Bruce T Lahn

Bruce T Lahn

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Bruce T Lahn

Publications by authors named "Bruce T Lahn"

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Transcriptional Fingerprint of Hypomyelination in Zfp191null and Shiverer (Mbpshi) Mice.

ASN Neuro 2016 Oct 28;8(5). Epub 2016 Sep 28.

Department of Neurology, The University of Chicago Center for Peripheral Neuropathy, The University of Chicago, IL, USA

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http://dx.doi.org/10.1177/1759091416670749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046175PMC
October 2016

TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.

Cell Res 2016 09 9;26(9):1048-61. Epub 2016 Aug 9.

Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children's Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510623, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034111PMC
http://dx.doi.org/10.1038/cr.2016.93DOI Listing
September 2016

Nestin(+) kidney resident mesenchymal stem cells for the treatment of acute kidney ischemia injury.

Biomaterials 2015 May 14;50:56-66. Epub 2015 Feb 14.

Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, Guangzhou, China; Department of Biochemistry, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, China. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.01.029DOI Listing
May 2015

Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.

Cell Res 2014 Dec 21;24(12):1466-85. Epub 2014 Nov 21.

1] Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510630, China [2] Key Laboratory for Stem Cells and Tissue Engineering, Center for Stem Cell Biology and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong 510080, China [3] Department of Anatomy, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China [4] Reproductive Medicine Center and Guangdong provincial Key Laborartory of Reproductive Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China [5] Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.

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http://dx.doi.org/10.1038/cr.2014.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260348PMC
December 2014

Involvement of extracellular factors in maintaining self-renewal of neural stem cell by nestin.

Neuroreport 2014 Jul;25(10):782-7

aCenter for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangdong, China bThe Sixth Affiliated Hospital, Sun Yat-sen University, Guangdong, China cDepartment of Neuroscience, Ohio State University Medical Center, Columbus, Ohio, USA.

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http://dx.doi.org/10.1097/WNR.0000000000000177DOI Listing
July 2014

Evidence for a critical role of gene occlusion in cell fate restriction.

Cell Res 2012 May 29;22(5):848-58. Epub 2011 Nov 29.

Department of Human Genetics, University of Chicago, Howard Hughes Medical Institute, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1038/cr.2011.190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297702PMC
May 2012

PPARγ suppression inhibits adipogenesis but does not promote osteogenesis of human mesenchymal stem cells.

Int J Biochem Cell Biol 2012 Feb 23;44(2):377-84. Epub 2011 Nov 23.

Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-Sen University, 74# Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China.

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http://dx.doi.org/10.1016/j.biocel.2011.11.013DOI Listing
February 2012

Efficient genetic modification of cynomolgus monkey embryonic stem cells with lentiviral vectors.

Cell Transplant 2010 4;19(9):1181-93. Epub 2010 May 4.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Guangzhou, Guangdong, PR China.

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http://dx.doi.org/10.3727/096368910X504469DOI Listing
May 2011

The "occlusis" model of cell fate restriction.

Authors:
Bruce T Lahn

Bioessays 2011 Jan 15;33(1):13-20. Epub 2010 Oct 15.

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1002/bies.201000090DOI Listing
January 2011

Nestin is required for the proper self-renewal of neural stem cells.

Stem Cells 2010 Dec;28(12):2162-71

Department of Human Genetics, University of Chicago, Howard Hughes Medical Institute, Chicago, Illinois, USA.

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http://dx.doi.org/10.1002/stem.541DOI Listing
December 2010

A stem cell-based tool for small molecule screening in adipogenesis.

PLoS One 2010 Sep 27;5(9):e13014. Epub 2010 Sep 27.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou, Guangdong, People's Republic of China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013014PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946407PMC
September 2010

Multiple mesodermal lineage differentiation of Apodemus sylvaticus embryonic stem cells in vitro.

BMC Cell Biol 2010 Jun 19;11:42. Epub 2010 Jun 19.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, 74# Zhongshan Road 2, Guangzhou, 510080, China.

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http://dx.doi.org/10.1186/1471-2121-11-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900228PMC
June 2010

Expression of nestin in lymph node metastasis and lymphangiogenesis in non-small cell lung cancer patients.

