Bruce M Cohen

Bruce M Cohen

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Bruce M Cohen

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Establishing a Link Between Mitochondrial Dysfunction and Late-Life Depression.

Am J Geriatr Psychiatry 2019 Sep 4;27(9):972-974. Epub 2019 May 4.

Department of Psychiatry, Harvard Medical School, Belmont, MA.

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http://dx.doi.org/10.1016/j.jagp.2019.04.013DOI Listing
September 2019

Abnormalities in High-Energy Phosphate Metabolism in First-Episode Bipolar Disorder Measured Using P-Magnetic Resonance Spectroscopy.

Biol Psychiatry 2018 12 7;84(11):797-802. Epub 2017 Apr 7.

McLean Hospital, Belmont, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.03.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632123PMC
December 2018

The urgent need for more research on bipolar depression.

Lancet Psychiatry 2018 12;5(12):e29-e30

Harvard Medical School, Harvard, Boston, MA, USA; McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/S2215-0366(18)30422-XDOI Listing
December 2018

Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder.

Schizophr Res 2018 11 26;201:278-286. Epub 2018 May 26.

Schizophrenia and Bipolar Disorders Program, McLean Hospital, Harvard Medical School, Belmont, USA; Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.05.027DOI Listing
November 2018

Pharmacogenetics in Psychiatry: A Companion, Rather Than Competitor, to Protocol-Based Care-Reply.

JAMA Psychiatry 2018 Oct;75(10):1090-1091

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.2355DOI Listing
October 2018

On the Marketing and Use of Pharmacogenetic Tests for Psychiatric Treatment.

JAMA Psychiatry 2018 Aug;75(8):769-770

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2018.0834DOI Listing
August 2018

Using Smartphone Apps to Promote Psychiatric Rehabilitation in a Peer-Led Community Support Program: Pilot Study.

JMIR Ment Health 2018 Aug 15;5(3):e10092. Epub 2018 Aug 15.

Psychotic Disorders Division, McLean Hospital, Belmont, MA, United States.

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http://dx.doi.org/10.2196/10092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6115596PMC
August 2018

Antidepressant-Resistant Depression in Patients With Comorbid Subclinical Hypothyroidism or High-Normal TSH Levels.

Am J Psychiatry 2018 07;175(7):598-604

From the Department of Psychiatry, Harvard Medical School, Boston, and the Program for Neuropsychiatric Research, McLean Hospital, Belmont, Mass.; the Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif.; and the Pavilion, McLean Hospital, Belmont, Mass.

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http://dx.doi.org/10.1176/appi.ajp.2017.17080949DOI Listing
July 2018

In Vivo Brain Glycine and Glutamate Concentrations in Patients With First-Episode Psychosis Measured by Echo Time-Averaged Proton Magnetic Resonance Spectroscopy at 4T.

Biol Psychiatry 2018 03 7;83(6):484-491. Epub 2017 Sep 7.

Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.08.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809251PMC
March 2018

Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder.

Schizophr Bull 2018 02;44(2):432-442

Laboratory of Psychobiology, Department of Psychiatry, Rambam Health Care Campus, B. Rappaport Faculty of Medicine and Rappaport Family Institute for Research in Medical Sciences, Technion IIT, Haifa, Israel.

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http://dx.doi.org/10.1093/schbul/sbx077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814822PMC
February 2018

Acute and chronic effects of clozapine on cholinergic transmission in cultured mouse superior cervical ganglion neurons.

J Neurogenet 2016 Sep - Dec;30(3-4):297-305. Epub 2016 Sep 14.

b New England Primate Research Center, Harvard Medical School , Southborough , MA , USA.

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http://dx.doi.org/10.1080/01677063.2016.1229779DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061957PMC
December 2017

Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles.

Sci Rep 2017 10 25;7(1):14038. Epub 2017 Oct 25.

Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1038/s41598-017-14420-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656579PMC
October 2017

Brain bioenergetics and redox state measured by P magnetic resonance spectroscopy in unaffected siblings of patients with psychotic disorders.

Schizophr Res 2017 09 1;187:11-16. Epub 2017 Mar 1.

Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.schres.2017.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581291PMC
September 2017

Effects of Chronic Social Defeat Stress on Sleep and Circadian Rhythms Are Mitigated by Kappa-Opioid Receptor Antagonism.

