Bruce C Baguley

Bruce C Baguley

UNVERIFIED PROFILE

Are you Bruce C Baguley?   Register this Author

Register author
Bruce C Baguley

Bruce C Baguley

Publications by authors named "Bruce C Baguley"

Are you Bruce C Baguley?   Register this Author

100Publications

1770Reads

16Profile Views

Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

Bioorg Med Chem 2019 Apr 25;27(8):1529-1545. Epub 2019 Feb 25.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2019.02.050DOI Listing
April 2019

Correction: Sarkar, D., et al. Multiple Isoforms of in Melanoma Cells: Structural Complexity Suggests Variations in Processing. 2017, , 1378.

Int J Mol Sci 2018 05 2;19(5). Epub 2018 May 2.

Auckland Cancer Society Research Centre, University of Auckland, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd. Grafton, 1023 Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms19051343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983800PMC
May 2018

Optimization of Weight Ratio for DSPE-PEG/TPGS Hybrid Micelles to Improve Drug Retention and Tumor Penetration.

Pharm Res 2018 01 4;35(1):13. Epub 2018 Jan 4.

Department of Pharmaceutics, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-017-2340-yDOI Listing
January 2018

Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.

Bioorg Med Chem 2017 10 20;25(20):5859-5874. Epub 2017 Sep 20.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2017.09.025DOI Listing
October 2017

Multiple Isoforms of ANRIL in Melanoma Cells: Structural Complexity Suggests Variations in Processing.

Int J Mol Sci 2017 Jun 27;18(7). Epub 2017 Jun 27.

Auckland Cancer Society Research Centre, University of Auckland, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd. Grafton, 1023 Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms18071378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5535871PMC
June 2017

PIK3CA-mutated melanoma cells rely on cooperative signaling through mTORC1/2 for sustained proliferation.

Pigment Cell Melanoma Res 2017 05 20;30(3):353-367. Epub 2017 Apr 20.

Helen Diller Family Comprehensive Cancer Center, Department of Cellular & Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pcmr.12586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411292PMC
May 2017

Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors.

Bioorg Med Chem Lett 2017 01 25;27(2):187-190. Epub 2016 Nov 25.

Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Department of Molecular Medicine and Pathology, School of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2016.11.078DOI Listing
January 2017

Selected GRIN2A mutations in melanoma cause oncogenic effects that can be modulated by extracellular glutamate.

Cell Calcium 2016 12 14;60(6):384-395. Epub 2016 Sep 14.

Department of Molecular Medicine and Pathology, University of Auckland, Private Bag 92019, Auckland, New Zealand; LabPlus Haematology, Auckland City Hospital, Private Bag 92024, Auckland, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ceca.2016.09.003DOI Listing
December 2016

Optimization of the formation of embedded multicellular spheroids of MCF-7 cells: How to reliably produce a biomimetic 3D model.

Anal Biochem 2016 Dec 5;515:47-54. Epub 2016 Oct 5.

Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, PR China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ab.2016.10.004DOI Listing
December 2016

Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance.

Authors:
Bruce C Baguley

Methods Mol Biol 2016 ;1395:19-37

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3347-1_2DOI Listing
November 2016

The Regulatory Role of Long Noncoding RNAs in Cancer Drug Resistance.

Methods Mol Biol 2016 ;1395:207-27

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-3347-1_12DOI Listing
November 2016

ZFAS1: a long noncoding RNA associated with ribosomes in breast cancer cells.

Biol Direct 2016 11 21;11(1):62. Epub 2016 Nov 21.

Auckland Cancer Society Research Centre, University of Auckland, 85 Park Rd, Grafton, Auckland, 1023, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13062-016-0165-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117590PMC
November 2016

Differences in the carcinogenic evaluation of glyphosate between the International Agency for Research on Cancer (IARC) and the European Food Safety Authority (EFSA).

