Brock C Christensen

Brock C Christensen

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Brock C Christensen

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Your DNA May Appear Older Than You Think.

Authors:
Brock C Christensen

J Natl Cancer Inst 2019 Oct;111(10):1007-1008

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http://dx.doi.org/10.1093/jnci/djz021DOI Listing
October 2019

PyMethylProcess - convenient high-throughput preprocessing workflow for DNA methylation data.

Authors:
Joshua J Levy Alexander J Titus Lucas A Salas Brock C Christensen

Bioinformatics 2019 Aug 1. Epub 2019 Aug 1.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH.

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http://dx.doi.org/10.1093/bioinformatics/btz594DOI Listing
August 2019

Chrysotile fibers in tissue adjacent to laryngeal squamous cell carcinoma in cases with a history of occupational asbestos exposure.

Authors:
Stephanie K Wronkiewicz Victor L Roggli Benjamin H Hinrichs Ady Kendler Rondi A Butler Brock C Christensen Carmen J Marsit Heather H Nelson Michael D McClean Karl T Kelsey Scott M Langevin

Mod Pathol 2019 Aug 5. Epub 2019 Aug 5.

Division of Epidemiology, Department of Environmental Health, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1038/s41379-019-0332-7DOI Listing
August 2019

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data.

Authors:
Kristina Gervin Lucas A Salas Kelly M Bakulski Menno C van Zelm Devin C Koestler John K Wiencke Liesbeth Duijts Henriëtte A Moll Karl T Kelsey Michael S Kobor Robert Lyle Brock C Christensen Janine F Felix Meaghan J Jones

Clin Epigenetics 2019 Aug 27;11(1):125. Epub 2019 Aug 27.

Department of Biochemistry and Medical Genetics, University of Manitoba, and Children's Hospital Research Institute of Manitoba, Winnipeg, Canada.

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http://dx.doi.org/10.1186/s13148-019-0717-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712867PMC
August 2019

Absence of an embryonic stem cell DNA methylation signature in human cancer.

Authors:
Ze Zhang John K Wiencke Devin C Koestler Lucas A Salas Brock C Christensen Karl T Kelsey

BMC Cancer 2019 Jul 19;19(1):711. Epub 2019 Jul 19.

Department of Epidemiology, School of Public Health, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1186/s12885-019-5932-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6642562PMC
July 2019

DNA Methylation Changes in Regional Lung Macrophages Are Associated with Metabolic Differences.

Authors:
David A Armstrong Youdinghuan Chen John A Dessaint Daniel S Aridgides Jacqueline Y Channon Diane L Mellinger Brock C Christensen Alix Ashare

Immunohorizons 2019 07 2;3(7):274-281. Epub 2019 Jul 2.

Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756;

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http://dx.doi.org/10.4049/immunohorizons.1900042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686200PMC
July 2019

Maternal swimming pool exposure during pregnancy in relation to birth outcomes and cord blood DNA methylation among private well users.

Authors:
Lucas A Salas Emily R Baker Mark J Nieuwenhuijsen Carmen J Marsit Brock C Christensen Margaret R Karagas

Environ Int 2019 02 5;123:459-466. Epub 2019 Jan 5.

Department of Epidemiology, The Geisel School of Medicine at Dartmouth, Dartmouth College, Lebanon 03756, NH, USA; The Children's Environmental Health and Disease Prevention Research Center at Dartmouth, Lebanon 03756, NH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.envint.2018.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599635PMC
February 2019

MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma.

Authors:
Owen M Wilkins Alexander J Titus Lucas A Salas Jiang Gui Melissa Eliot Rondi A Butler Erich M Sturgis Guojun Li Karl T Kelsey Brock C Christensen

Cancer Epidemiol Biomarkers Prev 2019 01 7;28(1):127-136. Epub 2018 Jun 7.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
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http://dx.doi.org/10.1158/1055-9965.EPI-18-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286226PMC
January 2019

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.

Authors:
Youdinghuan Chen Yue Wang Lucas A Salas Todd W Miller Kenneth Mark Jonathan D Marotti Arminja N Kettenbach Chao Cheng Brock C Christensen

Breast Cancer Res 2019 01 25;21(1):14. Epub 2019 Jan 25.

Department of Epidemiology, Lebanon, USA.

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https://breast-cancer-research.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s13058-018-1090-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347811PMC
January 2019

Smoking and Other Risk Factors in Individuals With Synchronous Conventional High-Risk Adenomas and Clinically Significant Serrated Polyps.

Authors:
Joseph C Anderson Audrey H Calderwood Brock C Christensen Christina M Robinson Christopher I Amos Lynn Butterly

Am J Gastroenterol 2018 12 1;113(12):1828-1835. Epub 2018 Nov 1.

Department of Veterans Affairs Medical Center, White River Junction, Hartford, VT, USA. The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Section of Gastroenterology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. Department of Community and Family Medicine, The Geisel School of Medicine at Dartmouth, Hanover, NH, USA. Baylor College of Medicine, Houston, TX, USA. Lynn Butterly is the senior author on the paper and the Director of the New Hampshire Colonoscopy Registry.

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http://www.nature.com/articles/s41395-018-0393-0
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http://dx.doi.org/10.1038/s41395-018-0393-0DOI Listing
December 2018

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis.

Authors:
Youdinghuan Chen David A Armstrong Lucas A Salas Haley F Hazlett Amanda B Nymon John A Dessaint Daniel S Aridgides Diane L Mellinger Xiaoying Liu Brock C Christensen Alix Ashare

Clin Epigenetics 2018 12 10;10(1):152. Epub 2018 Dec 10.

Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

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http://dx.doi.org/10.1186/s13148-018-0580-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288922PMC
December 2018

Tracing human stem cell lineage during development using DNA methylation.

Authors:
Lucas A Salas John K Wiencke Devin C Koestler Ze Zhang Brock C Christensen Karl T Kelsey

Genome Res 2018 09 2;28(9):1285-1295. Epub 2018 Aug 2.

Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA.

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http://dx.doi.org/10.1101/gr.233213.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120629PMC
September 2018

Pan-Cancer Analysis Reveals Differential Susceptibility of Bidirectional Gene Promoters to DNA Methylation, Somatic Mutations, and Copy Number Alterations.

Authors:
Jeffrey A Thompson Brock C Christensen Carmen J Marsit

Int J Mol Sci 2018 Aug 5;19(8). Epub 2018 Aug 5.

Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.3390/ijms19082296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121907PMC
August 2018

expression in mesencephalic neurons and characterization of a rare polymorphism associated with decreased risk of Parkinson's disease.

Authors:
Katharine M von Herrmann Lucas A Salas Eileen M Martinez Alison L Young Joseph M Howard Mary S Feldman Brock C Christensen Owen M Wilkins Stephen L Lee William F Hickey Matthew C Havrda

NPJ Parkinsons Dis 2018 15;4:24. Epub 2018 Aug 15.

1Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, NH USA.

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http://dx.doi.org/10.1038/s41531-018-0061-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093937PMC
August 2018

Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner.

Authors:
Sara N Lundgren Juliette C Madan Jennifer A Emond Hilary G Morrison Brock C Christensen Margaret R Karagas Anne G Hoen

Microbiome 2018 07 5;6(1):109. Epub 2018 Jul 5.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1186/s40168-018-0490-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033232PMC
July 2018

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.

Authors:
Lucas A Salas Devin C Koestler Rondi A Butler Helen M Hansen John K Wiencke Karl T Kelsey Brock C Christensen

Genome Biol 2018 05 29;19(1):64. Epub 2018 May 29.

Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA.

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https://genomebiology.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13059-018-1448-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975716PMC
May 2018

Methylation-to-Expression Feature Models of Breast Cancer Accurately Predict Overall Survival, Distant-Recurrence Free Survival, and Pathologic Complete Response in Multiple Cohorts.

Authors:
Jeffrey A Thompson Brock C Christensen Carmen J Marsit

Sci Rep 2018 03 26;8(1):5190. Epub 2018 Mar 26.

Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, USA.

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http://dx.doi.org/10.1038/s41598-018-23494-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979962PMC
March 2018

Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival.

Authors:
John K Wiencke Devin C Koestler Lucas A Salas Joseph L Wiemels Ritu P Roy Helen M Hansen Terri Rice Lucie S McCoy Paige M Bracci Annette M Molinaro Karl T Kelsey Margaret R Wrensch Brock C Christensen

Clin Epigenetics 2017 2;9:10. Epub 2017 Feb 2.

Departments of Epidemiology, Pharmacology & Toxicology, and Community and Family Medicine, Geisel School of Medicine at Dartmouth College, Lebanon, NH 03756 USA.

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http://dx.doi.org/10.1186/s13148-017-0316-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288996PMC
December 2017

Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma.

Authors:
Owen M Wilkins Alexander J Titus Jiang Gui Melissa Eliot Rondi A Butler Erich M Sturgis Guojun Li Karl T Kelsey Brock C Christensen

Carcinogenesis 2017 10;38(10):986-993

Department of Epidemiology.

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http://dx.doi.org/10.1093/carcin/bgx056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5862295PMC
October 2017

Cell-type deconvolution from DNA methylation: a review of recent applications.

Authors:
Alexander J Titus Rachel M Gallimore Lucas A Salas Brock C Christensen

Hum Mol Genet 2017 10;26(R2):R216-R224

Department of Epidemiology.

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https://academic.oup.com/hmg/article/26/R2/R216/3979364
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http://dx.doi.org/10.1093/hmg/ddx275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886462PMC
October 2017

Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes.

Authors:
Alexander J Titus Gregory P Way Kevin C Johnson Brock C Christensen

Sci Rep 2017 09 14;7(1):11594. Epub 2017 Sep 14.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

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http://www.nature.com/articles/s41598-017-10199-z
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http://dx.doi.org/10.1038/s41598-017-10199-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5599639PMC
September 2017

Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS).

Authors:
Youdinghuan Chen Jonathan D Marotti Erik G Jenson Tracy L Onega Kevin C Johnson Brock C Christensen

Exp Mol Pathol 2017 08 12;103(1):78-83. Epub 2017 Jul 12.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144800173037
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http://dx.doi.org/10.1016/j.yexmp.2017.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572810PMC
August 2017

Integrative epigenetic and genetic pan-cancer somatic alteration portraits.

Authors:
Lucas A Salas Kevin C Johnson Devin C Koestler Dylan E O'Sullivan Brock C Christensen

Epigenetics 2017 07 20;12(7):561-574. Epub 2017 Apr 20.

a Department of Epidemiology , Geisel School of Medicine at Dartmouth , Hanover , NH , USA.

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http://dx.doi.org/10.1080/15592294.2017.1319043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687331PMC
July 2017

Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age.

Authors:
Kevin C Johnson E Andres Houseman Jessica E King Brock C Christensen

Breast Cancer Res 2017 Jul 10;19(1):81. Epub 2017 Jul 10.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, 03756, USA.

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http://breast-cancer-research.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s13058-017-0873-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5504720PMC
July 2017

Immune modulation associated with vascular endothelial growth factor (VEGF) blockade in patients with glioblastoma.

