Bruno Klaholz

Bruno Klaholz

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Bruno Klaholz

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Deriving and refining atomic models in crystallography and cryo-EM: the latest Phenix tools to facilitate structure analysis.

Authors:
Bruno P Klaholz

Acta Crystallogr D Struct Biol 2019 Oct 1;75(Pt 10):878-881. Epub 2019 Oct 1.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, 1 rue Laurent Fries, Illkirch 67404, France.

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http://dx.doi.org/10.1107/S2059798319013391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778849PMC
October 2019

CENP-A nucleosome clusters form rosette-like structures around HJURP during G1.

Nat Commun 2019 09 30;10(1):4436. Epub 2019 Sep 30.

Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France.

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http://dx.doi.org/10.1038/s41467-019-12383-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769019PMC
September 2019

Publisher Correction: N-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.

Nat Chem Biol 2019 05;15(5):549

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41589-019-0233-6DOI Listing
May 2019

NMethyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation.

Nat Chem Biol 2019 01 10;15(1):88-94. Epub 2018 Dec 10.

Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41589-018-0184-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463480PMC
January 2019

Tetracyclines Modify Translation by Targeting Key Human rRNA Substructures.

Cell Chem Biol 2018 12 11;25(12):1506-1518.e13. Epub 2018 Oct 11.

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183033
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http://dx.doi.org/10.1016/j.chembiol.2018.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309532PMC
December 2018

Visualizing the Role of 2'-OH rRNA Methylations in the Human Ribosome Structure.

Biomolecules 2018 10 25;8(4). Epub 2018 Oct 25.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.3390/biom8040125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316459PMC
October 2018

3DClusterViSu: 3D clustering analysis of super-resolution microscopy data by 3D Voronoi tessellations.

Bioinformatics 2018 09;34(17):3004-3012

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, 1 rue Laurent Fries, Illkirch, France.

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http://dx.doi.org/10.1093/bioinformatics/bty200DOI Listing
September 2018

New tools for the analysis and validation of cryo-EM maps and atomic models.

Acta Crystallogr D Struct Biol 2018 Sep 3;74(Pt 9):814-840. Epub 2018 Sep 3.

Centre for Integrative Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS-INSERM-UdS, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch, France.

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http://dx.doi.org/10.1107/S2059798318009324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130467PMC
September 2018

Volta phase plate data collection facilitates image processing and cryo-EM structure determination.

J Struct Biol 2018 06 11;202(3):191-199. Epub 2018 Jan 11.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (Inserm) U1258, Illkirch, France; Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.jsb.2018.01.003DOI Listing
June 2018

Structural features of the salivary gland hypertrophy virus of the tsetse fly revealed by cryo-electron microscopy and tomography.

Virology 2018 01 27;514:165-169. Epub 2017 Nov 27.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France; Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2017.11.016DOI Listing
January 2018

Visualization of chemical modifications in the human 80S ribosome structure.

Nature 2017 11 15;551(7681):472-477. Epub 2017 Nov 15.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC, CNRS, Inserm, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1038/nature24482DOI Listing
November 2017

Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes.

Curr Opin Struct Biol 2017 10 29;46:140-148. Epub 2017 Aug 29.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France; Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2017.07.007DOI Listing
October 2017

The Ribosome Holds the RNA Polymerase on Track in Bacteria.

Authors:
Bruno P Klaholz

Trends Biochem Sci 2017 09 8;42(9):686-689. Epub 2017 Aug 8.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France; Université de Strasbourg, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2017.07.003DOI Listing
September 2017

Importance of the Sequence-Directed DNA Shape for Specific Binding Site Recognition by the Estrogen-Related Receptor.

Front Endocrinol (Lausanne) 2017 20;8:140. Epub 2017 Jun 20.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, Institute of Genetics and of Molecular and Cellular Biology (IGBMC), Illkirch, France.

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http://dx.doi.org/10.3389/fendo.2017.00140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476932PMC
June 2017

Cryo-EM study of start codon selection during archaeal translation initiation.

Nat Commun 2016 11 7;7:13366. Epub 2016 Nov 7.

Laboratoire de Biochimie, Ecole polytechnique, CNRS, Université Paris-Saclay, 91128 Palaiseau cedex, France.

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http://dx.doi.org/10.1038/ncomms13366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103072PMC
November 2016

Structure-function insights reveal the human ribosome as a cancer target for antibiotics.

Nat Commun 2016 Sep 26;7:12856. Epub 2016 Sep 26.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch 67404, France.

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http://www.nature.com/doifinder/10.1038/ncomms12856
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http://dx.doi.org/10.1038/ncomms12856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052680PMC
September 2016

Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation.

Nat Commun 2016 08 24;7:12622. Epub 2016 Aug 24.

