Publications Authored by Bruno Clément

Urinary TIMP-2 and MMP-2 are significantly associated with poor bladder compliance in adult patients with spina bifida.

Authors:

Benoit Peyronnet Claire Richard Claude Bendavid Florian Naudet Juliette Hascoet Charlène Brochard Nelly Senal Magali Jezequel Quentin Alimi Zine-Eddine Khene Anne Corlu Bruno Clément Laurent Siproudhis Guillaume Bouguen Jacques Kerdraon Andrea Manunta Xavier Gamé

Neurourol Urodyn 2019 Nov 4;38(8):2151-2158. Epub 2019 Sep 4.

Département d'Urologie, Transplantation Rénale et Andrologie, CHU Rangueil, Toulouse, France.

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http://dx.doi.org/10.1002/nau.24163	DOI Listing

November 2019

DNAshell Protects DNA Stored at Room Temperature for Downstream Next-Generation Sequencing Studies.

Authors:

Kevin Washetine Simon Heeke Camille Ribeyre Camille Bourreau Corinne Normand Hélène Blons Pierre Laurent-Puig Claire Mulot Dominique Clermont Maha David Bruno Clément Georges Dagher Paul Hofman

Biopreserv Biobank 2019 Aug 26;17(4):352-354. Epub 2019 Mar 26.

1Laboratoire de Pathologie Clinique et Experimentale, Biobanque BB-0033-00025, FHU OncoAge, Université Côte d'Azur, Nice, France.

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http://dx.doi.org/10.1089/bio.2018.0129	DOI Listing

August 2019

Raman spectroscopic screening of high and low molecular weight fractions of human serum.

Authors:

Drishya Rajan Parachalil Clément Bruno Franck Bonnier Hélène Blasco Igor Chourpa Jennifer McIntyre Hugh J Byrne

Analyst 2019 Jul 12;144(14):4295-4311. Epub 2019 Jun 12.

FOCAS Research Institute, Technological University Dublin, Kevin Street, Dublin 8, Ireland.

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http://dx.doi.org/10.1039/c9an00599d	DOI Listing

July 2019

Analysis of bodily fluids using vibrational spectroscopy: a direct comparison of Raman scattering and infrared absorption techniques for the case of glucose in blood serum.

Authors:

Drishya Rajan Parachalil Clément Bruno Franck Bonnier Hélène Blasco Igor Chourpa Matthew J Baker Jennifer McIntyre Hugh J Byrne

Analyst 2019 May;144(10):3334-3346

FOCAS Research Institute, Technological University Dublin, Kevin Street, Dublin 8, Ireland.

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http://dx.doi.org/10.1039/c9an00125e	DOI Listing

May 2019

The bidirectional crosstalk between metastatic uveal melanoma cells and hepatic stellate cells engenders an inflammatory microenvironment.

Authors:

Narjes Babchia Solange Landreville Bruno Clément Cédric Coulouarn Frédéric Mouriaux

Exp Eye Res 2019 Apr 13;181:213-222. Epub 2019 Feb 13.

Inserm, Université de Rennes 1, UMR 1241, Nutrition, Métabolismes et Cancer (NuMeCan), Rennes, France; Département d'ophtalmologie, Faculté de Médecine, Université Laval, Québec, Canada; Centre Universitaire d'ophtalmologie-Recherche and Axe Médecine Régénératrice, Centre de Recherche du CHU de Québec-Université Laval, Québec, Canada; Centre de Recherche en Organogénèse Expérimentale de l'Université Laval/LOEX, Québec, Canada; Service d'ophtalmologie, CHU de Rennes, Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.exer.2019.02.012	DOI Listing

April 2019

[Tumor banks and complex data management: Current and future challenges].

Authors:

Paul Hofman Georges Dagher Pierre Laurent-Puig Charles-Hugo Marquette Fabrice Barlesi Frédéric Bibeau Bruno Clément

Ann Pathol 2019 Apr 25;39(2):137-143. Epub 2019 Feb 25.

Inserm, Inra, nutrition métabolismes et cancer, CRB-Santé, université de Rennes, rue Henri-Le-Guilloux, 35033 Rennes, France.

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http://dx.doi.org/10.1016/j.annpat.2019.01.017	DOI Listing

April 2019

Determination of thresholds values for platelet serotonin and urinary 5-HIAA concentrations for the biological diagnosis of digestive neuroendocrine tumors.

Authors:

Maël Padelli Clément Bruno Julia Lemarchand Patrick Vourc'h Christian Andres Hélène Blasco Isabelle Benz-de Bretagne

Ann Biol Clin (Paris) 2019 Apr;77(2):161-168

Laboratoire de biochimie et biologie moléculaire, CHRU de Tours, France, UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

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http://dx.doi.org/10.1684/abc.2019.1432	DOI Listing

April 2019

Post hoc analysis of plasma amino acid profiles: towards a specific pattern in autism spectrum disorder and intellectual disability.

Authors:

Jean-Baptiste Delaye Franck Patin Emmanuelle Lagrue Olivier Le Tilly Clement Bruno Marie-Laure Vuillaume Martine Raynaud Isabelle Benz-De Bretagne Frederic Laumonnier Patrick Vourc'h Christian Andres Helene Blasco

Ann Clin Biochem 2018 Sep 22;55(5):543-552. Epub 2018 Feb 22.

1 CHRU de Tours, Laboratoire de Biochimie et Biologie Moléculaire, Tours, France.

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http://dx.doi.org/10.1177/0004563218760351	DOI Listing

September 2018

Integrating Biobank Data into a Clinical Data Research Network: The IBCB Project.

