Publications by authors named "Brock C Christensen"

100Publications

A large-scale internal validation study of unsupervised virtual trichrome staining technologies on nonalcoholic steatohepatitis liver biopsies.

Mod Pathol 2020 Dec 9. Epub 2020 Dec 9.

Emerging Diagnostic and Investigative Technologies, Clinical Genomics and Advanced Technologies, Department of Pathology and Laboratory Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, 03756, USA.

View Article and Find Full Text PDF
December 2020

Altered immune phenotype and DNA methylation in panic disorder.

Clin Epigenetics 2020 Nov 18;12(1):177. Epub 2020 Nov 18.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03766, USA.

View Article and Find Full Text PDF
November 2020

Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors.

Dev Cell 2020 Dec 28;55(5):544-557.e6. Epub 2020 Oct 28.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA. Electronic address:

View Article and Find Full Text PDF
December 2020

MethylNet: an automated and modular deep learning approach for DNA methylation analysis.

BMC Bioinformatics 2020 Mar 17;21(1):108. Epub 2020 Mar 17.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

View Article and Find Full Text PDF
March 2020

Microbial Communities in Human Milk Relate to Measures of Maternal Weight.

Front Microbiol 2019 20;10:2886. Epub 2019 Dec 20.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

View Article and Find Full Text PDF
December 2019

Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue.

Epigenetics 2020 04 16;15(4):398-418. Epub 2019 Dec 16.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

View Article and Find Full Text PDF
April 2020

PathFlowAI: A High-Throughput Workflow for Preprocessing, Deep Learning and Interpretation in Digital Pathology.

Pac Symp Biocomput 2020 ;25:403-414

Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA,

View Article and Find Full Text PDF
January 2020

PyMethylProcess-convenient high-throughput preprocessing workflow for DNA methylation data.

Bioinformatics 2019 12;35(24):5379-5381

Department of Epidemiology, Geisel School of Medicine at Dartmouth.

View Article and Find Full Text PDF
December 2019

Absence of an embryonic stem cell DNA methylation signature in human cancer.

BMC Cancer 2019 Jul 19;19(1):711. Epub 2019 Jul 19.

Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.

View Article and Find Full Text PDF
July 2019

Your DNA May Appear Older Than You Think.

J Natl Cancer Inst 2019 10;111(10):1007-1008

View Article and Find Full Text PDF
October 2019

Maternal swimming pool exposure during pregnancy in relation to birth outcomes and cord blood DNA methylation among private well users.

Environ Int 2019 02 5;123:459-466. Epub 2019 Jan 5.

Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Dartmouth College, Lebanon 03756, NH, USA; The Children's Environmental Health and Disease Prevention Research Center at Dartmouth, Lebanon 03756, NH, USA. Electronic address:

View Article and Find Full Text PDF
February 2019

Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.

Am J Gastroenterol 2018 12 1;113(12):1828-1835. Epub 2018 Nov 1.

Department of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.

View Article and Find Full Text PDF
December 2018

Pan-Cancer Analysis Reveals Differential Susceptibility of Bidirectional Gene Promoters to DNA Methylation, Somatic Mutations, and Copy Number Alterations.

Int J Mol Sci 2018 Aug 5;19(8). Epub 2018 Aug 5.

Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA 30322, USA.

View Article and Find Full Text PDF
August 2018

Tracing human stem cell lineage during development using DNA methylation.

Genome Res 2018 09 2;28(9):1285-1295. Epub 2018 Aug 2.

Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA.

View Article and Find Full Text PDF
September 2018

MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma.

Cancer Epidemiol Biomarkers Prev 2019 01 7;28(1):127-136. Epub 2018 Jun 7.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

View Article and Find Full Text PDF
January 2019

Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes.

Sci Rep 2017 09 14;7(1):11594. Epub 2017 Sep 14.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

View Article and Find Full Text PDF
September 2017

Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS).

Exp Mol Pathol 2017 08 12;103(1):78-83. Epub 2017 Jul 12.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Electronic address:

View Article and Find Full Text PDF
August 2017

Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age.

Breast Cancer Res 2017 Jul 10;19(1):81. Epub 2017 Jul 10.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA.

View Article and Find Full Text PDF
July 2017

Integrative epigenetic and genetic pan-cancer somatic alteration portraits.

