Publications by authors named "Brian T Chait"

100Publications

Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.

Structure 2020 Nov 17. Epub 2020 Nov 17.

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.str.2020.11.001DOI Listing
November 2020

Long-range intramolecular allostery and regulation in the dynein-like AAA protein Mdn1.

Proc Natl Acad Sci U S A 2020 08 21;117(31):18459-18469. Epub 2020 Jul 21.

Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.2002792117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414173PMC
August 2020

Integrative structure and function of the yeast exocyst complex.

Protein Sci 2020 06 1;29(6):1486-1501. Epub 2020 May 1.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1002/pro.3863DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255525PMC
June 2020

Stepwise Promoter Melting by Bacterial RNA Polymerase.

Mol Cell 2020 04 10;78(2):275-288.e6. Epub 2020 Mar 10.

Laboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.02.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166197PMC
April 2020

Structural basis of substrate recognition by a polypeptide processing and secretion transporter.

Elife 2020 Jan 14;9. Epub 2020 Jan 14.

Laboratory of Membrane Biophysics and Biology, The Rockefeller University, New York, United States.

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http://dx.doi.org/10.7554/eLife.51492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959990PMC
January 2020

Asymmetric Molecular Architecture of the Human γ-Tubulin Ring Complex.

Cell 2020 01 17;180(1):165-175.e16. Epub 2019 Dec 17.

Laboratory of Chemistry and Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027161PMC
January 2020

Native Mass Spectrometry Analysis of Affinity-Captured Endogenous Yeast RNA Exosome Complexes.

Methods Mol Biol 2020 ;2062:357-382

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1007/978-1-4939-9822-7_17DOI Listing
January 2020

Interactions of nuclear transport factors and surface-conjugated FG nucleoporins: Insights and limitations.

PLoS One 2019 6;14(6):e0217897. Epub 2019 Jun 6.

Laboratory of Cellular and Structural Biology, the Rockefeller University, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6553764PMC
February 2020

Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression.

Proc Natl Acad Sci U S A 2019 01 31;116(3):798-803. Epub 2018 Dec 31.

Laboratory of DNA Replication, The Rockefeller University, New York, NY 10065;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1819107116
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http://dx.doi.org/10.1073/pnas.1819107116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338834PMC
January 2019

Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1.

Nat Struct Mol Biol 2018 09 6;25(9):859-867. Epub 2018 Sep 6.

Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41594-018-0118-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298426PMC
September 2018

Nuclear ARP2/3 drives DNA break clustering for homology-directed repair.

Nature 2018 07 20;559(7712):61-66. Epub 2018 Jun 20.

Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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http://www.nature.com/articles/s41586-018-0237-5
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http://dx.doi.org/10.1038/s41586-018-0237-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145447PMC
July 2018

Modular assembly of the nucleolar pre-60S ribosomal subunit.

Nature 2018 04 5;556(7699):126-129. Epub 2018 Mar 5.

Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1038/nature26156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118127PMC
April 2018

A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells.

Cell Chem Biol 2018 01 5;25(1):110-120.e3. Epub 2017 Nov 5.

Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5775914PMC
January 2018

The complete structure of the small-subunit processome.

Nat Struct Mol Biol 2017 Nov 25;24(11):944-953. Epub 2017 Sep 25.

Laboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3472DOI Listing
November 2017

Lineage-specific proteins essential for endocytosis in trypanosomes.

J Cell Sci 2017 04 23;130(8):1379-1392. Epub 2017 Feb 23.

School of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK

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http://dx.doi.org/10.1242/jcs.191478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399782PMC
April 2017

The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis.

PLoS Pathog 2017 01 23;13(1):e1006063. Epub 2017 Jan 23.

Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee, United Kingdom.

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http://dx.doi.org/10.1371/journal.ppat.1006063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256885PMC
January 2017

Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.

Cell Chem Biol 2017 Jan 5;24(1):76-86. Epub 2017 Jan 5.