Authors:

Guillaume Bouzille Vianney Jouhet Bruno Turlin Bruno Clement Mireille Desille Christine Riou Moufid Hajjar Denis Delamarre Danielle Le Quilleuc Frantz Thiessard Marc Cuggia

Stud Health Technol Inform 2018 ;247:16-20

Inserm, Univ Rennes, CHU Rennes, Inra, Laboratoire Traitement du Signal et de l'Image (LTSI-U1099), CIC-1414, Centre de Données Cliniques, Nutrition Metabolisms and Cancer (NuMeCan), The liver biobanks network, CRB-Santé, Biosit, Biogenouest, Rennes, France.

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June 2018

Ensuring the Safety and Security of Frozen Lung Cancer Tissue Collections through the Encapsulation of Dried DNA.

Cancers (Basel) 2018 Jun 11;10(6). Epub 2018 Jun 11.

Hospital-Integrated Biobank (BB-0033-00025), Université Côte d'Azur, CHU de Nice, 06001 Nice CEDEX 1, France.

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http://dx.doi.org/10.3390/cancers10060195	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025404	PMC

June 2018

Establishing a Dedicated Lung Cancer Biobank at the University Center Hospital of Nice (France). Why and How?

Cancers (Basel) 2018 Jun 29;10(7). Epub 2018 Jun 29.

Hospital-Integrated Biobank (BB-0033-00025), Université Côte d'Azur, CHU de Nice, 06001 Nice CEDEX 1, France.

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http://www.mdpi.com/2072-6694/10/7/220	Publisher Site
http://dx.doi.org/10.3390/cancers10070220	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070810	PMC

June 2018

A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma.

Authors:

Aude Merdrignac Gaëlle Angenard Coralie Allain Kilian Petitjean Damien Bergeat Pascale Bellaud Allain Fautrel Bruno Turlin Bruno Clément Steven Dooley Laurent Sulpice Karim Boudjema Cédric Coulouarn

Hepatol Commun 2018 03 30;2(3):254-269. Epub 2018 Jan 30.

Institut National de la Santé et de la Recherche Médicale, INRA, Université de Rennes, CHU Rennes, UMR 1241, Nutrition Metabolisms and Cancer, Service de Chirurgie Hépatobiliaire et Digestive, Biosit, Biogenouest, Core Facility H2P2 and CRB Santé Rennes France.

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http://dx.doi.org/10.1002/hep4.1142	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831019	PMC

March 2018

Human hepatocellular carcinomas with a periportal phenotype have the lowest potential for early recurrence after curative resection.

Authors:

Romain Désert Florian Rohart Frédéric Canal Marie Sicard Mireille Desille Stéphanie Renaud Bruno Turlin Pascale Bellaud Christine Perret Bruno Clément Kim-Anh Lê Cao Orlando Musso

Hepatology 2017 11 26;66(5):1502-1518. Epub 2017 Sep 26.

INSERM, INRA, Univ Rennes, CHU Rennes, Nutrition Metabolisms and Cancer (NuMeCan), CRB-Santé, Biosit, Biogenouest, UBL, Rennes, France.

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http://doi.wiley.com/10.1002/hep.29254	Publisher Site
http://dx.doi.org/10.1002/hep.29254	DOI Listing

November 2017

Local Anesthetics Inhibit the Growth of Human Hepatocellular Carcinoma Cells.

Authors:

Grégoire Le Gac Gaëlle Angenard Bruno Clément Bruno Laviolle Cédric Coulouarn Hélène Beloeil

Anesth Analg 2017 11;125(5):1600-1609

From the *INSERM, UMR 991, and Université de Rennes 1, Rennes, France; †CHU Rennes, Pôle Anesthésie et Réanimation, Inserm CIC 1414, Rennes, France; and ‡CHU Rennes, Clinical Pharmacology Department and Inserm CIC 1414, Université de Rennes 1, Rennes, France.

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http://dx.doi.org/10.1213/ANE.0000000000002429	DOI Listing

November 2017

Omics to Explore Amyotrophic Lateral Sclerosis Evolution: the Central Role of Arginine and Proline Metabolism.

Authors:

Franck Patin Philippe Corcia Patrick Vourc'h Lydie Nadal-Desbarats Thomas Baranek Jean-François Goossens Sylviane Marouillat Anne-Frédérique Dessein Amandine Descat Blandine Madji Hounoum Clément Bruno Samuel Leman Christian R Andres Hélène Blasco

Mol Neurobiol 2017 09 2;54(7):5361-5374. Epub 2016 Sep 2.

Imagerie et Cerveau, UMR U930, INSERM, Université François Rabelais, Tours, France.

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http://dx.doi.org/10.1007/s12035-016-0078-x	DOI Listing

September 2017

Quality Matters: 2016 Annual Conference of the National Infrastructures for Biobanking.

Biopreserv Biobank 2017 Jun 19;15(3):270-276. Epub 2016 Dec 19.

1 BIOBANQUES Infrastructure, Inserm US13, Hôpital de la Pitié Salpêtrière , Paris, France .

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http://dx.doi.org/10.1089/bio.2016.0053	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5586151	PMC

June 2017

An UPLC-MSMS method to measure plasma homocysteine concentration.

Authors:

Caroline Vayne Luc Deroche Nicolas Drillaud Franck Patin Clément Bruno François Maillot François Labarthe Philippe Corcia Isabelle Benz-de Bretagne Christian R Andres Patrick Emond Hélène Blasco

Ann Biol Clin (Paris) 2017 Jun;75(3):334-338

Laboratoire de biochimie et biologie moléculaire, CHRU Tours, France, Inserm U930, Université François Rabelais, Tours, France.