Authors:
Alissa A Thomas Jan L Fisher Thomas H Hampton Brock C Christensen Gregory J Tsongalis Gilbert J Rahme Chery A Whipple Sandra E Steel Melissa C Davis Arti B Gaur Lionel D Lewis Marc S Ernstoff Camilo E Fadul

Cancer Immunol Immunother 2017 Mar 9;66(3):379-389. Epub 2016 Dec 9.

Division of Neuro-Oncology, Department of Neurology, University of Virginia School of Medicine, P.O. Box 800432, Charlottesville, VA, 22908, USA.

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http://dx.doi.org/10.1007/s00262-016-1941-3DOI Listing
March 2017

DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes.

Authors:
Devin C Koestler Joseph Usset Brock C Christensen Carmen J Marsit Margaret R Karagas Karl T Kelsey John K Wiencke

Cancer Epidemiol Biomarkers Prev 2017 03 13;26(3):328-338. Epub 2016 Dec 13.

Department of Neurological Surgery, Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, California.

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http://cebp.aacrjournals.org/lookup/doi/10.1158/1055-9965.EP
Publisher Site
http://dx.doi.org/10.1158/1055-9965.EPI-16-0461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5336518PMC
March 2017

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.

Authors:
Costantine Albany Mary P Hever-Jardine Katherine M von Herrmann Christina Y Yim Janice Tam Joshua M Warzecha Leah Shin Sarah E Bock Brian S Curran Aneeq S Chaudhry Fred Kim George E Sandusky Pietro Taverna Sarah J Freemantle Brock C Christensen Lawrence H Einhorn Michael J Spinella

Oncotarget 2017 Jan;8(2):2949-2959

Department of Comparative Biosciences, The University of Illinois at Urbana-Champaign, Urbana, IL, USA.

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http://dx.doi.org/10.18632/oncotarget.13811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356854PMC
January 2017

5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients.

Authors:
Kevin C Johnson E Andres Houseman Jessica E King Katharine M von Herrmann Camilo E Fadul Brock C Christensen

Nat Commun 2016 11 25;7:13177. Epub 2016 Nov 25.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1038/ncomms13177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133638PMC
November 2016

A new timepiece: an epigenetic mitotic clock.

Authors:
Brock C Christensen Karl T Kelsey

Genome Biol 2016 10 19;17(1):216. Epub 2016 Oct 19.

Department of Epidemiology, Brown University, Providence, RI, 02912, USA.

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http://dx.doi.org/10.1186/s13059-016-1085-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072295PMC
October 2016

Hydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression.

Authors:
Benjamin B Green E Andres Houseman Kevin C Johnson Dylan J Guerin David A Armstrong Brock C Christensen Carmen J Marsit

FASEB J 2016 08 26;30(8):2874-84. Epub 2016 Apr 26.

Department of Epidemiology and Department of Pharmacology and Toxicology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA; and.

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http://dx.doi.org/10.1096/fj.201600310RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970608PMC
August 2016

OxyBS: estimation of 5-methylcytosine and 5-hydroxymethylcytosine from tandem-treated oxidative bisulfite and bisulfite DNA.

Authors:
E Andres Houseman Kevin C Johnson Brock C Christensen

Bioinformatics 2016 08 19;32(16):2505-7. Epub 2016 Apr 19.

Department of Pharmacology and Toxicology Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978924PMC
August 2016

methyLiftover: cross-platform DNA methylation data integration.

Authors:
Alexander J Titus E Andrés Houseman Kevin C Johnson Brock C Christensen

Bioinformatics 2016 08 8;32(16):2517-9. Epub 2016 Apr 8.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://bioinformatics.oxfordjournals.org/content/early/2016/
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http://dx.doi.org/10.1093/bioinformatics/btw180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006233PMC
August 2016

Human polyomaviruses and incidence of cutaneous squamous cell carcinoma in the New Hampshire skin cancer study.

Authors:
Anala Gossai Tim Waterboer Anne G Hoen Shohreh F Farzan Heather H Nelson Angelika Michel Martina Willhauck-Fleckenstein Brock C Christensen Ann E Perry Michael Pawlita Margaret R Karagas

Cancer Med 2016 06 21;5(6):1239-50. Epub 2016 Feb 21.

Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1002/cam4.674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924382PMC
June 2016

Prospective Study of Human Polyomaviruses and Risk of Cutaneous Squamous Cell Carcinoma in the United States.

Authors:
Anala Gossai Tim Waterboer Heather H Nelson Jennifer A Doherty Angelika Michel Martina Willhauck-Fleckenstein Shohreh F Farzan Brock C Christensen Anne G Hoen Ann E Perry Michael Pawlita Margaret R Karagas

Cancer Epidemiol Biomarkers Prev 2016 05 11;25(5):736-44. Epub 2016 Feb 11.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire. Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/1055-9965.EPI-15-1111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4883679PMC
May 2016

Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma.

Authors:
Dylan E O'Sullivan Kevin C Johnson Lucy Skinner Devin C Koestler Brock C Christensen

Epigenetics 2016 05 12;11(5):344-53. Epub 2016 Apr 12.

a Department of Epidemiology , Geisel School of Medicine at Dartmouth.

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http://dx.doi.org/10.1080/15592294.2016.1168673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889287PMC
May 2016

Deficiency of mitochondrial modulator MCJ promotes chemoresistance in breast cancer.