Department of Chemistry, Frick Chemistry Laboratory, Princeton University, Washington Road, Princeton, NJ 08544-0015, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456163044
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http://dx.doi.org/10.1016/j.chembiol.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5697745PMC
January 2017

Gel filtration of dilute human embryonic hemoglobins reveals basis for their increased oxygen binding.

Anal Biochem 2017 Feb 11;519:38-41. Epub 2016 Dec 11.

Department of Biology, Northeastern University, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237603PMC
February 2017

Phosphorylation-Dependent Targeting of Tetrahymena HP1 to Condensed Chromatin.

mSphere 2016 Jul-Aug;1(4). Epub 2016 Aug 24.

W. M. Keck Science Center of Claremont McKenna, Pitzer, and Scripps Colleges, Claremont, California, USA.

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http://dx.doi.org/10.1128/mSphere.00142-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999919PMC
August 2016

HIV-host interactome revealed directly from infected cells.

Nat Microbiol 2016 Jul 23;1(7):16068. Epub 2016 May 23.

Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, New York 10016, USA.

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http://dx.doi.org/10.1038/nmicrobiol.2016.68DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928716PMC
July 2016

High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes.

Methods Mol Biol 2016 ;1411:67-80

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/978-1-4939-3530-7_3DOI Listing
December 2017

Revealing Higher Order Protein Structure Using Mass Spectrometry.

J Am Soc Mass Spectrom 2016 06 14;27(6):952-65. Epub 2016 Apr 14.

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s13361-016-1385-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125627PMC
June 2016

Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA.

Sci Rep 2016 Apr 5;6:23904. Epub 2016 Apr 5.

Department of Chemistry, CUNY Graduate Center and Institute for Macromolecular Assemblies, College of Staten Island, City University of New York, Staten Island, NY 10314, USA.

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http://dx.doi.org/10.1038/srep23904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820689PMC
April 2016

Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex.

PLoS Biol 2016 Feb 18;14(2):e1002365. Epub 2016 Feb 18.

The Rockefeller University, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1002365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4758718PMC
February 2016

Proteomics of HCV virions reveals an essential role for the nucleoporin Nup98 in virus morphogenesis.

Proc Natl Acad Sci U S A 2016 Mar 16;113(9):2484-9. Epub 2016 Feb 16.

Department of Infectious Diseases, King's College London, London SE1 9RT, United Kingdom; Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065;

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http://dx.doi.org/10.1073/pnas.1518934113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780614PMC
March 2016

A Robust Workflow for Native Mass Spectrometric Analysis of Affinity-Isolated Endogenous Protein Assemblies.

Anal Chem 2016 Mar 18;88(5):2799-807. Epub 2016 Feb 18.

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University , New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.analchem.5b04477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4790104PMC
March 2016

Optimizing selection of large animals for antibody production by screening immune response to standard vaccines.

J Immunol Methods 2016 Mar 9;430:56-60. Epub 2016 Jan 9.

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2016.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769958PMC
March 2016

BECLIN 1-VPS34 COMPLEX ARCHITECTURE: UNDERSTANDING THE NUTS AND BOLTS OF THERAPEUTIC TARGETS.

Front Biol (Beijing) 2015 Oct 4;10(5):398-426. Epub 2015 Nov 4.

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY 40536 ; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY 40536, USA ; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1007/s11515-015-1374-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682202PMC
October 2015

The architecture of a eukaryotic replisome.

Nat Struct Mol Biol 2015 Dec 2;22(12):976-82. Epub 2015 Nov 2.

DNA Replication Laboratory, Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.3113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849863PMC
December 2015

Chemical proteomics reveals a γH2AX-53BP1 interaction in the DNA damage response.

Nat Chem Biol 2015 Oct 7;11(10):807-14. Epub 2015 Sep 7.

Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.1908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589150PMC
October 2015

β-Lactoglobulin detected in human milk forms noncovalent complexes with maltooligosaccharides as revealed by chip-nanoelectrospray high-resolution tandem mass spectrometry.