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http://dx.doi.org/10.1684/abc.2017.1248	DOI Listing

June 2017

"Fibrous nests" in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome.

Authors:

Romain Désert Sihem Mebarki Mireille Desille Marie Sicard Elise Lavergne Stéphanie Renaud Damien Bergeat Laurent Sulpice Christine Perret Bruno Turlin Bruno Clément Orlando Musso

Int J Biochem Cell Biol 2016 12 18;81(Pt A):195-207. Epub 2016 Aug 18.

Inserm, UMR991, Liver Metabolisms and Cancer, Rennes, France; Université de Rennes 1, F-35043 Rennes, France. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2016.08.017	DOI Listing

December 2016

Integrative Genomic Analysis Identifies the Core Transcriptional Hallmarks of Human Hepatocellular Carcinoma.

Authors:

Coralie Allain Gaëlle Angenard Bruno Clément Cédric Coulouarn

Cancer Res 2016 11 12;76(21):6374-6381. Epub 2016 Sep 12.

INSERM, UMR 991, Liver Metabolisms and Cancer, University of Rennes, Rennes, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1559	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660733	PMC

November 2016

Low specificity of urinary 3-methoxytyramine in screening of dopamine-secreting pheochromocytomas and paragangliomas.

Authors:

Franck Patin Lise Crinière Thomas Francia Sandra Kassem Peggy Pierre Clément Bruno Caroline Vayne Patrick Vourc'h Isabelle Benz-de Bretagne Christian R Andres Hélène Blasco

Clin Biochem 2016 Oct 18;49(15):1205-1208. Epub 2016 May 18.

Laboratoire de Biochimie et de Biologie Moléculaire, Hôpital Bretonneau, CHRU de Tours, 2, Bd Tonnellé, 37044 Tours Cedex 1, France; Unité INSERM U930, équipe "neurogénétique et neurométabolomique", Université François Rabelais, 10 BD Tonnellé, BP 3223, 37032 Tours Cedex 1, France.

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http://dx.doi.org/10.1016/j.clinbiochem.2016.05.008	DOI Listing

October 2016

Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism.

Authors:

Franck Patin Thomas Baranek Patrick Vourc'h Lydie Nadal-Desbarats Jean-François Goossens Sylviane Marouillat Anne-Frédérique Dessein Amandine Descat Blandine Madji Hounoum Clément Bruno Hervé Watier Mustafa Si-Tahar Samuel Leman Jean-Claude Lecron Christian R Andres Philippe Corcia Hélène Blasco

Neurotherapeutics 2016 10;13(4):905-917

INSERM, UMR U930 "Imagerie et Cerveau", Université François Rabelais, Tours, France.

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http://dx.doi.org/10.1007/s13311-016-0461-3	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081117	PMC

October 2016

De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas.

Authors:

Sihem Mebarki Romain Désert Laurent Sulpice Marie Sicard Mireille Desille Frédéric Canal Hélène Dubois-Pot Schneider Damien Bergeat Bruno Turlin Pascale Bellaud Elise Lavergne Rémy Le Guével Anne Corlu Christine Perret Cédric Coulouarn Bruno Clément Orlando Musso

Oncotarget 2016 Jun;7(26):39026-39043

Inserm, UMR991, Liver Metabolisms and Cancer, Rennes, France.

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http://www.oncotarget.com/fulltext/9346	Publisher Site
http://dx.doi.org/10.18632/oncotarget.9346	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129911	PMC

June 2016

Selective internal radiation therapy compared with sorafenib for hepatocellular carcinoma with portal vein thrombosis.

Authors:

Julien Edeline Laurence Crouzet Boris Campillo-Gimenez Yan Rolland Marc Pracht Anne Guillygomarc'h Karim Boudjema Laurence Lenoir Xavier Adhoute Tanguy Rohou Eveline Boucher Bruno Clément Jean-Frédéric Blanc Etienne Garin

Eur J Nucl Med Mol Imaging 2016 Apr 12;43(4):635-43. Epub 2015 Oct 12.

Inserm UMR991, Rennes, France.

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http://dx.doi.org/10.1007/s00259-015-3210-7	DOI Listing

April 2016

Gene expression profiling of the tumor microenvironment in human intrahepatic cholangiocarcinoma.

Authors:

Laurent Sulpice Mireille Desille Bruno Turlin Alain Fautrel Karim Boudjema Bruno Clément Cédric Coulouarn

Genom Data 2016 Mar 15;7:229-32. Epub 2016 Jan 15.

Inserm, UMR991, Liver Metabolisms and Cancer, F-35033 Rennes, France; Université de Rennes 1, F-35043 Rennes, France.

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http://dx.doi.org/10.1016/j.gdata.2016.01.012	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778675	PMC

March 2016

Gemcitabine and Oxaliplatin, but Not Sorafenib or Paclitaxel, Have a Synergistic Effect with Yttrium-90 in Reducing Hepatocellular Carcinoma and Cholangiocarcinoma Cell Line Viability.

Authors:

Julien Edeline Cédric Coulouarn Laurence Crouzet Marc Pracht Nicolas Lepareur Bruno Clément Etienne Garin

J Vasc Interv Radiol 2015 Dec;26(12):1874-78.e2

Department of Nuclear Medicine, Centre Eugène Marquis, Av de la bataille Flandres Dunkerque, Rennes 35043, France; Inserm UMR991, Rennes, France.

