Bruce Beutler

Bruce Beutler

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Bruce Beutler

Publications by authors named "Bruce Beutler"

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Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.

Nat Immunol 2019 Oct 19;20(10):1322-1334. Epub 2019 Aug 19.

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1038/s41590-019-0464-4DOI Listing
October 2019

B-1a Cell Development in Splenectomized Neonatal Mice.

Front Immunol 2018 30;9:1738. Epub 2018 Jul 30.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.3389/fimmu.2018.01738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077197PMC
September 2019

Research Techniques Made Simple: Forward Genetic Screening to Uncover Genes Involved in Skin Biology.

J Invest Dermatol 2019 Sep;139(9):1848-1853.e1

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Internal Medicine, Division of Gastroenterology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2019.04.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711397PMC
September 2019

Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR.

J Exp Med 2019 Sep 26. Epub 2019 Sep 26.

Oral and Craniofacial Biomedicine PhD Program, University of North Carolina at Chapel Hill, Chapel Hill, NC

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http://dx.doi.org/10.1084/jem.20190111DOI Listing
September 2019

Structural Basis of TLR2/TLR1 Activation by the Synthetic Agonist Diprovocim.

J Med Chem 2019 Mar 13;62(6):2938-2949. Epub 2019 Mar 13.

Department of Chemistry , The Scripps Research Institute , La Jolla , California 92037 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01583
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http://dx.doi.org/10.1021/acs.jmedchem.8b01583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537610PMC
March 2019

Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists.

J Am Chem Soc 2018 10 16;140(43):14440-14454. Epub 2018 Oct 16.

Department of Chemistry and the Skaggs Institute of Chemical Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 United States.

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http://pubs.acs.org/doi/10.1021/jacs.8b09223
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http://dx.doi.org/10.1021/jacs.8b09223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209530PMC
October 2018

Intracellular lipid metabolism impairs β cell compensation during diet-induced obesity.

J Clin Invest 2018 03 19;128(3):1178-1189. Epub 2018 Feb 19.

Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern (UTSW) Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1172/JCI97702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824868PMC
March 2018

Altered Marginal Zone B Cell Selection in the Absence of IκBNS.

J Immunol 2018 01 8;200(2):775-787. Epub 2017 Dec 8.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, S-171 77 Stockholm, Sweden;

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http://dx.doi.org/10.4049/jimmunol.1700791DOI Listing
January 2018

Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.

Proc Natl Acad Sci U S A 2017 06 12;114(26):E5197-E5206. Epub 2017 Jun 12.

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505;

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http://dx.doi.org/10.1073/pnas.1705312114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495269PMC
June 2017

Creatine maintains intestinal homeostasis and protects against colitis.

Proc Natl Acad Sci U S A 2017 02 30;114(7):E1273-E1281. Epub 2017 Jan 30.

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505;

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http://www.pnas.org/content/early/2017/01/25/1621400114.full
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http://dx.doi.org/10.1073/pnas.1621400114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321020PMC
February 2017

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity.

Cell 2017 02;168(5):789-800.e10

Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, 75015 Paris, France; Paris Descartes University, Imagine Institute, 75015 Paris, France; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.01.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328639PMC
February 2017

Innate immunity and the new forward genetics.

Authors:
Bruce Beutler

Best Pract Res Clin Haematol 2016 12 21;29(4):379-387. Epub 2016 Oct 21.

Center for the Genetics of Host Defense, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8505, United States. Electronic address:

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http://dx.doi.org/10.1016/j.beha.2016.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179328PMC
December 2016

Reconstruction of the Mouse Inflammasome System in HEK293T Cells.

Bio Protoc 2016 Nov;6(21)

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.21769/BioProtoc.1986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5431583PMC
November 2016

K Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.

Immunity 2016 10 27;45(4):761-773. Epub 2016 Sep 27.

Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München (TUM), 81675 Munich, Germany; TranslaTUM: Zentralinstitut für translationale Krebsforschung, TUM, 81675 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.08.010DOI Listing
October 2016

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

Proc Natl Acad Sci U S A 2016 10 5;113(42):E6418-E6426. Epub 2016 Oct 5.

Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;

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http://dx.doi.org/10.1073/pnas.1614467113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081616PMC
October 2016

Inhibiting TLR9 and other UNC93B1-dependent TLRs paradoxically increases accumulation of MYD88L265P plasmablasts in vivo.

Blood 2016 09 25;128(12):1604-8. Epub 2016 Jul 25.

Australian Cancer Research Foundation Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia;

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http://dx.doi.org/10.1182/blood-2016-03-708065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034740PMC
September 2016

Finding New Components of the Mammalian Immune System.

Authors:
Bruce Beutler

Rambam Maimonides Med J 2016 Jul 28;7(3). Epub 2016 Jul 28.

Nobe Prize Laureate in Physiology or Medicine, 2011. From the Center for Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.5041/RMMJ.10245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5005066PMC
July 2016

Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists.

J Med Chem 2016 05 25;59(10):4812-30. Epub 2016 Apr 25.

Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882283PMC
May 2016

Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection.

Proc Natl Acad Sci U S A 2015 Oct 5;112(42):E5706-14. Epub 2015 Oct 5.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1073/pnas.1515619112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620900PMC
October 2015

Current strategies for mutation detection in phenotype-driven screens utilising next generation sequencing.

Mamm Genome 2015 Oct 8;26(9-10):486-500. Epub 2015 Oct 8.

Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell Campus, Oxfordshire, OX11 0RD, UK.

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http://link.springer.com/10.1007/s00335-015-9603-x
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http://dx.doi.org/10.1007/s00335-015-9603-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602060PMC
October 2015

Q&A: Chance encounters.

Nature 2015 Oct;526(7574):S59-60

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http://dx.doi.org/10.1038/526S59aDOI Listing
October 2015

Sox17 regulates liver lipid metabolism and adaptation to fasting.

PLoS One 2014 20;9(8):e104925. Epub 2014 Aug 20.

Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille University, UM2, Marseille, France; Institut National de la Santé et de la Recherche Médicale (INSERM), U1104, Marseille, France; Centre National de la Recherche Scientifique (CNRS), UMR7280, Marseille, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104925PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139292PMC
May 2015

Soluble human TLR2 ectodomain binds diacylglycerol from microbial lipopeptides and glycolipids.

Innate Immun 2015 Feb 3;21(2):175-93. Epub 2014 Mar 3.

Department of Integrative Structural and Computational Biology, and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA

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http://dx.doi.org/10.1177/1753425914524077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392886PMC
February 2015

Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.

Immunol Cell Biol 2015 Feb 14;93(2):136-46. Epub 2014 Oct 14.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1038/icb.2014.82DOI Listing
February 2015

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.

Proc Natl Acad Sci U S A 2014 Sep 16;111(39):E4119-26. Epub 2014 Sep 16.

Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden; and

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http://dx.doi.org/10.1073/pnas.1415866111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191775PMC
September 2014

A gain-of-function voltage-gated sodium channel 1.8 mutation drives intense hyperexcitability of A- and C-fiber neurons.

Pain 2014 May 18;155(5):896-905. Epub 2014 Jan 18.

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.pain.2014.01.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989381PMC
May 2014

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance.

J Exp Med 2014 Mar 17;211(3):413-26. Epub 2014 Feb 17.

Department of Immunology, John Curtin School of Medical Research, 2 Australian Phenomics Facility, The Australian National University, Canberra, Australian Capital Territory 0200, Australia.

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http://www.jem.org/lookup/doi/10.1084/jem.20131424
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http://dx.doi.org/10.1084/jem.20131424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949567PMC
March 2014

Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice".

Nat Immunol 2013 Nov;14(11):1102-3

Institute of Medicine and Dentistry, Niigata University, Niigata, Japan.