Authors:
Maria J Fernández-Cabezudo Issam Faour Kenneth Jones Devin P Champagne Mohammed A Jaloudi Yassir A Mohamed Ghada Bashir Saeeda Almarzooqi Alia Albawardi M Jawad Hashim Thomas S Roberts Haytham El-Salhat Hakam El-Taji Adnan Kassis Dylan E O'Sullivan Brock C Christensen James DeGregori Basel K Al-Ramadi Mercedes Rincon

JCI Insight 2016 May;1(7)

Department of Medicine/Immunobiology Division, University of Vermont, Burlington, Vermont, USA.

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http://dx.doi.org/10.1172/jci.insight.86873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4888911PMC
May 2016

Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells.

Authors:
Jelena Kresoja-Rakic Esra Kapaklikaya Gabriela Ziltener Damian Dalcher Raffaella Santoro Brock C Christensen Kevin C Johnson Beat Schwaller Walter Weder Rolf A Stahel Emanuela Felley-Bosco

Oncotarget 2016 Apr;7(16):21272-86

Laboratory of Molecular Oncology, Clinic of Oncology, University Hospital Zürich, Zürich, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.7114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5008284PMC
April 2016

A coding variant in TMC8 (EVER2) is associated with high risk HPV infection and head and neck cancer risk.

Authors:
Caihua Liang Karl T Kelsey Michael D McClean Brock C Christensen Carmen J Marsit Margaret R Karagas Tim Waterboer Michael Pawlita Heather H Nelson

PLoS One 2015 8;10(4):e0123716. Epub 2015 Apr 8.

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States of America; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123716PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390289PMC
March 2016

Improving cell mixture deconvolution by identifying optimal DNA methylation libraries (IDOL).

Authors:
Devin C Koestler Meaghan J Jones Joseph Usset Brock C Christensen Rondi A Butler Michael S Kobor John K Wiencke Karl T Kelsey

BMC Bioinformatics 2016 Mar 8;17:120. Epub 2016 Mar 8.

Department of Pathology and Laboratory Medicine, Brown University, 70 Ship St., Providence, 02912, RI, USA.

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http://dx.doi.org/10.1186/s12859-016-0943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4782368PMC
March 2016

Distinct Histologic Subtypes and Risk Factors for Early Onset Basal Cell Carcinoma: A Population-Based Case Control Study from New Hampshire.

Authors:
Dorothea T Barton Michael S Zens Heather H Nelson Brock C Christensen Craig A Storm Ann E Perry Margaret R Karagas

J Invest Dermatol 2016 Feb 18;136(2):533-535. Epub 2015 Nov 18.

Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1016/j.jid.2015.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790460PMC
February 2016

Seroepidemiology of Human Polyomaviruses in a US Population.

Authors:
Anala Gossai Tim Waterboer Heather H Nelson Angelika Michel Martina Willhauck-Fleckenstein Shohreh F Farzan Anne G Hoen Brock C Christensen Karl T Kelsey Carmen J Marsit Michael Pawlita Margaret R Karagas

Am J Epidemiol 2016 Jan 13;183(1):61-9. Epub 2015 Dec 13.

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http://dx.doi.org/10.1093/aje/kwv155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006224PMC
January 2016

Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells.

Authors:
Karin A Vineretsky Margaret R Karagas Brock C Christensen Jacquelyn K Kuriger-Laber Ann E Perry Craig A Storm Heather H Nelson

Cancer Res 2016 Jan 7;76(2):370-6. Epub 2016 Jan 7.

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715977PMC
January 2016

DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.

Authors:
Kevin C Johnson Devin C Koestler Thomas Fleischer Panpan Chen Erik G Jenson Jonathan D Marotti Tracy Onega Vessela N Kristensen Brock C Christensen

Clin Epigenetics 2015 25;7:75. Epub 2015 Jul 25.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, HB 7650, Remsen 611, Hanover, NH 03755 USA ; Department of Epidemiology, Geisel School of Medicine at Dartmouth, HB 7650, Remsen 611, Hanover, NH 03755 USA ; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH 03755 USA.

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http://dx.doi.org/10.1186/s13148-015-0094-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514996PMC
July 2015

Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.

Authors:
Thomas Fleischer Arnoldo Frigessi Kevin C Johnson Hege Edvardsen Nizar Touleimat Jovana Klajic Margit Lh Riis Vilde D Haakensen Fredrik Wärnberg Bjørn Naume Aslaug Helland Anne-Lise Børresen-Dale Jörg Tost Brock C Christensen Vessela N Kristensen

Genome Biol 2014 22;15(8):435. Epub 2014 Aug 22.

Department of Genetics, Institute for Cancer Research, OUS Radiumhospitalet, Montebello, Oslo, 0310, Norway.

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http://dx.doi.org/10.1186/PREACCEPT-2333349012841587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165906PMC
June 2015

RNASEL and MIR146A SNP-SNP interaction as a susceptibility factor for non-melanoma skin cancer.

Authors:
Shohreh F Farzan Margaret R Karagas Brock C Christensen Zhongze Li Jacquelyn K Kuriger Heather H Nelson

PLoS One 2014 3;9(4):e93602. Epub 2014 Apr 3.

Division of Epidemiology and Community Health, The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0093602PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974770PMC
February 2015

Let-7 microRNA-binding-site polymorphism in the 3'UTR of KRAS and colorectal cancer outcome: a systematic review and meta-analysis.

Authors:
Scott M Langevin Brock C Christensen

Cancer Med 2014 Oct 2;3(5):1385-95. Epub 2014 Jun 2.

Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1002/cam4.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302689PMC
October 2014

Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.

Authors:
Scott M Langevin E Andres Houseman William P Accomando Devin C Koestler Brock C Christensen Heather H Nelson Margaret R Karagas Carmen J Marsit John K Wiencke Karl T Kelsey

Epigenetics 2014 Jun 26;9(6):884-95. Epub 2014 Mar 26.