Authors:
Christopher J Portier Bruce K Armstrong Bruce C Baguley Xaver Baur Igor Belyaev Robert Bellé Fiorella Belpoggi Annibale Biggeri Maarten C Bosland Paolo Bruzzi Lygia Therese Budnik Merete D Bugge Kathleen Burns Gloria M Calaf David O Carpenter Hillary M Carpenter Lizbeth López-Carrillo Richard Clapp Pierluigi Cocco Dario Consonni Pietro Comba Elena Craft Mohamed Aqiel Dalvie Devra Davis Paul A Demers Anneclaire J De Roos Jamie DeWitt Francesco Forastiere Jonathan H Freedman Lin Fritschi Caroline Gaus Julia M Gohlke Marcel Goldberg Eberhard Greiser Johnni Hansen Lennart Hardell Michael Hauptmann Wei Huang James Huff Margaret O James C W Jameson Andreas Kortenkamp Annette Kopp-Schneider Hans Kromhout Marcelo L Larramendy Philip J Landrigan Lawrence H Lash Dariusz Leszczynski Charles F Lynch Corrado Magnani Daniele Mandrioli Francis L Martin Enzo Merler Paola Michelozzi Lucia Miligi Anthony B Miller Dario Mirabelli Franklin E Mirer Saloshni Naidoo Melissa J Perry Maria Grazia Petronio Roberta Pirastu Ralph J Portier Kenneth S Ramos Larry W Robertson Theresa Rodriguez Martin Röösli Matt K Ross Deodutta Roy Ivan Rusyn Paulo Saldiva Jennifer Sass Kai Savolainen Paul T J Scheepers Consolato Sergi Ellen K Silbergeld Martyn T Smith Bernard W Stewart Patrice Sutton Fabio Tateo Benedetto Terracini Heinz W Thielmann David B Thomas Harri Vainio John E Vena Paolo Vineis Elisabete Weiderpass Dennis D Weisenburger Tracey J Woodruff Takashi Yorifuji Il Je Yu Paola Zambon Hajo Zeeb Shu-Feng Zhou

J Epidemiol Community Health 2016 08 3;70(8):741-5. Epub 2016 Mar 3.

College of Pharmacy, University of South Florida, Tampa, Florida, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/jech-2015-207005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975799PMC
August 2016

Signaling Pathways in Melanogenesis.

Int J Mol Sci 2016 Jul 15;17(7). Epub 2016 Jul 15.

Department of Molecular Medicine and Pathology, University of Auckland, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd. Grafton, Auckland 1023, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms17071144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4964517PMC
July 2016

Improving drug retention in liposomes by aging with the aid of glucose.

Int J Pharm 2016 May 25;505(1-2):194-203. Epub 2016 Mar 25.

School of Pharmacy, The University of Auckland, Auckland 1142, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2016.03.044DOI Listing
May 2016

Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.

Cancer Cell Int 2016 10;16:18. Epub 2016 Mar 10.

Auckland Cancer Society Research Centre, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand ; Molecular Medicine and Pathology Department, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-016-0293-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785615PMC
March 2016

Epigenetic regulation in human melanoma: past and future.

Epigenetics 2015 ;10(2):103-21

a Auckland Cancer Society Research Center ; University of Auckland ; Auckland , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15592294.2014.1003746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622872PMC
October 2015

Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.

Bioorg Med Chem 2015 Jul 4;23(13):3796-808. Epub 2015 Apr 4.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2015.03.073DOI Listing
July 2015

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth.

Front Oncol 2015 16;5:135. Epub 2015 Jun 16.

Auckland Cancer Society Research Centre, The University of Auckland , Auckland , New Zealand ; Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland , Auckland , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2015.00135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468830PMC
July 2015

Strategies to maximize liposomal drug loading for a poorly water-soluble anticancer drug.

Pharm Res 2015 Apr 30;32(4):1451-61. Epub 2014 Oct 30.

School of Pharmacy, The University of Auckland, 1142, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-014-1551-8DOI Listing
April 2015

Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation.

