Publications


Identification of GPC2 as an Oncoprotein and Candidate Immunotherapeutic Target in High-Risk Neuroblastoma.
Cancer Cell 2017 Sep;32(3):295-309.e12
Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

Pediatric Cystic Nephroma Is Morphologically, Immunohistochemically, and Genetically Distinct From Adult Cystic Nephroma.
Am J Surg Pathol 2017 Apr;41(4):472-481
Departments of *Pathology †Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD ‡Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA §Department of Pathology, Children's National Medical Center, Washington, DC.

T cells targeting NY-ESO-1 demonstrate efficacy against disseminated neuroblastoma.
Oncoimmunology 2016;5(1):e1040216. Epub 2015 Aug 12.
Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression.
Clin Cancer Res 2016 Sep 24;22(17):4391-404. Epub 2016 Mar 24.
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.


Serine catabolism regulates mitochondrial redox control during hypoxia.
Cancer Discov 2014 Dec 3;4(12):1406-17. Epub 2014 Sep 3.
Cancer Biology and Genetics Program and Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.

Asparagine plays a critical role in regulating cellular adaptation to glutamine depletion.
Mol Cell 2014 Oct 18;56(2):205-18. Epub 2014 Sep 18.
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address:

Malignant rhabdoid tumor of the bladder and ganglioglioma in a 14 year-old male with a germline 22q11.2 deletion.
Cancer Genet 2014 Sep 21;207(9):415-9. Epub 2014 May 21.
Division of Oncology, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. Electronic address:


Mutations in the ABCC6 gene as a cause of generalized arterial calcification of infancy: genotypic overlap with pseudoxanthoma elasticum.
J Invest Dermatol 2014 Mar 5;134(3):658-665. Epub 2013 Sep 5.
Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Dual CDK4/CDK6 inhibition induces cell-cycle arrest and senescence in neuroblastoma.
Clin Cancer Res 2013 Nov 17;19(22):6173-82. Epub 2013 Sep 17.
Authors' Affiliations: Division of Oncology and Center for Childhood Cancer Research; Division of Pathology, Children's Hospital of Philadelphia; Department of Pediatrics; Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.

Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group.
J Clin Oncol 2012 Nov 22;30(33):4148-54. Epub 2012 Oct 22.
Division of Oncology, CTRB 10, The Children's Hospital of Philadelphia, University of Pennsylvania, 3501 Civic Center Blvd, Philadelphia, PA 19104, USA.


Investigation of the insulin-like growth factor-1 signaling pathway in localized Ewing sarcoma: a report from the Children's Oncology Group.
Cancer 2011 Nov 8;117(21):4966-76. Epub 2011 Apr 8.
Department of Pediatrics, Division of Pediatric Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 20057-1469, USA.


Serial transcriptome analysis and cross-species integration identifies centromere-associated protein E as a novel neuroblastoma target.
Cancer Res 2010 Apr 16;70(7):2749-58. Epub 2010 Mar 16.
Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Interferon-gamma-dependent infiltration of human T cells into neuroblastoma tumors in vivo.
Clin Cancer Res 2009 Nov 13;15(21):6602-8. Epub 2009 Oct 13.
Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma.
Cancer Res 2008 Dec;68(23):9735-45
Division of Oncology, The Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4318, USA.

Primary cardiac sarcomas: a clinicopathologic analysis of a series with follow-up information in 17 patients and emphasis on long-term survival.
Hum Pathol 2008 Sep 7;39(9):1385-95. Epub 2008 Jul 7.
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.


Congenital pulmonary lymphangiectasis sequence: a rare, heterogeneous, and lethal etiology for prenatal pleural effusion.
Prenat Diagn 2006 Nov;26(11):1058-61
The Center for Fetal Diagnosis and Treatment, Department of Surgery at The Children's Hospital of Philadelphia/University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4399, USA.

Two novel TP63 mutations associated with the ankyloblepharon, ectodermal defects, and cleft lip and palate syndrome: a skin fragility phenotype.
Arch Dermatol 2005 Dec;141(12):1567-73
Department of Dermatology, University of Pennsylvania, 220 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA.

Detection and diagnostic utilization of placental alkaline phosphatase in muscular tissue and tumors with myogenic differentiation.
Am J Surg Pathol 2002 Dec;26(12):1627-33
Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19147, USA.


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