Publications by authors named "Bruce C Carleton"

86Publications

Guillain-Barré Syndrome Following Influenza Vaccines Affords Opportunity to Improve Vaccine Confidence.

J Infect Dis 2020 Nov 2. Epub 2020 Nov 2.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, Canada.

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November 2020

Challenges and Opportunities in Implementing Pharmacogenetic Testing in Clinical Settings.

Annu Rev Pharmacol Toxicol 2021 01 2;61:65-84. Epub 2020 Oct 2.

Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia V6H 3V4, Canada; email:

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January 2021

Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy.

Annu Rev Pharmacol Toxicol 2021 01 25;61:679-699. Epub 2020 Sep 25.

Department of Pediatrics, Schulich School of Medicine and Dentistry, Western University, London, Ontario N6A 3M7, Canada; email:

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January 2021

Prevention of adverse drug effects: a pharmacogenomic approach.

Curr Opin Pediatr 2020 Oct;32(5):646-653

Department of Medical Genetics, Faculty of Medicine, University of British Columbia.

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October 2020

An update on CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects.

Expert Opin Drug Metab Toxicol 2020 Aug 16;16(8):723-734. Epub 2020 Jul 16.

Department of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital , Linkou, Taipei, Taiwan.

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August 2020

Les tests pharmacogénomiques: Améliorer le recours personnalisé aux médicaments pour les patients.

Can Fam Physician 2020 Apr;66(4):247-249

Professeur et directeur à la Division de la thérapeutique translationnelle du Département de pédiatrie de l'Université de la Colombie-Britannique.

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April 2020

Pharmacogenomic testing: Enhancing personalized medication use for patients.

Can Fam Physician 2020 04;66(4):241-243

Professor and Chair in the Division of Translational Therapeutics in the Department of Pediatrics at the University of British Columbia.

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April 2020

Genome-Wide Association Studies of Drug-Induced Liver Injury Make Progress Beyond the HLA Region.

Gastroenterology 2019 10 23;157(4):1167-1168. Epub 2019 Jul 23.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

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October 2019

Pharmacogenomics of Cisplatin-Induced Ototoxicity: Successes, Shortcomings, and Future Avenues of Research.

Clin Pharmacol Ther 2019 08 12;106(2):350-359. Epub 2019 Jun 12.

BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

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August 2019

Analyses of Adverse Drug Reactions-Nationwide Active Surveillance Network: Canadian Pharmacogenomics Network for Drug Safety Database.

J Clin Pharmacol 2019 03 19;59(3):356-363. Epub 2018 Nov 19.

Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.

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March 2019

The incidence of symptomatic osteonecrosis after allogeneic haematopoietic stem cell transplantation in children with acute lymphoblastic leukaemia - controversy on dexamethasone as a risk factor.

Br J Haematol 2019 06 8;185(5):958-959. Epub 2018 Nov 8.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

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June 2019

Tumor necrosis factor inhibitors and risk of peripheral neuropathy in patients with rheumatic diseases.

Semin Arthritis Rheum 2019 06 27;48(6):1083-1086. Epub 2018 Sep 27.

Arthritis Research Canada, Richmond, BC, Canada; Division of Rheumatology, Department of Medicine, The University of British Columbia, Vancouver, Canada.

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June 2019

Reducing anthracycline-induced cardiotoxicity through pharmacogenetics.

Pharmacogenomics 2018 10 14;19(15):1147-1150. Epub 2018 Sep 14.

Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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October 2018

Antipsychotic-Associated Symptoms of Tourette Syndrome: A Systematic Review.

CNS Drugs 2018 10;32(10):917-938

Department of Psychiatry, University of British Columbia, Room A3-111, 938 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.

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October 2018

HUME: large-scale detection of causal genetic factors of adverse drug reactions.

Bioinformatics 2018 12;34(24):4274-4283

Department of Computing Science, Simon Fraser University, Burnaby, British Columbia, Canada.

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December 2018

Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study.

J Clin Psychopharmacol 2018 Aug;38(4):349-356

Child & Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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August 2018

Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy.

PM R 2018 03 1;10(3):235-243. Epub 2017 Sep 1.

Division of Rehabilitation Medicine, Children's Mercy-Kansas City, 2401 Gillham Road, Kansas City, MO 64108; Division of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy, Kansas City, MO.

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March 2018

Risk of hair loss with different antidepressants: a comparative retrospective cohort study.

Int Clin Psychopharmacol 2018 01;33(1):44-48

Pediatrics, Division of Translational Therapeutics, Faculty of Medicine.

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January 2018

Fluoroquinolone Use and Risk of Carpal Tunnel Syndrome: A Pharmacoepidemiologic Study.

Clin Infect Dis 2017 08;65(4):684-686

Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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August 2017

Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines.

PLoS One 2017 13;12(4):e0175711. Epub 2017 Apr 13.

Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

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April 2017

Pharmacogenomic screening for anthracycline-induced cardiotoxicity in childhood cancer.