J Control Release 2015 Apr 19;203:161-9. Epub 2015 Feb 19.

School of Pharmacy, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2015.02.026DOI Listing
April 2015

Retrotransposon hypomethylation in melanoma and expression of a placenta-specific gene.

PLoS One 2014 23;9(4):e95840. Epub 2014 Apr 23.

Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand; Gravida: National Centre for Growth and Development, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0095840PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997481PMC
January 2015

Evidence for the existence of triple-negative variants in the MCF-7 breast cancer cell population.

Biomed Res Int 2014 4;2014:836769. Epub 2014 Mar 4.

Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2014/836769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960520PMC
December 2014

Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma.

Cancer Discov 2014 Dec 24;4(12):1418-29. Epub 2014 Sep 24.

Department of Genetics, University of North Carolina School of Medicine, Chapel Hill, North Carolina. The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2159-8290.CD-14-0729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258185PMC
December 2014

Keeping abreast with long non-coding RNAs in mammary gland development and breast cancer.

Front Genet 2014 31;5:379. Epub 2014 Oct 31.

Auckland Cancer Society Research Centre, University of Auckland Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2014.00379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215690PMC
November 2014

Preliminary Evidence That High-Dose Vitamin C has a Vascular Disrupting Action in Mice.

Front Oncol 2014 5;4:310. Epub 2014 Nov 5.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland , Auckland , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2014.00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220656PMC
November 2014

Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: stability, solubility, lipophilicity and ionization.

Int J Pharm 2014 Oct 28;473(1-2):528-35. Epub 2014 Jul 28.

School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 114, New Zealand. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2014.07.033DOI Listing
October 2014

Selective cellular uptake and retention of SN 28049, a new DNA-binding topoisomerase II-directed antitumor agent.

Cancer Chemother Pharmacol 2014 Jul 7;74(1):25-35. Epub 2014 May 7.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-014-2469-xDOI Listing
July 2014

Review of high-dose intravenous vitamin C as an anticancer agent.

Asia Pac J Clin Oncol 2014 Mar;10(1):22-37

Auckland City Hospital, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajco.12173DOI Listing
March 2014

Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival.

Front Oncol 2014 Jan 13;3:333. Epub 2014 Jan 13.

Department of Molecular Medicine and Pathology, School of Medical Sciences, University of Auckland , Auckland , New Zealand ; LabPlus Haematology, Auckland District Health Board , Auckland , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2013.00333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888952PMC
January 2014

Tumour tissue selectivity in the uptake and retention of SN 28049, a new topoisomerase II-directed anticancer agent.

Cancer Chemother Pharmacol 2013 Nov 14;72(5):1013-22. Epub 2013 Sep 14.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00280-013-2280
Web Search
http://link.springer.com/10.1007/s00280-013-2280-0
Publisher Site
http://dx.doi.org/10.1007/s00280-013-2280-0DOI Listing
November 2013

Variable Expression of GLIPR1 Correlates with Invasive Potential in Melanoma Cells.

Front Oncol 2013 30;3:225. Epub 2013 Aug 30.

School of Pharmacy, University of Otago , Dunedin , New Zealand ; Department of Pathology, Dunedin School of Medicine, University of Otago , Dunedin , New Zealand ; Department of Biochemistry, Otago School of Medical Sciences, University of Otago , Dunedin , New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2013.00225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757444PMC
September 2013

Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.

Front Genet 2013 31;4:97. Epub 2013 May 31.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2013.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668138PMC
June 2013

Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors.

Front Genet 2013 8;4:66. Epub 2013 May 8.

Department of Obstetrics and Gynaecology, The University of Auckland Auckland, New Zealand ; Auckland Cancer Society Research Centre, The University of Auckland Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fgene.2013.00
Publisher Site
http://dx.doi.org/10.3389/fgene.2013.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647113PMC
May 2013

The role of the hippo pathway in melanocytes and melanoma.

Front Oncol 2013 16;3:123. Epub 2013 May 16.

