Publications by authors named "Bruce D Walker"

100Publications

Evolution and Diversity of Immune Responses during Acute HIV Infection.

Immunity 2020 Nov;53(5):908-924

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Institute for Medical Engineering and Science (IMES), Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. Electronic address:

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November 2020

Envelope characteristics in individuals who developed neutralizing antibodies targeting different epitopes in HIV-1 subtype C infection.

Virology 2020 07 25;546:1-12. Epub 2020 Mar 25.

HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA; Max Planck Institute for Infection Biology, Berlin, Germany; Division of Infection and Immunity, University College London, UK. Electronic address:

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July 2020

Nanoscale imaging of clinical specimens using conventional and rapid-expansion pathology.

Nat Protoc 2020 05 1;15(5):1649-1672. Epub 2020 Apr 1.

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA.

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May 2020

CD8 T cells in HIV control, cure and prevention.

Nat Rev Immunol 2020 08 12;20(8):471-482. Epub 2020 Feb 12.

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.

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August 2020

Immunological Fingerprints of Controllers Developing Neutralizing HIV-1 Antibodies.

Cell Rep 2020 01;30(4):984-996.e4

Ragon Institute of MGH, MIT, and Harvard, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA, USA; Infectious Disease Division, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

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January 2020

Natural HIV-1 Nef Polymorphisms Impair SERINC5 Downregulation Activity.

Cell Rep 2019 11;29(6):1449-1457.e5

Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, BC, Canada. Electronic address:

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November 2019

Toward T Cell-Mediated Control or Elimination of HIV Reservoirs: Lessons From Cancer Immunology.

Front Immunol 2019 10;10:2109. Epub 2019 Sep 10.

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, United States.

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October 2020

HIV Controllers Exhibit Effective CD8 T Cell Recognition of HIV-1-Infected Non-activated CD4 T Cells.

Cell Rep 2019 04;27(1):142-153.e4

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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April 2019

Metabolic pathway activation distinguishes transcriptional signatures of CD8+ T cells from HIV-1 elite controllers.

AIDS 2018 11;32(18):2669-2677

Ragon Institute of MGH, MIT and Harvard, Massachusetts General Hospital, Cambridge, Massachusetts.

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November 2018

A FRESH approach: Combining basic science and social good.

Sci Immunol 2018 09;3(27)

Thumbi Ndung'u is a professor and the scientific director of the HIV Pathogenesis Programme and Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), and an investigator at the Africa Health Research Institute, Durban 4001, South Africa; an investigator at the Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard, Cambridge, MA 02139, USA; and a group leader at the Max Planck Institute for Infection Biology, Berlin, Germany.

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September 2018

Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load.

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa

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August 2018

Engineering modular intracellular protein sensor-actuator devices.

Nat Commun 2018 05 14;9(1):1881. Epub 2018 May 14.

Department of Biological Engineering, Synthetic Biology Center, Massachusetts Institute of Technology, 500 Technology Square, Cambridge, MA, 02139, USA.

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May 2018

Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study.

Lancet HIV 2018 01 1;5(1):e35-e44. Epub 2017 Oct 1.

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal, Durban, South Africa; Africa Health Research Institute, University of KwaZulu-Natal, Durban, South Africa; Max Planck Institute for Infection Biology, Berlin, Germany. Electronic address:

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January 2018

HIV Infection of Macrophages: Implications for Pathogenesis and Cure.

Pathog Immun 2017 24;2(2):179-192. Epub 2017 May 24.

Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts.

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May 2017

Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation.

Cell Mol Immunol 2017 07 29;14(7):631-634. Epub 2017 May 29.

Department of Medical Oncology and Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

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July 2017

Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

Immunity 2017 01 10;46(1):29-37. Epub 2017 Jan 10.

Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Harvard Medical School, Boston, MA 02115, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02115, USA. Electronic address:

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January 2017

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.

Nat Genet 2017 Feb 19;49(2):193-203. Epub 2016 Dec 19.

Ragon Institute of Massachusetts General Hospital (MGH), Massachusetts Institute of Technology (MIT), and Harvard University, Cambridge, Massachusetts, USA.

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February 2017

Antigen recognition-triggered drug delivery mediated by nanocapsule-functionalized cytotoxic T-cells.

Biomaterials 2017 02 25;117:44-53. Epub 2016 Nov 25.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA; Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA, USA; Dept. of Biological Engineering, MIT, Cambridge, MA, USA; Dept. of Materials Science & Engineering, MIT, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address:

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February 2017

Antiviral CD8 T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion.

