Publications by authors named "Bruno Casciaro"

35Publications

Antipseudomonal and Immunomodulatory Properties of Esc Peptides: Promising Features for Treatment of Chronic Infectious Diseases and Inflammation.

Int J Mol Sci 2021 Jan 8;22(2). Epub 2021 Jan 8.

Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P. le Aldo Moro 5, 00185 Rome, Italy.

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January 2021

The Antimicrobial Peptide Temporin G: Anti-Biofilm, Anti-Persister Activities, and Potentiator Effect of Tobramycin Efficacy Against .

Int J Mol Sci 2020 Dec 10;21(24). Epub 2020 Dec 10.

Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

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December 2020

Development of Antimicrobial Peptides from Amphibians.

Antibiotics (Basel) 2020 Nov 4;9(11). Epub 2020 Nov 4.

Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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November 2020

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections.

Molecules 2020 Aug 9;25(16). Epub 2020 Aug 9.

Department of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

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August 2020

Frog Skin-Derived Peptides Against Correlation between Antibacterial and Cytotoxic Activities.

Antibiotics (Basel) 2020 Jul 26;9(8). Epub 2020 Jul 26.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy.

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July 2020

The Revaluation of Plant-Derived Terpenes to Fight Antibiotic-Resistant Infections.

Antibiotics (Basel) 2020 Jun 13;9(6). Epub 2020 Jun 13.

Center For Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy.

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June 2020

Structural Elucidation and Antimicrobial Characterization of Novel Diterpenoids from var. .

ACS Med Chem Lett 2020 May 30;11(5):760-765. Epub 2020 Jan 30.

Department of Biochemical Sciences, Laboratory Affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, P.le Aldo Moro 5 00185, Rome, Italy.

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May 2020

Nanotechnologies to Improve the Pharmacological Profile of Therapeutic Peptides.

Curr Protein Pept Sci 2020 ;21(4):332-333

Department of Biochemical Sciences "A. Rossi Fanelli" Sapienza University of Rome Piazzale Aldo Moro, 5 00185 Roma, Italy.

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January 2021

Antimicrobial Peptides and their Multiple Effects at Sub-Inhibitory Concentrations.

Curr Top Med Chem 2020 ;20(14):1264-1273

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy.

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January 2020

Bronchial epithelium repair by Esculentin-1a-derived antimicrobial peptides: involvement of metalloproteinase-9 and interleukin-8, and evaluation of peptides' immunogenicity.

Sci Rep 2019 12 12;9(1):18988. Epub 2019 Dec 12.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

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December 2019

Inorganic Gold and Polymeric Poly(Lactide-co-glycolide) Nanoparticles as Novel Strategies to Ameliorate the Biological Properties of Antimicrobial Peptides.

Curr Protein Pept Sci 2020 ;21(4):429-438

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

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January 2021

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of -Induced Infections.

Toxins (Basel) 2019 09 1;11(9). Epub 2019 Sep 1.

Department of Chemistry and Technology of Drugs, "Department of Excellence 2018-2022", Sapienza University of Rome, P.le Aldo Moro 5, Rome 00185, Italy.

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September 2019

The Potential of Frog Skin Peptides for Anti-Infective Therapies: The Case of Esculentin-1a(1-21)NH2.

Curr Med Chem 2020 ;27(9):1405-1419

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.

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May 2020

Inhibition of Pseudomonas aeruginosa biofilm formation and expression of virulence genes by selective epimerization in the peptide Esculentin-1a(1-21)NH.

FEBS J 2019 10 13;286(19):3874-3891. Epub 2019 Jun 13.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Italy.

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October 2019

Poly(lactide- co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies.

Biomacromolecules 2019 05 23;20(5):1876-1888. Epub 2019 Apr 23.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences "A. Rossi Fanelli" , Sapienza University of Rome , via degli Apuli, 9 , 00185 Rome , Italy.

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May 2019

Thyroid hormones, metabolic syndrome and Vitamin D in middle-aged and older euthyroid subjects: a preliminary study.

