Publications by authors named "Brinton Seashore-Ludlow"

32Publications

Nanomedicine for improvement of dendritic cell-based cancer immunotherapy.

Int Immunopharmacol 2020 Jun 31;83:106446. Epub 2020 Mar 31.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.intimp.2020.106446DOI Listing
June 2020

Immediate Adaptation Analysis Implicates BCL6 as an EGFR-TKI Combination Therapy Target in NSCLC.

Mol Cell Proteomics 2020 06 31;19(6):928-943. Epub 2020 Mar 31.

Department of Oncology-Pathology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1074/mcp.RA120.002036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261823PMC
June 2020

Perspective on CETSA Literature: Toward More Quantitative Data Interpretation.

SLAS Discov 2020 02 30;25(2):118-126. Epub 2019 Oct 30.

Chemical Biology Consortium Sweden, Science for Life Laboratories, Karolinska Institutet, Solna, Sweden.

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http://dx.doi.org/10.1177/2472555219884524DOI Listing
February 2020

Using High Content Imaging to Quantify Target Engagement in Adherent Cells.

J Vis Exp 2018 11 29(141). Epub 2018 Nov 29.

Chemical Biology Consortium Sweden, Science for Life Laboratory, Karolinska Institutet, Solna; Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm;

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https://www.jove.com/video/58670/using-high-content-imaging-
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http://dx.doi.org/10.3791/58670DOI Listing
November 2018

Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.

Methods Mol Biol 2019 ;1888:233-254

Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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http://link.springer.com/10.1007/978-1-4939-8891-4_14
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http://dx.doi.org/10.1007/978-1-4939-8891-4_14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563933PMC
June 2019

Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay.

Biochemistry 2018 12 19;57(48):6715-6725. Epub 2018 Nov 19.

Chemical Biology Consortium Sweden, Science for Life Laboratories , Karolinska Institutet , SE-171 65 Solna , Sweden.

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http://pubs.acs.org/doi/10.1021/acs.biochem.8b01057
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http://dx.doi.org/10.1021/acs.biochem.8b01057DOI Listing
December 2018

Reprint of: A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.

Biochem Biophys Res Commun 2018 05 23;499(2):136-142. Epub 2018 Mar 23.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.03.001DOI Listing
May 2018

In Situ Target Engagement Studies in Adherent Cells.

ACS Chem Biol 2018 04 21;13(4):942-950. Epub 2018 Feb 21.

Chemical Biology Consortium Sweden, Science for Life Laboratory , Karolinska Institutet , SE-171 65 Solna , Sweden.

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http://dx.doi.org/10.1021/acschembio.7b01079DOI Listing
April 2018

A chemical screen identifies trifluoperazine as an inhibitor of glioblastoma growth.

Biochem Biophys Res Commun 2017 12 21;494(3-4):477-483. Epub 2017 Oct 21.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.10.106DOI Listing
December 2017

Early Perspective.

J Biomol Screen 2016 Dec 20;21(10):1019-1033. Epub 2016 Jul 20.

1 Chemical Biology Consortium Sweden, Science for Life Laboratories, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1087057116659256DOI Listing
December 2016

Inhibitors of the Cysteine Synthase CysM with Antibacterial Potency against Dormant Mycobacterium tuberculosis.

J Med Chem 2016 07 13;59(14):6848-59. Epub 2016 Jul 13.

Division of Molecular Structural Biology, Department of Medical Biochemistry & Biophysics, Karolinska Institutet , S-171 77 Stockholm, Sweden.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00674DOI Listing
July 2016

Discovery of a Small-Molecule Probe for V-ATPase Function.

J Am Chem Soc 2015 Apr 20;137(16):5563-8. Epub 2015 Apr 20.

∥Center for Computational and Integrative Biology, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, United States.

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http://dx.doi.org/10.1021/jacs.5b02150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4416280PMC
April 2015

Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality.

Cell 2014 Aug;158(5):1199-1209

The Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 6997801, Israel; The Sackler School of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.027DOI Listing
August 2014

NAMPT is the cellular target of STF-31-like small-molecule probes.

ACS Chem Biol 2014 Oct 7;9(10):2247-54. Epub 2014 Aug 7.

Center for the Science of Therapeutics and ∥Howard Hughes Medical Institute, Broad Institute , 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/cb500347pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201331PMC
October 2014

Asymmetric transfer hydrogenation coupled with dynamic kinetic resolution in water: synthesis of anti-β-hydroxy-α-amino acid derivatives.

Org Lett 2012 Dec 10;14(24):6334-7. Epub 2012 Dec 10.

Organic Chemistry, Department of Chemical Science and Engineering, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.

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http://dx.doi.org/10.1021/ol303115vDOI Listing
December 2012

Domino carbopalladation-cross-coupling for the synthesis of 3,3-disubstituted oxindoles.

Org Lett 2012 Aug 17;14(15):3858-61. Epub 2012 Jul 17.

Chemical Science and Engineering, Organic Chemistry, KTH Royal Institute of Technology, 100 44 Stockholm, Sweden.

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http://pubs.acs.org/doi/10.1021/ol301539p
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http://dx.doi.org/10.1021/ol301539pDOI Listing
August 2012

Enantioselective synthesis of anti-β-hydroxy-α-amido esters by asymmetric transfer hydrogenation in emulsions.

Chemistry 2012 Jun 24;18(23):7219-23. Epub 2012 Apr 24.

Organic Chemistry, Department of Chemical Science and Engineering, KTH Royal Institute of Technology, Teknikringen 36, 10044 Stockholm, Sweden.

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http://dx.doi.org/10.1002/chem.201103739DOI Listing
June 2012

Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation.

Org Lett 2010 Nov 21;12(22):5274-7. Epub 2010 Oct 21.

Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, 100 44 Stockholm, Sweden.

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http://dx.doi.org/10.1021/ol102323kDOI Listing
November 2010

A general enantioselective route to the chamigrene natural product family.

Tetrahedron 2010 Mar;66(26):4668-4686

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125.

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http://dx.doi.org/10.1016/j.tet.2010.04.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925317PMC
March 2010

Domino carbopalladation-carbonylation: generating quaternary stereocenters while controlling beta-hydride elimination.

Org Lett 2010 Sep;12(17):3732-5

Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, SE-10044 Stockholm, Sweden.

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http://pubs.acs.org/doi/abs/10.1021/ol1009703
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http://dx.doi.org/10.1021/ol1009703DOI Listing
September 2010