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http://dx.doi.org/10.1016/j.jvir.2015.06.032	DOI Listing

December 2015

Personalized dosimetry with intensification using 90Y-loaded glass microsphere radioembolization induces prolonged overall survival in hepatocellular carcinoma patients with portal vein thrombosis.

Authors:

Etienne Garin Yan Rolland Julien Edeline Nicolas Icard Laurence Lenoir Sophie Laffont Habiba Mesbah Mathias Breton Laurent Sulpice Karim Boudjema Tanguy Rohou Jean-Luc Raoul Bruno Clement Eveline Boucher

J Nucl Med 2015 Mar 12;56(3):339-46. Epub 2015 Feb 12.

Department of Nuclear Medicine, Cancer Institute Eugène Marquis, Rennes, France U-991, Liver Metabolism and Cancer, INSERM, Rennes, France Department of Medical Imaging, Cancer Institute Eugène Marquis, Rennes, France.

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http://jnm.snmjournals.org/content/early/2015/02/11/jnumed.1	Web Search
http://jnm.snmjournals.org/content/56/3/339.full.pdf	Web Search
http://jnm.snmjournals.org/cgi/doi/10.2967/jnumed.114.145177	Publisher Site
http://dx.doi.org/10.2967/jnumed.114.145177	DOI Listing

March 2015

Epithelial cell adhesion molecule is a prognosis marker for intrahepatic cholangiocarcinoma.

Authors:

Laurent Sulpice Michel Rayar Bruno Turlin Eveline Boucher Pascale Bellaud Mireille Desille Bernard Meunier Bruno Clément Karim Boudjema Cédric Coulouarn

J Surg Res 2014 Nov 10;192(1):117-23. Epub 2014 May 10.

Liver Metabolisms and Cancer, INSERM UMR991, Rennes, France; Université de Rennes 1, Rennes, France.

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http://dx.doi.org/10.1016/j.jss.2014.05.017	DOI Listing

November 2014

High prognostic value of 18F-FDG PET for metastatic gastroenteropancreatic neuroendocrine tumors: a long-term evaluation.

Authors:

Haïfa Bahri Lenoir Laurence Julien Edeline Houda Leghzali Anne Devillers Jean-Luc Raoul Marc Cuggia Habiba Mesbah Bruno Clement Eveline Boucher Etienne Garin

J Nucl Med 2014 Nov 6;55(11):1786-90. Epub 2014 Oct 6.

Department of Nuclear Medicine, Cancer Institute Eugène Marquis, Rennes, France Inserm, UMR991, Liver Metabolisms and Cancer, Rennes, France University of Rennes 1, Rennes, France

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http://dx.doi.org/10.2967/jnumed.114.144386	DOI Listing

November 2014

Public biobanks: calculation and recovery of costs.

Authors:

Bruno Clément Martin Yuille Kurt Zaltoukal Heinz-Erich Wichmann Gabriele Anton Barbara Parodi Lukasz Kozera Christian Bréchot Paul Hofman Georges Dagher

Sci Transl Med 2014 Nov;6(261):261fs45

INSERM, National Biobank Infrastructure, Paris, France.

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https://www.ucdmc.ucdavis.edu/biorepositories/pdfs/sustainab	Web Search
http://dx.doi.org/10.1126/scitranslmed.3010444	DOI Listing

November 2014

Stellate cells and the development of liver cancer: therapeutic potential of targeting the stroma.

Authors:

Cédric Coulouarn Bruno Clément

J Hepatol 2014 Jun 12;60(6):1306-9. Epub 2014 Feb 12.

Inserm, UMR991, Liver Metabolisms and Cancer, F-35033 Rennes, France; Université de Rennes 1, F-35043 Rennes, France.

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http://dx.doi.org/10.1016/j.jhep.2014.02.003	DOI Listing

June 2014

Public-private relationships in biobanking: a still underestimated key component of open innovation.

Authors:

Paul Hofman Christian Bréchot Kurt Zatloukal Georges Dagher Bruno Clément

Virchows Arch 2014 Jan 14;464(1):3-9. Epub 2013 Dec 14.

Hospital-Integrated Tumor Biobank, Pasteur Hospital, Nice, France,

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http://dx.doi.org/10.1007/s00428-013-1524-z	DOI Listing

January 2014

Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma.

Authors:

Laurent Sulpice Michel Rayar Mireille Desille Bruno Turlin Alain Fautrel Eveline Boucher Francisco Llamas-Gutierrez Bernard Meunier Karim Boudjema Bruno Clément Cédric Coulouarn

Hepatology 2013 Dec 17;58(6):1992-2000. Epub 2013 Oct 17.

Inserm, UMR991, Liver Metabolisms and Cancer, Rennes, France; Université de Rennes 1, Rennes, France; CHU Rennes, Service de Chirurgie Hépatobiliaire et Digestive, Rennes, France.

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http://dx.doi.org/10.1002/hep.26577	DOI Listing

December 2013

In vitro demonstration of synergy/additivity between (188)rhenium and sorafenib on hepatoma lines: preliminary results.

Authors:

Marc Pracht Julien Edeline Nicolas Lepareur Laurence Lenoir Valerie Ardisson Bruno Clement Jean-Luc Raoul Odile Audrain Evelyne Boucher Etienne Garin

Anticancer Res 2013 Sep;33(9):3871-7

Medical Information, Centre Eugène Marquis, CS 44229 - 35042 Rennes Cedex, France.

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September 2013

Volumetric changes after (90)y radioembolization for hepatocellular carcinoma in cirrhosis: an option to portal vein embolization in a preoperative setting?