Department of Epidemiology; Brown University; Providence, RI USA; Department of Pathology & Laboratory Medicine; Brown University; Providence, RI USA.

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http://dx.doi.org/10.4161/epi.28575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065186PMC
June 2014

Effect of estrogen receptor α binding on functional DNA methylation in breast cancer.

Authors:
Matthew Ung Xiaotu Ma Kevin C Johnson Brock C Christensen Chao Cheng

Epigenetics 2014 Apr 16;9(4):523-32. Epub 2014 Jan 16.

Department of Genetics; Geisel School of Medicine at Dartmouth; Hanover, NH USA; Institute for Quantitative Biomedical Sciences; Geisel School of Medicine at Dartmouth; Lebanon, NH USA; Norris Cotton Cancer Center; Geisel School of Medicine at Dartmouth; Lebanon, NH USA.

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http://dx.doi.org/10.4161/epi.27688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121363PMC
April 2014

Epigenetic silencing of Na,K-ATPase β 1 subunit gene ATP1B1 by methylation in clear cell renal cell carcinoma.

Authors:
Ponniah Selvakumar Tori A Owens Justin M David Nicholas J Petrelli Brock C Christensen Ashakumary Lakshmikuttyamma Ayyappan K Rajasekaran

Epigenetics 2014 Apr 22;9(4):579-86. Epub 2014 Jan 22.

Nemours Center for Childhood Cancer Research; Alfred I. duPont Hospital for Children; Wilmington, DE USA.

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http://dx.doi.org/10.4161/epi.27795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121368PMC
April 2014

Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation.

Authors:
Kevin C Johnson Devin C Koestler Chao Cheng Brock C Christensen

Epigenetics 2014 Feb 6;9(2):268-75. Epub 2013 Nov 6.

Department of Community and Family Medicine; Section of Biostatistics and Epidemiology; Geisel School of Medicine at Dartmouth; Hanover, NH USA; Department of Pharmacology and Toxicology; Geisel School of Medicine at Dartmouth; Hanover, NH USA.

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http://dx.doi.org/10.4161/epi.27015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962537PMC
February 2014

A recursively partitioned mixture model for clustering time-course gene expression data.

Authors:
Devin C Koestler Carmen J Marsit Brock C Christensen Karl T Kelsey E Andres Houseman

Transl Cancer Res 2014 ;3(3):217-232

Department of Public Health, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.3978/j.issn.2218-676X.2014.06.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4208690PMC
January 2014

Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia.

Authors:
Leigh A Humphries J Claire Godbersen Olga V Danilova Prabhjot Kaur Brock C Christensen Alexey V Danilov

Br J Haematol 2013 Dec 30;163(5):590-602. Epub 2013 Sep 30.

Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

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http://dx.doi.org/10.1111/bjh.12580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939033PMC
December 2013

Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation.

Authors:
Bijesh K Biswal Maroun J Beyrouthy Mary P Hever-Jardine David Armstrong Craig R Tomlinson Brock C Christensen Carmen J Marsit Michael J Spinella

PLoS One 2012 27;7(12):e53003. Epub 2012 Dec 27.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0053003PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531428PMC
June 2013

Gastric reflux is an independent risk factor for laryngopharyngeal carcinoma.

Authors:
Scott M Langevin Dominique S Michaud Carmen J Marsit Heather H Nelson Ariel E Birnbaum Melissa Eliot Brock C Christensen Michael D McClean Karl T Kelsey

Cancer Epidemiol Biomarkers Prev 2013 Jun 23;22(6):1061-8. Epub 2013 May 23.

Department of Epidemiology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-13-0183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681904PMC
June 2013

Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures.

Authors:
Devin C Koestler Brock C Christensen Carmen J Marsit Karl T Kelsey E Andres Houseman

Stat Appl Genet Mol Biol 2013 Mar 5;12(2):225-40. Epub 2013 Mar 5.

Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, 1 Medical Center Dr., Lebanon, NH 03756, USA.

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http://dx.doi.org/10.1515/sagmb-2012-0068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007267PMC
March 2013

Epigenetic biomarkers of T-cells in human glioma.

Authors:
John K Wiencke William P Accomando Shichun Zheng Joe Patoka Xiaoqin Dou Joanna J Phillips George Hsuang Brock C Christensen E Andres Houseman Devin C Koestler Paige Bracci Joseph L Wiemels Margaret Wrensch Heather H Nelson Karl T Kelsey

Epigenetics 2012 Dec 29;7(12):1391-402. Epub 2012 Oct 29.

Department of Neurological Surgery, University of California San Francisco, San Francisco, CA USA.

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http://dx.doi.org/10.4161/epi.22675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528694PMC
December 2012

Epigenomics in environmental health.

Authors:
Brock C Christensen Carmen J Marsit

Front Genet 2011 22;2:84. Epub 2011 Nov 22.

Section on Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School Hanover, NH, USA.

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http://dx.doi.org/10.3389/fgene.2011.00084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268636PMC
October 2012

Biomarkers of HPV in head and neck squamous cell carcinoma.

Authors:
Caihua Liang Carmen J Marsit Michael D McClean Heather H Nelson Brock C Christensen Robert I Haddad John R Clark Richard O Wein Gregory A Grillone E Andres Houseman Gordana Halec Tim Waterboer Michael Pawlita Jeffrey F Krane Karl T Kelsey

Cancer Res 2012 Oct 18;72(19):5004-13. Epub 2012 Sep 18.

Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, Rhode Island, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-3277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463756PMC
October 2012

Allergies and risk of head and neck cancer.

