Brit Mollenhauer

Brit Mollenhauer

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Brit Mollenhauer

Publications by authors named "Brit Mollenhauer"

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A combined miRNA-piRNA signature to detect Alzheimer's disease.

Transl Psychiatry 2019 Oct 7;9(1):250. Epub 2019 Oct 7.

Department for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Goettingen, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1038/s41398-019-0579-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6779890PMC
October 2019

SEAweb: the small RNA Expression Atlas web application.

Nucleic Acids Res 2019 Oct 10. Epub 2019 Oct 10.

Institute of Medical Systems Biology, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

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http://dx.doi.org/10.1093/nar/gkz869DOI Listing
October 2019

White matter hyperintensities are not associated with cognitive decline in early Parkinson's disease - The DeNoPa cohort.

Parkinsonism Relat Disord 2019 Oct 19;69:61-67. Epub 2019 Oct 19.

Institute of Epidemiology and Social Medicine, University of Muenster, Albert-Schweitzer-Campus 1, D-48149, Muenster, Germany.

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http://dx.doi.org/10.1016/j.parkreldis.2019.10.016DOI Listing
October 2019

Parkinson's disease biomarkers based on α-synuclein.

J Neurochem 2019 Sep 28;150(5):626-636. Epub 2019 Jul 28.

Neurological Disorder Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation, Doha, Qatar.

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http://dx.doi.org/10.1111/jnc.14809DOI Listing
September 2019

Quantification of Alpha-Synuclein in Biological Fluids by Electrochemiluminescence-Based Detection.

Methods Mol Biol 2019 ;1948:59-68

Paracelsus-Elena-Klinik, Kassel, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9124-2_6DOI Listing
July 2019

Cerebrospinal fluid biomarker for Parkinson's disease: An overview.

Mol Cell Neurosci 2019 Jun 10;97:60-66. Epub 2018 Dec 10.

University Medical Center, Department of Neurology, Robert-Koch Strasse 40, 37075 Goettingen, Germany.

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http://dx.doi.org/10.1016/j.mcn.2018.12.005DOI Listing
June 2019

CSF and blood biomarkers for Parkinson's disease.

Lancet Neurol 2019 Jun 10;18(6):573-586. Epub 2019 Apr 10.

Section of Neurology, Department of Medicine, University of Perugia, Perugia, Italy; IRCCS Fondazione Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1016/S1474-4422(19)30024-9DOI Listing
June 2019

Risk of Parkinson's disease dementia related to level I MDS PD-MCI.

Mov Disord 2019 03 17;34(3):430-435. Epub 2019 Jan 17.

Department of Medical Psychology, Academic Medical Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1002/mds.27617DOI Listing
March 2019

Psychometric Properties of an Abbreviated Version of the Apathy Evaluation Scale for Parkinson Disease (AES-12PD).

Am J Geriatr Psychiatry 2018 10 30;26(10):1079-1090. Epub 2018 Jun 30.

Institute of Clinical Psychology and Psychotherapy, Department of Psychology, Technische Universität Dresden, Dresden, Germany; Department of Clinical Epidemiology, Leibniz Institute for Prevention Research and Epidemiology - BIPS GmbH, Bremen, Germany.

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http://dx.doi.org/10.1016/j.jagp.2018.06.012DOI Listing
October 2018

Characterization of Cerebrospinal Fluid via Data-Independent Acquisition Mass Spectrometry.

J Proteome Res 2018 10 12;17(10):3418-3430. Epub 2018 Sep 12.

Ruhr University Bochum, Medical Faculty , Medizinisches Proteom-Center , Universitaetsstrasse 150 , D-44801 Bochum , Germany.

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http://dx.doi.org/10.1021/acs.jproteome.8b00308DOI Listing
October 2018

LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder.

Parkinsonism Relat Disord 2018 07 21;52:98-101. Epub 2018 Mar 21.

Montreal Neurological Institute, McGill University, Montréal, QC, H3A 0G4, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, H3A 0G4, Canada, Canada; Department of Human Genetics, McGill University, H3A 0G4, Montréal, QC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.parkreldis.2018.03.019DOI Listing
July 2018

Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

World J Biol Psychiatry 2018 06 27;19(4):244-328. Epub 2017 Oct 27.

a Department of Psychiatry and Psychotherapy , Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg , Erlangen , Germany.

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http://dx.doi.org/10.1080/15622975.2017.1375556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5916324PMC
June 2018

The importance of an independent validation cohort for metabolomics biomarker studies.

Mov Disord 2018 05 3;33(5):856. Epub 2018 May 3.

Paracelsus-Elena Klinik, Kassel and University Medical Center, Goettingen, Germany.

