Brigitte Marian

Brigitte Marian

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Brigitte Marian

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Destabilization of FoxM1 and Inhibition of Topoisomerase I Contribute to Cytotoxicity of Prenylated Xanthones Isolated from Metaxya rostrata.

Planta Med 2020 Feb 5. Epub 2020 Feb 5.

Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1055/a-1097-8722DOI Listing
February 2020

Importance of Translational Research for Targeting Fibroblast Growth Factor Receptor Signaling in Cancer.

Cells 2019 10 2;8(10). Epub 2019 Oct 2.

Medical University of Vienna, Comprehensive Cancer Center, Department of Medicine I, Division of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/cells8101191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830323PMC
October 2019

Expression of FGF8, FGF18, and FGFR4 in Gastroesophageal Adenocarcinomas.

Cells 2019 09 16;8(9). Epub 2019 Sep 16.

Department of Surgery, Medical University of Vienna and Gastroesophageal Tumor Unit, Comprehensive Cancer Center (CCC), Spitalgasse 23, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/cells8091092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770911PMC
September 2019

Impact of Fibroblast-Derived SPARC on Invasiveness of Colorectal Cancer Cells.

Cancers (Basel) 2019 Sep 24;11(10). Epub 2019 Sep 24.

Department of Medicine 1, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/cancers11101421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827058PMC
September 2019

Prenylated xanthones from Metaxya rostrata suppress FoxM1 and induce active cell death by distinct mechanisms.

Phytomedicine 2019 Jul 2;60:152912. Epub 2019 Apr 2.

Medical University Vienna, Department of Medicine I, Institute of Cancer Research, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152912DOI Listing
July 2019

Proteomic profiling identifies markers for inflammation-related tumor-fibroblast interaction.

Clin Proteomics 2017 6;14:33. Epub 2017 Oct 6.

Department of Medicine 1, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1186/s12014-017-9168-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689177PMC
October 2017

A Facile Oxidative Opening of the C-Ring in Luotonin A and Derivatives.

Molecules 2017 Sep 12;22(9). Epub 2017 Sep 12.

Department of Pharmaceutical Chemistry, University of Vienna, Althanstraße 14, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3390/molecules22091540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151605PMC
September 2017

Irinotecan Upregulates Fibroblast Growth Factor Receptor 3 Expression in Colorectal Cancer Cells, Which Mitigates Irinotecan-Induced Apoptosis.

Transl Oncol 2017 Jun 22;10(3):332-339. Epub 2017 Mar 22.

Medical University of Vienna, Department of Medicine 1, Institute of Cancer Research and Comprehensive Cancer Center Vienna, Borschkegasse 8a, 1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367848PMC
June 2017

Effect of 1,25-dihydroxyvitamin D3 on the Wnt pathway in non-malignant colonic cells.

J Steroid Biochem Mol Biol 2016 Jan 14;155(Pt B):224-30. Epub 2015 Mar 14.

Department of Pathophysiology and Allergy Research, Comprehensive Cancer Center, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2015.02.011DOI Listing
January 2016

Fibroblast growth factor receptor 3 isoforms: Novel therapeutic targets for hepatocellular carcinoma?

Hepatology 2015 Dec 16;62(6):1767-78. Epub 2015 Oct 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/hep.28023DOI Listing
December 2015

IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis.

Cancer Immunol Res 2015 Nov 30;3(11):1227-35. Epub 2015 Jun 30.

Medical University of Vienna, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Vienna, Austria.

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http://dx.doi.org/10.1158/2326-6066.CIR-15-0031DOI Listing
November 2015

Is fibroblast growth factor receptor 4 a suitable target of cancer therapy?

Curr Pharm Des 2014 ;20(17):2881-98

Institute of Cancer Research, Department of Medicine 1, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453246PMC
http://dx.doi.org/10.2174/13816128113199990594DOI Listing
September 2015

Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling.

Mol Carcinog 2015 Sep 9;54(9):841-52. Epub 2014 Apr 9.

Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.

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http://doi.wiley.com/10.1002/mc.22155
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http://dx.doi.org/10.1002/mc.22155DOI Listing
September 2015

Autonomous inhibition of apoptosis correlates with responsiveness of colon carcinoma cell lines to ciglitazone.

PLoS One 2014 11;9(12):e114158. Epub 2014 Dec 11.

Department of Medicine I, Clinic for Internal Medicine I, Institute of Cancer Research, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4263530PMC
September 2015

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

Carcinogenesis 2014 Oct 16;35(10):2331-8. Epub 2014 Jul 16.

Department of Medicine I, Division: Institute of Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria and Institute of Clinical Pathology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

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http://carcin.oxfordjournals.org/content/35/10/2331.full.pdf
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http://www.carcin.oxfordjournals.org/cgi/doi/10.1093/carcin/
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http://dx.doi.org/10.1093/carcin/bgu151DOI Listing
October 2014

Modulation of Wnt Activity and Cell Physiology by Butyrate in LT97 Microadenoma Cells.