Authors:
Dominique S Michaud Scott M Langevin Melissa Eliot Heather H Nelson Michael D McClean Brock C Christensen Carmen J Marsit Karl T Kelsey

Cancer Causes Control 2012 Aug 19;23(8):1317-22. Epub 2012 Jun 19.

Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1007/s10552-012-0009-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598569PMC
August 2012

Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers.

Authors:
Devin C Koestler Carmen J Marsit Brock C Christensen William Accomando Scott M Langevin E Andres Houseman Heather H Nelson Margaret R Karagas John K Wiencke Karl T Kelsey

Cancer Epidemiol Biomarkers Prev 2012 Aug 19;21(8):1293-302. Epub 2012 Jun 19.

Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-12-0361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415587PMC
August 2012

Identification of an epigenetic profile classifier that is associated with survival in head and neck cancer.

Authors:
Graham M Poage Rondi A Butler E Andrés Houseman Michael D McClean Heather H Nelson Brock C Christensen Carmen J Marsit Karl T Kelsey

Cancer Res 2012 Jun 16;72(11):2728-37. Epub 2012 Apr 16.

Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-4121-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650639PMC
June 2012

Key epigenetic changes associated with lung cancer development: results from dense methylation array profiling.

Authors:
Heather H Nelson Carmen J Marsit Brock C Christensen E Andres Houseman Milica Kontic Joseph L Wiemels Margaret R Karagas Margaret R Wrensch Shichun Zheng John K Wiencke Karl T Kelsey

Epigenetics 2012 Jun 1;7(6):559-66. Epub 2012 Jun 1.

Masonic Cancer Center, Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.

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http://dx.doi.org/10.4161/epi.20219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398985PMC
June 2012

DNA methylation arrays as surrogate measures of cell mixture distribution.

Authors:
Eugene Andres Houseman William P Accomando Devin C Koestler Brock C Christensen Carmen J Marsit Heather H Nelson John K Wiencke Karl T Kelsey

BMC Bioinformatics 2012 May 8;13:86. Epub 2012 May 8.

College of Public Health and Human Sciences, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.1186/1471-2105-13-86DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3532182PMC
May 2012

Peripheral blood DNA methylation profiles are indicative of head and neck squamous cell carcinoma: an epigenome-wide association study.

Authors:
Scott M Langevin Devin C Koestler Brock C Christensen Rondi A Butler John K Wiencke Heather H Nelson E Andres Houseman Carmen J Marsit Karl T Kelsey

Epigenetics 2012 Mar;7(3):291-9

Department of Epidemiology, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.4161/epi.7.3.19134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335952PMC
March 2012

History of Parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia.

Authors:
Gisele M Vasconcelos Brock C Christensen E Andrés Houseman Jianqiao Xiao Carmen J Marsit John K Wiencke Shichun Zheng Margaret R Karagas Heather H Nelson Margaret R Wrensch Karl T Kelsey Maria S Pombo-de-Oliveira Joseph L Wiemels

Epigenetics 2011 Dec;6(12):1436-43

Programa de Hematologia e Oncologia Pediátricas, Centro de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.4161/epi.6.12.18464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256332PMC
December 2011

Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.

Authors:
Sara E Pacheco E Andres Houseman Brock C Christensen Carmen J Marsit Karl T Kelsey Mark Sigman Kim Boekelheide

PLoS One 2011 2;6(6):e20280. Epub 2011 Jun 2.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020280PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107223PMC
September 2011

Analgesic and nonsteroidal anti-inflammatory use in relation to nonmelanoma skin cancer: a population-based case-control study.

Authors:
Dorothea C Torti Brock C Christensen Craig A Storm Joan Fortuny Ann E Perry Michael S Zens Therese Stukel Steven K Spencer Heather H Nelson Margaret R Karagas

J Am Acad Dermatol 2011 Aug 6;65(2):304-312. Epub 2011 May 6.

Section of Biostatistics and Epidemiology, Dartmouth Medical School, Hanover, New Hampshire. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2010.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140678PMC
August 2011

Association of secondhand smoke exposures with DNA methylation in bladder carcinomas.

Authors:
Charlotte S Wilhelm-Benartzi Brock C Christensen Devin C Koestler E Andres Houseman Alan R Schned Margaret R Karagas Karl T Kelsey Carmen J Marsit

Cancer Causes Control 2011 Aug 10;22(8):1205-13. Epub 2011 Jun 10.

Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1007/s10552-011-9788-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140591PMC
August 2011

The relationship between tumor MSLN methylation and serum mesothelin (SMRP) in mesothelioma.

Authors:
Heather H Nelson Lindsay M Almquist Jessica L LaRocca Silvia L Plaza Geralyn M Lambert-Messerlian David J Sugarbaker Raphael Bueno John J Godleski Carmen J Marsit Brock C Christensen Karl T Kelsey

Epigenetics 2011 Aug 1;6(8):1029-34. Epub 2011 Aug 1.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, USA. roduction

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http://dx.doi.org/10.4161/epi.6.8.16074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3219084PMC
August 2011

The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood.

Authors:
Scott M Langevin E Andres Houseman Brock C Christensen John K Wiencke Heather H Nelson Margaret R Karagas Carmen J Marsit Karl T Kelsey

Epigenetics 2011 Jul 1;6(7):908-19. Epub 2011 Jul 1.

Department of Community Health, Brown University, Providence, RI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154431PMC
http://dx.doi.org/10.4161/epi.6.7.16431DOI Listing
July 2011

Global hypomethylation identifies Loci targeted for hypermethylation in head and neck cancer.

Authors:
Graham M Poage E Andres Houseman Brock C Christensen Rondi A Butler Michele Avissar-Whiting Michael D McClean Tim Waterboer Michael Pawlita Carmen J Marsit Karl T Kelsey

Clin Cancer Res 2011 Jun 19;17(11):3579-89. Epub 2011 Apr 19.