Amino Acids 2015 Nov 27;47(11):2399-407. Epub 2015 Jun 27.

Mass Spectrometry Laboratory, National Institute for Research and Development in Electrochemistry and Condensed Matter, Plautius Andronescu Str. 1, 300224, Timisoara, Romania.

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http://link.springer.com/content/pdf/10.1007/s00726-015-2030
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http://link.springer.com/10.1007/s00726-015-2030-1
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http://dx.doi.org/10.1007/s00726-015-2030-1DOI Listing
November 2015

Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics.

Mol Cell Proteomics 2015 Jul 30;14(7):1911-26. Epub 2015 Apr 30.

‖Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, UK, DD1 5EH.

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http://dx.doi.org/10.1074/mcp.M114.047647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587319PMC
July 2015

Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives.

Biotechniques 2015 Mar 1;58(3):103-19. Epub 2015 Mar 1.

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York.

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http://dx.doi.org/10.2144/000114262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465938PMC
March 2015

Optimizing electrospray interfaces using slowly diverging conical duct (ConDuct) electrodes.

J Am Soc Mass Spectrom 2015 Apr 10;26(4):659-67. Epub 2015 Feb 10.

Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s13361-014-1063-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361383PMC
April 2015

Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function.

J Neurochem 2015 Mar 4;132(6):677-86. Epub 2015 Mar 4.

Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, USA; Department of Pharmacology, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Department of Psychiatry, Kurume University School of Medicine, Kurume, Fukuoka, Japan; Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, Kurume, Fukuoka, Japan.

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http://dx.doi.org/10.1111/jnc.13038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359654PMC
March 2015

Maximizing ion transmission from atmospheric pressure into the vacuum of mass spectrometers with a novel electrospray interface.

J Am Soc Mass Spectrom 2015 Apr 15;26(4):649-58. Epub 2015 Jan 15.

Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY, 10065, USA.

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http://dx.doi.org/10.1007/s13361-014-1062-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361285PMC
April 2015

Touching from a distance.

Nucleus 2014 Jul-Aug;5(4):304-10

a Division of Biological Chemistry and Drug Discovery; University of Dundee, Dundee, UK.

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http://dx.doi.org/10.4161/nucl.32228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152344PMC
September 2015

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit.

Nat Struct Mol Biol 2014 Dec 10;21(12):1028-34. Epub 2014 Nov 10.

Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nsmb.2914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259101PMC
December 2014

A robust pipeline for rapid production of versatile nanobody repertoires.

Nat Methods 2014 Dec 2;11(12):1253-60. Epub 2014 Nov 2.

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1038/nmeth.3170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272012PMC
December 2014

A pipeline for determining protein-protein interactions and proximities in the cellular milieu.

Mol Cell Proteomics 2014 Nov 29;13(11):2824-35. Epub 2014 Aug 29.

From the ‡The Rockefeller University 1230 York Ave, New York, New York

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http://dx.doi.org/10.1074/mcp.M114.041095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223475PMC
November 2014

Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex.

Mol Cell Proteomics 2014 Nov 26;13(11):2927-43. Epub 2014 Aug 26.

From the ‡Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, New York 10065;

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http://dx.doi.org/10.1074/mcp.M114.041673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223482PMC
November 2014

Integrative structure-function mapping of the nucleoporin Nup133 suggests a conserved mechanism for membrane anchoring of the nuclear pore complex.

Mol Cell Proteomics 2014 Nov 19;13(11):2911-26. Epub 2014 Aug 19.

From the ‡Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, Byers Hall, 1700 4th Street, Suite 503B, University of California San Francisco, San Francisco, California 94158;

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http://dx.doi.org/10.1074/mcp.M114.040915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223481PMC
November 2014

Molecular architecture and function of the SEA complex, a modulator of the TORC1 pathway.

Mol Cell Proteomics 2014 Nov 29;13(11):2855-70. Epub 2014 Jul 29.