J Cancer 2014 14;5(3):203-13. Epub 2014 Feb 14.

1. Department of Basic Sciences, the Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, USA.

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http://www.jcancer.org/v05p0203.pdf
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http://www.jcancer.org/v05p0203.htm
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http://dx.doi.org/10.7150/jca.8569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931268PMC
February 2014

Taurine chloramine induces apoptosis in human osteosarcoma cell lines.

J Orthop Res 2012 Dec 4;30(12):2046-51. Epub 2012 Jun 4.

Department of Hospital Hygiene, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.

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http://dx.doi.org/10.1002/jor.22161DOI Listing
December 2012

Two Unusual Methylidenecyclopropane Glucosides from C.Presl.

Helv Chim Acta 2012 Sep 13;95(9):1531-1537. Epub 2012 Sep 13.

Department of Pharmacognosy, University of Vienna Althanstr. 14, AT-1090 Vienna.

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http://dx.doi.org/10.1002/hlca.201200111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569612PMC
September 2012

Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer.

J Nucleic Acids 2012 12;2012:950508. Epub 2011 Dec 12.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1155/2012/950508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238399PMC
August 2012

The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cells.

Cancer Lett 2012 Jun 17;319(2):164-172. Epub 2012 Jan 17.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090 Vienna, Austria. Electronic address:

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http://linkinghub.elsevier.com/retrieve/pii/S030438351200027
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http://dx.doi.org/10.1016/j.canlet.2012.01.002DOI Listing
June 2012

Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells.

Exp Cell Res 2012 Apr 14;318(7):819-27. Epub 2012 Feb 14.

Department of Gastroenterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1016/j.yexcr.2012.02.004DOI Listing
April 2012

The PI3 kinase/mTOR blocker NVP-BEZ235 overrides resistance against irreversible ErbB inhibitors in breast cancer cells.

Breast Cancer Res Treat 2011 Sep 3;129(2):387-400. Epub 2010 Nov 3.

Signaling Networks Program, Division of Oncology, Department of Medicine I, Medical University Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

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http://dx.doi.org/10.1007/s10549-010-1232-1DOI Listing
September 2011

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy.

Expert Opin Ther Targets 2011 Jul 7;15(7):829-46. Epub 2011 Mar 7.

Medical University Vienna, Institute of Cancer Research, Department of Medicine 1, Vienna,Austria.

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http://dx.doi.org/10.1517/14728222.2011.566217DOI Listing
July 2011

Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.

J Cancer Res Clin Oncol 2011 Jan 11;137(1):29-39. Epub 2010 Mar 11.

Department of Medicine 1, Clinic for Internal Medicine I, Institute of Cancer Research, Medical University of Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1007/s00432-010-0856-1DOI Listing
January 2011

Neoplastic stem cells: current concepts and clinical perspectives.

Crit Rev Oncol Hematol 2010 Nov 25;76(2):79-98. Epub 2010 Feb 25.

Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.critrevonc.2010.01.001DOI Listing
November 2010

Interaction between fatty acid synthase- and ErbB-systems in ovarian cancer cells.

Biochem Biophys Res Commun 2009 Jul 23;385(3):454-9. Epub 2009 May 23.

Signaling Networks Program, Department of Medicine I, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.085DOI Listing
July 2009

Chemical and pharmacological investigations of Metaxya rostrata.

Z Naturforsch C J Biosci 2008 Jul-Aug;63(7-8):469-75

Department of Pharmacognosy, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria.

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http://dx.doi.org/10.1515/znc-2008-7-801DOI Listing
October 2008

The dietary antioxidants resveratrol and quercetin protect cells from exogenous pro-oxidative damage.

Food Chem Toxicol 2008 Apr 11;46(4):1320-6. Epub 2007 Sep 11.

Department of Medicine 1, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S027869150700337
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http://dx.doi.org/10.1016/j.fct.2007.09.002DOI Listing
April 2008

Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells.

Food Chem Toxicol 2008 Apr 11;46(4):1221-9. Epub 2007 Sep 11.

Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1016/j.fct.2007.09.005DOI Listing
April 2008

FGF18 in colorectal tumour cells: autocrine and paracrine effects.

Carcinogenesis 2008 Jan 22;29(1):15-24. Epub 2007 Sep 22.

Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Vienna, Austria.

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http://dx.doi.org/10.1093/carcin/bgm202DOI Listing
January 2008

Cytotoxicity of the novel spin trapping compound 5-ethoxycarbonyl-3,5-dimethyl-pyrroline N-oxide (3,5-EDPO) and its derivatives.

Bioorg Med Chem Lett 2007 Oct 19;17(20):5698-703. Epub 2007 Aug 19.

Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0700862
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http://dx.doi.org/10.1016/j.bmcl.2007.07.054DOI Listing
October 2007

Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes.

Toxicol Sci 2007 Apr 27;96(2):279-84. Epub 2006 Dec 27.

Institute for Nutrition, Dornburger Strasse 25, Friedrich-Schiller-University Jena, 07743 Jena, Germany.

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http://dx.doi.org/10.1093/toxsci/kfl197DOI Listing
April 2007

Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme.

Food Chem Toxicol 2007 Mar 30;45(3):508-14. Epub 2006 Aug 30.

Department of Internal Medicine 1, Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S027869150600245
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http://dx.doi.org/10.1016/j.fct.2006.08.013DOI Listing
March 2007

Neoplastic stem cells: a novel therapeutic target in clinical oncology.

Cancer 2006 Nov;107(10):2512-20

Bone Marrow Transplantation Unit, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/cncr.22277DOI Listing
November 2006

[Aspects of gender in colorectal tumors].

Wien Med Wochenschr 2006 Oct;156(19-20):541-4

Klinische Abteilung für Allgemeinchirurgie, Medizinische Universität Wien, Wien, Austria.

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http://dx.doi.org/10.1007/s10354-006-0345-yDOI Listing
October 2006

Apoptosis in a tissue-like culture model of human colorectal adenoma cells.

Tissue Cell 2006 Jun 30;38(3):203-8. Epub 2006 May 30.

Institution of Cell Imaging and Ultrastructure Research University of Vienna, Austria.

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http://dx.doi.org/10.1016/j.tice.2006.03.003DOI Listing
June 2006

2-Dodecylcyclobutanone, a radiolytic product of palmitic acid, is genotoxic in primary human colon cells and in cells from preneoplastic lesions.

Mutat Res 2006 Feb 8;594(1-2):10-9. Epub 2005 Sep 8.

Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich Schiller University, Dornburger Strasse 25, D-07743 Jena, Germany.

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http://dx.doi.org/10.1016/j.mrfmmm.2005.07.015DOI Listing
February 2006

Cytotoxicity of novel derivatives of the spin trap EMPO.

Bioorg Med Chem Lett 2006 Feb 10;16(3):541-6. Epub 2005 Nov 10.

Research Institute of Biochemical Pharmacology and Molecular Toxicology, Veterinary University of Vienna, Veterinaerplatz 1, A-1210 Vienna, Austria.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0501335
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http://dx.doi.org/10.1016/j.bmcl.2005.10.060DOI Listing
February 2006

Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone.

Anticancer Res 2005 Jul-Aug;25(4):2793-800

Research Institute of Biochemical Pharmacology and Toxicology, University of Veterinary Medicine Vienna, A-1210 Vienna, Austria.

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September 2005

The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells.

Cancer Lett 2005 Aug;226(2):115-21

Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, A 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.canlet.2005.01.002DOI Listing
August 2005

Dietary lipid hydroperoxides induce expression of vascular endothelial growth factor (VEGF) in human colorectal tumor cells.

FASEB J 2005 Jan 2;19(1):97-9. Epub 2004 Nov 2.

Institute of Cancer Research, Medical University Vienna, Vienna, Austria.

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http://www.fasebj.org/doi/10.1096/fj.04-2111fje
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http://dx.doi.org/10.1096/fj.04-2111fjeDOI Listing
January 2005

Bile acid induced gene expression in LT97 colonic adenoma cells.

Food Chem Toxicol 2005 Jan;43(1):87-93

Institute of Cancer Research, Medical University Vienna, Borschkegasse 8a, 1090 Vienna, Austria.

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http://dx.doi.org/10.1016/j.fct.2004.08.015DOI Listing
January 2005

Flavaglines: a group of efficient growth inhibitors block cell cycle progression and induce apoptosis in colorectal cancer cells.

Int J Cancer 2004 May;109(6):933-40

Institute of Cancer Research, University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1002/ijc.20033DOI Listing
May 2004

Induction of apoptosis by vitamin D metabolites and analogs in a glioma cell line.

Recent Results Cancer Res 2003 ;164:319-32

Institute of Pharmaceutical Chemistry, University of Vienna, Althanstrasse 15, 1090 Vienna, Austria.

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http://dx.doi.org/10.1007/978-3-642-55580-0_22DOI Listing
December 2003

Induction of lipid peroxidation in biomembranes by dietary oil components.

Food Chem Toxicol 2003 Nov;41(11):1481-9

Basic Pharmacology and Toxicology, Veterinary University of Vienna, A-1210 Vienna, Austria.

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http://dx.doi.org/10.1016/s0278-6915(03)00164-9DOI Listing
November 2003

Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal.

Mutat Res 2003 May;526(1-2):19-32

Department of Nutritional Toxicology, Institute for Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 25, Germany.

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http://dx.doi.org/10.1016/s0027-5107(03)00012-5DOI Listing
May 2003