Brian T Tsuji

Brian T Tsuji

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Brian T Tsuji

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Rational Combinations of Polymyxins with Other Antibiotics.

Adv Exp Med Biol 2019 ;1145:251-288

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA.

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http://dx.doi.org/10.1007/978-3-030-16373-0_16DOI Listing
September 2019

Successful cure of daptomycin-non-susceptible, vancomycin-intermediate Staphylococcus aureus prosthetic aortic valve endocarditis directed by synergistic in vitro time-kill study.

Infect Dis (Lond) 2019 04 14;51(4):287-292. Epub 2019 Feb 14.

d Department of Pharmacy , Veterans Administration Western New York Healthcare System , Buffalo , NY , USA.

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http://dx.doi.org/10.1080/23744235.2018.1533646DOI Listing
April 2019

Shifting Gears: The Future of Polymyxin Antibiotics.

Antibiotics (Basel) 2019 Apr 12;8(2). Epub 2019 Apr 12.

Department of Internal Medicine; Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.3390/antibiotics8020042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6628003PMC
April 2019

Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis.

Clin Pharmacokinet 2019 02;58(2):143-156

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.

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http://dx.doi.org/10.1007/s40262-018-0678-xDOI Listing
February 2019

Concentration-dependent plasma protein binding: Expect the unexpected.

Eur J Pharm Sci 2018 Sep 3;122:341-346. Epub 2018 Jul 3.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, 701 Ellicott Street, Buffalo, NY, 14203, United States of America.

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http://dx.doi.org/10.1016/j.ejps.2018.07.004DOI Listing
September 2018

Polymyxin B and fosfomycin thwart KPC-producing Klebsiella pneumoniae in the hollow-fibre infection model.

Int J Antimicrob Agents 2018 Jul 24;52(1):114-118. Epub 2018 Feb 24.

School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09248579183004
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http://dx.doi.org/10.1016/j.ijantimicag.2018.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938411PMC
July 2018

Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models.

J Antimicrob Chemother 2018 02;73(2):462-468

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1093/jac/dkx409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890666PMC
February 2018

Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.

Antimicrob Agents Chemother 2018 02 25;62(2). Epub 2018 Jan 25.

Division of Infectious Diseases, University at Buffalo, the State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.01995-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786777PMC
February 2018

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli.

J Antimicrob Chemother 2017 08;72(8):2297-2303

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA.

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http://dx.doi.org/10.1093/jac/dkx121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890756PMC
August 2017

Defining the Active Fraction of Daptomycin against Methicillin-Resistant Staphylococcus aureus (MRSA) Using a Pharmacokinetic and Pharmacodynamic Approach.

PLoS One 2016 10;11(6):e0156131. Epub 2016 Jun 10.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, Buffalo, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156131PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4902307PMC
July 2017

Pharmacodynamics of colistin and fosfomycin: a 'treasure trove' combination combats KPC-producing Klebsiella pneumoniae.

J Antimicrob Chemother 2017 07;72(7):1985-1990

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1093/jac/dkx070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890748PMC
July 2017

Polymyxin Combinations Combat Harboring and : Preparation for a Postantibiotic Era.

mBio 2017 07 25;8(4). Epub 2017 Jul 25.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA

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http://dx.doi.org/10.1128/mBio.00540-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527306PMC
July 2017

A combination of ceftaroline and daptomycin has synergistic and bactericidal activity in vitro against daptomycin nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA).

Infect Dis (Lond) 2017 May 24;49(5):410-416. Epub 2017 Jan 24.

a Laboratory for Antimicrobial Pharmacodynamics, Department of Pharmacy Practice, University at Buffalo School of Pharmacy and Pharmaceutical Sciences , Buffalo , NY , USA.

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http://dx.doi.org/10.1080/23744235.2016.1277587DOI Listing
May 2017

Influence of and on Polymyxin Pharmacodynamics in Pseudomonas aeruginosa and Implications for Quorum Sensing Inhibition with Azithromycin.

Antimicrob Agents Chemother 2017 04 24;61(4). Epub 2017 Mar 24.

Laboratory for Antimicrobial Pharmacodynamics, University at Buffalo School of Pharmacy and Pharmaceutical Sciences, Buffalo, New York, USA

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http://aac.asm.org/lookup/doi/10.1128/AAC.00096-16
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http://dx.doi.org/10.1128/AAC.00096-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365695PMC
April 2017

New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae.