Architecture et Réactivité de l'ARN, Centre National de la Recherche Scientifique (CNRS) UPR9002, Institute of Molecular and Cellular Biology (IBMC), Université de Strasbourg, 15 rue René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1038/ncomms12622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999511PMC
August 2016

SharpViSu: integrated analysis and segmentation of super-resolution microscopy data.

Bioinformatics 2016 07 18;32(14):2239-41. Epub 2016 Mar 18.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Illkirch, France Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1093/bioinformatics/btw123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937188PMC
July 2016

ClusterViSu, a method for clustering of protein complexes by Voronoi tessellation in super-resolution microscopy.

Sci Rep 2016 Apr 12;6:24084. Epub 2016 Apr 12.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France.

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http://www.nature.com/articles/srep24084
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http://dx.doi.org/10.1038/srep24084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828638PMC
April 2016

IBiSS, a versatile and interactive tool for integrated sequence and 3D structure analysis of large macromolecular complexes.

Bioinformatics 2015 Oct 19;31(20):3339-44. Epub 2015 Jun 19.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Illkirch, France, Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France, Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France and Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1093/bioinformatics/btv347DOI Listing
October 2015

Structure and function insights into the NuRD chromatin remodeling complex.

Cell Mol Life Sci 2015 Jul 22;72(13):2491-507. Epub 2015 Mar 22.

Department of Integrated Structural Biology, Centre for Integrative Biology (CBI), Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France.

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http://dx.doi.org/10.1007/s00018-015-1880-8DOI Listing
July 2015

Structure-function relationships in nuclear receptors: the facts.

Trends Biochem Sci 2015 Jun 19;40(6):287-90. Epub 2015 Apr 19.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, Institute of Genetics and of Molecular and Cellular Biology (IGBMC), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France; Université de Strasbourg, Strasbourg, France.

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http://dx.doi.org/10.1016/j.tibs.2015.03.009DOI Listing
June 2015

X-ray and Cryo-electron Microscopy Structures of Monalysin Pore-forming Toxin Reveal Multimerization of the Pro-form.

J Biol Chem 2015 May 5;290(21):13191-201. Epub 2015 Apr 5.

From the CNRS, Architecture et Fonction des Macromolécules Biologiques (AFMB), Unité Mixte de Recherche (UMR) 7257, 13288 Marseille, France, the Aix-Marseille Université, Architecture et Fonction des Macromolécules Biologiques, UMR 7257, 13288 Marseille, France,

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http://dx.doi.org/10.1074/jbc.M115.646109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505573PMC
May 2015

Structure of the human 80S ribosome.

Nature 2015 Apr 22;520(7549):640-5. Epub 2015 Apr 22.

1] Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, 67404 Illkirch, France [2] Centre National de la Recherche Scientifique (CNRS), UMR 7104, 67404 Illkirch, France [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U964, 67404 Illkirch, France [4] Université de Strasbourg, 67081 Strasbourg, France.

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http://dx.doi.org/10.1038/nature14427DOI Listing
April 2015

Structural insight into the mechanism of stabilization of the 7SK small nuclear RNA by LARP7.

Nucleic Acids Res 2015 Mar 9;43(6):3373-88. Epub 2015 Mar 9.

Department of functional genomics, Institut de Biologie de l'Ecole Normale Supérieure (IBENS), 75005 Paris, France CNRS UMR 8197, 75005 Paris, France INSERM U1024, 75005 Paris, France

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http://dx.doi.org/10.1093/nar/gkv173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381077PMC
March 2015

Live cell immunogold labelling of RNA polymerase II.

Sci Rep 2015 Feb 9;5:8324. Epub 2015 Feb 9.

Department of Integrated Structural Biology, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) INSERM, U964; CNRS/Strasbourg University, UMR7104 1, rue Laurent Fries, BP10142 67404 Illkirch, France.

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http://dx.doi.org/10.1038/srep08324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321181PMC
February 2015

Conformation transitions of eukaryotic polyribosomes during multi-round translation.

Nucleic Acids Res 2015 Jan 17;43(1):618-28. Epub 2014 Dec 17.

Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

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http://dx.doi.org/10.1093/nar/gku1270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288168PMC
January 2015

Nuclear position dictates DNA repair pathway choice.

Genes Dev 2014 Nov 3;28(22):2450-63. Epub 2014 Nov 3.

Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), 67404 Illkirch CEDEX, France; U964, Institut National de la Santé et de la Recherche Médicale (INSERM), 67404 Illkirch CEDEX, France; UMR7104, Centre National de Recherche Scientifique (CNRS), 67404 Illkirch CEDEX, France; Université de Strasbourg (UDS), 67404 Illkirch CEDEX, France;

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http://dx.doi.org/10.1101/gad.248369.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233239PMC
November 2014

The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes.

Nat Commun 2014 Nov 7;5:5294. Epub 2014 Nov 7.

1] Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France [2] Centre National de la Recherche Scientifique (CNRS) UMR 7104, 67404 Illkirch, France [3] Institut National de la Santé et de la Recherche Médicale (INSERM), 67404 Illkirch, France [4] Université de Strasbourg, 67400 Strasbourg, France.

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http://dx.doi.org/10.1038/ncomms6294DOI Listing
November 2014

Cryo-electron microscopy structure of lactococcal siphophage 1358 virion.

J Virol 2014 Aug 28;88(16):8900-10. Epub 2014 May 28.

Centre National de la Recherche Scientifique, Architecture et Fonction des Macromolécules Biologiques, UMR 7257, Campus de Luminy, Case 932, Marseille, France Aix-Marseille University, Architecture et Fonction des Macromolécules Biologiques, UMR 7257, Campus de Luminy, Case 932, Marseille, France

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http://dx.doi.org/10.1128/JVI.01040-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136242PMC
August 2014

Formation of circular polyribosomes on eukaryotic mRNA without cap-structure and poly(A)-tail: a cryo electron tomography study.

Nucleic Acids Res 2014 Aug 12;42(14):9461-9. Epub 2014 Jul 12.

Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia

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http://dx.doi.org/10.1093/nar/gku599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132722PMC
August 2014

The palindromic DNA-bound USP/EcR nuclear receptor adopts an asymmetric organization with allosteric domain positioning.

Nat Commun 2014 Jun 19;5:4139. Epub 2014 Jun 19.

1] Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, 67404 Illkirch, France [2] Centre National de la Recherche Scientifique (CNRS) UMR 7104, 67404 Illkirch, France [3] Institut National de la Santé et de la Recherche Médicale (INSERM) U964, 67404 Illkirch, France [4] Université de Strasbourg, 67404 Strasbourg, France.

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http://www.nature.com/articles/ncomms5139
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http://dx.doi.org/10.1038/ncomms5139DOI Listing
June 2014

Purification, characterization and crystallization of the human 80S ribosome.

Nucleic Acids Res 2014 Apr 21;42(6):e49. Epub 2014 Jan 21.

Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale (INSERM) U964/Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1093/nar/gkt1404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973290PMC
April 2014

Escherichia coli ribosomal protein S1 unfolds structured mRNAs onto the ribosome for active translation initiation.

PLoS Biol 2013 Dec 10;11(12):e1001731. Epub 2013 Dec 10.

Architecture et Réactivité de l'ARN, Université de Strasbourg, Institut de Biologie Moléculaire et Cellulaire-CNRS, Strasbourg, France.

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http://dx.doi.org/10.1371/journal.pbio.1001731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858243PMC
December 2013

On effective and optical resolutions of diffraction data sets.

Acta Crystallogr D Biol Crystallogr 2013 Oct 20;69(Pt 10):1921-34. Epub 2013 Sep 20.

Architecture et Réactivité de l'ARN, UPR 9002 CNRS, IBMC (Institute of Molecular and Cellular Biology), 15 Rue René Descartes, 67084 Strasbourg, France; Université Louis Pasteur de Strasbourg, 67000 Strasbourg, France.

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http://dx.doi.org/10.1107/S0907444913016673DOI Listing
October 2013

Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.

Proc Natl Acad Sci U S A 2013 Sep 12;110(39):15656-61. Epub 2013 Sep 12.

Centre for Integrative Biology, Department of Integrated Structural Biology, Institute of Genetics and of Molecular and Cellular Biology, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 7104, Institut National de la Santé de la Recherche Médicale U964, Université de Strasbourg, 67404 Illkirch, France.

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http://dx.doi.org/10.1073/pnas.1309578110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785770PMC
September 2013

Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases.

Proc Natl Acad Sci U S A 2013 Sep 12;110(39):15662-7. Epub 2013 Sep 12.

Departments of Chemistry and Molecular Biochemistry and Biophysics, Yale University, New Haven, CT 06520.

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http://dx.doi.org/10.1073/pnas.1309360110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785736PMC
September 2013

Structure of the protein core of translation initiation factor 2 in apo, GTP-bound and GDP-bound forms.

Acta Crystallogr D Biol Crystallogr 2013 Jun 23;69(Pt 6):925-33. Epub 2013 Apr 23.

Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Centre National de la Recherche Scientifique (CNRS) UMR 7104/Institut National de la Santé de la Recherche Médicale (INSERM) U964/Université de Strasbourg, 1 Rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1107/S0907444913006422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663118PMC
June 2013

Phosphatase-dead myotubularin ameliorates X-linked centronuclear myopathy phenotypes in mice.

PLoS Genet 2012 11;8(10):e1002965. Epub 2012 Oct 11.

Department of Translational Medecine, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR7104, Université de Strasbourg, Collège de France, Illkirch, France.

