Bridget K Wagner

Bridget K Wagner

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Bridget K Wagner

Bridget K Wagner

Publications by authors named "Bridget K Wagner"

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6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels.

Cell Chem Biol 2019 Sep 13;26(9):1306-1314.e5. Epub 2019 Jun 13.

Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2019.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754299PMC
September 2019

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.

Nat Chem Biol 2019 06 13;15(6):565-574. Epub 2019 May 13.

Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://dx.doi.org/10.1038/s41589-019-0271-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551522PMC
June 2019

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.

Cell 2019 May;177(4):1067-1079.e19

Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Divisions of Renal Medicine and Engineering, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.04.009DOI Listing
May 2019

When Small Molecules Are Like Real Estate: It's All about Location, Location, Location.

Cell Chem Biol 2018 10;25(10):1169-1170

Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.10.004DOI Listing
October 2018

Isoform-selective inhibitor of histone deacetylase 3 (HDAC3) limits pancreatic islet infiltration and protects female nonobese diabetic mice from diabetes.

J Biol Chem 2017 10 31;292(43):17598-17608. Epub 2017 Aug 31.

From the Department of Islet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, Massachusetts 02215,

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http://dx.doi.org/10.1074/jbc.M117.804328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663865PMC
October 2017

The resurgence of phenotypic screening in drug discovery and development.

Authors:
Bridget K Wagner

Expert Opin Drug Discov 2016 10;11(2):121-5. Epub 2015 Dec 10.

a Center for the Science of Therapeutics , Broad Institute , Cambridge , MA , USA.

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http://dx.doi.org/10.1517/17460441.2016.1122589DOI Listing
September 2016

The Genetic Landscape of β-Cell Proliferation: Toward a Road Map.

Authors:
Bridget K Wagner

Diabetes 2016 07;65(7):1789-90

Center for the Science of Therapeutics, Broad Institute, Cambridge, MA

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http://dx.doi.org/10.2337/dbi16-0018DOI Listing
July 2016

Real-Time Biological Annotation of Synthetic Compounds.

J Am Chem Soc 2016 07 11;138(28):8920-7. Epub 2016 Jul 11.

Department of Chemistry and Chemical Biology, Harvard University , 12 Oxford Street, Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/jacs.6b04614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976700PMC
July 2016

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods.

Cell Chem Biol 2016 Jan;23(1):3-9

Center for the Science of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1016/j.chembiol.2015.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779180PMC
January 2016

Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides.

Org Lett 2015 Feb 8;17(3):418-21. Epub 2015 Jan 8.

Center for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/ol503273vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323038PMC
February 2015

HDAC inhibitor-mediated beta-cell protection against cytokine-induced toxicity is STAT1 Tyr701 phosphorylation independent.

J Interferon Cytokine Res 2015 Jan 25;35(1):63-70. Epub 2014 Jul 25.

1 Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark .

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http://dx.doi.org/10.1089/jir.2014.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291159PMC
January 2015

Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.

Trends Genet 2015 Jan 12;31(1):16-23. Epub 2014 Dec 12.

Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tig.2014.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281276PMC
January 2015

High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function.

Cell Metab 2015 Jan;21(1):126-37

Diabetes Unit of the Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Medical and Population Genetics Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cmet.2014.12.010DOI Listing
January 2015

Evaluation of compounds in primary human islet cell culture.

Curr Protoc Chem Biol 2014 Sep 9;6(3):157-68. Epub 2014 Sep 9.

Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts.

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http://dx.doi.org/10.1002/9780470559277.ch140088DOI Listing
September 2014

Targeting the pancreatic β-cell to treat diabetes.

Nat Rev Drug Discov 2014 Apr 14;13(4):278-89. Epub 2014 Feb 14.

Chemical Biology Program, Center for the Science of Therapeutics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.

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http://www.nature.com/articles/nrd4231
Publisher Site
http://dx.doi.org/10.1038/nrd4231DOI Listing
April 2014

Inhibition of HDAC3 as a strategy for developing novel diabetes therapeutics.