J Neurosci 2017 08 3;37(32):7656-7668. Epub 2017 Jul 3.

Basic Neuroscience Division, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478,

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http://dx.doi.org/10.1523/JNEUROSCI.0885-17.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551063PMC
August 2017

Aberrant cerebellar connectivity in bipolar disorder with psychosis.

Biol Psychiatry Cogn Neurosci Neuroimaging 2017 Jul;2(5):438-448

Program for Neuropsychiatric Research, McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1016/j.bpsc.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512437PMC
July 2017

Decreased Cingulate Cortex activation during cognitive control processing in bipolar disorder.

J Affect Disord 2017 Apr 7;213:86-95. Epub 2017 Feb 7.

Department of Psychiatry, Harvard Medical School, Boston, MA 02215, United States; Schizophrenia and Bipolar Disorders Research Program, McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.

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http://dx.doi.org/10.1016/j.jad.2017.02.003DOI Listing
April 2017

Clozapine Modulates Glucosylceramide, Clears Aggregated Proteins, and Enhances ATG8/LC3 in Caenorhabditis elegans.

Neuropsychopharmacology 2017 Mar 6;42(4):951-962. Epub 2016 Oct 6.

Program for Neuropsychiatric Research, Mailman Research Center 331, McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1038/npp.2016.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312067PMC
March 2017

Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines.

J Proteome Res 2017 02 28;16(2):481-493. Epub 2016 Nov 28.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital , Boston, Massachusetts 02114, United States.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.6b00628
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http://dx.doi.org/10.1021/acs.jproteome.6b00628DOI Listing
February 2017

Redox Dysregulation in Schizophrenia Revealed by in vivo NAD+/NADH Measurement.

Schizophr Bull 2017 01 24;43(1):197-204. Epub 2016 Sep 24.

Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, MA.

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http://dx.doi.org/10.1093/schbul/sbw129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216857PMC
January 2017

Differential brain network activity across mood states in bipolar disorder.

J Affect Disord 2017 Jan 6;207:367-376. Epub 2016 Oct 6.

Psychotic Disorders Division, McLean Hospital, Belmont, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.jad.2016.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107137PMC
January 2017

Embracing Complexity in Psychiatric Diagnosis, Treatment, and Research.

Authors:
Bruce M Cohen

JAMA Psychiatry 2016 12;73(12):1211-1212

Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2016.2466DOI Listing
December 2016

Forward Genetic Screen in Suggests F57A10.2 and acp-4 As Suppressors of C9ORF72 Related Phenotypes.

Front Mol Neurosci 2016 8;9:113. Epub 2016 Nov 8.

Program for Neuropsychiatric Research, McLean Hospital and Harvard Medical School Belmont, MA, USA.

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http://dx.doi.org/10.3389/fnmol.2016.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100550PMC
November 2016

State dependent cortico-amygdala circuit dysfunction in bipolar disorder.

J Affect Disord 2016 Sep 28;201:79-87. Epub 2016 Apr 28.

Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087105PMC
http://dx.doi.org/10.1016/j.jad.2016.04.052DOI Listing
September 2016

Kappa-opioid receptors differentially regulate low and high levels of ethanol intake in female mice.

Brain Behav 2016 09 24;6(9):e00523. Epub 2016 Jul 24.

Department of Psychiatry Harvard Medical School McLean Hospital Belmont MA USA; National Institute on Alcohol Abuse and Alcoholism National Institutes of Health Bethesda MD USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036438PMC
http://dx.doi.org/10.1002/brb3.523DOI Listing
September 2016

Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates α-Aminoadipate as a Potential Biomarker for Bipolar Disorder.

Mol Neuropsychiatry 2016 Jul 24;2(2):97-106. Epub 2016 Jun 24.

Center for Experimental Drugs and Diagnostics, Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Harvard Medical School and Massachusetts General Hospital, Boston, Mass., USA; Chemical Biology Program, Broad Institute of Harvard and MIT, Mass., USA; Chemical Biology Program, Broad Institute of Harvard and MIT, Mass., USA.

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http://dx.doi.org/10.1159/000446654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996006PMC
July 2016

Factors associated with overweight and obesity in schizophrenia, schizoaffective and bipolar disorders.

Psychiatry Res 2016 Mar 14;237:304-10. Epub 2016 Jan 14.

Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA; Harvard Medical School, Department of Psychiatry, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.psychres.2016.01.024DOI Listing
March 2016

MiR-126 Regulates Growth Factor Activities and Vulnerability to Toxic Insult in Neurons.

Mol Neurobiol 2016 Jan 19;53(1):95-108. Epub 2014 Nov 19.

Department of Psychiatry, McLean Hospital, Harvard Medical School, MRC 223, 115 Mill Street, Belmont, MA, 02478, USA.

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http://dx.doi.org/10.1007/s12035-014-8989-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437970PMC
January 2016

Using Smartphone Apps to Promote Psychiatric and Physical Well-Being.

Psychiatr Q 2015 Dec;86(4):505-19

Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11126-015-9337-7DOI Listing
December 2015

Prescription stimulant use is associated with earlier onset of psychosis.

J Psychiatr Res 2015 Dec 21;71:41-7. Epub 2015 Sep 21.

McLean Hospital, Psychotic Disorders Division, Belmont, MA, Harvard Medical School, United States.

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http://dx.doi.org/10.1016/j.jpsychires.2015.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630672PMC
December 2015

Are Single-Item Global Ratings Useful for Assessing Health Status?

J Clin Psychol Med Settings 2015 Oct 22. Epub 2015 Oct 22.

Wellframe, Inc., Boston, MA, USA.

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http://dx.doi.org/10.1007/s10880-015-9436-5DOI Listing
October 2015

Phosphorus magnetic resonance spectroscopy studies in schizophrenia.

J Psychiatr Res 2015 Sep 25;68:157-66. Epub 2015 Jun 25.

McLean Hospital, 115 Mill Street, Belmont, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2015.06.014DOI Listing
September 2015

Glial abnormalities in mood disorders.

Harv Rev Psychiatry 2014 Nov-Dec;22(6):334-7

From Harvard Medical School and McLean Hospital, Belmont, MA.

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http://dx.doi.org/10.1097/HRP.0000000000000060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336524PMC
July 2015

Measuring Cognition in Bipolar Disorder with Psychosis Using the MATRICS Consensus Cognitive Battery.

J Int Neuropsychol Soc 2015 Jul 8;21(6):468-72. Epub 2015 Jul 8.

1Schizophrenia and Bipolar Disorder Program,McLean Hospital,Belmont,Massachusetts.

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http://dx.doi.org/10.1017/S1355617715000442DOI Listing
July 2015

Blockade of the GLT-1 Transporter in the Central Nucleus of the Amygdala Induces both Anxiety and Depressive-Like Symptoms.

Neuropsychopharmacology 2015 Jun 14;40(7):1700-8. Epub 2015 Jan 14.

National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1038/npp.2015.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915252PMC
June 2015

Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression.

J Clin Psychopharmacol 2015 Jun;35(3):338-40

Geriatric Psychiatry Research Program McLean Hospital Belmont, MA and Harvard Medical School Department of Psychiatry Boston, MA Geriatric Psychiatry Research Program McLean Hospital Belmont, MA and Harvard Medical School Department of Psychiatry Boston, MA Geriatric Psychiatry Research Program McLean Hospital Belmont, MA Harvard Medical School Department of Psychiatry Boston, MA and McLean Hospital Laboratory for Psychiatric Biostatistics Belmont, MA Geriatric Psychiatry Research Program McLean Hospital Belmont, MA Harvard Medical School Department of Psychiatry Boston, MA and Shervert Frazier Research Institute McLean Hospital Belmont, MA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/JCP.0000000000000326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414830PMC
June 2015

Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.

Am J Med Genet B Neuropsychiatr Genet 2015 Jun 23;168B(4):316. Epub 2015 Mar 23.

Harvard Medical School, Massachusetts, Boston.

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http://dx.doi.org/10.1002/ajmg.b.32301DOI Listing
June 2015

Genomewide association analyses of electrophysiological endophenotypes for schizophrenia and psychotic bipolar disorders: a preliminary report.

Am J Med Genet B Neuropsychiatr Genet 2015 Apr 4;168B(3):151-61. Epub 2015 Mar 4.

Department of Psychiatry Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Boston, Massachusetts; Department of Psychiatry Psychosis Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Boston, Massachusetts; Psychiatric and Neurodevelopmental Genetics Unit Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1002/ajmg.b.32298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458348PMC
April 2015

Aberrant cerebellar connectivity in motor and association networks in schizophrenia.