Authors:

Julien Edeline Laurence Lenoir Karim Boudjema Yan Rolland Anne Boulic Fanny Le Du Marc Pracht Jean-Luc Raoul Bruno Clément Etienne Garin Eveline Boucher

Ann Surg Oncol 2013 Aug 15;20(8):2518-25. Epub 2013 Mar 15.

Medical Oncology Department, Comprehensive Cancer Institute Eugène Marquis, Rennes, France.

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http://link.springer.com/10.1245/s10434-013-2906-9	Publisher Site
http://dx.doi.org/10.1245/s10434-013-2906-9	DOI Listing

August 2013

Measuring the contribution of tumor biobanks to research in oncology: surrogate indicators and bibliographic output.

Authors:

Véronique Hofman Marius Ilie Elodie Long Kevin Washetine Christian Chabannon Dominique Figarella-Branger Bruno Clément Laurence Mabile Anne Cambon-Thomsen Pascal Boucher Georges Dagher Robert Hewitt Barbara Parodi Paul Hofman

Biopreserv Biobank 2013 Aug;11(4):235-44

1 Hospital-Integrated Biobank, Pasteur Hospital, University of Nice Sophia Antipolis , Nice, France .

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http://dx.doi.org/10.1089/bio.2013.0015	DOI Listing

August 2013

Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways.

Authors:

Cédric Coulouarn Catherine Cavard Laura Rubbia-Brandt Anne Audebourg Florent Dumont Sébastien Jacques Pierre-Alexandre Just Bruno Clément Hélène Gilgenkrantz Christine Perret Benoît Terris

Carcinogenesis 2012 Sep 13;33(9):1791-6. Epub 2012 Jun 13.

INSERM, UMR991, Université de Rennes 1, Liver Metabolisms and Cancer Rennes, France.

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http://dx.doi.org/10.1093/carcin/bgs208	DOI Listing

September 2012

Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.

Authors:

Ismaïl Hendaoui Elise Lavergne Heun-Sik Lee Seong Hyun Hong Hak-Zoo Kim Christelle Parent Nathalie Heuzé-Vourc'h Bruno Clément Orlando Musso

PLoS One 2012 27;7(1):e30601. Epub 2012 Jan 27.

Institut National de la Santé et de la Recherche Médicale, Unit 991, Liver Metabolisms and Cancer, Rennes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030601	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3267734	PMC

June 2012

Usefulness and pitfalls of MAA SPECT/CT in identifying digestive extrahepatic uptake when planning liver radioembolization.

Authors:

Laurence Lenoir Julien Edeline Yann Rolland Marc Pracht Jean-Luc Raoul Valérie Ardisson Patrick Bourguet Bruno Clément Eveline Boucher Etienne Garin

Eur J Nucl Med Mol Imaging 2012 May 12;39(5):872-80. Epub 2012 Jan 12.

Department of Nuclear Medicine, Comprehensive Cancer Institute Eugène Marquis, CS 44229, 35042 Rennes, France.

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http://dx.doi.org/10.1007/s00259-011-2033-4	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326232	PMC

May 2012

Hepatocyte-stellate cell cross-talk in the liver engenders a permissive inflammatory microenvironment that drives progression in hepatocellular carcinoma.

Authors:

Cédric Coulouarn Anne Corlu Denise Glaise Isabelle Guénon Snorri S Thorgeirsson Bruno Clément

Cancer Res 2012 May 14;72(10):2533-42. Epub 2012 Mar 14.

INSERM, UMR991, Liver Metabolisms and Cancer, Rennes, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3317	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498759	PMC

May 2012

Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.

Authors:

Cécile Guichard Giuliana Amaddeo Sandrine Imbeaud Yannick Ladeiro Laura Pelletier Ichrafe Ben Maad Julien Calderaro Paulette Bioulac-Sage Mélanie Letexier Françoise Degos Bruno Clément Charles Balabaud Eric Chevet Alexis Laurent Gabrielle Couchy Eric Letouzé Fabien Calvo Jessica Zucman-Rossi

Nat Genet 2012 May 6;44(6):694-8. Epub 2012 May 6.

Institut National de la Santé et de la Recherche Médicale (INSERM), Unité Mixte de Recherche (UMR)-674, Génomique Fonctionnelle des Tumeurs Solides, Paris, France.

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http://dx.doi.org/10.1038/ng.2256	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819251	PMC

May 2012

Dosimetry based on 99mTc-macroaggregated albumin SPECT/CT accurately predicts tumor response and survival in hepatocellular carcinoma patients treated with 90Y-loaded glass microspheres: preliminary results.

Authors:

Etienne Garin Laurence Lenoir Yan Rolland Julien Edeline Habiba Mesbah Sophie Laffont Philippe Porée Bruno Clément Jean-Luc Raoul E Boucher

J Nucl Med 2012 Feb;53(2):255-63

Department of Nuclear Medicine, Comprehensive Cancer Institute Eugène Marquis, CS 44229, F-35042 Rennes, France.

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http://dx.doi.org/10.2967/jnumed.111.094235	DOI Listing

February 2012

[Control of hepatocellular carcinoma progression by the tumor microenvironment].

Authors:

Bruno Clement

Bull Acad Natl Med 2012 Jan;196(1):75-84

INSERM, UMR 991, Foie, Métabolismes et Cancer, CHU Pontchaillou, Université de Rennes I, 35033 Rennes.

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January 2012

Effectiveness of quantitative MAA SPECT/CT for the definition of vascularized hepatic volume and dosimetric approach: phantom validation and clinical preliminary results in patients with complex hepatic vascularization treated with yttrium-90-labeled microspheres.