Epigenomics 2014 Apr;6(2):209-14

Chemical Biology Program, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.2217/epi.14.11DOI Listing
April 2014

Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility.

J Med Chem 2013 May 13;56(10):4125-9. Epub 2013 May 13.

Chemical Biology Program and Chemical Biology Platform, The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/jm400397xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3690275PMC
May 2013

Target identification and mechanism of action in chemical biology and drug discovery.

Nat Chem Biol 2013 Apr;9(4):232-40

Proteomics Platform, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543995PMC
April 2013

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.

Proc Natl Acad Sci U S A 2012 Sep 4;109(38):15115-20. Epub 2012 Sep 4.

Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1212802109
Publisher Site
http://dx.doi.org/10.1073/pnas.1212802109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458345PMC
September 2012

Chemical methods to induce Beta-cell proliferation.

Int J Endocrinol 2012 28;2012:925143. Epub 2012 Jun 28.

Chemical Biology Program, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1155/2012/925143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3395230PMC
August 2012

Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis.

ACS Med Chem Lett 2011 Sep;2(9):698-702

Chemical Biology Program and Chemical Biology Platform, The Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/ml200120mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171963PMC
September 2011

Screening: Low-fat worms on drugs.

Authors:
Bridget K Wagner

Nat Chem Biol 2011 Apr;7(4):194-5

Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.540DOI Listing
April 2011

The binding of fluorophores to proteins depends on the cellular environment.

Angew Chem Int Ed Engl 2011 Mar 2;50(12):2761-3. Epub 2011 Mar 2.

Department of Chemistry, National University of Singapore, Singapore.

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http://dx.doi.org/10.1002/anie.201007626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758120PMC
March 2011

Grand challenge commentary: Chemical transdifferentiation and regenerative medicine.

Authors:
Bridget K Wagner

Nat Chem Biol 2010 Dec;6(12):877-9

Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.472DOI Listing
December 2010

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

Proc Natl Acad Sci U S A 2010 Aug 9;107(34):15099-104. Epub 2010 Aug 9.

Howard Hughes Medical Institute, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142.

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http://dx.doi.org/10.1073/pnas.1010018107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2930573PMC
August 2010

Connecting synthetic chemistry decisions to cell and genome biology using small-molecule phenotypic profiling.

Curr Opin Chem Biol 2009 Dec 12;13(5-6):539-48. Epub 2009 Oct 12.

Chemical Biology Program, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cbpa.2009.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787914PMC
December 2009

High-throughput real-time PCR for detection of gene-expression levels.

Methods Mol Biol 2009 ;486:167-75

Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

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http://link.springer.com/10.1007/978-1-60327-545-3_12
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http://dx.doi.org/10.1007/978-1-60327-545-3_12DOI Listing
June 2009

Using biological performance similarity to inform disaccharide library design.

J Am Chem Soc 2009 Apr;131(14):5075-83

Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1021/ja806583yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730776PMC
April 2009

Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening.

J Am Chem Soc 2008 Apr 8;130(13):4208-9. Epub 2008 Mar 8.

Chemical Biology Program, Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/ja077656dDOI Listing
April 2008

Large-scale chemical dissection of mitochondrial function.

Nat Biotechnol 2008 Mar 24;26(3):343-51. Epub 2008 Feb 24.

Broad Institute of Massachusetts Institute of Technology and Harvard, Seven Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nbt1387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715872PMC
March 2008

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation.

Proc Natl Acad Sci U S A 2008 Mar 17;105(12):4721-6. Epub 2008 Mar 17.

Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0800979105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290788PMC
March 2008

Chemical genomics: probing protein function using small molecules.

Am J Pharmacogenomics 2004 ;4(5):313-20

The Eli and Edythe L. Broad Institute, Massachusetts Institute of Technology & Harvard University, Institute of Chemistry & Cell Biology (ICCB), Initiative for Chemical Genetics, Cambridge, Massachusetts, USA.

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December 2004