From the ‡CNRS UMR 8126, Université Paris-Sud 11, Institut Gustave Roussy, 114, rue Edouard Vaillant, 94805, Villejuif, France;

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http://dx.doi.org/10.1074/mcp.M114.039388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223477PMC
November 2014

Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes.

Proc Natl Acad Sci U S A 2014 Aug 21;111(31):11323-8. Epub 2014 Jul 21.

Laboratory of Mass Spectrometry and Gaseous Ion Chemistry and

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http://dx.doi.org/10.1073/pnas.1409666111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128132PMC
August 2014

NPC mimics: probing the mechanism of nucleocytoplasmic transport.

Methods Cell Biol 2014 ;122:379-93

Laboratory of Cellular and Structural Biology, The Rockefeller University, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-417160-2.00017-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272007PMC
April 2015

Sample limited characterization of a novel disulfide-rich venom peptide toxin from terebrid marine snail Terebra variegata.

PLoS One 2014 8;9(4):e94122. Epub 2014 Apr 8.

Department of Chemistry and Biochemistry, City University of New York- Hunter College and Graduate Center, New York, New York, United States of America; The American Museum of Natural History, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094122PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979744PMC
January 2015

Nuclear pore complex evolution: a trypanosome Mlp analogue functions in chromosomal segregation but lacks transcriptional barrier activity.

Mol Biol Cell 2014 May 5;25(9):1421-36. Epub 2014 Mar 5.

Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee DD1 5EH, United Kingdom The Rockefeller University, New York, NY 10021 Seattle Biomedical Research Institute and Institute for Systems Biology, Seattle, WA 98109 Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan City 701, Taiwan Department of Plant Sciences, University of Oxford, Oxford OX1 4JP, United Kingdom.

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http://dx.doi.org/10.1091/mbc.E13-12-0750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004592PMC
May 2014

The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome.

Mol Biol Cell 2013 Dec 23;24(24):3920-38. Epub 2013 Oct 23.

Department of Systems Biology, Harvard Medical School, Boston, MA 02115 Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, NY 10065 Laboratory of Cellular and Structural Biology, Rockefeller University, New York, NY 10065 Institute for Research in Biomedicine, 6500 Bellinzona, Switzerland Istituto Cantonale di Microbiologia, 6500 Bellinzona, Switzerland Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605.

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http://dx.doi.org/10.1091/mbc.E13-07-0412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861087PMC
December 2013

Supervillin binding to myosin II and synergism with anillin are required for cytokinesis.

Mol Biol Cell 2013 Dec 2;24(23):3603-19. Epub 2013 Oct 2.

Program in Cell and Developmental Dynamics, Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655 Laboratory of Cellular and Structural Biology, Rockefeller University, New York, NY 10065 Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, Rockefeller University, New York, NY 10065 Proteomics and Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA 01545.

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http://dx.doi.org/10.1091/mbc.E12-10-0714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842989PMC
December 2013

Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly.

Dev Cell 2013 Oct 26;27(1):47-59. Epub 2013 Sep 26.

Laboratory of Chromosome and Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.devcel.2013.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800493PMC
October 2013

The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress.

Mol Cell Biol 2013 Oct 22;33(19):3735-48. Epub 2013 Jul 22.

Laboratory of Chromatin Biology & Epigenetics, The Rockefeller University, New York, New York, USA.

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http://dx.doi.org/10.1128/MCB.00025-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811877PMC
October 2013

Activation of DSB processing requires phosphorylation of CtIP by ATR.

Mol Cell 2013 Feb 27;49(4):657-67. Epub 2012 Dec 27.

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.molcel.2012.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582837PMC
February 2013

The biochemical anatomy of cortical inhibitory synapses.

PLoS One 2012 29;7(6):e39572. Epub 2012 Jun 29.

Howard Hughes Medical Institute, Laboratory of Molecular Biology, The Rockefeller University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0039572PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387162PMC
November 2012

Constrained de novo sequencing of conotoxins.

