Brittney-Shea Herbert

Brittney-Shea Herbert

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Brittney-Shea Herbert

Brittney-Shea Herbert

Publications by authors named "Brittney-Shea Herbert"

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Development of a New Monochrome Multiplex qPCR Method for Relative Telomere Length Measurement in Cancer.

Neoplasia 2018 05 21;20(5):425-431. Epub 2018 Mar 21.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2018.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915991PMC
May 2018

Altered expression of telomere-associated genes in leukocytes among BRCA1 and BRCA2 carriers.

Mol Carcinog 2018 04 5;57(4):567-575. Epub 2018 Jan 5.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana.

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http://dx.doi.org/10.1002/mc.22773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832588PMC
April 2018

SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34 Progenitor Cells.

Circulation 2017 Jun 5;135(25):2505-2523. Epub 2017 Apr 5.

From Department of Pharmacology (L.Z., A.J., Z.H., G.M., P.T.T., A.B.M., J.R.), Department of Medicine, Division of Cardiology (J.R.), The University of Illinois College of Medicine, Chicago; and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis (B.-S.H.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.025722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472005PMC
June 2017

Hsp90 and PKM2 Drive the Expression of Aromatase in Li-Fraumeni Syndrome Breast Adipose Stromal Cells.

J Biol Chem 2016 07 1;291(31):16011-23. Epub 2016 Jun 1.

From the Department of Medicine, Weill Cornell Medical College, New York, New York 10065.

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http://dx.doi.org/10.1074/jbc.M115.698902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965552PMC
July 2016

The telomerase inhibitor imetelstat alone, and in combination with trastuzumab, decreases the cancer stem cell population and self-renewal of HER2+ breast cancer cells.

Breast Cancer Res Treat 2015 Feb 28;149(3):607-18. Epub 2015 Jan 28.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://link.springer.com/10.1007/s10549-015-3270-1
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http://dx.doi.org/10.1007/s10549-015-3270-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667948PMC
February 2015

Resveratrol augments paclitaxel treatment in MDA-MB-231 and paclitaxel-resistant MDA-MB-231 breast cancer cells.

Anticancer Res 2014 Oct;34(10):5363-74

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN, U.S.A. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, U.S.A. Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN, U.S.A. Indiana Institute for Personalized Medicine, Indianapolis, IN, U.S.A.

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October 2014

p53 modulates Hsp90 ATPase activity and regulates aryl hydrocarbon receptor signaling.

Cancer Prev Res (Phila) 2014 Jun 15;7(6):596-606. Epub 2014 Apr 15.

Authors' Affiliations: Department of Medicine, Weill Cornell Medical College; Department of Basic Sciences, College of Dentistry; and Department of Environmental Medicine, School of Medicine, New York University, New York; Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland; and Department of Medical and Molecular Genetics, Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana

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http://dx.doi.org/10.1158/1940-6207.CAPR-14-0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074578PMC
June 2014

p53 protein regulates Hsp90 ATPase activity and thereby Wnt signaling by modulating Aha1 expression.

J Biol Chem 2014 Mar 22;289(10):6513-25. Epub 2014 Jan 22.

From the Department of Medicine, Weill Cornell Medical College, New York, New York 10065.

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http://dx.doi.org/10.1074/jbc.M113.532523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945316PMC
March 2014

Heritable one-hit events defining cancer prevention?

Cell Cycle 2013 Aug 29;12(16):2553-7. Epub 2013 Jul 29.

Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.4161/cc.25690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865044PMC
August 2013

Pharmaceutical regulation of telomerase and its clinical potential.

J Cell Mol Med 2012 Jan;16(1):1-7

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01460.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251731PMC
January 2012

Medical genetics and epigenetics of telomerase.

J Cell Mol Med 2011 Mar;15(3):457-67

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01276.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3922369PMC
March 2011

Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab.

Breast Cancer Res Treat 2009 Nov 14;118(1):21-32. Epub 2008 Oct 14.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202-5251, USA.

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http://dx.doi.org/10.1007/s10549-008-0201-4DOI Listing
November 2009

Meeting report: second international meeting on quadruplex DNA.

Biochimie 2009 Sep 23;91(9):1059-65. Epub 2009 Jun 23.

Dept of Medical and Molecular Genetics, Indiana University Melvin and Bren Simon Cancer Center, Indiana University Center for Regenerative Biology and Medicine, Indiana University School of Medicine, IB 242 Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1016/j.biochi.2009.06.011DOI Listing
September 2009

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel.

Mol Cancer Ther 2009 Jul 9;8(7):2027-35. Epub 2009 Jun 9.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202-5251, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-1188DOI Listing
July 2009

Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists.

