipases A2.

Toxicon 2014 Nov 1;90:26-35. Epub 2014 Aug 1.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, 1000 San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2014.07.010DOI Listing
November 2014

Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia.

Toxicon 2014 Nov 1;90:15-25. Epub 2014 Aug 1.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2014.07.012DOI Listing
November 2014

Immunological profile of antivenoms: preclinical analysis of the efficacy of a polyspecific antivenom through antivenomics and neutralization assays.

J Proteomics 2014 Jun 28;105:340-50. Epub 2014 Feb 28.

Instituto de Biomedicina de Valencia, CSIC, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2014.02.021DOI Listing
June 2014

Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia.

PeerJ 2014 22;2:e246. Epub 2014 Jan 22.

Instituto Clodomiro Picado , Facultad de Microbiología , Universidad de Costa Rica , San José , Costa Rica.

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http://dx.doi.org/10.7717/peerj.246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3912449PMC
February 2014

Venomics of New World pit vipers: genus-wide comparisons of venom proteomes across Agkistrodon.

J Proteomics 2014 Jan 7;96:103-16. Epub 2013 Nov 7.

Laboratorio de Venómica y Proteinómica Estructural, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2013.10.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294458PMC
January 2014

Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with Bothrops asper venom.

J Proteomics 2014 Jan 11;96:159-72. Epub 2013 Nov 11.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2013.11.005DOI Listing
January 2014

Amino acid sequence and biological characterization of BlatPLA₂, a non-toxic acidic phospholipase A₂ from the venom of the arboreal snake Bothriechis lateralis from Costa Rica.

Toxicon 2013 Oct 16;73:71-80. Epub 2013 Jul 16.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José 11501, Costa Rica.

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http://dx.doi.org/10.1016/j.toxicon.2013.07.008DOI Listing
October 2013

Muscle phospholipid hydrolysis by Bothrops asper Asp49 and Lys49 phospholipase A₂ myotoxins--distinct mechanisms of action.

FEBS J 2013 Aug 12;280(16):3878-86. Epub 2013 Jul 12.

Department of Biomedical Sciences and National Research Council Institute of Neuroscience, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/febs.12386DOI Listing
August 2013

Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: different expression of crotoxin results in highly variable toxicity in the venoms of three subspecies.

J Proteomics 2013 Jul 29;87:103-21. Epub 2013 May 29.

Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.

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http://dx.doi.org/10.1016/j.jprot.2013.05.024DOI Listing
July 2013

Proteomic analysis of Bothrops pirajai snake venom and characterization of BpirMP, a new P-I metalloproteinase.

J Proteomics 2013 Mar 4;80:250-67. Epub 2013 Feb 4.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, FCFRP-USP, Ribeirão Preto, SP, Brazil.

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http://linkinghub.elsevier.com/retrieve/pii/S187439191300051
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http://dx.doi.org/10.1016/j.jprot.2013.01.021DOI Listing
March 2013

Why myotoxin-containing snake venoms possess powerful nucleotidases?

Biochem Biophys Res Commun 2013 Jan 19;430(4):1289-93. Epub 2012 Dec 19.

Dipartimento di Scienze Biomediche, Università di Padova, and Istituto di Neuroscienze-CNR Sezione di Padova, Padova 35121, Italy.

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http://dx.doi.org/10.1016/j.bbrc.2012.11.129DOI Listing
January 2013