Antimicrob Agents Chemother 2017 04 24;61(4). Epub 2017 Mar 24.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02023-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365650PMC
April 2017

Impact of Staphylococcus aureus accessory gene regulator (agr) system on linezolid efficacy by profiling pharmacodynamics and RNAIII expression.

J Antibiot (Tokyo) 2017 01 8;70(1):98-101. Epub 2016 Jun 8.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1038/ja.2016.59DOI Listing
January 2017

In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model.

Int J Antimicrob Agents 2017 Jan 1;49(1):25-30. Epub 2016 Sep 1.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY, USA; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.07.015DOI Listing
January 2017

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii.

Int J Antimicrob Agents 2016 Dec 20;48(6):719-724. Epub 2016 Sep 20.

Laboratory for Antimicrobial Pharmacodynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, NY, USA; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237376PMC
December 2016

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

Int J Antimicrob Agents 2016 Dec 18;48(6):592-597. Epub 2016 Oct 18.

Monash Biomedicine Discovery Institute, Department of Microbiology, School of Biomedical Sciences, Monash University, Melbourne, VIC, Australia; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.09.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154767PMC
December 2016

Synergistic combinations of polymyxins.

Int J Antimicrob Agents 2016 Dec 24;48(6):607-613. Epub 2016 Oct 24.

Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, NY, USA; School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237374PMC
December 2016

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies.

J Antimicrob Chemother 2016 11 3;71(11):3148-3156. Epub 2016 Aug 3.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, USA

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http://dx.doi.org/10.1093/jac/dkw293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079300PMC
November 2016

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosa.

J Antimicrob Chemother 2016 11 11;71(11):3157-3167. Epub 2016 Aug 11.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), Parkville, Victoria 3052, Australia

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http://dx.doi.org/10.1093/jac/dkw297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079302PMC
November 2016

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii.

Int J Antimicrob Agents 2016 Sep 12;48(3):331-6. Epub 2016 Jul 12.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA; The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, SUNY, Buffalo, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijantimicag.2016.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256686PMC
September 2016

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance.

Antimicrob Agents Chemother 2016 07 20;60(7):3921-33. Epub 2016 Jun 20.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria, Australia

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http://dx.doi.org/10.1128/AAC.02927-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914682PMC
July 2016

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii.

Antimicrob Agents Chemother 2016 07 20;60(7):3913-20. Epub 2016 Jun 20.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.

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http://dx.doi.org/10.1128/AAC.02831-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914656PMC
July 2016

Effect of Fluoroquinolones and Macrolides on Eradication and Resistance of Haemophilus influenzae in Chronic Obstructive Pulmonary Disease.

Antimicrob Agents Chemother 2016 07 20;60(7):4151-8. Epub 2016 Jun 20.

Division of Infectious Diseases and Clinical and Translational Research Center, University at Buffalo, the State University of New York, Buffalo, New York, USA Department of Microbiology and Immunology University at Buffalo, the State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.00301-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914697PMC
July 2016

Optimization of Polymyxin B in Combination with Doripenem To Combat Mutator Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2016 05 22;60(5):2870-80. Epub 2016 Apr 22.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02377-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4862466PMC
May 2016

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.

Sci Rep 2016 05 19;6:26233. Epub 2016 May 19.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1038/srep26233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872528PMC
May 2016

Combinatorial Pharmacodynamics of Ceftolozane-Tazobactam against Genotypically Defined β-Lactamase-Producing Escherichia coli: Insights into the Pharmacokinetics/Pharmacodynamics of β-Lactam-β-Lactamase Inhibitor Combinations.

Antimicrob Agents Chemother 2016 Apr 25;60(4):1967-73. Epub 2016 Mar 25.

Laboratory for Antimicrobial Pharmacodynamics, New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, New York, USA School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02635-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808171PMC
April 2016

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria.

Infect Dis Ther 2015 Dec 8;4(4):391-415. Epub 2015 Dec 8.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, NY, USA.

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http://dx.doi.org/10.1007/s40121-015-0093-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675771PMC
December 2015

Sequential Evolution of Vancomycin-Intermediate Resistance Alters Virulence in Staphylococcus aureus: Pharmacokinetic/Pharmacodynamic Targets for Vancomycin Exposure.