Faculty of Medical and Health Sciences, Auckland Cancer Society Research Centre, The University of Auckland Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2013.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655322PMC
May 2013

Therapeutic reactivation of mutant p53 protein by quinazoline derivatives.

Invest New Drugs 2012 Oct 13;30(5):2035-45. Epub 2011 Sep 13.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-011-9744-zDOI Listing
October 2012

Mathematical determination of cell population doubling times for multiple cell lines.

Bull Math Biol 2012 Oct 23;74(10):2510-34. Epub 2012 Aug 23.

Biomathematics Research Centre, Department of Mathematics and Statistics, University of Canterbury, Christchurch, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11538-012-9764-7DOI Listing
October 2012

Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics.

Cancer Chemother Pharmacol 2012 Jul 3;70(1):151-60. Epub 2012 Jun 3.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00280-012-1892-0
Publisher Site
http://dx.doi.org/10.1007/s00280-012-1892-0DOI Listing
July 2012

A rapid LC-MS/MS method for the quantitation of a series of benzonaphthyridine derivatives: application to in vivo pharmacokinetic and lipophilicity studies in drug development.

J Pharm Biomed Anal 2012 Apr 28;63:9-16. Epub 2012 Jan 28.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2012.01.022DOI Listing
April 2012

In vivo and in vitro assessment of the action of SN 28049, a benzonaphthyridine derivative targeting topoisomerase II, on the murine Colon 38 carcinoma.

Invest New Drugs 2011 Dec 10;29(6):1504-10. Epub 2010 Aug 10.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-010-9509-0DOI Listing
December 2011

Action of SN 28049, a new DNA binding topoisomerase II-directed antitumour drug: comparison with doxorubicin and etoposide.

Invest New Drugs 2011 Oct 22;29(5):1102-10. Epub 2010 Jun 22.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-010-9473-8DOI Listing
October 2011

Centrosomal dysregulation in human metastatic melanoma cell lines.

Cancer Genet 2011 Sep;204(9):477-85

Auckland Cancer Society Research Centre, The University of Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cancergen.2011.07.001DOI Listing
September 2011

Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells.

Cancer Biol Ther 2011 Jun 1;11(11):938-46. Epub 2011 Jun 1.

Auckland Cancer Society Research Centre, University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127046PMC
http://dx.doi.org/10.4161/cbt.11.11.15527DOI Listing
June 2011

Preclinical efficacy of vascular disrupting agents in non-small-cell lung cancer.

Authors:
Bruce C Baguley

Clin Lung Cancer 2011 Mar 8;12(2):81-6. Epub 2011 Apr 8.

Auckland Cancer Society Research Centre, The University of Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2011.03.001DOI Listing
March 2011

PAX3 knockdown in metastatic melanoma cell lines does not reduce MITF expression.

Melanoma Res 2011 Feb;21(1):24-34

aDepartment of Pathology, Dunedin School of Medicine, University of Otago, Dunedin bAuckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CMR.0b013e328341c7e0DOI Listing
February 2011

The paradox of cancer cell apoptosis.

Authors:
Bruce C Baguley

Front Biosci (Landmark Ed) 2011 Jan 1;16:1759-67. Epub 2011 Jan 1.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2741/3819DOI Listing
January 2011

Multiple drug resistance mechanisms in cancer.

Authors:
Bruce C Baguley

Mol Biotechnol 2010 Nov;46(3):308-16

Auckland Cancer Society Research Centre, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12033-010-9321-2DOI Listing
November 2010

Temporal aspects of the action of ASA404 (vadimezan; DMXAA).

Expert Opin Investig Drugs 2010 Nov;19(11):1413-25

The University of Auckland, Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543784.2010.529128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583340PMC
November 2010

ASA404: a tumor vascular-disrupting agent with broad potential for cancer therapy.

