Publications

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.
Nat Commun 2015 Aug 20;6:8045. Epub 2015 Aug 20.
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

IGF-1 receptor antagonism inhibits autophagy.
Hum Mol Genet 2013 Nov 25;22(22):4528-44. Epub 2013 Jun 25.
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 2012 Apr;8(4):445-544
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.


α-Synuclein impairs macroautophagy: implications for Parkinson's disease.
J Cell Biol 2010 Sep;190(6):1023-37
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, England, UK.

Mammalian macroautophagy at a glance.
J Cell Sci 2009 Jun;122(Pt 11):1707-11
Department of Medical Genetics, Cambridge Institute for Medical Research, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Nat Neurosci 2006 Jun 14;9(6):824-31. Epub 2006 May 14.
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.

Rapamycin alleviates toxicity of different aggregate-prone proteins.
Hum Mol Genet 2006 Feb 20;15(3):433-42. Epub 2005 Dec 20.
Department of Medical Genetics,Cambridge Institute for Medical Research,Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.
Nat Genet 2004 Jun 16;36(6):585-95. Epub 2004 May 16.
Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by decreasing mTOR phosphorylation and inducing autophagy.
Hum Mol Genet 2003 May;12(9):985-94
Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK.

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