Hum Pathol 2010 May 4;41(5):737-44. Epub 2010 Feb 4.

Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.

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http://linkinghub.elsevier.com/retrieve/pii/S004681770900397
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http://dx.doi.org/10.1016/j.humpath.2009.10.018DOI Listing
May 2010

Generation of functional hepatocytes from mouse induced pluripotent stem cells.

J Cell Physiol 2010 Mar;222(3):492-501

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangzhou 510080, P.R.China.

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http://dx.doi.org/10.1002/jcp.22000DOI Listing
March 2010

Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test.

Toxicol Mech Methods 2010 Mar;20(3):112-8

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, 74# Zhongshan Road 2, Guangzhou, Guangdong. PR China 510080.

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http://dx.doi.org/10.3109/15376510903585450DOI Listing
March 2010

Geometric cues for directing the differentiation of mesenchymal stem cells.

Proc Natl Acad Sci U S A 2010 Mar 1;107(11):4872-7. Epub 2010 Mar 1.

Department of Chemistry, and Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0903269107
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http://dx.doi.org/10.1073/pnas.0903269107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841932PMC
March 2010

Let's celebrate human genetic diversity.

Nature 2009 Oct;461(7265):726-8

Department of Human Genetics, University of Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/461726aDOI Listing
October 2009

Chromatin analysis of occluded genes.

Hum Mol Genet 2009 Jul 20;18(14):2567-74. Epub 2009 Apr 20.

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddp188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701328PMC
July 2009

The radial glia antibody RC2 recognizes a protein encoded by Nestin.

Biochem Biophys Res Commun 2009 May 18;382(3):588-92. Epub 2009 Mar 18.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, 929E, 57th, W503B, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.03.074DOI Listing
May 2009

Derivation, characterization and gene modification of cynomolgus monkey mesenchymal stem cells.

Differentiation 2009 Mar 2;77(3):256-62. Epub 2008 Dec 2.

Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-Sen University, Ministry of Education, Guangzhou 510080, China.

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http://linkinghub.elsevier.com/retrieve/pii/S030146810800024
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http://dx.doi.org/10.1016/j.diff.2008.09.021DOI Listing
March 2009

Genetic basis of human brain evolution.

Trends Neurosci 2008 Dec 8;31(12):637-44. Epub 2008 Oct 8.

Division of Neurochemistry, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.

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http://dx.doi.org/10.1016/j.tins.2008.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715140PMC
December 2008

Effects of thymic polypeptides on the thymopoiesis of mouse embryonic stem cells.

Cell Biol Int 2008 Oct 23;32(10):1265-71. Epub 2008 Jul 23.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, 74# Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China.

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http://dx.doi.org/10.1016/j.cellbi.2008.07.011DOI Listing
October 2008

Critical role of phosphoinositide 3-kinase cascade in adipogenesis of human mesenchymal stem cells.

Mol Cell Biochem 2008 Mar 2;310(1-2):11-8. Epub 2007 Dec 2.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, 74 Zhongshan Road 2, Guangzhou, Guangdong 510080, PR China.

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http://dx.doi.org/10.1007/s11010-007-9661-9DOI Listing
March 2008

Isolation, characterization and gene modification of fetal neural stem/progenitor cells from cynomolgus monkey.

Neuroreport 2008 Mar;19(4):419-24

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-Sen University, Guangdong, PR China.

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http://dx.doi.org/10.1097/WNR.0b013e3282f76136DOI Listing
March 2008

A genetic legacy from archaic Homo.

Trends Genet 2008 Jan 3;24(1):19-23. Epub 2007 Dec 3.

Department of Anthropology, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.tig.2007.10.003DOI Listing
January 2008

A genome-wide screen for noncoding elements important in primate evolution.

BMC Evol Biol 2008 Jan 23;8:17. Epub 2008 Jan 23.

Department of Human Genetics and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1186/1471-2148-8-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2242780PMC
January 2008

Proteomic identification of differently expressed proteins responsible for osteoblast differentiation from human mesenchymal stem cells.

Mol Cell Biochem 2007 Oct 26;304(1-2):167-79. Epub 2007 May 26.

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, No. 74, Zhongshan Road 2, Guangzhou 510080, China.

