Bruce M Spiegelman

Bruce M Spiegelman

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Bruce M Spiegelman

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Publisher Correction: Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Nature 2019 Jun;570(7760):E32

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1267-3DOI Listing
June 2019

Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis.

Nature 2019 May 1;569(7755):229-235. Epub 2019 May 1.

Department of Cancer Biology, Dana Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41586-019-1156-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6589139PMC
May 2019

New Advances in Adaptive Thermogenesis: UCP1 and Beyond.

Cell Metab 2019 01 29;29(1):27-37. Epub 2018 Nov 29.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.11.002DOI Listing
January 2019

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Cell Metab 2018 10 2;28(4):631-643.e3. Epub 2018 Aug 2.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183044
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http://dx.doi.org/10.1016/j.cmet.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170693PMC
October 2018

Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity.

Cell 2017 Nov 5;171(4):836-848.e13. Epub 2017 Oct 5.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679747PMC
November 2017

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.

J Biol Chem 2017 10 24;292(41):16810-16816. Epub 2017 Aug 24.

From the Dana-Farber Cancer Institute, Harvard Medical School and

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http://dx.doi.org/10.1074/jbc.R117.789628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641863PMC
October 2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Cell Metab 2017 Oct 24;26(4):660-671.e3. Epub 2017 Aug 24.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629120PMC
October 2017

Do Adipocytes Emerge from Mural Progenitors?

Cell Stem Cell 2017 05;20(5):585-586

Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.03.013DOI Listing
May 2017

The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.

Endocrinology 2016 Nov 2;157(11):4184-4191. Epub 2016 Sep 2.

Section of Molecular Physiology (L.S., E.A.R.), Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen 2100, Denmark; and Department of Cell Biology (J.L., I.A.L., X.Z., B.M.S.), Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1210/en.2016-1398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086530PMC
November 2016

Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction.

Med Sci Sports Exerc 2016 09;48(9):1699-707

1Faculty of Physical Education, University of Campinas, Campinas, BRAZIL; 2Laboratory of Neuromuscular Adaptations to Resistance Training, Department of Physical Education, Federal University of São Carlos, São Carlos, BRAZIL; 3School of Physical Education and Sport, University of São Paulo, São Paulo, BRAZIL; 4Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; 5Mary MacKillop Institute for Health Research, Centre for Exercise and Nutrition, Australian Catholic University, Melbourne, AUSTRALIA; and 6Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, England, UNITED KINGDOM.

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http://dx.doi.org/10.1249/MSS.0000000000000970DOI Listing
September 2016

CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER.

Trends Cancer 2016 09;2(9):461-463

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.trecan.2016.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5407404PMC
September 2016

Cell biology of fat storage.

Mol Biol Cell 2016 08;27(16):2523-7

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1091/mbc.E15-10-0749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985254PMC
August 2016

Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation.

Genes Dev 2016 08 26;30(16):1822-36. Epub 2016 Aug 26.

Dana-Farber Cancer Institute, Boston, Massachusetts, 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115, USA;

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http://dx.doi.org/10.1101/gad.285312.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024681PMC
August 2016

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer.

Cell Metab 2016 Feb 6;23(2):315-23. Epub 2015 Dec 6.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749423PMC
February 2016

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

Cell Metab 2015 Oct 13;22(4):734-740. Epub 2015 Aug 13.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4802359PMC
October 2015

Brown and Beige Fat: Physiological Roles beyond Heat Generation.

Cell Metab 2015 Oct;22(4):546-59

Institute for Diabetes, Obesity, and Metabolism, Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613812PMC
October 2015

A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Cell 2015 Oct 22;163(3):643-55. Epub 2015 Oct 22.

Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.09.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4656041PMC
October 2015

The future of brown adipose tissues in the treatment of type 2 diabetes.

Diabetologia 2015 Aug 9;58(8):1704-7. Epub 2015 May 9.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO Box 616, 6200MD, Maastricht, the Netherlands,

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http://dx.doi.org/10.1007/s00125-015-3611-yDOI Listing
August 2015

Brown and Beige Fat: Molecular Parts of a Thermogenic Machine.

Diabetes 2015 Jul 7;64(7):2346-51. Epub 2015 Jun 7.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db15-0318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477363PMC
July 2015

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

J Clin Endocrinol Metab 2015 Apr 19;100(4):1654-63. Epub 2015 Jan 19.