Biochim Biophys Acta 2009 Apr 9;1792(4):240-7. Epub 2009 Feb 9.

Department of Biochemistry, University of Hacettepe, 06100 Sihhiye, Ankara, Turkey.

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http://dx.doi.org/10.1016/j.bbadis.2009.01.018DOI Listing
April 2009

Factors impacting human telomere homeostasis and age-related disease.

Mech Ageing Dev 2008 Jan-Feb;129(1-2):27-34. Epub 2007 Oct 30.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States.

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http://dx.doi.org/10.1016/j.mad.2007.10.010DOI Listing
April 2008

Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent.

Nucleosides Nucleotides Nucleic Acids 2007 ;26(10-12):1577-9

Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA.

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http://dx.doi.org/10.1080/15257770701547271DOI Listing
March 2008

Shared environmental factors associated with telomere length maintenance in elderly male twins.

Aging Cell 2007 Oct 24;6(5):709-13. Epub 2007 Aug 24.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2007.00330.xDOI Listing
October 2007

Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol.

Nat Protoc 2006 ;1(3):1583-90

Department of Medical and Molecular Genetics, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202-5251, USA.

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http://link.springer.com/content/pdf/10.1385/1-59259-189-2:1
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http://www.nature.com/doifinder/10.1038/nprot.2006.239
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http://dx.doi.org/10.1038/nprot.2006.239DOI Listing
June 2007

Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells.

Int J Radiat Oncol Biol Phys 2007 Mar 15;67(3):897-905. Epub 2006 Dec 15.

Department of Radiation Oncology, Radiation and Cancer Biology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202-5251, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2006.09.038DOI Listing
March 2007

A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker.

Proc Natl Acad Sci U S A 2006 Dec 11;103(51):19472-7. Epub 2006 Dec 11.

Division of Hematology and Oncology, Indiana University School of Medicine, and Indiana Cancer Center, Indianapolis, IN 46202, USA.

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http://dx.doi.org/10.1073/pnas.0604614103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1697829PMC
December 2006

Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier.

Breast Cancer Res Treat 2006 Sep 16;99(1):103-15. Epub 2006 Mar 16.

Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1007/s10549-006-9189-9DOI Listing
September 2006

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer.

Clin Cancer Res 2006 May;12(10):3184-92

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202-5251, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-2760DOI Listing
May 2006

Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.

Oncogene 2005 Aug;24(33):5262-8

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9039, USA.

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http://dx.doi.org/10.1038/sj.onc.1208760DOI Listing
August 2005

Telomere dysfunction in aging and cancer.

Int J Biochem Cell Biol 2005 May;37(5):1000-13

Department of Medical and Molecular Genetics, The Indiana University Cancer Center, Indiana University School of Medicine, 975 West Walnut St, IB 242, Indianapolis, IN 46202-5251, USA.

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http://dx.doi.org/10.1016/j.biocel.2004.09.003DOI Listing
May 2005

Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions.

Oncogene 2004 Aug;23(37):6193-8

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5120, USA.

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http://dx.doi.org/10.1038/sj.onc.1207834DOI Listing
August 2004

Cell-type-specific responses to chemotherapeutics in breast cancer.

Cancer Res 2004 Jun;64(12):4218-26

Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 27599, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-0107DOI Listing
June 2004

Novel short oligonucleotide conjugates as inhibitors of human telomerase.

Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1627-9

Geron Corporation, Menlo Park, California 94025, USA.

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http://dx.doi.org/10.1081/NCN-120023085DOI Listing
December 2003

Analysis of telomeres and telomerase.

Curr Protoc Cell Biol 2003 Nov;Chapter 18:Unit 18.6

The University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1002/0471143030.cb1806s20DOI Listing
November 2003

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells.

Cancer Res 2003 Sep;63(18):5813-20

University of Southern California/Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089-9181, USA.

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September 2003

A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells.

Cancer Res 2003 Apr;63(8):1914-9

Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9039, USA.

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April 2003

Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.

Oncogene 2003 Jan;22(3):433-44

Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390-8593, USA.

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http://dx.doi.org/10.1038/sj.onc.1206046DOI Listing
January 2003

p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells.

Oncogene 2002 Nov;21(51):7897-900

Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390-9039, USA.

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http://dx.doi.org/10.1038/sj.onc.1205902DOI Listing
November 2002

Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors.

Oncogene 2002 Jan;21(4):638-42

Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390-9039, USA.

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http://dx.doi.org/10.1038/sj.onc.1205064DOI Listing
January 2002