Publications by authors named "Bruce R Blazar"

100Publications

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity 2020 Nov 24. Epub 2020 Nov 24.

Institute of Infection Immunology, TWINCORE, Center for Experimental and Clinical Infection Research, Hannover Medical School and the Helmholtz Center for Infection Research, Hannover 30625, Germany; Institute of Medical Microbiology and Hygiene, University Medical Center of the Johannes Gutenberg-University, Mainz 55131, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2020.11.001DOI Listing
November 2020

PD-1 Blockade Reverses Obesity-Mediated T Cell Priming Impairment.

Front Immunol 2020 29;11:590568. Epub 2020 Oct 29.

Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2020.590568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658608PMC
October 2020

A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells.

Leukemia 2020 Oct 23. Epub 2020 Oct 23.

Division of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1038/s41375-020-01065-5DOI Listing
October 2020

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD.

Nat Rev Clin Oncol 2020 08 20;17(8):475-492. Epub 2020 Apr 20.

Departments of Dermatology and Internal Medicine, UC Davis School of Medicine, Sacramento, CA, USA.

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http://dx.doi.org/10.1038/s41571-020-0356-4DOI Listing
August 2020

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease.

Front Immunol 2020 12;11:181. Epub 2020 Feb 12.

Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.

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http://dx.doi.org/10.3389/fimmu.2020.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028690PMC
February 2020

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.

Br J Haematol 2020 Jun 21;189(5):926-930. Epub 2020 Feb 21.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.1111/bjh.16458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536617PMC
June 2020

Author Correction: Human in vitro-induced regulatory T cells display Dlgh1 dependent and PKC-θ restrained suppressive activity.

Sci Rep 2020 Feb 19;10(1):3317. Epub 2020 Feb 19.

Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY, 10016, USA.

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http://dx.doi.org/10.1038/s41598-020-60485-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031276PMC
February 2020

Mesenchymal stromal cells shape the MDS microenvironment by inducing suppressive monocytes that dampen NK cell function.

JCI Insight 2020 03 12;5(5). Epub 2020 Mar 12.

Department of Medicine, Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1172/jci.insight.130155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141401PMC
March 2020

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration.

Cell Rep 2020 01;30(4):1052-1062.e5

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.12.083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009789PMC
January 2020

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol.

Cytotherapy 2019 12 3;21(12):1216-1233. Epub 2019 Dec 3.

School of Biomedical Engineering, University of British Columbia, Vancouver, BC, Canada; BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcyt.2019.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7474528PMC
December 2019

Distinct Regulatory and Effector T Cell Metabolic Demands during Graft-Versus-Host Disease.

Trends Immunol 2020 01 30;41(1):77-91. Epub 2019 Nov 30.

University of Minnesota Cancer Center, Minneapolis, MN 55455, USA; Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934920PMC
January 2020

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

Immunity 2019 11 18;51(5):885-898.e7. Epub 2019 Sep 18.

Bone Marrow Transplantation Laboratory, Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia; Department of Haematology and Bone Marrow Transplantation, Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD 4029, Australia; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington, Seattle, WA 98109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2019.08.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959419PMC
November 2019

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.

Nat Immunol 2019 10 2;20(10):1360-1371. Epub 2019 Sep 2.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41590-019-0472-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754271PMC
October 2019

Pediatric acute GVHD: clinical phenotype and response to upfront steroids.

Bone Marrow Transplant 2020 01 2;55(1):165-171. Epub 2019 Sep 2.

Blood and Marrow Transplant Program, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN, USA.

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http://www.nature.com/articles/s41409-019-0651-9
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http://dx.doi.org/10.1038/s41409-019-0651-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940525PMC
January 2020

Outcomes and Predictors of Response in Steroid-Refractory Acute Graft-versus-Host Disease.

Biol Blood Marrow Transplant 2019 11 17;25(11):2297-2302. Epub 2019 Jul 17.

Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1016/j.bbmt.2019.07.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861661PMC
November 2019

Validation of Minnesota acute graft--host disease Risk Score.