Antimicrob Agents Chemother 2015 Dec 28;60(3):1584-91. Epub 2015 Dec 28.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA New York State Center of Excellence in Life Sciences and Bioinformatics, University at Buffalo, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.02657-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776009PMC
December 2015

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators.

Antimicrob Agents Chemother 2015 Jul 27;59(7):4343-6. Epub 2015 Apr 27.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York, USA The New York State Center of Excellence in Bioinformatics Life Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1128/AAC.04629-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4468730PMC
July 2015

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance.

J Antimicrob Chemother 2015 May 23;70(5):1434-42. Epub 2015 Feb 23.

Laboratory for Antimicrobial and Bacterial Dynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA

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http://jac.oxfordjournals.org/content/early/2015/02/23/jac.d
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http://www.jac.oxfordjournals.org/lookup/doi/10.1093/jac/dku
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http://dx.doi.org/10.1093/jac/dku567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398476PMC
May 2015

Two mechanisms of killing of Pseudomonas aeruginosa by tobramycin assessed at multiple inocula via mechanism-based modeling.

Antimicrob Agents Chemother 2015 Apr 2;59(4):2315-27. Epub 2015 Feb 2.

School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York.

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http://dx.doi.org/10.1128/AAC.04099-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356757PMC
April 2015

Shape does matter: short high-concentration exposure minimizes resistance emergence for fluoroquinolones in Pseudomonas aeruginosa.

J Antimicrob Chemother 2015 Mar 6;70(3):818-26. Epub 2014 Nov 6.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), Parkville, Victoria 3052, Australia School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA

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http://dx.doi.org/10.1093/jac/dku437DOI Listing
March 2015

Evolution of Staphylococcus aureus under vancomycin selective pressure: the role of the small-colony variant phenotype.

Antimicrob Agents Chemother 2015 Feb 1;59(2):1347-51. Epub 2014 Dec 1.

Laboratory for Antimicrobial Pharmacodynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, Buffalo, New York, USA School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA

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http://aac.asm.org/content/59/2/1347.full.pdf
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http://aac.asm.org/content/early/2014/11/25/AAC.04508-14.ful
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http://aac.asm.org/lookup/doi/10.1128/AAC.04508-14
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http://dx.doi.org/10.1128/AAC.04508-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335873PMC
February 2015

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus.

Lancet Infect Dis 2015 Feb 21;15(2):225-34. Epub 2014 Oct 21.

Departments of Pathology and Paediatrics and School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, SA, Australia.

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http://www.thelancet.com/pdfs/journals/laninf/PIIS1473309914
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http://linkinghub.elsevier.com/retrieve/pii/S147330991470850
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http://dx.doi.org/10.1016/S1473-3099(14)70850-3DOI Listing
February 2015

Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use.

Pharmacotherapy 2015 Jan;35(1):34-42

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, SUNY, Buffalo, New York.

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http://dx.doi.org/10.1002/phar.1537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215892PMC
January 2015

Consistent global approach on reporting of colistin doses to promote safe and effective use.

Clin Infect Dis 2014 Jan 8;58(1):139-41. Epub 2013 Oct 8.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1093/cid/cit680DOI Listing
January 2014

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats.

J Antimicrob Chemother 2013 Oct 7;68(10):2311-7. Epub 2013 Jun 7.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1093/jac/dkt207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772743PMC
October 2013

Pharmacokinetic/pharmacodynamic evaluation of the efficacy and safety of daptomycin against Staphylococcus aureus.

Int J Antimicrob Agents 2013 Jul 15;42(1):53-8. Epub 2013 May 15.

State University of New York at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY 14214, USA.

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http://dx.doi.org/10.1016/j.ijantimicag.2013.02.009DOI Listing
July 2013

Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design.

Antimicrob Agents Chemother 2013 May 11;57(5):2343-51. Epub 2013 Mar 11.

Centre for Medicine Use and Safety, Monash University, Parkville Campus, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1128/AAC.00092-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632905PMC
May 2013

Activity of AFN-1252, a novel FabI inhibitor, against Staphylococcus aureus in an in vitro pharmacodynamic model simulating human pharmacokinetics.

J Chemother 2013 Feb;25(1):32-5

Laboratory for Antimicrobial Pharmacodynamics, The New York State Center of Excellence in Bioinformatics, University at Buffalo, State University of New York, NY14203, USA.