Immunity 2016 10;45(4):917-930

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 01239, USA; Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 01239, USA; Broad Institute, Cambridge, MA 01239, USA. Electronic address:

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October 2016

Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.

Sci Transl Med 2016 09;8(358):358ra125

Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, University of Oxford, Oxford OX1 3SY, U.K. HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal (UKZN), Durban, South Africa. Department of Paediatric Infectious Diseases, Great Ormond Street Hospital for Children, London, U.K.

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September 2016

CD8(+) T Cells and cART: A Dynamic Duo?

Immunity 2016 09;45(3):466-468

Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Institute for Medical Engineering and Science, MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 02815, USA. Electronic address:

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September 2016

Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection.

Protein Cell 2016 10;7(10):761-765

School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China.

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October 2016

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Cell Host Microbe 2016 Sep 18;20(3):368-380. Epub 2016 Aug 18.

Research Centre of the Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montreal, QC H2X 0A9, Canada; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (CHAVI-ID), La Jolla, CA 92037, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address:

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September 2016

Elite controller CD8+ T cells exhibit comparable viral inhibition capacity, but better sustained effector properties compared to chronic progressors.

J Leukoc Biol 2016 12 12;100(6):1425-1433. Epub 2016 Jul 12.

Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard Medical School, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

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December 2016

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictable.

Nat Commun 2016 05 23;7:11660. Epub 2016 May 23.

Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts 02139, USA.

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May 2016

HIV-1 Vpu Mediates HLA-C Downregulation.

Cell Host Microbe 2016 May;19(5):686-95

Cancer and Inflammation Program, Leidos Biomedical Research, Frederick National Laboratory, Frederick, MD 21702, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139-3583, USA. Electronic address:

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May 2016

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.

J Infect Dis 2016 08 6;214(3):379-89. Epub 2016 Mar 6.

Department of Paediatrics HIV-1 Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZulu-Natal.

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August 2016

CXCL13 is a plasma biomarker of germinal center activity.

Proc Natl Acad Sci U S A 2016 Mar 23;113(10):2702-7. Epub 2016 Feb 23.

Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, La Jolla, CA 92037;

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March 2016

Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression.

Immunity 2016 Feb 2;44(2):391-405. Epub 2016 Feb 2.

KwaZulu-Natal Research Institute for Tuberculosis & HIV (K-RITH), University of KwaZulu-Natal (UKZN), 4001 Durban, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139-4307, USA.

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February 2016

Accelerated graft dysfunction in heart transplant patients with persistent atrioventricular conduction block.

Europace 2016 Dec 3;18(12):1837-1841. Epub 2016 Feb 3.

St Vincent's Hospital, Suite 802, 438 Victoria St., Darlinghurst, NSW 2010, Australia.

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December 2016

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.

mBio 2016 Jan 19;7(1):e01516-15. Epub 2016 Jan 19.

Center for AIDS Research, Kumamoto University, Kumamoto, Japan International Research Center for Medical Sciences (IRCMS), Kumamoto University, Kumamoto, Japan

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January 2016

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.

PLoS Pathog 2016 Jan 8;12(1):e1005315. Epub 2016 Jan 8.

Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America.

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January 2016

HIV-specific CD8⁺ T cells and HIV eradication.

J Clin Invest 2016 Feb 5;126(2):455-63. Epub 2016 Jan 5.

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February 2016

HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.

J Virol 2015 Dec 9;90(5):2208-20. Epub 2015 Dec 9.

Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital and Harvard Medical School, Cambridge, Massachusetts, USA Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, USA

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December 2015

Follicular Dendritic Cells Retain Infectious HIV in Cycling Endosomes.

PLoS Pathog 2015 Dec 1;11(12):e1005285. Epub 2015 Dec 1.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

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December 2015

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.

PLoS Pathog 2015 Oct 30;11(10):e1005238. Epub 2015 Oct 30.

Laboratory of Molecular Immunology, The Rockefeller University, New York, New York, United States of America; Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America.

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October 2015

Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial.

J Acquir Immune Defic Syndr 2016 Mar;71(3):246-53

*Massachusetts General Hospital, Division of Infectious Diseases, Boston, MA; †Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard, Cambridge, MA; ‡Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; §Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and University of Montreal, Montréal, QC, Canada; ‖Howard Hughes Medical Institute, Chevy Chase, MD; ¶Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY; and #Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.

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March 2016

Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.

Immunity 2015 Sep 8;43(3):591-604. Epub 2015 Sep 8.

HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, 400 Technology Square, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA. Electronic address:

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September 2015