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http://dx.doi.org/10.1371/journal.pgen.1002965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469422PMC
March 2013

Single particle and molecular assembly analysis of polyribosomes by single- and double-tilt cryo electron tomography.

Ultramicroscopy 2013 Mar 20;126:33-9. Epub 2012 Dec 20.

IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Integrative Structural Biology, Centre National de la Recherche Scientifique (CNRS) UMR 7104/ Institut National de la Santé de la Recherche Médicale (INSERM) U964/ Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France.

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http://dx.doi.org/10.1016/j.ultramic.2012.12.009DOI Listing
March 2013

Rapid purification of ribosomal particles assembled on histone H4 mRNA: a new method based on mRNA-DNA chimaeras.

Biochem J 2013 Feb;449(3):719-28

Institut de Biologie Moléculaire et Cellulaire, 'Architecture et Réactivité de l'ARN' CNRS UPR9002, Université de Strasbourg, 15, rue René Descartes, 67084 Strasbourg, France.

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http://dx.doi.org/10.1042/BJ20121211DOI Listing
February 2013

Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA.

EMBO J 2012 Jan 16;31(2):291-300. Epub 2011 Dec 16.

Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France.

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http://dx.doi.org/10.1038/emboj.2011.445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261568PMC
January 2012

Molecular recognition and catalysis in translation termination complexes.

Authors:
Bruno P Klaholz

Trends Biochem Sci 2011 May 17;36(5):282-92. Epub 2011 Mar 17.

IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, France.

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http://dx.doi.org/10.1016/j.tibs.2011.02.001DOI Listing
May 2011

Let's see how tmRNA rescues a stuck ribosome.

Authors:
Bruno P Klaholz

EMBO J 2010 Nov 17;29(22):3747-9. Epub 2010 Nov 17.

Department of Structural Biology and Genomics, Centre National de la Recherche Scientifique, Institute of Genetics and of Molecular and Cellular Biology, Université de Strasbourg, Illkirch, France.

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http://dx.doi.org/10.1038/emboj.2010.269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989111PMC
November 2010

Structure-function insights into prokaryotic and eukaryotic translation initiation.

Curr Opin Struct Biol 2009 Jun 1;19(3):300-9. Epub 2009 Jun 1.

IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch F-67404, France.

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http://linkinghub.elsevier.com/retrieve/pii/S0959440X0900070
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http://dx.doi.org/10.1016/j.sbi.2009.04.010DOI Listing
June 2009

Structure of the 30S translation initiation complex.

Nature 2008 Sep 31;455(7211):416-20. Epub 2008 Aug 31.

Institute of Genetics and of Molecular and Cellular Biology, Department of Structural Biology and Genomics, Illkirch F-67404, France.

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http://dx.doi.org/10.1038/nature07192DOI Listing
September 2008

Structured mRNAs regulate translation initiation by binding to the platform of the ribosome.

Cell 2007 Sep;130(6):1019-31

IGBMC (Institute of Genetics and of Molecular and Cellular Biology), Department of Structural Biology and Genomics, Illkirch, F-67404 France.

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http://dx.doi.org/10.1016/j.cell.2007.07.008DOI Listing
September 2007

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.

Nat Struct Mol Biol 2005 Dec 13;12(12):1145-9. Epub 2005 Nov 13.

Department of Structural Biology and Genomics, Institute of Genetics and Molecular and Cellular Biology, Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale, Université Louis Pasteur, Illkirch, France.

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http://www.nature.com/articles/nsmb1012
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http://dx.doi.org/10.1038/nsmb1012DOI Listing
December 2005

Determination of Escherichia coli RNA polymerase structure by single particle cryoelectron microscopy.

Methods Enzymol 2003 ;370:24-42

Department of Biological Sciences, Wolfson Laboratories, Imperial College of London, Rm. 313, London SW7 2AY, United Kingdom.

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http://dx.doi.org/10.1016/s0076-6879(03)70003-2DOI Listing
February 2004

Visualization of release factor 3 on the ribosome during termination of protein synthesis.

Nature 2004 Feb;427(6977):862-5

Department of Biological Sciences, Imperial College London, London SW7 2AY, UK.

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http://www.nature.com/articles/nature02332
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http://dx.doi.org/10.1038/nature02332DOI Listing
February 2004

Structure of the Escherichia coli ribosomal termination complex with release factor 2.

Nature 2003 Jan;421(6918):90-4

Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London SW7 2AY, UK.

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http://dx.doi.org/10.1038/nature01225DOI Listing
January 2003

C-H...O hydrogen bonds in the nuclear receptor RARgamma--a potential tool for drug selectivity.

Structure 2002 Sep;10(9):1197-204

Laboratoire de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 rue Laurent Fries, BP 163, F-67404 Illkirch Cédex, France.

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http://dx.doi.org/10.1016/s0969-2126(02)00828-6DOI Listing
September 2002