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http://dx.doi.org/10.1179/1973947812Y.0000000060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558987PMC
February 2013

Pharmacodynamics of early, high-dose linezolid against vancomycin-resistant enterococci with elevated MICs and pre-existing genetic mutations.

J Antimicrob Chemother 2012 Sep 8;67(9):2182-90. Epub 2012 Jun 8.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.1093/jac/dks201DOI Listing
September 2012

Front-loaded linezolid regimens result in increased killing and suppression of the accessory gene regulator system of Staphylococcus aureus.

Antimicrob Agents Chemother 2012 Jul 23;56(7):3712-9. Epub 2012 Apr 23.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.

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http://aac.asm.org/lookup/doi/10.1128/AAC.05453-11
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http://dx.doi.org/10.1128/AAC.05453-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3393439PMC
July 2012

Impact of two-component regulatory systems PhoP-PhoQ and PmrA-PmrB on colistin pharmacodynamics in Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2012 Jun 2;56(6):3453-6. Epub 2012 Apr 2.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.

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http://dx.doi.org/10.1128/AAC.06380-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370801PMC
June 2012

Synergistic killing of multidrug-resistant Pseudomonas aeruginosa at multiple inocula by colistin combined with doripenem in an in vitro pharmacokinetic/pharmacodynamic model.

Antimicrob Agents Chemother 2011 Dec 12;55(12):5685-95. Epub 2011 Sep 12.

Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1128/AAC.05298-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232764PMC
December 2011

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula.

Antimicrob Agents Chemother 2011 Nov 29;55(11):5134-42. Epub 2011 Aug 29.

Facility for Anti-Infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1128/AAC.05028-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195049PMC
November 2011

Characterization of heterogeneous vancomycin-intermediate resistance, MIC and accessory gene regulator (agr) dysfunction among clinical bloodstream isolates of staphyloccocus aureus.

BMC Infect Dis 2011 Oct 25;11:287. Epub 2011 Oct 25.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, New York, USA.

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http://dx.doi.org/10.1186/1471-2334-11-287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215976PMC
October 2011

Impact of accessory gene regulator (agr) dysfunction on vancomycin pharmacodynamics among Canadian community and health-care associated methicillin-resistant Staphylococcus aureus.

Ann Clin Microbiol Antimicrob 2011 May 20;10:20. Epub 2011 May 20.

Laboratory Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1186/1476-0711-10-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3120648PMC
May 2011

Resurgence of colistin: a review of resistance, toxicity, pharmacodynamics, and dosing.

Pharmacotherapy 2010 Dec;30(12):1279-91

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences Buffalo, and The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, Buffalo, New York 14260, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410713PMC
December 2010

Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model.

Antimicrob Agents Chemother 2010 Sep 28;54(9):3783-9. Epub 2010 Jun 28.

Facility for Anti-infective Drug Development and Innovation, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

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http://dx.doi.org/10.1128/AAC.00903-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2934992PMC
September 2010

Attenuation of colistin bactericidal activity by high inoculum of Pseudomonas aeruginosa characterized by a new mechanism-based population pharmacodynamic model.

Antimicrob Agents Chemother 2010 May 8;54(5):2051-62. Epub 2010 Mar 8.

School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1128/AAC.00881-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863601PMC
May 2010

A comparative review of the lipoglycopeptides: oritavancin, dalbavancin, and telavancin.

Pharmacotherapy 2010 Jan;30(1):80-94

New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, 14260, USA.

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January 2010

Vancomycin and daptomycin pharmacodynamics differ against a site-directed Staphylococcus epidermidis mutant displaying the small-colony-variant phenotype.

Antimicrob Agents Chemother 2009 Sep 29;53(9):3992-5. Epub 2009 Jun 29.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1128/AAC.01597-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737885PMC
September 2009

Pharmacodynamics of vancomycin at simulated epithelial lining fluid concentrations against methicillin-resistant Staphylococcus aureus (MRSA): implications for dosing in MRSA pneumonia.

Antimicrob Agents Chemother 2009 Sep 13;53(9):3894-901. Epub 2009 Jul 13.

Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences and The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1128/AAC.01585-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2737835PMC
September 2009

Loss of vancomycin bactericidal activity against accessory gene regulator (agr) dysfunctional Staphylococcus aureus under conditions of high bacterial density.