Departments of Molecular Pharmacology and Physiology, Community Health-Center for Environmental Health and Technology, and Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107873PMC
June 2011

Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.

Authors:
Michele Avissar-Whiting Devin C Koestler E Andres Houseman Brock C Christensen Karl T Kelsey Carmen J Marsit

Epigenetics 2011 Jun 1;6(6):703-9. Epub 2011 Jun 1.

Department of Pathology, Brown University, Providence, RI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230543PMC
http://dx.doi.org/10.4161/epi.6.6.16158DOI Listing
June 2011

The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer.

Authors:
Lindsay M Almquist Margaret R Karagas Brock C Christensen Marleen M Welsh Ann E Perry Craig A Storm Heather H Nelson

Carcinogenesis 2011 Mar 1;32(3):327-30. Epub 2010 Dec 1.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.

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http://dx.doi.org/10.1093/carcin/bgq256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105583PMC
March 2011

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.

Authors:
Shichun Zheng E Andres Houseman Zachary Morrison Margaret R Wrensch Joseph S Patoka Christian Ramos Daphne A Haas-Kogan Sean McBride Carmen J Marsit Brock C Christensen Heather H Nelson David Stokoe Joseph L Wiemels Susan M Chang Michael D Prados Tarik Tihan Scott R Vandenberg Karl T Kelsey Mitchel S Berger John K Wiencke

Neuro Oncol 2011 Mar;13(3):280-9

Department of Neurological Surgery, University of California-San Francisco, Helen Diller Family Cancer Center, 1450 3rd Street, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1093/neuonc/noq190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064601PMC
March 2011

DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer.

Authors:
Carmen J Marsit Devin C Koestler Brock C Christensen Margaret R Karagas E Andres Houseman Karl T Kelsey

J Clin Oncol 2011 Mar 22;29(9):1133-9. Epub 2011 Feb 22.

Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1200/JCO.2010.31.3577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083868PMC
March 2011

DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma.

Authors:
Brock C Christensen Ashley A Smith Shichun Zheng Devin C Koestler E Andres Houseman Carmen J Marsit Joseph L Wiemels Heather H Nelson Margaret R Karagas Margaret R Wrensch Karl T Kelsey John K Wiencke

J Natl Cancer Inst 2011 Jan 16;103(2):143-53. Epub 2010 Dec 16.

Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1093/jnci/djq497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022619PMC
January 2011

Downregulated microRNAs in the differential diagnosis of malignant pleural mesothelioma.

Authors:
Gretchen V Gee Devin C Koestler Brock C Christensen David J Sugarbaker Donatella Ugolini Giovanni P Ivaldi Murray B Resnick E Andres Houseman Karl T Kelsey Carmen J Marsit

Int J Cancer 2010 Dec;127(12):2859-69

Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1002/ijc.25285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911512PMC
December 2010

Semi-supervised recursively partitioned mixture models for identifying cancer subtypes.

Authors:
Devin C Koestler Carmen J Marsit Brock C Christensen Margaret R Karagas Raphael Bueno David J Sugarbaker Karl T Kelsey E Andres Houseman

Bioinformatics 2010 Oct 16;26(20):2578-85. Epub 2010 Aug 16.

Department of Community Health, Section for Biostatistics, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951086PMC
October 2010

Identification of methylated genes associated with aggressive bladder cancer.

Authors:
Carmen J Marsit E Andres Houseman Brock C Christensen Luc Gagne Margaret R Wrensch Heather H Nelson Joseph Wiemels Shichun Zheng John K Wiencke Angeline S Andrew Alan R Schned Margaret R Karagas Karl T Kelsey

PLoS One 2010 Aug 23;5(8):e12334. Epub 2010 Aug 23.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012334PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925945PMC
August 2010

Mature microRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer.

Authors:
Brock C Christensen Michele Avissar-Whiting Lauren G Ouellet Rondi A Butler Heather H Nelson Michael D McClean Carmen J Marsit Karl T Kelsey

Clin Cancer Res 2010 Jul 25;16(14):3713-20. Epub 2010 May 25.

Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914465PMC
July 2010

Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma.

Authors:
Brock C Christensen E Andres Houseman Graham M Poage John J Godleski Raphael Bueno David J Sugarbaker John K Wiencke Heather H Nelson Carmen J Marsit Karl T Kelsey

Cancer Res 2010 Jul 29;70(14):5686-94. Epub 2010 Jun 29.

Departments of Pathology and Laboratory Medicine, Community Health, Center for Environmental Health and Technology, and Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island 02903, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2905466PMC
July 2010

Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake.

Authors:
Brock C Christensen Karl T Kelsey Shichun Zheng E Andres Houseman Carmen J Marsit Margaret R Wrensch Joseph L Wiemels Heather H Nelson Margaret R Karagas Lawrence H Kushi Marilyn L Kwan John K Wiencke

PLoS Genet 2010 Jul 29;6(7):e1001043. Epub 2010 Jul 29.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1001043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912395PMC
July 2010

Genetic and epigenetic somatic alterations in head and neck squamous cell carcinomas are globally coordinated but not locally targeted.

Authors:
Graham M Poage Brock C Christensen E Andres Houseman Michael D McClean John K Wiencke Marshall R Posner John R Clark Heather H Nelson Carmen J Marsit Karl T Kelsey

PLoS One 2010 Mar 11;5(3):e9651. Epub 2010 Mar 11.

Departments of Molecular Pharmacology and Physiology, Brown University, Providence, Rhode Island, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009651PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836370PMC
March 2010

Copy number variation has little impact on bead-array-based measures of DNA methylation.