Future Oncol 2010 Oct;6(10):1537-43

Auckland Cancer Society Research Center, Faculty of Medical & Health Sciences, The University of Auckland, New Zealand.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/fon.10.122
Publisher Site
http://dx.doi.org/10.2217/fon.10.122DOI Listing
October 2010

The ubiquitin-proteasome system is inhibited by p53 protein expression in human ovarian cancer cells.

Cancer Lett 2010 Aug 13;294(1):82-90. Epub 2010 Feb 13.

Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2010.01.025DOI Listing
August 2010

Pharmacokinetics and distribution of SN 28049, a novel DNA binding anticancer agent, in mice.

Cancer Chemother Pharmacol 2010 May 23;65(6):1145-52. Epub 2009 Sep 23.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-009-1123-5DOI Listing
May 2010

Disrupting established tumor blood vessels: an emerging therapeutic strategy for cancer.

Cancer 2010 Apr;116(8):1859-71

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Grafton, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cncr.24975DOI Listing
April 2010

Pharmacokinetics and pharmacodynamics of chlorambucil delivered in long-circulating nanoemulsion.

J Drug Target 2010 Feb;18(2):125-33

School of Pharmacy, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/10611860903244199DOI Listing
February 2010

Multidrug resistance in cancer.

Authors:
Bruce C Baguley

Methods Mol Biol 2010 ;596:1-14

Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-60761-416-6_1DOI Listing
January 2010

Activin is a potent growth suppressor of epithelial ovarian cancer cells.

Cancer Lett 2009 Nov 2;285(2):157-65. Epub 2009 Jun 2.

Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2009.05.010DOI Listing
November 2009

Using a stem cell and progeny model to illustrate the relationship between cell cycle times of in vivo human tumour cell tissue populations, in vitro primary cultures and the cell lines derived from them.

J Theor Biol 2009 Oct 30;260(4):563-71. Epub 2009 Jun 30.

Biomathematics Research Centre, Department of Mathematics and Statistics, University of Canterbury, Private Bag 4800, Christchurch 8140, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtbi.2009.06.019DOI Listing
October 2009

Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.

Invest New Drugs 2009 Jun 12;27(3):280-4. Epub 2008 Aug 12.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-008-9167-7DOI Listing
June 2009

Formulation and pharmacokinetic evaluation of an asulacrine nanocrystalline suspension for intravenous delivery.

Int J Pharm 2009 Feb 21;367(1-2):179-86. Epub 2008 Sep 21.

School of Pharmacy, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2008.09.022DOI Listing
February 2009

Development and validation of a liquid chromatography-mass spectrometry (LC-MS) assay for the determination of the anti-cancer agent N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide (SN 28049).

J Chromatogr B Analyt Technol Biomed Life Sci 2008 Nov 26;875(2):368-72. Epub 2008 Sep 26.

Auckland Cancer Society Research Centre, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2008.09.023DOI Listing
November 2008

The role of topoisomerases and RNA transcription in the action of the antitumour benzonaphthyridine derivative SN 28049.

Cancer Chemother Pharmacol 2008 Oct 3;62(5):753-62. Epub 2008 Jan 3.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019 Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00280-007-0660
Web Search
http://link.springer.com/10.1007/s00280-007-0660-z
Publisher Site
http://dx.doi.org/10.1007/s00280-007-0660-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500182PMC
October 2008

Pharmacokinetics and pharmacodynamics of chlorambucil delivered in parenteral emulsion.

Int J Pharm 2008 Aug 22;360(1-2):115-21. Epub 2008 Apr 22.

School of Pharmacy, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2008.04.027DOI Listing
August 2008

Population pharmacokinetic-pharmacodynamic model of the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid in cancer patients.

Clin Cancer Res 2008 Apr;14(7):2102-10

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-07-1475DOI Listing
April 2008

Consequences of increased vascular permeability induced by treatment of mice with 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and thalidomide.

Cancer Chemother Pharmacol 2008 Mar 1;61(3):497-502. Epub 2007 May 1.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00280-007-0495-7
Publisher Site
http://dx.doi.org/10.1007/s00280-007-0495-7DOI Listing
March 2008

In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake.