Br J Clin Pharmacol 2017 05 19;83(5):1143-1145. Epub 2017 Mar 19.

BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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May 2017

Association of Repeated Intravitreous Bevacizumab Injections With Risk for Glaucoma Surgery.

JAMA Ophthalmol 2017 04;135(4):363-368

Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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April 2017

Risk of Gambling Disorder and Impulse Control Disorder With Aripiprazole, Pramipexole, and Ropinirole: A Pharmacoepidemiologic Study.

J Clin Psychopharmacol 2017 Feb;37(1):102-104

From the Departments of *Ophthalmology and Visual Sciences, and †Psychology, University of British Columbia, Vancouver, British Columbia, Canada; ‡Department of Neurology, University of Washington, Seattle, WA; §Department of Psychiatry, ∥Division of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, and ¶Child & Family Research Institute, University of British Columbia; and #Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

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February 2017

Risk of Extrapyramidal Adverse Events With Aripiprazole.

J Clin Psychopharmacol 2016 Oct;36(5):472-4

From the *Department of Ophthalmology and Visual Sciences, University of British Columbia; †British Columbia Mental Health and Addictions Research Institute; ‡Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada; §Department of Neurology, University of Washington, Seattle, WA; ∥Department of Pediatrics, Faculty of Medicine, and ¶Child & Family Research Institute, University of British Columbia; and #Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.

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October 2016

Risk of sensorineural hearing loss with macrolide antibiotics: A nested case-control study.

Laryngoscope 2017 01 6;127(1):229-232. Epub 2016 Aug 6.

Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

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January 2017

Asthma in British Columbia: Are we finally breathing easier? A population-based study of the burden of disease over 14 years.

J Asthma 2017 04 14;54(3):308-317. Epub 2016 Jul 14.

f Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia , Vancouver , British Columbia , Canada.

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April 2017

Pharmacogenomics in Pediatric Patients: Towards Personalized Medicine.

Paediatr Drugs 2016 Aug;18(4):251-60

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands.

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August 2016

Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers.

Ther Drug Monit 2016 08;38(4):423-31

*Center for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada; †Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; ‡Child and Family Research Institute, Vancouver, British Columbia, Canada; §Department of Pediatrics, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; ¶Department of Medical Oncology, Tom Baker Cancer Center, University of Calgary, Calgary, Alberta, Canada; ‖Department of Medical Oncology, Princess Margaret Cancer Center, University of Toronto, Toronto, Ontario, Canada; **Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada; ††Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; and ‡‡Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, Bern, Switzerland.

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August 2016

Risk of Myocardial Infarction and Stroke With Single or Repeated Doses of Intravitreal Bevacizumab in Age-Related Macular Degeneration.

Am J Ophthalmol 2016 Mar 15;163:53-58. Epub 2015 Dec 15.

Pharmaceutical Outcomes Programme, British Columbia Children Hospital, Vancouver, Canada; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

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March 2016

Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.

Pharmacogenomics 2015 31;16(10):1065-76. Epub 2015 Jul 31.

Centre for Molecular Medicine & Therapeutics, Child & Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.

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June 2016

Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.

Ther Drug Monit 2015 Aug;37(4):428-36

*Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia; †Pharmaceutical Outcomes Programme, British Columbia Children's Hospital; ‡Child and Family Research Institute, Vancouver, British Columbia, Canada; §Institute of Clinical Chemistry, Inselspital Bern University Hospital, University of Bern, Switzerland; ¶Division of Clinical Pharmacology, Department of Medicine, Western University, London, Ontario, Canada; ‖Department of Pharmaceutics, University of Florida, Orlando; **CRCHUM, Centre Hospitalier de l'Université de Montréal and Faculty of Pharmacy, Université de Montréal, Québec; ††Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver; and ‡‡Division of Clinical Pharmacology and Toxicology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

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August 2015

Use of pharmacogenomics in pediatric renal transplant recipients.

Front Genet 2015 18;6:41. Epub 2015 Feb 18.

Pharmaceutical Outcomes Programme, Pediatrics, BC Children's Hospital, University of British Columbia Vancouver, BC, Canada ; Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia Vancouver, BC, Canada ; Child and Family Research Institute, University of British Columbia Vancouver, BC, Canada.

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March 2015

Codeine-related deaths: The role of pharmacogenetics and drug interactions.

Forensic Sci Int 2014 Jun 26;239:50-6. Epub 2014 Mar 26.

Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Canada; Toxicology Section, Centre of Forensic Sciences, Toronto, Canada. Electronic address:

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June 2014

Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.

Epilepsia 2014 Apr 5;55(4):496-506. Epub 2014 Mar 5.

Division of Translational Therapeutics, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada; Pharmaceutical Outcomes Programme, British Columbia Children's Hospital, Vancouver, British Columbia, Canada; Child and Family Research Institute, Vancouver, British Columbia, Canada; Department of Clinical Chemistry, University of Bern and Inselspital University Hospital, Bern, Switzerland.