J Proteome Res 2012 Aug 2;11(8):4191-200. Epub 2012 Jul 2.

Palo Alto Research Center, 3333 Coyote Hill Road, Palo Alto, California 94304, United States.

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http://dx.doi.org/10.1021/pr300312hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412931PMC
August 2012

Improved methodology for the affinity isolation of human protein complexes expressed at near endogenous levels.

Biotechniques 2012 May;0(0):1-6

Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark.

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http://dx.doi.org/10.2144/000113864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3605737PMC
May 2012

RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates.

Proc Natl Acad Sci U S A 2012 Apr 2;109(16):6072-7. Epub 2012 Apr 2.

Molecular Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.1201207109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341019PMC
April 2012

Proteomics on the rims: insights into the biology of the nuclear envelope and flagellar pocket of trypanosomes.

Parasitology 2012 Aug 6;139(9):1158-67. Epub 2012 Feb 6.

Department of Pathology, University of Cambridge, Cambridge, UK.

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http://dx.doi.org/10.1017/S0031182011002125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241632PMC
August 2012

Quantitative chemical proteomics approach to identify post-translational modification-mediated protein-protein interactions.

J Am Chem Soc 2012 Feb 24;134(4):1982-5. Epub 2012 Jan 24.

Laboratory of Chemistry and Cell Biology, The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1021/ja210528vDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520067PMC
February 2012

Intrinsic regulation of hemoglobin expression by variable subunit interface strengths.

FEBS J 2012 Feb 22;279(3):361-9. Epub 2011 Dec 22.

Department of Biology, Northeastern University, Boston, MA 02115, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2011.08437.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270300PMC
February 2012

Protein arginine methyltransferase Prmt5-Mep50 methylates histones H2A and H4 and the histone chaperone nucleoplasmin in Xenopus laevis eggs.

J Biol Chem 2011 Dec 18;286(49):42221-31. Epub 2011 Oct 18.

Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1074/jbc.M111.303677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234966PMC
December 2011

Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair.

J Cell Biol 2011 Sep;194(5):705-20

Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA.

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http://dx.doi.org/10.1083/jcb.201103103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171114PMC
September 2011

Mass spectrometry in the postgenomic era.

Authors:
Brian T Chait

Annu Rev Biochem 2011 ;80:239-46

Laboratory for Mass Spectrometry and Gaseous Ion Chemistry, The Rockefeller University, New York, NY 10021, USA.

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http://dx.doi.org/10.1146/annurev-biochem-110810-095744DOI Listing
October 2011

Conjugation of magnetic beads for immunopurification of protein complexes.

Cold Spring Harb Protoc 2011 May 1;2011(5):pdb.prot5610. Epub 2011 May 1.

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http://dx.doi.org/10.1101/pdb.prot5610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666400PMC
May 2011

Affinity purification of protein complexes.

Cold Spring Harb Protoc 2011 May 1;2011(5):pdb.prot5611. Epub 2011 May 1.

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http://dx.doi.org/10.1101/pdb.prot5611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666412PMC
May 2011

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.

PLoS One 2011 Mar 1;6(3):e17153. Epub 2011 Mar 1.

Department of Neurology and Neuroscience, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0017153PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046972PMC
March 2011

Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes.

J Biol Chem 2011 Feb 2;286(7):5434-45. Epub 2010 Dec 2.

The Rockefeller University, New York, New York 10065, USA.

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http://dx.doi.org/10.1074/jbc.M110.205054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037656PMC
February 2011

Escherichia coli condensin MukB stimulates topoisomerase IV activity by a direct physical interaction.

Proc Natl Acad Sci U S A 2010 Nov 4;107(44):18832-7. Epub 2010 Oct 4.

Department of Chemistry, Indiana University, 212 South Hawthorne Street, Bloomington, IN 47405-7102, USA.

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http://dx.doi.org/10.1073/pnas.1008678107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2973889PMC
November 2010