Publications by authors named "Brian Spencer"

91Publications

Noncanonical transnitrosylation network contributes to synapse loss in Alzheimer's disease.

Science 2021 01 3;371(6526). Epub 2020 Dec 3.

Departments of Molecular Medicine and Neuroscience, and Neuroscience Translational Center, The Scripps Research Institute, La Jolla, CA 92037, USA.

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January 2021

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.

Transl Neurodegener 2020 06 18;9(1):26. Epub 2020 Jun 18.

Department of Neurosciences, University of California San Diego School of Medicine, Room 312 MC-0624,9500 Gilman Drive, La Jolla, CA, 92093-0624, USA.

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June 2020

Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease.

Neurobiol Dis 2019 07 5;127:163-177. Epub 2019 Mar 5.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System San Diego, CA, USA. Electronic address:

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July 2019

Identification of Insulin Receptor Splice Variant B in Neurons by in situ Detection in Human Brain Samples.

Sci Rep 2018 03 6;8(1):4070. Epub 2018 Mar 6.

Department of Neurosciences, School of Medicine, University of California - San Diego, La Jolla, CA, 92093, USA.

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March 2018

A Fokker-Planck reaction model for the epitaxial growth and shape transition of quantum dots.

Proc Math Phys Eng Sci 2017 Oct 18;473(2206):20170308. Epub 2017 Oct 18.

Department of Mathematics, State University of New York at Buffalo, Buffalo, NY 14260-2900, USA.

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October 2017

In vitro co-expression of human amyloidogenic immunoglobulin light and heavy chain proteins: a relevant cell-based model of AL amyloidosis.

Amyloid 2017 Jun 20;24(2):115-122. Epub 2017 Jun 20.

a Gerry Amyloidosis Research Laboratory, Amyloidosis Center , Boston University School of Medicine , Boston , MA , USA.

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June 2017

Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy.

Acta Neuropathol Commun 2017 01 5;5(1). Epub 2017 Jan 5.

Department of Neurosciences, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA, 92093-0624, USA.

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January 2017

Asymmetric shape transitions of epitaxial quantum dots.

Proc Math Phys Eng Sci 2016 Jun;472(2190):20160262

Department of Mathematics , University at Buffalo, State University of New York , Buffalo, NY 14260-2900, USA.

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June 2016

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease.

Hum Mol Genet 2016 Mar 5;25(6):1100-15. Epub 2016 Jan 5.

Department of Neuroscience and Department of Pathology, University of California, San Diego, San Diego, CA 92103, USA and

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March 2016

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders.

Neurobiol Dis 2016 Feb 22;86:154-69. Epub 2015 Nov 22.

Department of Pathology, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. Electronic address:

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February 2016

Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy.

Cell Rep 2015 Oct 17;13(4):771-782. Epub 2015 Oct 17.

Department of Neurosciences and Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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October 2015

A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy.

Mol Neurodegener 2015 Sep 23;10:48. Epub 2015 Sep 23.

Department of Neurosciences, University of California, San Diego, La Jolla, CA, 92093, USA.

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September 2015

Applications of ApoB LDLR-Binding Domain Approach for the Development of CNS-Penetrating Peptides for Alzheimer's Disease.

Methods Mol Biol 2015 ;1324:331-7

Departments of Neuroscience and Pathology, University of California-San Diego, La Jolla, CA, USA.

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April 2016

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.

PLoS One 2015 24;10(3):e0121570. Epub 2015 Mar 24.

Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America; Department of Pathology, University of California San Diego, La Jolla, California, United States of America.

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February 2016

Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders.

Curr HIV Res 2015 ;13(1):43-54

Department of Neurosciences, School of Medicine, University of California San Diego, 9500 Gilman Dr., MTF 348, La Jolla, CA 92093-0624, USA.

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December 2015

The influence of environmental temperatures on farrowing rates and litter sizes in South African pig breeding units.

Onderstepoort J Vet Res 2014 11 20;81(1):e1-e7. Epub 2014 Nov 20.

Department of Agriculture, Forestry and Fisheries.

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November 2014

Molecular determinants of α-synuclein mutants' oligomerization and membrane interactions.

ACS Chem Neurosci 2015 Mar 21;6(3):403-16. Epub 2015 Jan 21.

†San Diego Supercomputer Center, ‡Moores Cancer Center, §Department of Neurosciences, and ∥Department of Pathology, University of California San Diego, La Jolla, California 92093, United States.

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March 2015

Genetic variation of the transthyretin gene in wild-type transthyretin amyloidosis (ATTRwt).

Hum Genet 2015 Jan 4;134(1):111-21. Epub 2014 Nov 4.

Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 72 East Concord Street, K507, Boston, MA, 02118, USA,

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January 2015

Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy.

Cell Metab 2014 Oct;20(4):626-38

Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA; Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Rady Children's Hospital, San Diego, CA 92123, USA. Electronic address:

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October 2014

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.

Mol Ther 2014 Oct 10;22(10):1753-67. Epub 2014 Jul 10.

1] Department of Neurosciences, University of California, San Diego, La Jolla, California, USA [2] Department of Pathology, University of California, San Diego, La Jolla, California, USA.

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October 2014

Immunotherapy for Alzheimer's disease: past, present and future.

Front Aging Neurosci 2014 10;6:114. Epub 2014 Jun 10.

Department of Neurosciences, University of California San Diego, La Jolla, CA, USA ; Department of Pathology, University of California San Diego, La Jolla, CA, USA.

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June 2014

A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis.

J Biol Chem 2014 Jun 13;289(25):17917-31. Epub 2014 May 13.

the Departments of Neuroscience and Pathology, University of California at San Diego, San Diego, California 92093.

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June 2014

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.

Neuron 2013 Sep;79(5):873-86

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA; Center for Tissue Regeneration, Repair and Restoration, Veterans Administration Palo Alto Health Care System, Palo Alto, CA 94304, USA.

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September 2013

Glenohumeral articular cartilage lesions: prospective comparison of non-contrast magnetic resonance imaging and findings at arthroscopy.

Arthroscopy 2013 Sep 25;29(9):1466-70. Epub 2013 Jul 25.

Department of Orthopedics, Mount Nittany Medical Center, State College, Pennsylvania 16803, USA.

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September 2013

FOXO4 is necessary for neural differentiation of human embryonic stem cells.

Aging Cell 2013 Jun;12(3):518-22

Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

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June 2013

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

Ann Rheum Dis 2013 May 12;72(5):761-8. Epub 2012 Sep 12.

Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany.

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May 2013

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11.

Nature 2012 Sep;489(7415):304-8

Howard Hughes Medical Institute, Glenn Center for Aging Research, Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

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September 2012

α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1.

J Biol Chem 2012 Sep 25;287(38):31691-702. Epub 2012 Jul 25.

Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California 92093, USA.

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September 2012

Cell-to-cell transmission of α-synuclein aggregates.

Methods Mol Biol 2012 ;849:347-59

Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Korea.

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August 2012

Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy.

PLoS One 2012 13;7(4):e34713. Epub 2012 Apr 13.

Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America.

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August 2012

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation.

FEBS J 2012 Mar 27;279(6):1000-13. Epub 2012 Feb 27.

San Diego Supercomputer Center, University of California, San Diego, La Jolla, CA, USA.

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March 2012

Dysregulation of miRNAs in AL amyloidosis.

Amyloid 2011 Sep 11;18(3):128-35. Epub 2011 Aug 11.

Amyloid Treatment and Research Program, Boston University School of Medicine and Boston Medical Center, Boston, MA, USA.

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September 2011

Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease.

PLoS One 2011 Jan 31;6(1):e16575. Epub 2011 Jan 31.

Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America.

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January 2011

Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases.

J Biol Chem 2011 Mar 4;286(11):9031-7. Epub 2011 Feb 4.

Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92093, USA.

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March 2011

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein.

Proc Natl Acad Sci U S A 2009 Aug 27;106(31):13010-5. Epub 2009 Jul 27.

Department of Neurosciences and Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

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August 2009

AL-Base: a visual platform analysis tool for the study of amyloidogenic immunoglobulin light chain sequences.

Amyloid 2009 Mar;16(1):1-8

Amyloid Treatment and Research Program, Alan and Sandra Gerry Amyloid Research Laboratory, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.

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March 2009

Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease.

J Neurochem 2008 Jun 28;105(5):1656-67. Epub 2008 Jan 28.

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0624, USA.

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June 2008

Novel strategies for Alzheimer's disease treatment.

Expert Opin Biol Ther 2007 Dec;7(12):1853-67

University of California, Department of Neurosciences, San Diego, La Jolla, CA 92093-0624, USA.

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December 2007

Targeted delivery of proteins across the blood-brain barrier.

Proc Natl Acad Sci U S A 2007 May 26;104(18):7594-9. Epub 2007 Apr 26.

Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

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May 2007

Climbing the scaffolds of Parkinson's disease pathogenesis.

Neuron 2007 Feb;53(4):469-70

Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

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February 2007

Asymptotic solutions for the equilibrium crystal shape with small corner energy regularization.

Authors:
Brian J Spencer

Phys Rev E Stat Nonlin Soft Matter Phys 2004 Jan 20;69(1 Pt 1):011603. Epub 2004 Jan 20.