Epigenetics 2017 07 20;12(7):561-574. Epub 2017 Apr 20.

a Department of Epidemiology , Geisel School of Medicine at Dartmouth , Hanover , NH , USA.

View Article and Find Full Text PDF
July 2017

Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival.

Clin Epigenetics 2017 2;9:10. Epub 2017 Feb 2.

Departments of Epidemiology, Pharmacology & Toxicology, and Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH 03756 USA.

View Article and Find Full Text PDF
December 2017

DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.

Cancer Epidemiol Biomarkers Prev 2017 03 13;26(3):328-338. Epub 2016 Dec 13.

Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California.

View Article and Find Full Text PDF
March 2017

Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.

Cancer Immunol Immunother 2017 Mar 9;66(3):379-389. Epub 2016 Dec 9.

Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, P.O. Box 800432, Charlottesville, VA, 22908, USA.

View Article and Find Full Text PDF
March 2017

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients.

Nat Commun 2016 11 25;7:13177. Epub 2016 Nov 25.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.

View Article and Find Full Text PDF
November 2016

A new timepiece: an epigenetic mitotic clock.

Genome Biol 2016 10 19;17(1):216. Epub 2016 Oct 19.

Department of Epidemiology, Brown University, Providence, RI, 02912, USA.

View Article and Find Full Text PDF
October 2016

methyLiftover: cross-platform DNA methylation data integration.

Bioinformatics 2016 08 8;32(16):2517-9. Epub 2016 Apr 8.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

View Article and Find Full Text PDF
August 2016

OxyBS: estimation of 5-methylcytosine and 5-hydroxymethylcytosine from tandem-treated oxidative bisulfite and bisulfite DNA.

Bioinformatics 2016 08 19;32(16):2505-7. Epub 2016 Apr 19.

Department of Pharmacology and Toxicology Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

View Article and Find Full Text PDF
August 2016

Hydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression.

FASEB J 2016 08 26;30(8):2874-84. Epub 2016 Apr 26.

Department of Epidemiology and Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA; and.

View Article and Find Full Text PDF
August 2016

Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.

Epigenetics 2016 05 12;11(5):344-53. Epub 2016 Apr 12.

a Department of Epidemiology , Geisel School of Medicine at Dartmouth.

View Article and Find Full Text PDF
May 2016

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).

BMC Bioinformatics 2016 Mar 8;17:120. Epub 2016 Mar 8.

Department of Pathology and Laboratory Medicine, Brown University, 70 Ship St., Providence, 02912, RI, USA.

View Article and Find Full Text PDF
March 2016

Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States.

Cancer Epidemiol Biomarkers Prev 2016 05 11;25(5):736-44. Epub 2016 Feb 11.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

View Article and Find Full Text PDF
May 2016

Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells.

Cancer Res 2016 Jan 7;76(2):370-6. Epub 2016 Jan 7.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.

View Article and Find Full Text PDF
January 2016

DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.

Clin Epigenetics 2015 25;7:75. Epub 2015 Jul 25.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, HB 7650, Remsen 611, Hanover, NH 03755 USA ; Department of Epidemiology, Geisel School of Medicine at Dartmouth, HB 7650, Remsen 611, Hanover, NH 03755 USA ; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 USA.

View Article and Find Full Text PDF
July 2015

A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.

PLoS One 2015 8;10(4):e0123716. Epub 2015 Apr 8.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States of America; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America.

View Article and Find Full Text PDF
March 2016

A recursively partitioned mixture model for clustering time-course gene expression data.

Transl Cancer Res 2014 ;3(3):217-232

Department of Public Health, Oregon State University, Corvallis, OR 97331, USA.

View Article and Find Full Text PDF
January 2014

Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.

Cancer Med 2014 Oct 2;3(5):1385-95. Epub 2014 Jun 2.

Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.

View Article and Find Full Text PDF
October 2014

RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer.

PLoS One 2014 3;9(4):e93602. Epub 2014 Apr 3.

Division of Epidemiology and Community Health, The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.

View Article and Find Full Text PDF
February 2015

Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.

Epigenetics 2014 Jun 26;9(6):884-95. Epub 2014 Mar 26.

Department of Epidemiology; Brown University; Providence, RI USA; Department of Pathology & Laboratory Medicine; Brown University; Providence, RI USA.