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http://dx.doi.org/10.1002/mds.27374DOI Listing
May 2018

Biomarkers for cognitive impairment in Lewy body disorders: Status and relevance for clinical trials.

Mov Disord 2018 04;33(4):528-536

Voyager Therapeutics, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1002/mds.27355DOI Listing
April 2018

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease.

Mol Neurobiol 2018 03 21;55(3):2249-2257. Epub 2017 Mar 21.

Clinical Dementia Center, Department of Neurology, University Medical Center Göttingen, Robert Koch Stasse 40, 37075, Göttingen, Germany.

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http://dx.doi.org/10.1007/s12035-017-0479-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840235PMC
March 2018

Cerebrospinal Fluid Biomarkers of Cognitive Decline in Parkinson's Disease.

Int Rev Neurobiol 2017 8;132:275-294. Epub 2017 Feb 8.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2016.12.001DOI Listing
March 2018

Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt-Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress.

Mol Neurobiol 2018 01 14;55(1):517-537. Epub 2016 Dec 14.

Department of Neurology, University Medical Center Goettingen (UMG) and German Center for Neurodegenerative Diseases (DZNE) Goettingen, Robert-Koch-Str., 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s12035-016-0294-4DOI Listing
January 2018

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder.

Mov Disord 2018 01 26;33(1):88-98. Epub 2017 Aug 26.

Eco-Systems Biology Research Group, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.

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http://dx.doi.org/10.1002/mds.27105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811909PMC
January 2018

Longitudinal CSF biomarkers in patients with early Parkinson disease and healthy controls.

Neurology 2017 Nov 13;89(19):1959-1969. Epub 2017 Oct 13.

From the Department of Neurology (B.M.), University Medical Center, Göttingen; Paracelsus-Elena-Klinik (B.M.), Kassel, Germany; Department of Biostatistics (C.J.C.-G., C.S.C.), College of Public Health, University of Iowa, Iowa City; BioLegend Inc. (P.T.), San Diego, CA; Department of Pathology & Laboratory Medicine (L.M.S., J.Q.T.), Center for Neurodegenerative Disease Research, Institute on Aging (L.M.S. , J.Q.T.), and Morris K. Udall Center of Excellence for Parkinson's Disease Research (J.Q.T.), Perelman School of Medicine, University of Pennsylvania, Philadelphia; Molecular Genetics Section (A.S.), Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD; The Michael J. Fox Foundation for Parkinson's Research (M.F.), New York, NY; Institute for Neurodegenerative Disorders (K.M.), New Haven, CT; and Department of Neurosciences (D.G.), University of California, San Diego.

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http://dx.doi.org/10.1212/WNL.0000000000004609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679418PMC
November 2017

Evaluation of α-synuclein as a novel cerebrospinal fluid biomarker in different forms of prion diseases.

Alzheimers Dement 2017 Jun 18;13(6):710-719. Epub 2016 Nov 18.

Department of Neurology, Clinical Dementia Center, University Medical Center Göttingen, Göttingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Site Göttingen, Germany.

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http://dx.doi.org/10.1016/j.jalz.2016.09.013DOI Listing
June 2017

Decrease in Aβ42 predicts dopa-resistant gait progression in early Parkinson disease.

Neurology 2017 Apr 22;88(16):1501-1511. Epub 2017 Mar 22.

From the Institute of Neuroscience (L.R., B.G., S.L., A.J.Y., R.M., G.D., T.K.K., D.J.B.), Clinical Ageing Research Unit, Newcastle University; Department of Geriatric Medicine (G.D.), University of Edinburgh, UK; School of Medicine & Menzies Health Institute (T.K.K.), Griffith University, Australia; and Paracelsus-Elena Klinik, Kassel and University Medical Centre (Institute of Neuropathology and Department of Neurosurgery) (B.M.), Göttingen, Germany.

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http://dx.doi.org/10.1212/WNL.0000000000003840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395075PMC
April 2017

The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease.

Biomark Med 2017 Apr 29;11(4):359-368. Epub 2017 Mar 29.

Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.

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http://dx.doi.org/10.2217/bmm-2016-0366DOI Listing
April 2017

Validation of electrochemiluminescence assays for highly sensitive and reproducible quantification of α-synuclein in cerebrospinal fluid.

Bioanalysis 2017 Apr 15;9(8):621-630. Epub 2017 May 15.

Department of Neuropathology, University Medical Center, Robert-Koch-Str. 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.4155/bio-2017-0005DOI Listing
April 2017

The depressed brain in Parkinson's disease: Implications for an inflammatory biomarker.

Proc Natl Acad Sci U S A 2017 03 10;114(12):3004-3005. Epub 2017 Mar 10.

Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1700737114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373331PMC
March 2017

Development of a Biochemical Diagnosis of Parkinson Disease by Detection of α-Synuclein Misfolded Aggregates in Cerebrospinal Fluid.

JAMA Neurol 2017 Feb;74(2):163-172

Mitchell Center for Alzheimer's Disease and Related Brain Disorders, The University of Texas School of Medicine at Houston.

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http://dx.doi.org/10.1001/jamaneurol.2016.4547DOI Listing
February 2017

Metabolic profiling of body fluids and multivariate data analysis.

MethodsX 2017 20;4:95-103. Epub 2017 Feb 20.

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg; Braunschweig Integrated Centre of Systems Biology, University of Braunschweig, Rebenring 56, Braunschweig, Germany; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.

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http://dx.doi.org/10.1016/j.mex.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5329063PMC
February 2017

Cerebrospinal α-synuclein in α-synuclein aggregation disorders: tau/α-synuclein ratio as potential biomarker for dementia with Lewy bodies.

J Neurol 2016 Nov 20;263(11):2271-2277. Epub 2016 Aug 20.

Department of Neurology, Clinical Dementia Center, University Medical Center, Georg-August University, Robert Koch Strasse 40, Göttingen, Germany.

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http://dx.doi.org/10.1007/s00415-016-8259-0DOI Listing
November 2016

Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders.

J Neurochem 2016 10 10;139 Suppl 1:290-317. Epub 2016 Feb 10.

Program in Neuroscience and Division of Neurology, The Ottawa Hospital, University of Ottawa Brain & Mind Research Institute, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1111/jnc.13390DOI Listing
October 2016

The utility of α-synuclein as biofluid marker in neurodegenerative diseases: a systematic review of the literature.

Biomark Med 2016 28;10(1):19-34. Epub 2015 Aug 28.

Paracelsus-Elena-Klinik, Kassel & University Medical Center (Departments of Neuropathology & Neurosurgery), Georg-August University Goettingen, Germany.

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http://dx.doi.org/10.2217/BMM.14.105DOI Listing
September 2016

Non-Motor Correlates of Smoking Habits in de Novo Parkinson's Disease.

J Parkinsons Dis 2015 ;5(4):913-24

Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, Department of Medicine, University of Salerno, Salerno, Italy.

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http://dx.doi.org/10.3233/JPD-150639DOI Listing
September 2016

Associations between Cerebrospinal Fluid Biomarkers and Cognition in Early Untreated Parkinson's Disease.

J Parkinsons Dis 2015 ;5(4):783-92

Center forAlzheimer's Disease Research, Department of Neurobiology, CareSciences and Society, Karolinska Institutet H1, Division of Neurogeriatrics, Sweden.

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http://dx.doi.org/10.3233/JPD-150682DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031486PMC
September 2016

Chemical profiling of cerebrospinal fluid by multiple reaction monitoring mass spectrometry.

Analyst 2016 Sep 12;141(18):5252-5. Epub 2016 Aug 12.

Department of Chemistry and Center for Analytical Instrumentation Development (CAID), Purdue University, West Lafayette, IN 47907, USA.

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http://xlink.rsc.org/?DOI=C6AN01618A
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http://dx.doi.org/10.1039/c6an01618aDOI Listing
September 2016

Monitoring of 30 marker candidates in early Parkinson disease as progression markers.

Neurology 2016 07 6;87(2):168-77. Epub 2016 May 6.

From Paracelsus-Elena-Klinik (B.M., F.S.-D., T.W., J.E., M.S., E.L., E.T., C.T.), Kassel; Departments of Neurosurgery (B.M., C.T.) and Medical Statistics (T.F.) and Institute of Neuropathology (B.M.), University Medical Centre Göttingen; Psychologische Hochschule Berlin (J.Z.); Department of Neurology/Epileptology and Hertie Institute of Clinical Brain Research (N.K.F.), University of Tübingen, Germany; Clinical Neurochemistry Laboratory (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; UCL Institute of Neurology (H.Z.), Queen Square, London, UK; and BioLegend (P.T.), Dedham, MA.

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http://dx.doi.org/10.1212/WNL.0000000000002651DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940068PMC
July 2016

Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.

Front Aging Neurosci 2016 22;8:147. Epub 2016 Jun 22.

Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of TübingenTübingen, Germany; German Center for Neurodegenerative Diseases, University of TübingenTübingen, Germany; Department of Neurology, Christian-Albrechts-UniversityKiel, Germany.

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http://dx.doi.org/10.3389/fnagi.2016.00147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916171PMC
July 2016

Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.

Front Aging Neurosci 2016 27;8:121. Epub 2016 May 27.