Authors:

Etienne Garin Laurence Lenoir Yan Rolland Sophie Laffont Marc Pracht Habiba Mesbah Philippe Porée Valérie Ardisson Patrick Bourguet Bruno Clement Eveline Boucher

Nucl Med Commun 2011 Dec;32(12):1245-55

Department of Nuclear Medicine, Comprehensive Cancer Institute Eugène Marquis, Rennes, France.

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http://dx.doi.org/10.1097/MNM.0b013e32834a716b	DOI Listing

December 2011

Utility of Quantitative Tc-MAA SPECT/CT for yttrium-Labelled Microsphere Treatment Planning: Calculating Vascularized Hepatic Volume and Dosimetric Approach.

Authors:

Etienne Garin Yan Rolland Laurence Lenoir Marc Pracht Habiba Mesbah Philippe Porée Sophie Laffont Bruno Clement Jean-Luc Raoul Eveline Boucher

Int J Mol Imaging 2011 28;2011:398051. Epub 2011 Jul 28.

Department of Nuclear Medicine, Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, France.

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https://www.hindawi.com/archive/2011/398051/	Publisher Site
http://dx.doi.org/10.1155/2011/398051	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3147134	PMC

November 2011

Automation of labelling of Lipiodol with high-activity generator-produced 188Re.

Authors:

Nicolas Lepareur Valérie Ardisson Nicolas Noiret Eveline Boucher Jean-Luc Raoul Bruno Clément Etienne Garin

Appl Radiat Isot 2011 Feb 12;69(2):426-30. Epub 2010 Nov 12.

Service de Médecine Nucléaire, Centre Régional de Lutte Contre le Cancer Eugène Marquis, CS 44229, 35042 Rennes, France.

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http://linkinghub.elsevier.com/retrieve/pii/S096980431000429	Publisher Site
http://dx.doi.org/10.1016/j.apradiso.2010.11.001	DOI Listing

February 2011

Increased Lipiodol uptake in hepatocellular carcinoma possibly due to increased membrane fluidity by dexamethasone and tamoxifen.

Authors:

Stéphanie Becker Valérie Ardisson Nicolas Lepareur Odile Sergent Sahar Bayat Nicolas Noiret François Gaboriau Bruno Clément Evelyne Boucher Jean-Luc Raoul Etienne Garin

Nucl Med Biol 2010 Oct;37(7):777-84

Department of Nuclear Medicine, Centre E. Marquis, F-35042 Rennes, France.

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http://linkinghub.elsevier.com/retrieve/pii/S096980511000099	Publisher Site
http://dx.doi.org/10.1016/j.nucmedbio.2010.03.013	DOI Listing

October 2010

International network of cancer genome projects.

Authors:

Thomas J Hudson Warwick Anderson Axel Artez Anna D Barker Cindy Bell Rosa R Bernabé M K Bhan Fabien Calvo Iiro Eerola Daniela S Gerhard Alan Guttmacher Mark Guyer Fiona M Hemsley Jennifer L Jennings David Kerr Peter Klatt Patrik Kolar Jun Kusada David P Lane Frank Laplace Lu Youyong Gerd Nettekoven Brad Ozenberger Jane Peterson T S Rao Jacques Remacle Alan J Schafer Tatsuhiro Shibata Michael R Stratton Joseph G Vockley Koichi Watanabe Huanming Yang Matthew M F Yuen Bartha M Knoppers Martin Bobrow Anne Cambon-Thomsen Lynn G Dressler Stephanie O M Dyke Yann Joly Kazuto Kato Karen L Kennedy Pilar Nicolás Michael J Parker Emmanuelle Rial-Sebbag Carlos M Romeo-Casabona Kenna M Shaw Susan Wallace Georgia L Wiesner Nikolajs Zeps Peter Lichter Andrew V Biankin Christian Chabannon Lynda Chin Bruno Clément Enrique de Alava Françoise Degos Martin L Ferguson Peter Geary D Neil Hayes Thomas J Hudson Amber L Johns Arek Kasprzyk Hidewaki Nakagawa Robert Penny Miguel A Piris Rajiv Sarin Aldo Scarpa Tatsuhiro Shibata Marc van de Vijver P Andrew Futreal Hiroyuki Aburatani Mónica Bayés David D L Botwell Peter J Campbell Xavier Estivill Daniela S Gerhard Sean M Grimmond Ivo Gut Martin Hirst Carlos López-Otín Partha Majumder Marco Marra John D McPherson Hidewaki Nakagawa Zemin Ning Xose S Puente Yijun Ruan Tatsuhiro Shibata Michael R Stratton Hendrik G Stunnenberg Harold Swerdlow Victor E Velculescu Richard K Wilson Hong H Xue Liu Yang Paul T Spellman Gary D Bader Paul C Boutros Peter J Campbell Paul Flicek Gad Getz Roderic Guigó Guangwu Guo David Haussler Simon Heath Tim J Hubbard Tao Jiang Steven M Jones Qibin Li Nuria López-Bigas Ruibang Luo Lakshmi Muthuswamy B F Francis Ouellette John V Pearson Xose S Puente Victor Quesada Benjamin J Raphael Chris Sander Tatsuhiro Shibata Terence P Speed Lincoln D Stein Joshua M Stuart Jon W Teague Yasushi Totoki Tatsuhiko Tsunoda Alfonso Valencia David A Wheeler Honglong Wu Shancen Zhao Guangyu Zhou Lincoln D Stein Roderic Guigó Tim J Hubbard Yann Joly Steven M Jones Arek Kasprzyk Mark Lathrop Nuria López-Bigas B F Francis Ouellette Paul T Spellman Jon W Teague Gilles Thomas Alfonso Valencia Teruhiko Yoshida Karen L Kennedy Myles Axton Stephanie O M Dyke P Andrew Futreal Daniela S Gerhard Chris Gunter Mark Guyer Thomas J Hudson John D McPherson Linda J Miller Brad Ozenberger Kenna M Shaw Arek Kasprzyk Lincoln D Stein Junjun Zhang Syed A Haider Jianxin Wang Christina K Yung Anthony Cros Anthony Cross Yong Liang Saravanamuttu Gnaneshan Jonathan Guberman Jack Hsu Martin Bobrow Don R C Chalmers Karl W Hasel Yann Joly Terry S H Kaan Karen L Kennedy Bartha M Knoppers William W Lowrance Tohru Masui Pilar Nicolás Emmanuelle Rial-Sebbag Laura Lyman Rodriguez Catherine Vergely Teruhiko Yoshida Sean M Grimmond Andrew V Biankin David D L Bowtell Nicole Cloonan Anna deFazio James R Eshleman Dariush Etemadmoghadam Brooke B Gardiner Brooke A Gardiner James G Kench Aldo Scarpa Robert L Sutherland Margaret A Tempero Nicola J Waddell Peter J Wilson John D McPherson Steve Gallinger Ming-Sound Tsao Patricia A Shaw Gloria M Petersen Debabrata Mukhopadhyay Lynda Chin Ronald A DePinho Sarah Thayer Lakshmi Muthuswamy Kamran Shazand Timothy Beck Michelle Sam Lee Timms Vanessa Ballin Youyong Lu Jiafu Ji Xiuqing Zhang Feng Chen Xueda Hu Guangyu Zhou Qi Yang Geng Tian Lianhai Zhang Xiaofang Xing Xianghong Li Zhenggang Zhu Yingyan Yu Jun Yu Huanming Yang Mark Lathrop Jörg Tost Paul Brennan Ivana Holcatova David Zaridze Alvis Brazma Lars Egevard Egor Prokhortchouk Rosamonde Elizabeth Banks Mathias Uhlén Anne Cambon-Thomsen Juris Viksna Fredrik Ponten Konstantin Skryabin Michael R Stratton P Andrew Futreal Ewan Birney Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Sancha Martin Jorge S Reis-Filho Andrea L Richardson Christos Sotiriou Hendrik G Stunnenberg Giles Thoms Marc van de Vijver Laura van't Veer Fabien Calvo Daniel Birnbaum Hélène Blanche Pascal Boucher Sandrine Boyault Christian Chabannon Ivo Gut Jocelyne D Masson-Jacquemier Mark Lathrop Iris Pauporté Xavier Pivot Anne Vincent-Salomon Eric Tabone Charles Theillet Gilles Thomas Jörg Tost Isabelle Treilleux Fabien Calvo Paulette Bioulac-Sage Bruno Clément Thomas Decaens Françoise Degos Dominique Franco Ivo Gut Marta Gut Simon Heath Mark Lathrop Didier Samuel Gilles Thomas Jessica Zucman-Rossi Peter Lichter Roland Eils Benedikt Brors Jan O Korbel Andrey Korshunov Pablo Landgraf Hans Lehrach Stefan Pfister Bernhard Radlwimmer Guido Reifenberger Michael D Taylor Christof von Kalle Partha P Majumder Rajiv Sarin T S Rao M K Bhan Aldo Scarpa Paolo Pederzoli Rita A Lawlor Massimo Delledonne Alberto Bardelli Andrew V Biankin Sean M Grimmond Thomas Gress David Klimstra Giuseppe Zamboni Tatsuhiro Shibata Yusuke Nakamura Hidewaki Nakagawa Jun Kusada Tatsuhiko Tsunoda Satoru Miyano Hiroyuki Aburatani Kazuto Kato Akihiro Fujimoto Teruhiko Yoshida Elias Campo Carlos López-Otín Xavier Estivill Roderic Guigó Silvia de Sanjosé Miguel A Piris Emili Montserrat Marcos González-Díaz Xose S Puente Pedro Jares Alfonso Valencia Heinz Himmelbauer Heinz Himmelbaue Victor Quesada Silvia Bea Michael R Stratton P Andrew Futreal Peter J Campbell Anne Vincent-Salomon Andrea L Richardson Jorge S Reis-Filho Marc van de Vijver Gilles Thomas Jocelyne D Masson-Jacquemier Samuel Aparicio Ake Borg Anne-Lise Børresen-Dale Carlos Caldas John A Foekens Hendrik G Stunnenberg Laura van't Veer Douglas F Easton Paul T Spellman Sancha Martin Anna D Barker Lynda Chin Francis S Collins Carolyn C Compton Martin L Ferguson Daniela S Gerhard Gad Getz Chris Gunter Alan Guttmacher Mark Guyer D Neil Hayes Eric S Lander Brad Ozenberger Robert Penny Jane Peterson Chris Sander Kenna M Shaw Terence P Speed Paul T Spellman Joseph G Vockley David A Wheeler Richard K Wilson Thomas J Hudson Lynda Chin Bartha M Knoppers Eric S Lander Peter Lichter Lincoln D Stein Michael R Stratton Warwick Anderson Anna D Barker Cindy Bell Martin Bobrow Wylie Burke Francis S Collins Carolyn C Compton Ronald A DePinho Douglas F Easton P Andrew Futreal Daniela S Gerhard Anthony R Green Mark Guyer Stanley R Hamilton Tim J Hubbard Olli P Kallioniemi Karen L Kennedy Timothy J Ley Edison T Liu Youyong Lu Partha Majumder Marco Marra Brad Ozenberger Jane Peterson Alan J Schafer Paul T Spellman Hendrik G Stunnenberg Brandon J Wainwright Richard K Wilson Huanming Yang

Nature 2010 Apr;464(7291):993-8

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http://dx.doi.org/10.1038/nature08987	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902243	PMC

April 2010

A national collection of liver tumours: lessons learnt from 6 years of biobanking in France.