Department of Mathematics, University at Buffalo, Buffalo, New York 14260-2900, USA.

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January 2004

Initial sequencing and comparative analysis of the mouse genome.

Authors:
Robert H Waterston Kerstin Lindblad-Toh Ewan Birney Jane Rogers Josep F Abril Pankaj Agarwal Richa Agarwala Rachel Ainscough Marina Alexandersson Peter An Stylianos E Antonarakis John Attwood Robert Baertsch Jonathon Bailey Karen Barlow Stephan Beck Eric Berry Bruce Birren Toby Bloom Peer Bork Marc Botcherby Nicolas Bray Michael R Brent Daniel G Brown Stephen D Brown Carol Bult John Burton Jonathan Butler Robert D Campbell Piero Carninci Simon Cawley Francesca Chiaromonte Asif T Chinwalla Deanna M Church Michele Clamp Christopher Clee Francis S Collins Lisa L Cook Richard R Copley Alan Coulson Olivier Couronne James Cuff Val Curwen Tim Cutts Mark Daly Robert David Joy Davies Kimberly D Delehaunty Justin Deri Emmanouil T Dermitzakis Colin Dewey Nicholas J Dickens Mark Diekhans Sheila Dodge Inna Dubchak Diane M Dunn Sean R Eddy Laura Elnitski Richard D Emes Pallavi Eswara Eduardo Eyras Adam Felsenfeld Ginger A Fewell Paul Flicek Karen Foley Wayne N Frankel Lucinda A Fulton Robert S Fulton Terrence S Furey Diane Gage Richard A Gibbs Gustavo Glusman Sante Gnerre Nick Goldman Leo Goodstadt Darren Grafham Tina A Graves Eric D Green Simon Gregory Roderic Guigó Mark Guyer Ross C Hardison David Haussler Yoshihide Hayashizaki LaDeana W Hillier Angela Hinrichs Wratko Hlavina Timothy Holzer Fan Hsu Axin Hua Tim Hubbard Adrienne Hunt Ian Jackson David B Jaffe L Steven Johnson Matthew Jones Thomas A Jones Ann Joy Michael Kamal Elinor K Karlsson Donna Karolchik Arkadiusz Kasprzyk Jun Kawai Evan Keibler Cristyn Kells W James Kent Andrew Kirby Diana L Kolbe Ian Korf Raju S Kucherlapati Edward J Kulbokas David Kulp Tom Landers J P Leger Steven Leonard Ivica Letunic Rosie Levine Jia Li Ming Li Christine Lloyd Susan Lucas Bin Ma Donna R Maglott Elaine R Mardis Lucy Matthews Evan Mauceli John H Mayer Megan McCarthy W Richard McCombie Stuart McLaren Kirsten McLay John D McPherson Jim Meldrim Beverley Meredith Jill P Mesirov Webb Miller Tracie L Miner Emmanuel Mongin Kate T Montgomery Michael Morgan Richard Mott James C Mullikin Donna M Muzny William E Nash Joanne O Nelson Michael N Nhan Robert Nicol Zemin Ning Chad Nusbaum Michael J O'Connor Yasushi Okazaki Karen Oliver Emma Overton-Larty Lior Pachter Genís Parra Kymberlie H Pepin Jane Peterson Pavel Pevzner Robert Plumb Craig S Pohl Alex Poliakov Tracy C Ponce Chris P Ponting Simon Potter Michael Quail Alexandre Reymond Bruce A Roe Krishna M Roskin Edward M Rubin Alistair G Rust Ralph Santos Victor Sapojnikov Brian Schultz Jörg Schultz Matthias S Schwartz Scott Schwartz Carol Scott Steven Seaman Steve Searle Ted Sharpe Andrew Sheridan Ratna Shownkeen Sarah Sims Jonathan B Singer Guy Slater Arian Smit Douglas R Smith Brian Spencer Arne Stabenau Nicole Stange-Thomann Charles Sugnet Mikita Suyama Glenn Tesler Johanna Thompson David Torrents Evanne Trevaskis John Tromp Catherine Ucla Abel Ureta-Vidal Jade P Vinson Andrew C Von Niederhausern Claire M Wade Melanie Wall Ryan J Weber Robert B Weiss Michael C Wendl Anthony P West Kris Wetterstrand Raymond Wheeler Simon Whelan Jamey Wierzbowski David Willey Sophie Williams Richard K Wilson Eitan Winter Kim C Worley Dudley Wyman Shan Yang Shiaw-Pyng Yang Evgeny M Zdobnov Michael C Zody Eric S Lander

Nature 2002 Dec;420(6915):520-62

Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA.

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December 2002