Haematologica 2020 31;105(2):519-524. Epub 2020 Jan 31.

Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN.

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http://dx.doi.org/10.3324/haematol.2019.220970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012472PMC
January 2020

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming.

J Clin Invest 2019 06 18;129(9):3770-3785. Epub 2019 Jun 18.

Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1172/JCI125916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715389PMC
June 2019

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets.

PLoS One 2019 6;14(6):e0217761. Epub 2019 Jun 6.

Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217761PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553739PMC
February 2020

Achievement of Tolerance Induction to Prevent Acute Graft-vs.-Host Disease.

Front Immunol 2019 6;10:309. Epub 2019 Mar 6.

Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00309
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http://dx.doi.org/10.3389/fimmu.2019.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419712PMC
September 2020

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination.

EMBO J 2019 05 18;38(9). Epub 2019 Mar 18.

Translational Medicine Research Center of Affiliated Jiangning Hospital, Liver Transplantation Center of First Affiliated Hospital, and Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, Jiangsu, China

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http://dx.doi.org/10.15252/embj.201899766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484404PMC
May 2019

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth.

Cancer Gene Ther 2020 04 1;27(3-4):235-245. Epub 2019 Mar 1.

Department of Immuno-Oncology, Beckman Research Institute of the City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41417-019-0089-7DOI Listing
April 2020

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program.

J Exp Med 2019 03 31;216(3):605-620. Epub 2019 Jan 31.

Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.1084/jem.20181134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400538PMC
March 2019

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways.

Cell Death Dis 2019 01 8;10(1):13. Epub 2019 Jan 8.

Hepatobiliary Center, First Affiliated Hospital, Jiangsu Key Laboratory of Xenotransplantation, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, 211166, Nanjing, Jiangsu, China.

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http://www.nature.com/articles/s41419-018-1273-7
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http://dx.doi.org/10.1038/s41419-018-1273-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325106PMC
January 2019

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans.

JCI Insight 2018 12 20;3(24). Epub 2018 Dec 20.

Department of Medicine, Translational Transplant Research Center, Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1172/jci.insight.124646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338317PMC
December 2018

Pretransplant Serum Citrulline Predicts Acute Graft-versus-Host Disease.

Biol Blood Marrow Transplant 2018 11 7;24(11):2190-2196. Epub 2018 Jul 7.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

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https://linkinghub.elsevier.com/retrieve/pii/S10838791183038
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http://dx.doi.org/10.1016/j.bbmt.2018.06.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251308PMC
November 2018

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

Cell 2018 12 1;175(7):1780-1795.e19. Epub 2018 Nov 1.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Center for Immunobiology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183130
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http://dx.doi.org/10.1016/j.cell.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361668PMC
December 2018

Thymic Epithelial Cell Support of Thymopoiesis Does Not Require .

J Immunol 2018 12 29;201(11):3320-3328. Epub 2018 Oct 29.

Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455;

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1800670
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http://dx.doi.org/10.4049/jimmunol.1800670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275142PMC
December 2018

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets.

J Immunol 2018 10 12;201(8):2215-2219. Epub 2018 Sep 12.

Department of Surgery and Center for Transplantation Sciences; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129;

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http://dx.doi.org/10.4049/jimmunol.1800311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179917PMC
October 2018

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD.

Bone Marrow Transplant 2019 03 31;54(3):490-493. Epub 2018 Aug 31.

Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

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http://www.nature.com/articles/s41409-018-0331-1
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http://dx.doi.org/10.1038/s41409-018-0331-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395530PMC
March 2019

How ibrutinib, a B-cell malignancy drug, became an FDA-approved second-line therapy for steroid-resistant chronic GVHD.

Blood Adv 2018 08;2(15):2012-2019

Division of Blood and Marrow Transplantation, Department of Pediatrics, The University of Minnesota, Minneapolis, MN.

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http://dx.doi.org/10.1182/bloodadvances.2018013060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093735PMC
August 2018