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http://dx.doi.org/10.1038/ni.2734DOI Listing
November 2013

A conversation with Bruce Beutler. Interview by Ushma S. Neill.

Authors:
Bruce Beutler

J Clin Invest 2013 Sep 3;123(9):3637-8. Epub 2013 Sep 3.

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http://dx.doi.org/10.1172/JCI71317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754279PMC
September 2013

Going forward with genetics: recent technological advances and forward genetics in mice.

Am J Pathol 2013 May;182(5):1462-73

Center for Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75235-8505, USA.

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http://dx.doi.org/10.1016/j.ajpath.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644711PMC
May 2013

The central answer. Interview by Kristie Nybo.

Authors:
Bruce Beutler

Biotechniques 2013 May;54(5):241

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May 2013

Bruce Beutler: the persistent prospector. Interview by Ruth Williams.

Authors:
Bruce Beutler

Circ Res 2013 Mar;112(5):751-4

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http://dx.doi.org/10.1161/CIRCRESAHA.113.301093DOI Listing
March 2013

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):2940-5. Epub 2013 Feb 4.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1222798110
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http://dx.doi.org/10.1073/pnas.1222798110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581947PMC
February 2013

Creating diseases to understand what prevents them: genetic analysis of inflammation in the gastrointestinal tract.

Curr Opin Immunol 2012 Dec 1;24(6):678-85. Epub 2012 Nov 1.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, United States.

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http://dx.doi.org/10.1016/j.coi.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729218PMC
December 2012

The BTB-ZF transcription factors.

Cell Cycle 2012 Sep 16;11(18):3358-69. Epub 2012 Aug 16.

Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.4161/cc.21277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466544PMC
September 2012

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13733-8. Epub 2012 Aug 6.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1211499109
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http://dx.doi.org/10.1073/pnas.1211499109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427069PMC
August 2012

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

Proc Natl Acad Sci U S A 2012 Jul 3;109(31):12286-93. Epub 2012 Jul 3.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1209134109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411946PMC
July 2012

QnAs with Bruce Beutler. Interview by Nicholette Zeliadt.

Authors:
Bruce Beutler

Proc Natl Acad Sci U S A 2012 Jul 16;109(31):12265. Epub 2012 Jul 16.

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http://dx.doi.org/10.1073/pnas.1210583109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411980PMC
July 2012

iRhom2 is required for the secretion of mouse TNFα.

Blood 2012 Jun 1;119(24):5769-71. Epub 2012 May 1.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2012-03-417949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382936PMC
June 2012

Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.

J Virol 2012 Feb 23;86(3):1802-8. Epub 2011 Nov 23.

Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1128/JVI.05660-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3264364PMC
February 2012

ZBTB1 is a determinant of lymphoid development.

J Exp Med 2012 Jan 26;209(1):19-27. Epub 2011 Dec 26.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1084/jem.20112084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260866PMC
January 2012

Inflammatory bowel disease and ADAM17 deletion.

N Engl J Med 2012 01;366(2):190; author reply 190

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http://dx.doi.org/10.1056/NEJMc1113859DOI Listing
January 2012

Prion-like behavior of MAVS in RIG-I signaling.

Cell Res 2011 Dec 20;21(12):1643-5. Epub 2011 Sep 20.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1038/cr.2011.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357987PMC
December 2011

Mutation of the gastric hydrogen-potassium ATPase alpha subunit causes iron-deficiency anemia in mice.

Blood 2011 Dec 5;118(24):6418-25. Epub 2011 Oct 5.

Department of Genetics, The Scripps Research Institute, La Jolla, CA, USA.

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http://dx.doi.org/10.1182/blood-2011-04-350082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236123PMC
December 2011

Intracellular nucleic acid sensors and autoimmunity.

J Interferon Cytokine Res 2011 Dec 27;31(12):867-86. Epub 2011 Oct 27.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92137, USA.