View Article and Find Full Text PDF
June 2014

Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.

Epigenetics 2014 Apr 22;9(4):579-86. Epub 2014 Jan 22.

Nemours Center for Childhood Cancer Research; Alfred I. duPont Hospital for Children; Wilmington, DE USA.

View Article and Find Full Text PDF
April 2014

Effect of estrogen receptor α binding on functional DNA methylation in breast cancer.

Epigenetics 2014 Apr 16;9(4):523-32. Epub 2014 Jan 16.

Department of Genetics; Geisel School of Medicine at Dartmouth; Hanover, NH USA; Institute for Quantitative Biomedical Sciences; Geisel School of Medicine at Dartmouth; Lebanon, NH USA; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Lebanon, NH USA.

View Article and Find Full Text PDF
April 2014

Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation.

Epigenetics 2014 Feb 6;9(2):268-75. Epub 2013 Nov 6.

Department of Community and Family Medicine; Section of Biostatistics and Epidemiology; Geisel School of Medicine at Dartmouth; Hanover, NH USA; Department of Pharmacology and Toxicology; Geisel School of Medicine at Dartmouth; Hanover, NH USA.

View Article and Find Full Text PDF
February 2014

Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma.

Cancer Epidemiol Biomarkers Prev 2013 Jun 23;22(6):1061-8. Epub 2013 May 23.

Department of Epidemiology, Brown University, Providence, RI 02912, USA.

View Article and Find Full Text PDF
June 2013

Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures.

Stat Appl Genet Mol Biol 2013 Mar 5;12(2):225-40. Epub 2013 Mar 5.

Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Dr., Lebanon, NH 03756, USA.

View Article and Find Full Text PDF
March 2013

Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.

Cancer Epidemiol Biomarkers Prev 2012 Aug 19;21(8):1293-302. Epub 2012 Jun 19.

Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

View Article and Find Full Text PDF
August 2012

Allergies and risk of head and neck cancer.

Cancer Causes Control 2012 Aug 19;23(8):1317-22. Epub 2012 Jun 19.

Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA.

View Article and Find Full Text PDF
August 2012

DNA methylation arrays as surrogate measures of cell mixture distribution.

BMC Bioinformatics 2012 May 8;13:86. Epub 2012 May 8.

College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.

View Article and Find Full Text PDF
May 2012

Identification of an epigenetic profile classifier that is associated with survival in head and neck cancer.

Cancer Res 2012 Jun 16;72(11):2728-37. Epub 2012 Apr 16.

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

View Article and Find Full Text PDF
June 2012

Epigenomics in environmental health.

Front Genet 2011 22;2:84. Epub 2011 Nov 22.

Section on Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School Hanover, NH, USA.

View Article and Find Full Text PDF
October 2012

Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.

PLoS One 2011 2;6(6):e20280. Epub 2011 Jun 2.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America.

View Article and Find Full Text PDF
September 2011

Association of secondhand smoke exposures with DNA methylation in bladder carcinomas.

Cancer Causes Control 2011 Aug 10;22(8):1205-13. Epub 2011 Jun 10.

Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA.

View Article and Find Full Text PDF
August 2011

Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer.

Clin Cancer Res 2011 Jun 19;17(11):3579-89. Epub 2011 Apr 19.

Departments of Molecular Pharmacology and Physiology, Community Health-Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA.

View Article and Find Full Text PDF
June 2011

The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer.

Carcinogenesis 2011 Mar 1;32(3):327-30. Epub 2010 Dec 1.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.

View Article and Find Full Text PDF
March 2011

Semi-supervised recursively partitioned mixture models for identifying cancer subtypes.

Bioinformatics 2010 Oct 16;26(20):2578-85. Epub 2010 Aug 16.

Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA.

View Article and Find Full Text PDF
October 2010

Identification of methylated genes associated with aggressive bladder cancer.

PLoS One 2010 Aug 23;5(8):e12334. Epub 2010 Aug 23.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America.

View Article and Find Full Text PDF
August 2010

Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.

Cancer Res 2010 Jul 29;70(14):5686-94. Epub 2010 Jun 29.

Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA.

View Article and Find Full Text PDF
July 2010

Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer.

Clin Cancer Res 2010 Jul 25;16(14):3713-20. Epub 2010 May 25.

Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA.

View Article and Find Full Text PDF
July 2010