Division of Endocrinology (B.A.I., I.R.L., G.D.H., K.S.N.), Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905; Department of Cancer Biology (R.R.R., B.M.S.), Dana-Farber Cancer Institute, Boston, Massachusetts 02215; and Department of Cell Biology (R.R.R., B.M.S.), Harvard Medical School, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1210/jc.2014-3081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399307PMC
April 2015

miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.

Cell Metab 2015 Apr;21(4):584-95

Cardiovascular Division of the Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Massachusetts General Hospital Cardiovascular Division and Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393846PMC
April 2015

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

Nature 2015 Jan 17;517(7534):391-5. Epub 2014 Nov 17.

1] Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA [2] Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297557PMC
January 2015

Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects.

Proc Natl Acad Sci U S A 2015 Jan 30;112(2):482-7. Epub 2014 Dec 30.

Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1423486112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299242PMC
January 2015

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming.

Genes Dev 2014 Nov 14;28(21):2361-9. Epub 2014 Oct 14.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA

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http://dx.doi.org/10.1101/gad.249367.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215181PMC
November 2014

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.

Proc Natl Acad Sci U S A 2014 Nov 21;111(44):15756-61. Epub 2014 Oct 21.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115; Department of Cell Biology, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1417898111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226111PMC
November 2014

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia.

Nature 2014 Sep 13;513(7516):100-4. Epub 2014 Jul 13.

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature13528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4224962PMC
September 2014

Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383.

Diabetes 2014 Sep;63(9):e17

Spiegelman Laboratory, Cancer Biology, Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db14-0898DOI Listing
September 2014

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Cell 2014 Jul;158(1):69-83

Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116691PMC
July 2014

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Cell 2014 Jun;157(6):1279-91

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.03.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131287PMC
June 2014

A smooth muscle-like origin for beige adipocytes.

Cell Metab 2014 May 4;19(5):810-20. Epub 2014 Apr 4.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2014.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052772PMC
May 2014

Irisin ERKs the fat.

Diabetes 2014 Feb;63(2):381-3

Dana Farber Cancer Institute, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.2337/db13-1586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4876758PMC
February 2014

β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.

Cell Metab 2014 Jan;19(1):96-108

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017355PMC
January 2014

What we talk about when we talk about fat.

Cell 2014 Jan;156(1-2):20-44

Departments of Genetics and Cell Biology, Harvard Medical School, Boston, MA 02215, USA; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674130154
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http://dx.doi.org/10.1016/j.cell.2013.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934003PMC
January 2014

Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway.

Cell Metab 2013 Nov 10;18(5):649-59. Epub 2013 Oct 10.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2013.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980968PMC
November 2013

Time window expansion for HDX analysis of an intrinsically disordered protein.

J Am Soc Mass Spectrom 2013 Oct 25;24(10):1584-92. Epub 2013 Jul 25.

Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL, 33458, USA.

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http://dx.doi.org/10.1007/s13361-013-0669-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773365PMC
October 2013

The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1.

Mol Cell Biol 2013 Jul 6;33(13):2603-13. Epub 2013 May 6.

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

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http://dx.doi.org/10.1128/MCB.01672-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3700121PMC
July 2013

Fat cells directly sense temperature to activate thermogenesis.

Proc Natl Acad Sci U S A 2013 Jul 1;110(30):12480-5. Epub 2013 Jul 1.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1310261110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725077PMC
July 2013

Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease.

Diabetes 2013 Jun;62(6):1774-82

Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-1665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661621PMC
June 2013

PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress.

Cancer Cell 2013 Mar 14;23(3):287-301. Epub 2013 Feb 14.

Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ccr.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708305PMC
March 2013

Adaptive thermogenesis in adipocytes: is beige the new brown?

Genes Dev 2013 Feb;27(3):234-50

Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1101/gad.211649.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3576510PMC
February 2013

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

Proc Natl Acad Sci U S A 2012 Jun 29;109(24):9635-40. Epub 2012 May 29.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1207287109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386123PMC
June 2012

Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science.

Skelet Muscle 2012 Jun 7;2(1):11. Epub 2012 Jun 7.

Novartis Institutes for Biomedical Research, 100 Technology Square, RM4210, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1186/2044-5040-2-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514131PMC
June 2012

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

Cell Metab 2012 Mar;15(3):395-404

UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, 35 Medical Center Way, San Francisco, CA 94143-0669, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.01.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410936PMC
March 2012

Identifying novel transcriptional components controlling energy metabolism.