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http://dx.doi.org/10.1089/jir.2011.0092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234494PMC
December 2011

Resisting viral infection: the gene by gene approach.

Curr Opin Virol 2011 Dec 6;1(6):513-8. Epub 2011 Nov 6.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.coviro.2011.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131635PMC
December 2011

The role of Vldlr in intraretinal angiogenesis in mice.

Invest Ophthalmol Vis Sci 2011 Aug 22;52(9):6572-9. Epub 2011 Aug 22.

School of Optometry and Vision Science Program, University of California, Berkeley, USA.

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http://jov.arvojournals.org/data/Journals/IOVS/933460/z7g009
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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.10-7082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176028PMC
August 2011

ATP-sensitive potassium channel (K(ATP))-dependent regulation of cardiotropic viral infections.

Proc Natl Acad Sci U S A 2011 Jul 30;108(29):12024-9. Epub 2011 Jun 30.

Centre National de la Recherche Scientifique, Unité Propre de Recherche 9022, Institut de Biologie Moléculaire et Cellulaire, Université de Strasbourg, 67 084 Strasbourg Cedex, France.

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http://dx.doi.org/10.1073/pnas.1108926108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141999PMC
July 2011

Toll-like receptors.

Curr Biol 2011 Jul;21(13):R488-93

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822110059
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http://dx.doi.org/10.1016/j.cub.2011.05.039DOI Listing
July 2011

Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice.

Blood 2011 Jun 6;117(24):6582-8. Epub 2011 May 6.

Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1182/blood-2011-01-329607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123024PMC
June 2011

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.

Nat Immunol 2011 May 20;12(5):434-40. Epub 2011 Mar 20.

Department of Genetics, The Scripps Research Institute, La Jolla, California, USA.

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http://www.nature.com/articles/ni.2012
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http://dx.doi.org/10.1038/ni.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079768PMC
May 2011

X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.

Proc Natl Acad Sci U S A 2011 May 25;108(19):7890-5. Epub 2011 Apr 25.

Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.1104631108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093471PMC
May 2011

Special delivery: granulin brings CpG DNA to Toll-like receptor 9.

Immunity 2011 Apr;34(4):453-5

Department of Genetics, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093957PMC
April 2011

Rapid identification of a disease allele in mouse through whole genome sequencing and bulk segregation analysis.

Genetics 2011 Mar 31;187(3):633-41. Epub 2010 Dec 31.

Department of Genetics, Institute for Childhood and Neglected Disease, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1534/genetics.110.124586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063661PMC
March 2011

Impact of β2 integrin deficiency on mouse natural killer cell development and function.

Blood 2011 Mar 14;117(10):2874-82. Epub 2011 Jan 14.

Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille, France.

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http://dx.doi.org/10.1182/blood-2010-10-315457DOI Listing
March 2011

Ernest Beutler: his life and contribution to medical science.

Br J Haematol 2011 Mar 17;152(5):543-50. Epub 2011 Jan 17.

Redlands Community Hospital, Redlands, CA, USA.

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http://dx.doi.org/10.1111/j.1365-2141.2010.08542.xDOI Listing
March 2011

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

Cell Host Microbe 2011 Mar;9(3):212-222

Department of Immunology and Microbial Sciences, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/j.chom.2011.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058147PMC
March 2011

How host defense is encoded in the mammalian genome.

Mamm Genome 2011 Feb 25;22(1-2):1-5. Epub 2010 Dec 25.

Department of Genetics, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00335-010-9312-4DOI Listing
February 2011

JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis.

Proc Natl Acad Sci U S A 2010 Dec 6;107(51):22122-7. Epub 2010 Dec 6.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Pathology, Division of Rheumatology,School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1016401107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3009768PMC
December 2010

Plant and animal sensors of conserved microbial signatures.

Science 2010 Nov;330(6007):1061-4

Department of Plant Pathology, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1126/science.1189468DOI Listing
November 2010