Front Hum Neurosci 2015 18;9:134. Epub 2015 Mar 18.

Schizophrenia and Bipolar Disorder Program, Psychotic Disorders Division, McLean Hospital Belmont, MA, USA ; Department of Psychiatry, Harvard Medical School Boston, MA, USA.

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http://dx.doi.org/10.3389/fnhum.2015.00134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364170PMC
April 2015

Myelin vs axon abnormalities in white matter in bipolar disorder.

Neuropsychopharmacology 2015 Mar 13;40(5):1243-9. Epub 2015 Mar 13.

1] McLean Hospital Schizophrenia and Bipolar Disorder Program, Belmont, MA, USA [2] McLean Hospital, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/npp2014310
Publisher Site
http://dx.doi.org/10.1038/npp.2014.310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367469PMC
March 2015

Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients.

Schizophr Res 2015 Feb 24;161(2-3):329-39. Epub 2014 Dec 24.

McLean Hospital, 115 Mill St., Belmont, MA 02478, USA; Harvard Medical School, Department of Psychiatry, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2014.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308443PMC
February 2015

Transient receptor potential melastatin (TRPM) channels mediate clozapine-induced phenotypes in Caenorhabditis elegans.

J Neurogenet 2014 Mar-Jun;28(1-2):86-97. Epub 2014 Feb 25.

Department of Psychiatry, Harvard Medical School , Boston, Massachusetts , USA.

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http://dx.doi.org/10.3109/01677063.2013.879717DOI Listing
January 2015

Social functioning and age across affective and nonaffective psychoses.

J Nerv Ment Dis 2015 Jan;203(1):37-42

*Department of Psychology and Social Behavior, University of California, Irvine; †Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA; and ‡Department of Psychiatry, Harvard Medical School, Boston, MA.

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http://dx.doi.org/10.1097/NMD.0000000000000232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4290159PMC
January 2015

Pathway analyses implicate glial cells in schizophrenia.

PLoS One 2014 24;9(2):e89441. Epub 2014 Feb 24.

Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America ; Shervert Frazier Research Institute, McLean Hospital, Belmont, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089441PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933626PMC
December 2014

Naltrexone in bipolar disorder with depression: a double-blind, placebo-controlled study.

J Clin Psychopharmacol 2014 Dec;34(6):749-51

Frazier Research Institute McLean Hospital Belmont, MA and Harvard Medical School Boston, MA Harvard Medical School Boston, MA and Laboratory for Psychiatric Biostatistics McLean Hospital Belmont, MA Frazier Research Institute McLean Hospital Belmont, MA and Harvard Medical School Boston, MA.

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http://dx.doi.org/10.1097/JCP.0000000000000222DOI Listing
December 2014

Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.

Am J Med Genet B Neuropsychiatr Genet 2014 Sep 25;165B(6):457-66. Epub 2014 Jul 25.

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/ajmg.b.32257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431889PMC
September 2014

Rapid mood-elevating effects of low field magnetic stimulation in depression.

Biol Psychiatry 2014 Aug 12;76(3):186-93. Epub 2013 Nov 12.

Departments of Neuroscience (Mind and Brain Institute), Psychiatry, and Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York.

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http://dx.doi.org/10.1016/j.biopsych.2013.10.024DOI Listing
August 2014

Oral SAMe in persistent treatment-refractory bipolar depression: a double-blind, randomized clinical trial.

J Clin Psychopharmacol 2014 Jun;34(3):413-6

Frazier Research Institute McLean Hospital Belmont, MA and Harvard Medical School Boston, MA Frazier Research Institute McLean Hospital Belmont, MA and Harvard Medical School Boston, MA Harvard Medical School Boston, MA and Laboratory for Psychiatric Biostatistics McLean Hospital Belmont, MA Frazier Research Institute McLean Hospital Belmont, MA and Harvard Medical School Boston, MA.

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http://dx.doi.org/10.1097/JCP.0000000000000064DOI Listing
June 2014

Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice.

Alcohol Clin Exp Res 2014 May 21;38(5):1307-14. Epub 2014 Mar 21.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts; Laboratory of Addictive Disorders, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts.