Authors:
E Andrés Houseman Brock C Christensen Margaret R Karagas Margaret R Wrensch Heather H Nelson Joseph L Wiemels Shichun Zheng John K Wiencke Karl T Kelsey Carmen J Marsit

Bioinformatics 2009 Aug 19;25(16):1999-2005. Epub 2009 Jun 19.

Department of Community Health Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2723008PMC
August 2009

Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles.

Authors:
Brock C Christensen Carmen J Marsit E Andres Houseman John J Godleski Jennifer L Longacker Shichun Zheng Ru-Fang Yeh Margaret R Wrensch Joseph L Wiemels Margaret R Karagas Raphael Bueno David J Sugarbaker Heather H Nelson John K Wiencke Karl T Kelsey

Cancer Res 2009 Aug 28;69(15):6315-21. Epub 2009 Jul 28.

Department of Community Health, Center for Environmental Health and Technology, Brown University, Providence, Rhode Island 02903, USA.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-09-1073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755616PMC
August 2009

Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context.

Authors:
Brock C Christensen E Andres Houseman Carmen J Marsit Shichun Zheng Margaret R Wrensch Joseph L Wiemels Heather H Nelson Margaret R Karagas James F Padbury Raphael Bueno David J Sugarbaker Ru-Fang Yeh John K Wiencke Karl T Kelsey

PLoS Genet 2009 Aug 14;5(8):e1000602. Epub 2009 Aug 14.

Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.

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https://dx.plos.org/10.1371/journal.pgen.1000602
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http://dx.doi.org/10.1371/journal.pgen.1000602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718614PMC
August 2009

Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.

Authors:
Katie M Applebaum Michael D McClean Heather H Nelson Carmen J Marsit Brock C Christensen Karl T Kelsey

Int J Cancer 2009 Jun;124(11):2690-6

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1002/ijc.24256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746567PMC
June 2009

Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer.

Authors:
Alyce A Chen Carmen J Marsit Brock C Christensen E Andrés Houseman Michael D McClean Judith F Smith Janine T Bryan Marshall R Posner Heather H Nelson Karl T Kelsey

Carcinogenesis 2009 Jun 3;30(6):977-81. Epub 2009 Apr 3.

Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/carcin/bgp076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691140PMC
June 2009

A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers.

Authors:
Brock C Christensen Benjamin J Moyer Michele Avissar Lauren G Ouellet Silvia L Plaza Michael D McClean Carmen J Marsit Karl T Kelsey

Carcinogenesis 2009 Jun 20;30(6):1003-7. Epub 2009 Apr 20.

Department of Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912, USA.

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http://dx.doi.org/10.1093/carcin/bgp099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691138PMC
June 2009

MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma.

Authors:
Michele Avissar Brock C Christensen Karl T Kelsey Carmen J Marsit

Clin Cancer Res 2009 Apr 7;15(8):2850-5. Epub 2009 Apr 7.

Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-3131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669849PMC
April 2009

Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma.

Authors:
Carmen J Marsit Brock C Christensen E Andres Houseman Margaret R Karagas Margaret R Wrensch Ru-Fang Yeh Heather H Nelson Joseph L Wiemels Shichun Zheng Marshall R Posner Michael D McClean John K Wiencke Karl T Kelsey

Carcinogenesis 2009 Mar 6;30(3):416-22. Epub 2009 Jan 6.

Department of Pathology and Laboratory Medicine, Brown University, Providence, RI 02912, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgp006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650795PMC
March 2009

Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome.

Authors:
Brock C Christensen E A Houseman John J Godleski Carmen J Marsit Jennifer L Longacker Cora R Roelofs Margaret R Karagas Margaret R Wrensch Ru-Fang Yeh Heather H Nelson Joe L Wiemels Shichun Zheng John K Wiencke Raphael Bueno David J Sugarbaker Karl T Kelsey

Cancer Res 2009 Jan;69(1):227-34

Department of Community Health, Center for Environmental Health and Technology, Brown University, 70 Ship Street, Providence, RI 02903, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2744125PMC
January 2009

Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions.

Authors:
E Andres Houseman Brock C Christensen Ru-Fang Yeh Carmen J Marsit Margaret R Karagas Margaret Wrensch Heather H Nelson Joseph Wiemels Shichun Zheng John K Wiencke Karl T Kelsey

BMC Bioinformatics 2008 Sep 9;9:365. Epub 2008 Sep 9.

Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, 02115, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-9-365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553421PMC
September 2008

Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma.

Authors:
Brock C Christensen John J Godleski Carmen J Marsit E A Houseman Cristina Y Lopez-Fagundo Jennifer L Longacker Raphael Bueno David J Sugarbaker Heather H Nelson Karl T Kelsey

Carcinogenesis 2008 Aug 28;29(8):1555-9. Epub 2008 Feb 28.

Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1093/carcin/bgn059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516493PMC
August 2008

Asbestos burden predicts survival in pleural mesothelioma.

Authors:
Brock C Christensen John J Godleski Cora R Roelofs Jennifer L Longacker Raphael Bueno David J Sugarbaker Carmen J Marsit Heather H Nelson Karl T Kelsey

Environ Health Perspect 2008 Jun;116(6):723-6

Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1289/ehp.11151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430226PMC
June 2008

Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors.

Authors:
Carmen J Marsit E Andres Houseman Brock C Christensen Karen Eddy Raphael Bueno David J Sugarbaker Heather H Nelson Margaret R Karagas Karl T Kelsey

Cancer Res 2006 Nov;66(21):10621-9

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-1687DOI Listing
November 2006