Center of Neurology, Department of Neurodegeneration and Hertie-Institute for Clinical Brain Research, University of TuebingenTuebingen, Germany; German Center for Neurodegenerative Diseases, University of TuebingenTuebingen, Germany; Department of Neurology, Christian-Albrechts UniversityKiel, Germany.

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http://dx.doi.org/10.3389/fnagi.2016.00121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4882324PMC
June 2016

Can we prevent and slow down neurodegeneration with diet and exercise?

Authors:
Brit Mollenhauer

Mov Disord 2016 Mar 21;31(3):299. Epub 2015 Dec 21.

Paracelsus-Elena-Klinik, Kassel, Germany, University Medical Center Goettingen, Germany.

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http://dx.doi.org/10.1002/mds.26449DOI Listing
March 2016

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies.

Brain 2016 Feb 8;139(Pt 2):481-94. Epub 2015 Dec 8.

1 Department of Psychiatry and Psychotherapy, University Medicine Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany 2 Max-Planck-Institute for Experimental Medicine, Hermann-Rein-Str. 3, 37075 Göttingen, Germany 3 Cluster of Excellence 'Nanoscale Microscopy and Molecular Physiology of the Brain' (CNMPB), Göttingen, Germany 7 German Centre for Neurodegenerative Diseases (DZNE), Göttingen, Von-Siebold-Str. 5, 37075 Göttingen, Germany

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http://dx.doi.org/10.1093/brain/awv346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805087PMC
February 2016

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early-stage Parkinson's disease.

Ann Neurol 2015 Dec 13;78(6):1000-4. Epub 2015 Nov 13.

Mitochondrial Research Group, University of Newcastle Upon Tyne, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1002/ana.24515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551217PMC
December 2015

Validation of a commercially available enzyme-linked immunoabsorbent assay for the quantification of human α-Synuclein in cerebrospinal fluid.

J Immunol Methods 2015 Nov 10;426:70-5. Epub 2015 Aug 10.

Department of Neuropathology, University Medical Center, Robert-Koch-Str. 40, 37075 Göttingen, Germany; Paracelsus-Elena-Klinik, Klinikstr. 16, 34128 Kassel, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2015.08.003DOI Listing
November 2015

Quantification of CSF biomarkers using an electrochemiluminescence-based detection system in the differential diagnosis of AD and sCJD.

J Neurol 2015 Oct 11;262(10):2305-11. Epub 2015 Jul 11.

Department of Neurology, Clinical Dementia Center, University Medical Center, Georg-August University and German Center for Neurodegenerative Diseases (DZNE), Robert-Koch-Str. 40, 37075, Goettingen, Germany.

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http://dx.doi.org/10.1007/s00415-015-7837-xDOI Listing
October 2015

Fluid biomarkers in multiple system atrophy: A review of the MSA Biomarker Initiative.

Neurobiol Dis 2015 Aug 15;80:29-41. Epub 2015 May 15.

Service de Neurologie, CHU de Bordeaux, F-33076 Bordeaux, France; Centre de référence atrophie multisystématisée, CHU de Bordeaux, F-33076 Bordeaux, France; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33076 Bordeaux, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2015.05.004DOI Listing
August 2015

Improved preparation of nasal lavage fluid (NLF) as a noninvasive sample for proteomic biomarker discovery.

Biochim Biophys Acta 2015 Jul 10;1854(7):741-5. Epub 2015 Feb 10.

Abteilung für Funktionelle Proteomik, Medizinisches Proteom-Center, Ruhr-Universitaet Bochum, 44801 Bochum, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbapap.2015.01.015DOI Listing
July 2015

Prediagnostic presentation of Parkinson's disease in primary care: A case-control study.

Authors:
Brit Mollenhauer

Mov Disord 2015 May 16;30(6):787. Epub 2015 Apr 16.

Paracelsus-Elena-Klinik, Kassel, Germany.

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http://dx.doi.org/10.1002/mds.26234DOI Listing
May 2015

REM Sleep Behavioral Events and Dreaming.

J Clin Sleep Med 2015 Apr 15;11(5):537-41. Epub 2015 Apr 15.

Paracelsus Elena Klinik Kassel, Germany.

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http://dx.doi.org/10.5664/jcsm.4698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410927PMC
April 2015

REM sleep-associated motor behaviors in Parkinson's disease patients with heterozygous Parkin mutations.

Mov Disord 2015 Apr 15;30(4):597-8. Epub 2015 Mar 15.

Paracelsus-Elena Klinik, Center for Parkinsonism and Movement Disorders, Kassel, Germany; Department of Neurology, Philipps-University Marburg, Germany.

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http://dx.doi.org/10.1002/mds.26193DOI Listing
April 2015