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http://dx.doi.org/10.1111/acer.12361DOI Listing
May 2014

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

PLoS One 2013 14;8(8):e70701. Epub 2013 Aug 14.

McLean Hospital, Belmont, Massachusetts, United States of America ; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, United States of America ; School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, Australia.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0070701PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747596PMC
April 2014

Anxiety disorder comorbidity in bipolar disorder, schizophrenia and schizoaffective disorder.

Psychopathology 2013 16;46(3):176-85. Epub 2012 Aug 16.

McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1159/000339556DOI Listing
March 2014

Alterations of brain anatomy in mouse model of MDD created by replacement of homologous mouse DNA sequence with an illness-associated 6-base human CREB1 promoter sequence.

Am J Med Genet B Neuropsychiatr Genet 2014 Jan 4;165B(1):1-8. Epub 2013 Sep 4.

Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1002/ajmg.b.32198DOI Listing
January 2014

In vivo evidence for cerebral bioenergetic abnormalities in schizophrenia measured using 31P magnetization transfer spectroscopy.

JAMA Psychiatry 2014 Jan;71(1):19-27

Psychotic Disorders Division, McLean Hospital, Belmont, Massachusetts2Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamapsychiatry.2013.2287DOI Listing
January 2014

Studies toward bivalent κ opioids derived from salvinorin A: heteromethylation of the furan ring reduces affinity.

Beilstein J Org Chem 2013 Dec 20;9:2916-24. Epub 2013 Dec 20.

McLean Hospital, Belmont, MA 02478, USA and Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.3762/bjoc.9.328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896271PMC
December 2013

Neuropsychological functioning predicts community outcomes in affective and non-affective psychoses: a 6-month follow-up.

Schizophr Res 2013 Aug 19;148(1-3):34-7. Epub 2013 Jun 19.

Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St., Belmont, MA 02478 USA.

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http://dx.doi.org/10.1016/j.schres.2013.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751391PMC
August 2013

Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.

Bipolar Disord 2013 Jun 2;15(4):434-9. Epub 2013 May 2.

Department of Psychiatry, Beth-Israel Deaconess Hospital, Salt Lake City, UT, USA; Department of Psychiatry, Harvard Medical School, Salt Lake City, UT, USA; Department of Psychiatry, Massachusetts Mental Health Center, Boston, USA; Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1111/bdi.12074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504910PMC
June 2013

Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia.

Schizophr Res 2013 Feb 31;143(2-3):260-8. Epub 2012 Dec 31.

McLean Hospital, Psychotic Disorders Division, Belmont, MA, United States.

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http://dx.doi.org/10.1016/j.schres.2012.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601525PMC
February 2013

Creatine kinase and ATP synthase reaction rates in human frontal lobe measured by ³¹P magnetization transfer spectroscopy at 4T.

Magn Reson Imaging 2013 Jan 13;31(1):102-8. Epub 2012 Aug 13.

Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.mri.2012.06.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501567PMC
January 2013

Corticotropin-releasing factor (CRF)-induced disruption of attention in rats is blocked by the κ-opioid receptor antagonist JDTic.

Neuropsychopharmacology 2012 Dec 5;37(13):2809-16. Epub 2012 Sep 5.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1038/npp.2012.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499711PMC
December 2012

Categorical vs dimensional classifications of psychotic disorders.

Compr Psychiatry 2012 Nov 7;53(8):1118-29. Epub 2012 Jun 7.

Psychotic Disorders Division, McLean Hospital, 1125 Mill St., Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.comppsych.2012.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488145PMC
November 2012

Salvinorin B meth-oxy-methyl ether.

Acta Crystallogr Sect E Struct Rep Online 2012 Nov 27;68(Pt 11):o3225-6. Epub 2012 Oct 27.

McLean Hospital, Belmont, MA, USA ; Harvard Medical School, Department of Psychiatry, Boston, MA, USA.

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http://dx.doi.org/10.1107/S1600536812043449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515309PMC
November 2012

Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia.

Neuropsychopharmacology 2012 Oct 27;37(11):2467-75. Epub 2012 Jun 27.

Department of Psychiatry, Harvard Medical School-McLean Hospital, Belmont, MA, USA.

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http://dx.doi.org/10.1038/npp.2012.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3442341PMC
October 2012

Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats.