Cell Metab 2011 Dec;14(6):739-45

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131110042
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http://dx.doi.org/10.1016/j.cmet.2011.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240865PMC
December 2011

Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex.

Proc Natl Acad Sci U S A 2011 Nov 2;108(46):18678-83. Epub 2011 Nov 2.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1113813108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219099PMC
November 2011

QnAs with Bruce M. Spiegelman.

Proc Natl Acad Sci U S A 2011 Nov 14;108(48):19121. Epub 2011 Nov 14.

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http://dx.doi.org/10.1073/pnas.1117668108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228470PMC
November 2011

Molecular mechanisms of cancer development in obesity.

Nat Rev Cancer 2011 11 24;11(12):886-95. Epub 2011 Nov 24.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrc3174DOI Listing
November 2011

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Nature 2011 Sep 4;477(7365):477-81. Epub 2011 Sep 4.

Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature10383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179551PMC
September 2011

Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.

Endocrinology 2011 Aug 28;152(8):2996-3004. Epub 2011 Jun 28.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1210/en.2011-0281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138239PMC
August 2011

Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase.

Genes Dev 2011 Jun 6;25(12):1232-44. Epub 2011 Jun 6.

Department of Cell Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.2054711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127426PMC
June 2011

PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination.

Cell Metab 2011 Apr;13(4):351

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131110009
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http://dx.doi.org/10.1016/j.cmet.2011.03.008DOI Listing
April 2011

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

J Clin Invest 2011 Jan 1;121(1):96-105. Epub 2010 Dec 1.

Institute for Diabetes, Obesity, and Metabolism and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1172/JCI44271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3007155PMC
January 2011

PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.

Proc Natl Acad Sci U S A 2010 Dec 24;107(50):21866-71. Epub 2010 Nov 24.

Department of Cell Biology, The Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1016089107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003089PMC
December 2010

Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons.

Development 2010 Oct 15;137(20):3489-99. Epub 2010 Sep 15.

Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1242/dev.053348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947760PMC
October 2010

NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection.

Proc Natl Acad Sci U S A 2010 Jul 21;107(27):12317-22. Epub 2010 Jun 21.

Ludwig Institute for Cancer Research, 171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1073/pnas.1007088107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901488PMC
July 2010

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

Nature 2010 Jul;466(7305):451-6

Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature09291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987584PMC
July 2010

Transcriptional control of brown fat development.

Cell Metab 2010 Apr;11(4):257-62

Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2010.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857670PMC
April 2010

Transcriptional control of preadipocyte determination by Zfp423.

Nature 2010 Mar 3;464(7288):619-23. Epub 2010 Mar 3.

Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845731PMC
March 2010

For a pragmatic approach to exercise studies.

J Appl Physiol (1985) 2010 01;108(1):223-3; author reply 226

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http://dx.doi.org/10.1152/japplphysiol.01233.2009DOI Listing
January 2010

Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging.

Proc Natl Acad Sci U S A 2009 Dec 16;106(48):20405-10. Epub 2009 Nov 16.

Department of Neurology, University of Miami School of Medicine, Miami, FL33136, USA.

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http://dx.doi.org/10.1073/pnas.0911570106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787152PMC
December 2009

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.

Proc Natl Acad Sci U S A 2009 Dec 14;106(52):22510-5. Epub 2009 Dec 14.

Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0912533106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799738PMC
December 2009

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.

Nature 2009 Aug 29;460(7259):1154-8. Epub 2009 Jul 29.

Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754867PMC
August 2009

Transcriptional control of brown adipocyte development and physiological function--of mice and men.

Genes Dev 2009 Apr;23(7):788-97

Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1779209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763499PMC
April 2009

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

Proc Natl Acad Sci U S A 2008 Dec 9;105(50):19926-31. Epub 2008 Dec 9.

Departments of Internal Medicine and Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.

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http://dx.doi.org/10.1073/pnas.0810339105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598730PMC
December 2008

Cell Differentiation.

Curr Opin Cell Biol 2007 Dec 3;19(6):603-604. Epub 2007 Dec 3.

Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA, email:

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http://dx.doi.org/10.1016/j.ceb.2007.11.002DOI Listing
December 2007