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http://dx.doi.org/10.1007/s11010-007-9497-3DOI Listing
October 2007

Uncovering the mutation-fixation correlation in short lineages.

BMC Evol Biol 2007 Sep 21;7:168. Epub 2007 Sep 21.

Howard Hughes Medical Institute, Department of Human Genetics, and Committee on Genetics, University of Chicago, USA.

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http://dx.doi.org/10.1186/1471-2148-7-168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2071921PMC
September 2007

Mathematical models for the proliferation of neural stem/progenitor cells in clonogenic culture.

Rejuvenation Res 2007 Jun;10(2):205-14

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Guangzhou 510080, China.

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http://dx.doi.org/10.1089/rej.2006.0532DOI Listing
June 2007

Evolutionary and biomedical insights from the rhesus macaque genome.

Authors:
Richard A Gibbs Jeffrey Rogers Michael G Katze Roger Bumgarner George M Weinstock Elaine R Mardis Karin A Remington Robert L Strausberg J Craig Venter Richard K Wilson Mark A Batzer Carlos D Bustamante Evan E Eichler Matthew W Hahn Ross C Hardison Kateryna D Makova Webb Miller Aleksandar Milosavljevic Robert E Palermo Adam Siepel James M Sikela Tony Attaway Stephanie Bell Kelly E Bernard Christian J Buhay Mimi N Chandrabose Marvin Dao Clay Davis Kimberly D Delehaunty Yan Ding Huyen H Dinh Shannon Dugan-Rocha Lucinda A Fulton Ramatu Ayiesha Gabisi Toni T Garner Jennifer Godfrey Alicia C Hawes Judith Hernandez Sandra Hines Michael Holder Jennifer Hume Shalini N Jhangiani Vandita Joshi Ziad Mohid Khan Ewen F Kirkness Andrew Cree R Gerald Fowler Sandra Lee Lora R Lewis Zhangwan Li Yih-Shin Liu Stephanie M Moore Donna Muzny Lynne V Nazareth Dinh Ngoc Ngo Geoffrey O Okwuonu Grace Pai David Parker Heidie A Paul Cynthia Pfannkoch Craig S Pohl Yu-Hui Rogers San Juana Ruiz Aniko Sabo Jireh Santibanez Brian W Schneider Scott M Smith Erica Sodergren Amanda F Svatek Teresa R Utterback Selina Vattathil Wesley Warren Courtney Sherell White Asif T Chinwalla Yucheng Feng Aaron L Halpern Ladeana W Hillier Xiaoqiu Huang Pat Minx Joanne O Nelson Kymberlie H Pepin Xiang Qin Granger G Sutton Eli Venter Brian P Walenz John W Wallis Kim C Worley Shiaw-Pyng Yang Steven M Jones Marco A Marra Mariano Rocchi Jacqueline E Schein Robert Baertsch Laura Clarke Miklós Csürös Jarret Glasscock R Alan Harris Paul Havlak Andrew R Jackson Huaiyang Jiang Yue Liu David N Messina Yufeng Shen Henry Xing-Zhi Song Todd Wylie Lan Zhang Ewan Birney Kyudong Han Miriam K Konkel Jungnam Lee Arian F A Smit Brygg Ullmer Hui Wang Jinchuan Xing Richard Burhans Ze Cheng John E Karro Jian Ma Brian Raney Xinwei She Michael J Cox Jeffery P Demuth Laura J Dumas Sang-Gook Han Janet Hopkins Anis Karimpour-Fard Young H Kim Jonathan R Pollack Tomas Vinar Charles Addo-Quaye Jeremiah Degenhardt Alexandra Denby Melissa J Hubisz Amit Indap Carolin Kosiol Bruce T Lahn Heather A Lawson Alison Marklein Rasmus Nielsen Eric J Vallender Andrew G Clark Betsy Ferguson Ryan D Hernandez Kashif Hirani Hildegard Kehrer-Sawatzki Jessica Kolb Shobha Patil Ling-Ling Pu Yanru Ren David Glenn Smith David A Wheeler Ian Schenck Edward V Ball Rui Chen David N Cooper Belinda Giardine Fan Hsu W James Kent Arthur Lesk David L Nelson William E O'brien Kay Prüfer Peter D Stenson James C Wallace Hui Ke Xiao-Ming Liu Peng Wang Andy Peng Xiang Fan Yang Galt P Barber David Haussler Donna Karolchik Andy D Kern Robert M Kuhn Kayla E Smith Ann S Zwieg

Science 2007 Apr;316(5822):222-34

Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/science.1139247DOI Listing
April 2007

Establishment and characterization of two new human embryonic stem cell lines, SYSU-1 and SYSU-2.