Brain Res 2012 Oct 25;1479:44-51. Epub 2012 Aug 25.

Mailman Research Center, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.brainres.2012.08.030DOI Listing
October 2012

Auditory hallucinations in a cross-diagnostic sample of psychotic disorder patients: a descriptive, cross-sectional study.

Compr Psychiatry 2012 Aug 22;53(6):718-26. Epub 2011 Dec 22.

Schizophrenia and Bipolar Disorder Program, McLean Hospital and Harvard Medical School, Department of Psychiatry, USA.

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http://dx.doi.org/10.1016/j.comppsych.2011.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314103PMC
August 2012

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity.

BMC Pharmacol 2012 May 29;12. Epub 2012 May 29.

McLean Hospital, Belmont, MA & Department of Psychiatry, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2210-12-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411462PMC
May 2012

Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression.

J Geriatr Psychiatry Neurol 2012 Mar;25(1):43-50

Geriatric Psychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1177/0891988712436688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651420PMC
March 2012

Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Bioorg Med Chem Lett 2012 Jan 7;22(2):1023-6. Epub 2011 Dec 7.

Mailman Research Center, McLean Hospital, Belmont, MA 02478, USA; Department of Psychiatry, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.bmcl.2011.11.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3926198PMC
January 2012

Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychoses.

Schizophr Res 2011 Dec 12;133(1-3):212-7. Epub 2011 Oct 12.

Schizophrenia and Bipolar Disorder Program, McLean Hospital, 115 Mill St, Belmont, MA, 02478 USA.

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http://dx.doi.org/10.1016/j.schres.2011.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225688PMC
December 2011

Repeated exposure to the κ-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity.

Biol Psychiatry 2011 Oct 14;70(8):744-53. Epub 2011 Jul 14.

Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1016/j.biopsych.2011.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186866PMC
October 2011

Abnormal medial prefrontal cortex resting-state connectivity in bipolar disorder and schizophrenia.

Neuropsychopharmacology 2011 Sep 8;36(10):2009-17. Epub 2011 Jun 8.

Department of Brain and Cognitive Sciences, Poitras Center for Affective Disorders Research, McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/npp.2011.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158318PMC
September 2011

CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy.

Psychopharmacology (Berl) 2011 Jun 28;215(4):689-95. Epub 2011 Jan 28.

Department of Psychiatry, Harvard Medical School-McLean Hospital, 115 Mill Street, MRC 215, Belmont, MA 02478, USA.

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http://link.springer.com/10.1007/s00213-011-2169-8
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http://dx.doi.org/10.1007/s00213-011-2169-8DOI Listing
June 2011

Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial.

Psychopharmacology (Berl) 2011 Apr 8;214(4):933-9. Epub 2010 Dec 8.

Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00213-010-2103-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063546PMC
April 2011

BZP-party pills: a review of research on benzylpiperazine as a recreational drug.

Int J Drug Policy 2011 Mar 15;22(2):95-101. Epub 2011 Jan 15.

Department of Sociology, University of Auckland, Human Sciences Building, Room 920, 10 Symonds Street, Private Bag 92019, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.drugpo.2010.12.002DOI Listing
March 2011

Brain metabolite concentrations across cortical regions in healthy adults.

Brain Res 2011 Jan 7;1369:89-94. Epub 2010 Dec 7.

Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.11.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018151PMC
January 2011

Elevated gamma-aminobutyric acid levels in chronic schizophrenia.

Biol Psychiatry 2010 Oct 2;68(7):667-70. Epub 2010 Jul 2.

McLean Hospital, Belmont, Massachusetts 02478, USA.

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http://dx.doi.org/10.1016/j.biopsych.2010.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2942977PMC
October 2010

Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory.

Neuropsychopharmacology 2010 Sep 9;35(10):2049-59. Epub 2010 Jun 9.

Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1038/npp.2010.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055299PMC
September 2010

Default mode network abnormalities in bipolar disorder and schizophrenia.

Psychiatry Res 2010 Jul 9;183(1):59-68. Epub 2010 Jun 9.

McLean Hospital, Belmont, MA and Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/j.pscychresns.2010.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902695PMC
July 2010

Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats.

Psychopharmacology (Berl) 2010 Jun 1;210(2):263-74. Epub 2010 Apr 1.

Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1007/s00213-010-1834-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869248PMC
June 2010