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April 2014

VKORC1 and CYP2C9 genotypes are predictors of warfarin-related outcomes in children.

Pediatr Blood Cancer 2014 Jun 29;61(6):1055-62. Epub 2014 Jan 29.

Department of Pediatrics, Faculty of Medicine, University of British Columbia (UBC), Vancouver, BC, Canada; Pharmaceutical Outcomes Programme, B.C. Children's Hospital, Vancouver, BC, Canada.

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June 2014

High use of health services in patients with suboptimal asthma drug regimens: a population-based assessment in British Columbia, Canada.

Pharmacoepidemiol Drug Saf 2013 Jul 5;22(7):744-51. Epub 2013 Apr 5.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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July 2013

Cancer pharmacogenomics in children: research initiatives and progress to date.

Paediatr Drugs 2013 Apr;15(2):71-81

Department of Pediatrics, Division of Pediatric Hematology/Oncology/BMT, University of British Columbia, Vancouver, BC, Canada.

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April 2013

The use of long-acting β2- agonists as monotherapy in children and adults.

J Popul Ther Clin Pharmacol 2013 23;20(1):e1-12. Epub 2013 Jan 23.

UBC James Hogg Research Centre and the Institute for Heart & Lung Health, St. Paul’s Hospital,Vancouver, British Columbia.

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November 2013

Using pharmacogenetics to understand adverse drug reactions in children.

Paediatr Child Health 2011 Nov;16(9):537-8

Faculty of Medicine, Department of Paediatrics, University of British Columbia; ; Pharmaceutical Outcomes Programme, BC Children's Hospital; ; Child & Family Research Institute, Vancouver, British Columbia.

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November 2011

Prescription drug dispensing profiles for one million children: a population-based analysis.

Eur J Clin Pharmacol 2013 Mar 12;69(3):581-8. Epub 2012 Jul 12.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada.

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March 2013

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: the devil is in the details.

Ther Drug Monit 2012 Aug;34(4):378-80

Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada.

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August 2012

Suspected opioid overdose case resolved by CYP2D6 genotyping.

Ther Drug Monit 2012 Apr;34(2):121-3

Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Canada.

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April 2012

Diagnostic testing for vaccinomics: is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe.

OMICS 2011 Sep 5;15(9):597-605. Epub 2011 Jul 5.

Centre of Genomics and Policy, McGill University, Faculty of Medicine, Department of Human Genetics, Montreal, Canada.

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September 2011

Improving pediatric drug safety: need for more efficient clinical translation of pharmacovigilance knowledge.

J Popul Ther Clin Pharmacol 2011 21;18:e76-88. Epub 2011 Mar 21.

Departamento de Ciencias Químico Biològicas, Universidad de las Américas Puebla, México.

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August 2011

Pharmacogenomics of cardiovascular drugs and adverse effects in pediatrics.

J Cardiovasc Pharmacol 2011 Sep;58(3):228-39

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

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September 2011

Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.

Pediatrics 2010 Oct 13;126(4):e986-9. Epub 2010 Sep 13.

Motherisk Program, Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8.

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October 2010

The Canadian Pharmacogenomics Network for Drug Safety: a model for safety pharmacology.

Thyroid 2010 Jul;20(7):681-7

Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.

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July 2010

The added burden of comorbidity in patients with asthma.

J Asthma 2009 Dec;46(10):1021-6

Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

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December 2009

Statin use and the risk of Parkinson disease: a nested case control study.

J Clin Neurosci 2008 Nov 26;15(11):1272-3. Epub 2008 Sep 26.

Department of Neurology, University of Washington, Seattle VA Parkinson Disease Research Education and Clinical Center (PADRECC), VA Puget Sound Health Care System, 1660 S. Columbian Way, MS-127, Seattle, WA 98108, USA.

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November 2008

Medication errors: neonates, infants and children are the most vulnerable!

J Pediatr Pharmacol Ther 2008 Apr;13(2):65-7

Director of Pharmacy, Lucile Packard Children's Hospital at Stanford and Stanford School of Medicine, Department of Pediatrics Neonatal and Developmental Medicine, Palo Alto, California.

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April 2008

Identifying persons with treated asthma using administrative data via latent class modelling.

Health Serv Res 2008 Apr;43(2):733-54

Pharmaceutical Outcomes Programme, Children's and Women's Health Centre of British Columbia, University of British Columbia, 4480 Oak Street, Room B404, Vancouver, BC, Canada V6H 3V4.

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April 2008

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: a retrospective cohort study.

J Clin Neurosci 2008 May 14;15(5):576-7. Epub 2008 Mar 14.

Center for Clinical Epidemiology and Evaluation, Vancouver General Hospital, Vancouver, British Columbia, Canada.

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May 2008

Paediatric adverse drug reaction reporting: understanding and future directions.

Can J Clin Pharmacol 2007 12;14(1):e45-57. Epub 2007 Feb 12.

Faculty of Pharmaceutical Sciences, University of British Columbia, Canada.

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March 2007