Chin Med J (Engl) 2007 Apr;120(7):589-94

Centre for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Guangzhou 510080, China.

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April 2007

Systematically assessing the influence of 3-dimensional structural context on the molecular evolution of mammalian proteomes.

Mol Biol Evol 2006 Nov 10;23(11):2131-3. Epub 2006 Aug 10.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, USA.

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http://dx.doi.org/10.1093/molbev/msl086DOI Listing
November 2006

SPEED: a molecular-evolution-based database of mammalian orthologous groups.

Bioinformatics 2006 Nov 11;22(22):2835-7. Epub 2006 Sep 11.

Department of Human Genetics and Committee on Genetics, Howard Hughes Medical Institute, University of Chicago 920 East 58th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl471DOI Listing
November 2006

The evolution of word composition in metazoan promoter sequence.

PLoS Comput Biol 2006 Nov 28;2(11):e150. Epub 2006 Sep 28.

Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.0020150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1630712PMC
November 2006

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.

Proc Natl Acad Sci U S A 2006 Nov 7;103(48):18178-83. Epub 2006 Nov 7.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.0606966103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1635020PMC
November 2006

Multiple independent origins of sex chromosomes in amniotes.

Proc Natl Acad Sci U S A 2006 Nov 20;103(48):18031-2. Epub 2006 Nov 20.

New England Primate Research Center, Division of Neurochemistry, Harvard Medical School, Southborough, MA 01772-9102, USA.

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http://dx.doi.org/10.1073/pnas.0608879103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838700PMC
November 2006

What makes us human: revisiting an age-old question in the genomic era.

J Biomed Discov Collab 2006 Nov 29;1:18. Epub 2006 Nov 29.

Howard Hughes Medical Institute, Department of Human Genetics and Committee on Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1186/1747-5333-1-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1716182PMC
November 2006

A primate-specific acceleration in the evolution of the caspase-dependent apoptosis pathway.

Hum Mol Genet 2006 Oct 15;15(20):3034-40. Epub 2006 Sep 15.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL, USA.

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http://dx.doi.org/10.1093/hmg/ddl245DOI Listing
October 2006

Improved DNA methylation analysis via enrichment of demethylated cells expressing an X-inactivated transgene.

Biotechniques 2006 Oct;41(4):461-6

University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.2144/000112246DOI Listing
October 2006

Localized methylation in the key regulator gene endothelin-1 is associated with cell type-specific transcriptional silencing.

FEBS Lett 2006 Aug 14;580(18):4560-6. Epub 2006 Jul 14.

Howard Hughes Medical Institute, Department of Human Genetics, and University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.febslet.2006.07.017DOI Listing
August 2006

Sonic Hedgehog, a key development gene, experienced intensified molecular evolution in primates.

Hum Mol Genet 2006 Jul 10;15(13):2031-7. Epub 2006 May 10.

Department of Human Genetics, Howard Hughes Medical Institute, USA.

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http://dx.doi.org/10.1093/hmg/ddl123DOI Listing
July 2006

Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ.

Gene 2006 Jun 14;375:75-9. Epub 2006 Mar 14.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gene.2006.02.019DOI Listing
June 2006

Different classes of tissue-specific genes show different levels of noncoding conservation.

Genomics 2006 Mar 21;87(3):433-6. Epub 2005 Nov 21.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.ygeno.2005.09.013DOI Listing
March 2006

Human polymorphism and human-chimpanzee divergence in pseudoautosomal region correlate with local recombination rate.

Gene 2006 Mar 13;368:94-100. Epub 2005 Dec 13.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, 920 East 58th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.gene.2005.10.020DOI Listing
March 2006

Slower cycling of nestin-positive cells in neurosphere culture.