J Inorg Biochem 2008 Feb 26;102(2):303-10. Epub 2007 Sep 26.

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland 1142, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jinorgbio.2007.09.003DOI Listing
February 2008

The use of human tumour cell lines in the discovery of new cancer chemotherapeutic drugs.

Expert Opin Drug Discov 2008 Feb;3(2):153-61

Professor and Co-Director The University of Auckland, Auckland Cancer Society Research Centre, Auckland 1142, New Zealand +64 9 3737599 ; +649 3737502 ;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/17460441.3.2.153DOI Listing
February 2008

Development and validation of bioanalytical method for the determination of asulacrine in plasma by liquid chromatography.

J Pharm Biomed Anal 2008 Jan 2;46(2):386-90. Epub 2007 Oct 2.

School of Pharmacy, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2007.09.025DOI Listing
January 2008

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

Bioorg Med Chem 2007 Dec 4;15(24):7677-87. Epub 2007 Sep 4.

Auckland Cancer Society Research Centre, School of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1020, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2007.08.062DOI Listing
December 2007

Evidence for the involvement of p38 MAP kinase in the action of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

Invest New Drugs 2007 Jun 3;25(3):271-6. Epub 2007 Jan 3.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-006-9029-0DOI Listing
June 2007

Antitumour action of 5,6-dimethylxanthenone-4-acetic acid in rats bearing chemically induced primary mammary tumours.

Cancer Chemother Pharmacol 2007 Apr 31;59(5):661-9. Epub 2006 Aug 31.

Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, Private bag 92019, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00280-006-0321-7DOI Listing
April 2007

NF-kappaB-independent induction of endothelial cell apoptosis by the vascular disrupting agent DMXAA.

Anticancer Res 2007 Jan-Feb;27(1A):327-34

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
March 2007

Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-kappaB inhibitors.

Oncol Res 2006 ;16(1):1-14

Auckland Cancer Society Research Center, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3727/000000006783981288DOI Listing
August 2006

Do negative feedback oscillations drive variations in the length of the tumor cell division cycle?

Oncol Res 2005 ;15(6):291-4

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3727/096504005776404544DOI Listing
March 2006

A comparison of the ability of DMXAA and xanthenone analogues to activate NF-kappaB in murine and human cell lines.

Oncol Res 2005 ;15(7-8):351-64

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3727/096504005776449743DOI Listing
March 2006

5,6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: a phase I safety study of a vascular disrupting agent.

Clin Cancer Res 2006 Mar;12(6):1776-84

Department of Pharmacology and Clinical Pharmacology, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-05-1939DOI Listing
March 2006

Phenazine-1-carboxamides: structure-cytotoxicity relationships for 9-substituents and changes in the H-bonding pattern of the cationic side chain.

Bioorg Med Chem 2006 Feb 10;14(4):1160-8. Epub 2005 Oct 10.

Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2005.09.032DOI Listing
February 2006

Tumor stem cell niches: a new functional framework for the action of anticancer drugs.

Authors:
Bruce C Baguley

Recent Pat Anticancer Drug Discov 2006 Jan;1(1):121-7

Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/157489206775246494DOI Listing
January 2006

Modelling the flow [corrected] cytometric data obtained from unperturbed human tumour cell lines: parameter fitting and comparison.

Bull Math Biol 2005 Jul 15;67(4):815-30. Epub 2004 Dec 15.

Max Planck Institute for Mathematics in the Sciences, Inselstrasse 22-26, 04103 Leipzig, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bulm.2004.10.003DOI Listing
July 2005

Disrupting tumour blood vessels.

Nat Rev Cancer 2005 Jun;5(6):423-35

Academic Unit of Surgical Oncology, Division of Clinical Sciences, University of Sheffield, Floor K, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrc1628
Publisher Site
http://dx.doi.org/10.1038/nrc1628DOI Listing
June 2005