Brian Zarnegar

Brian Zarnegar

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Brian Zarnegar

Brian Zarnegar

Publications by authors named "Brian Zarnegar"

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24Publications

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Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks.

Cell 2019 01 20;176(1-2):361-376.e17. Epub 2018 Dec 20.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.11.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329648PMC
January 2019

RNA-protein interaction detection in living cells.

Nat Methods 2018 03 5;15(3):207-212. Epub 2018 Feb 5.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nmeth.4601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886736PMC
March 2018

CSNK1a1 Regulates PRMT1 to Maintain the Progenitor State in Self-Renewing Somatic Tissue.

Dev Cell 2017 10 21;43(2):227-239.e5. Epub 2017 Sep 21.

Program in Epithelial Biology, Stanford University, 269 Campus Drive, Room 2145, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.08.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659279PMC
October 2017

irCLIP platform for efficient characterization of protein-RNA interactions.

Nat Methods 2016 06 25;13(6):489-92. Epub 2016 Apr 25.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

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http://www.nature.com/articles/nmeth.3840
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http://dx.doi.org/10.1038/nmeth.3840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477425PMC
June 2016

Network Analysis Identifies Mitochondrial Regulation of Epidermal Differentiation by MPZL3 and FDXR.

Dev Cell 2015 Nov;35(4):444-57

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2015.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845910PMC
November 2015

Dissecting noncoding and pathogen RNA-protein interactomes.

RNA 2015 Jan 19;21(1):135-43. Epub 2014 Nov 19.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California 94305, USA Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA

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http://dx.doi.org/10.1261/rna.047803.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274633PMC
January 2015

IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors.

Nat Med 2013 May 21;19(5):626-630. Epub 2013 Apr 21.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

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http://dx.doi.org/10.1038/nm.3165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190012PMC
May 2013

Genetic pathways in disorders of epidermal differentiation.

Trends Genet 2013 Jan 8;29(1):31-40. Epub 2012 Nov 8.

Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.tig.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477429PMC
January 2013

ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation.

Dev Cell 2012 Mar 23;22(3):669-77. Epub 2012 Feb 23.

Department of Medicine/Cellular and Molecular Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.devcel.2011.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306457PMC
March 2012

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

Sci Signal 2010 May 25;3(123):ra41. Epub 2010 May 25.

Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2000778
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http://dx.doi.org/10.1126/scisignal.2000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913610PMC
May 2010

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

Nat Immunol 2008 Dec 9;9(12):1371-8. Epub 2008 Nov 9.

Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/ni.1676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676931PMC
December 2008

Control of canonical NF-kappaB activation through the NIK-IKK complex pathway.

Proc Natl Acad Sci U S A 2008 Mar 21;105(9):3503-8. Epub 2008 Feb 21.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.0707959105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265190PMC
March 2008

IRF3-dependent type I interferon response in B cells regulates CpG-mediated antibody production.

J Biol Chem 2008 Jan 9;283(2):802-8. Epub 2007 Oct 9.

Department of Microbiology, Immunology and Molecular Genetics, University of California at Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M704755200DOI Listing
January 2008

TRAF3 and its biological function.

Adv Exp Med Biol 2007 ;597:48-59

Department of Microbiology, Immunology and Molecular Genetics, 8University of California, Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1007/978-0-387-70630-6_4DOI Listing
August 2007

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.

J Biol Chem 2007 Feb 11;282(6):3688-94. Epub 2006 Dec 11.

Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1074/jbc.M610271200DOI Listing
February 2007

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.

J Exp Med 2006 Oct 2;203(11):2413-8. Epub 2006 Oct 2.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1084/jem.20061166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118128PMC
October 2006

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.

EMBO J 2006 Jul 6;25(14):3257-63. Epub 2006 Jul 6.

Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7601220
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http://dx.doi.org/10.1038/sj.emboj.7601220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523175PMC
July 2006

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.

Nature 2006 Jan 23;439(7073):208-11. Epub 2005 Nov 23.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 609 Charles E. Young Dr. East, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nature04374DOI Listing
January 2006

Type I interferon production enhances susceptibility to Listeria monocytogenes infection.

J Exp Med 2004 Aug 9;200(4):437-45. Epub 2004 Aug 9.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 8-240 Factor Bldg., 10833 Le Conte Ave., 90095, USA.

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http://dx.doi.org/10.1084/jem.20040712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211937PMC
August 2004

Unique CD40-mediated biological program in B cell activation requires both type 1 and type 2 NF-kappaB activation pathways.

Proc Natl Acad Sci U S A 2004 May 17;101(21):8108-13. Epub 2004 May 17.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.0402629101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC419565PMC
May 2004

Cooperation of multiple signaling pathways in CD40-regulated gene expression in B lymphocytes.

Proc Natl Acad Sci U S A 2002 Feb;99(3):1497-502

Molecular Biology Institute and Medical Scientist Training Program, School of Medicine, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.032665099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122219PMC
February 2002