Neuroreport 2006 Mar;17(4):377-81

Center for Stem Cell Biology and Tissue Engineering, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1097/01.wnr.0000204981.36995.dbDOI Listing
March 2006

Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice.

Nat Genet 2006 Feb 25;38(2):245-50. Epub 2005 Dec 25.

Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ng1715DOI Listing
February 2006

Robust signals of coevolution of interacting residues in mammalian proteomes identified by phylogeny-aided structural analysis.

Nat Genet 2005 Dec 13;37(12):1367-71. Epub 2005 Nov 13.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ng1685DOI Listing
December 2005

Selective constraint on noncoding regions of hominid genomes.

PLoS Comput Biol 2005 Dec 16;1(7):e73. Epub 2005 Dec 16.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1371/journal.pcbi.0010073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1314883PMC
December 2005

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.

Science 2005 Sep;309(5741):1717-20

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1113722DOI Listing
September 2005

Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens.

Science 2005 Sep;309(5741):1720-2

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1116815DOI Listing
September 2005

Hereditary hyperekplexia caused by novel mutations of GLRA1 in Turkish families.

Mol Diagn 2004 ;8(3):151-5

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.

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July 2005

A highly unexpected strong correlation between fixation probability of nonsynonymous mutations and mutation rate.

Trends Genet 2005 Jul;21(7):381-5

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.tig.2005.05.005DOI Listing
July 2005

Genetic links between brain development and brain evolution.

Nat Rev Genet 2005 Jul;6(7):581-90

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nrg1634DOI Listing
July 2005

The X chromosome: not just her brother's keeper.

Nat Genet 2005 Apr;37(4):343-5

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http://dx.doi.org/10.1038/ng0405-343DOI Listing
April 2005

Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity.

Nat Genet 2004 Dec 7;36(12):1326-9. Epub 2004 Nov 7.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/ng1471DOI Listing
December 2004

Accelerated evolution of nervous system genes in the origin of Homo sapiens.

Cell 2004 Dec;119(7):1027-40

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1016/j.cell.2004.11.040DOI Listing
December 2004

Positive selection on the human genome.

Hum Mol Genet 2004 Oct;13 Spec No 2:R245-54

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddh253DOI Listing
October 2004

Effects of chromosomal rearrangements on human-chimpanzee molecular evolution.

Genomics 2004 Oct;84(4):757-61

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1016/j.ygeno.2004.07.005DOI Listing
October 2004

Diverse fates of paralogs following segmental duplication of telomeric genes.

Genomics 2004 Aug;84(2):239-47

Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.ygeno.2004.03.001DOI Listing
August 2004

Reconstructing the evolutionary history of microcephalin, a gene controlling human brain size.

Hum Mol Genet 2004 Jun 31;13(11):1139-45. Epub 2004 Mar 31.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddh126DOI Listing
June 2004

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.

Hum Mol Genet 2004 Mar 13;13(5):489-94. Epub 2004 Jan 13.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddh055DOI Listing
March 2004

How mammalian sex chromosomes acquired their peculiar gene content.

Bioessays 2004 Feb;26(2):159-69

Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, IL 60637, USA.

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http://dx.doi.org/10.1002/bies.10393DOI Listing
February 2004

Genic mutation rates in mammals: local similarity, chromosomal heterogeneity, and X-versus-autosome disparity.

Mol Biol Evol 2003 Oct 28;20(10):1633-41. Epub 2003 Jul 28.

Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, USA.

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http://dx.doi.org/10.1093/molbev/msg178DOI Listing
October 2003

Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception.

Genome Res 2003 Oct;13(10):2252-9

Howard Hughes Medical Institute and Department of Human Genetics, University of Chicago, Chicago, Illinois 60637, USA.

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http://www.genome.org/cgi/doi/10.1101/gr.1431603
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http://dx.doi.org/10.1101/gr.1431603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC403691PMC
October 2003

The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence.

Hum Mol Genet 2003 Jul;12(14):1643-50

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1093/hmg/ddg185DOI Listing
July 2003

Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.

Proc Natl Acad Sci U S A 2002 Jun 18;99(13):8707-12. Epub 2002 Jun 18.

Howard Hughes Medical Institute, Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1073/pnas.082248899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC124363PMC
June 2002