Aging Clin Exp Res 2019 Sep 7;31(9):1337-1341. Epub 2018 Nov 7.

Division of Gerontology, Department of Cardiovascular, Respiratory, Nephrological, Anesthesiological and Geriatric Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.

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September 2019

Esculentin-1a Derived Antipseudomonal Peptides: Limited Induction of Resistance and Synergy with Aztreonam.

Protein Pept Lett 2018 ;25(12):1155-1162

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, via degli Apuli, 9, 00185, Rome, Italy.

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February 2019

A Novel In Vitro Wound Healing Assay to Evaluate Cell Migration.

J Vis Exp 2018 03 17(133). Epub 2018 Mar 17.

Department of Biochemical Sciences, Sapienza University of Rome;

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March 2018

Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti-diabetic agents.

J Pept Sci 2018 02 19;24(2). Epub 2018 Jan 19.

SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, UK.

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February 2018

Esculentin-1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface.

Biopolymers 2017 Oct 31. Epub 2017 Oct 31.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy.

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October 2017

Membrane perturbing activities and structural properties of the frog-skin derived peptide Esculentin-1a(1-21)NH and its Diastereomer Esc(1-21)-1c: Correlation with their antipseudomonal and cytotoxic activity.

Biochim Biophys Acta Biomembr 2017 Dec 12;1859(12):2327-2339. Epub 2017 Sep 12.

Laboratory affiliated to Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, via degli Apuli, 9, 00185, Italy. Electronic address:

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December 2017

Promising Approaches to Optimize the Biological Properties of the Antimicrobial Peptide Esculentin-1a(1-21)NH: Amino Acids Substitution and Conjugation to Nanoparticles.

Front Chem 2017 25;5:26. Epub 2017 Apr 25.

Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of RomeRome, Italy.

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April 2017

Methods for In Vitro Analysis of Antimicrobial Activity and Toxicity of Anti-keratitis Peptides: Bacterial Viability in Tears, MTT, and TNF-α Release Assays.

Methods Mol Biol 2017 ;1548:395-409

Department of Biochemical Sciences, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy.

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February 2018

Effects of Aib residues insertion on the structural-functional properties of the frog skin-derived peptide esculentin-1a(1-21)NH.

Amino Acids 2017 01 11;49(1):139-150. Epub 2016 Oct 11.

Department of Biochemical Sciences, Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Via degli Apuli, 9, 00185, Rome, Italy.

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January 2017

Gold-nanoparticles coated with the antimicrobial peptide esculentin-1a(1-21)NH as a reliable strategy for antipseudomonal drugs.

Acta Biomater 2017 01 29;47:170-181. Epub 2016 Sep 29.

Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Rome, Italy. Electronic address:

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January 2017

Overcoming barriers in Pseudomonas aeruginosa lung infections: Engineered nanoparticles for local delivery of a cationic antimicrobial peptide.

Colloids Surf B Biointerfaces 2015 Nov 22;135:717-725. Epub 2015 Aug 22.

Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy. Electronic address:

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November 2015

D-Amino acids incorporation in the frog skin-derived peptide esculentin-1a(1-21)NH2 is beneficial for its multiple functions.

Amino Acids 2015 Dec 11;47(12):2505-19. Epub 2015 Jul 11.

Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Biochemical Sciences, Sapienza University of Rome, Via degli Apuli 9, 00185, Rome, Italy.

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December 2015

Naturally Occurring Peptides from Rana temporaria: Antimicrobial Properties and More.

Curr Top Med Chem 2016 ;16(1):54-64

Department of Biochemical Sciences, Sapienza University of Rome, Via degli Apuli, 9-00185 Rome, Italy.

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June 2016

Synergistic fungicidal activity of the lipopeptide bacillomycin D with amphotericin B against pathogenic Candida species.

FEMS Yeast Res 2015 Jun 7;15(4):fov022. Epub 2015 May 7.

Pasteur Institute-Cenci Bolognetti Foundation, Department of Biochemical Sciences, Sapienza University of Rome, Italy.

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June 2015