Authors:

Bruno Clément Geneviève Chêne Françoise Degos

Cancer Lett 2009 Dec 23;286(1):140-4. Epub 2009 May 23.

INSERM, U620, Université de Rennes I, 35043 Rennes, France.

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http://search.proquest.com/openview/260c6c632b6d8b2fab17866e	Web Search
http://linkinghub.elsevier.com/retrieve/pii/S030438350900301	Publisher Site
http://dx.doi.org/10.1016/j.canlet.2009.04.034	DOI Listing

December 2009

A cryptic frizzled module in cell surface collagen 18 inhibits Wnt/beta-catenin signaling.

Authors:

Delphine Quélard Elise Lavergne Ismaïl Hendaoui Harri Elamaa Ulla Tiirola Ritva Heljasvaara Taina Pihlajaniemi Bruno Clément Orlando Musso

PLoS One 2008 Apr 2;3(4):e1878. Epub 2008 Apr 2.

INSERM, U620, University of Rennes-1, Rennes, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001878	PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2270346	PMC

April 2008

Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma.

Authors:

Justin Monnier Claire Piquet-Pellorce Jean-Jacques Feige Orlando Musso Bruno Clement Bruno Turlin Nathalie Theret Michel Samson

World J Gastroenterol 2008 Feb;14(8):1182-91

INSERM U620 Universite de Rennes 1, 2 avenue du Prof. Leon Bernard, Rennes cedex 35043, France.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2690665	PMC
http://dx.doi.org/10.3748/wjg.14.1182	DOI Listing

February 2008

The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor.

Authors:

Azeddine Atfi Emmanuelle Dumont Frédéric Colland Dominique Bonnier Annie L'helgoualc'h Céline Prunier Nathalie Ferrand Bruno Clément Ulla M Wewer Nathalie Théret

J Cell Biol 2007 Jul 9;178(2):201-8. Epub 2007 Jul 9.

Institut National de la Santé et de la Recherche Medicale, Unite 673, Hôpital St-Antoine, Paris, France.

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http://dx.doi.org/10.1083/jcb.200612046	DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2064440	PMC

July 2007

Upregulation of the tumor suppressor gene menin in hepatocellular carcinomas and its significance in fibrogenesis.

Authors:

Pierre J Zindy Annie L'Helgoualc'h Dominique Bonnier Antony Le Béchec Katia Bourd-Boitin Chang Xian Zhang Orlando Musso Denise Glaise Marie Bérangère Troadec Olivier Loréal Bruno Turlin Jean Léger Bruno Clément Nathalie Théret

Hepatology 2006 Nov;44(5):1296-307

INSERM, U620, Rennes, France.

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http://dx.doi.org/10.1002/hep.21367	DOI Listing

November 2006

Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives.

Authors:

Ruurdtje Hoekstra Tanja Deurholt Lysbeth ten Bloemendaal Mireille Desille Albert C W A van Wijk Bruno Clement Ronald P J Oude Elferink Thomas M van Gulik Robert A F M Chamuleaut

Cell Transplant 2006 ;15(5):423-33

Surgical Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.

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October 2006

Assessment of in Vitro Applicability of Reversibly Immortalized NKNT-3 Cells and Clonal Derivatives.

Authors:

Ruurdtje Hoekstra Tanja Deurholt Lysbeth Ten Bloemendaal Mireille Desille Albert C W A van Wijk Bruno Clement Ronald P J Oude Elferink Thomas M van Gulik Robert A F M Chamuleau

Cell Transplant 2006 May;15(5):423-433

AMC Liver Center, Academic Medical Center, University of Amsterdam, The Netherlands.

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http://dx.doi.org/10.3727/000000006783981873	DOI Listing

May 2006

Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells.

Authors:

Hélène Le Pabic Annie L'Helgoualc'h Alexandre Coutant Ulla M Wewer Georges Baffet Bruno Clément Nathalie Théret

J Hepatol 2005 Dec 29;43(6):1038-44. Epub 2005 Jun 29.

INSERM U620, Détoxication et Réparation Tissulaire, Facultés de Médecine et Pharmacie, Université de Rennes I, IFR no. 140, 2 Av. Léon Bernard, 35043 Rennes Cedex, France.

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http://dx.doi.org/10.1016/j.jhep.2005.05.025	DOI Listing

December 2005

The human biological resource centres network. A key infrastructure for biomedical research in Europe.

Authors:

Bruno Clément Jean-Alexis Grimaud Jean-François Deleuze Eric Postaire

Therapie 2005 Jul-Aug;60(4):351-4, 355-7

INSERM-Transfert, Paris, France.

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http://dx.doi.org/10.2515/therapie:2005049	DOI Listing

December 2005

Upregulation of DNA repair genes in active cirrhosis associated with hepatocellular carcinoma.

Authors:

Pierre Zindy Lise Andrieux Dominique Bonnier Orlando Musso Sophie Langouët Jean Pierre Campion Bruno Turlin Bruno Clément Nathalie Théret

FEBS Lett 2005 Jan;579(1):95-9

INSERM U620, Détoxication et Réparation Tissulaire, Facultés de Médecine et Pharmacie, Université de Rennes I, 2 Av. Léon Bernard, 35043 Rennes Cedex, France.

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