Diagn Microbiol Infect Dis 2009 Jun 2;64(2):220-4. Epub 2009 Apr 2.

The New York State Center of Excellence in Bioinformatics & Life Sciences, University at Buffalo, New York 14205, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2009.01.028DOI Listing
June 2009

Daptomycin pharmacodynamics against Staphylococcus aureus hemB mutants displaying the small colony variant phenotype.

J Antimicrob Chemother 2009 May 19;63(5):977-81. Epub 2009 Mar 19.

The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1093/jac/dkp069DOI Listing
May 2009

Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosa.

Antimicrob Agents Chemother 2009 Jan 13;53(1):46-56. Epub 2008 Oct 13.

School of Pharmacy and Pharmaceutical Sciences, University of Buffalo, State University of New York, Buffalo, New York 14260, USA.

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http://dx.doi.org/10.1128/AAC.00489-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612150PMC
January 2009

In vitro pharmacodynamics of novel rifamycin ABI-0043 against Staphylococcus aureus.

J Antimicrob Chemother 2008 Jul 9;62(1):156-60. Epub 2008 Apr 9.

School of Pharmacy and Pharmaceutical Sciences and The New York State Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, State University of New York, NY 14260, USA.

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http://dx.doi.org/10.1093/jac/dkn133DOI Listing
July 2008

Evaluation of daptomycin, telavancin, teicoplanin, and vancomycin activity in the presence of albumin or serum.

Diagn Microbiol Infect Dis 2008 Apr 14;60(4):441-4. Epub 2008 Jan 14.

Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2007.11.011DOI Listing
April 2008

Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype.

Antimicrob Agents Chemother 2008 Apr 19;52(4):1533-7. Epub 2008 Feb 19.

School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, 331 Cooke Hall, Buffalo, NY 14260, USA.

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http://dx.doi.org/10.1128/AAC.01254-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292514PMC
April 2008

Optimizing use of quinolones in the critically ill.

Semin Respir Crit Care Med 2007 Dec;28(6):586-95

SUNY-Buffalo School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14206, USA.

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http://dx.doi.org/10.1055/s-2007-996405DOI Listing
December 2007

Linezolid-associated peripheral and optic neuropathy, lactic acidosis, and serotonin syndrome.

Pharmacotherapy 2007 Aug;27(8):1189-97

Infectious Disease Section, University of Pittsburgh, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania 15240, USA.

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http://doi.wiley.com/10.1592/phco.27.8.1189
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August 2007

Correlation of vancomycin and daptomycin susceptibility in Staphylococcus aureus in reference to accessory gene regulator (agr) polymorphism and function.

J Antimicrob Chemother 2007 Jun 13;59(6):1190-3. Epub 2007 Apr 13.

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, MI, USA.

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June 2007

Community- and health care-associated methicillin-resistant Staphylococcus aureus: a comparison of molecular epidemiology and antimicrobial activities of various agents.

Diagn Microbiol Infect Dis 2007 May 14;58(1):41-7. Epub 2007 Feb 14.

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Wayne State University, MI 48201, USA.

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http://dx.doi.org/10.1016/j.diagmicrobio.2006.10.021DOI Listing
May 2007

Evaluation of accessory gene regulator (agr) group and function in the proclivity towards vancomycin intermediate resistance in Staphylococcus aureus.

Antimicrob Agents Chemother 2007 Mar 11;51(3):1089-91. Epub 2006 Dec 11.

Anti-Infective Research Laboratory, Pharmacy Practice-4148, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1128/AAC.00671-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1803123PMC
March 2007

Etest synergy testing of clinical isolates of Staphylococcus aureus demonstrating heterogeneous resistance to vancomycin.

Diagn Microbiol Infect Dis 2006 Jan;54(1):73-7

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA

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http://dx.doi.org/10.1016/j.diagmicrobio.2005.08.014DOI Listing
January 2006

Short-course gentamicin in combination with daptomycin or vancomycin against Staphylococcus aureus in an in vitro pharmacodynamic model with simulated endocardial vegetations.

Antimicrob Agents Chemother 2005 Jul;49(7):2735-45

Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Detroit, Michigan 48201, USA.

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http://aac.asm.org/cgi/doi/10.1128/AAC.49.7.2735-2745.2005
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http://dx.doi.org/10.1128/AAC.49.7.2735-2745.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168654PMC
July 2005