Brian R Bettencourt

Brian R Bettencourt

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Brian R Bettencourt

Brian R Bettencourt

Publications by authors named "Brian R Bettencourt"

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25Publications

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A Highly Durable RNAi Therapeutic Inhibitor of PCSK9.

N Engl J Med 2017 01 13;376(1):41-51. Epub 2016 Nov 13.

From Alnylam Pharmaceuticals, Cambridge, MA (K.F., S.W., A. Borodovsky, B.R.B., A. Strahs, V.C., R.S.K., A.V., A. Simon); the Medicines Company, Parsippany, NJ (P.W., D.K.); University of Texas Southwestern Medical Center, Dallas (J.D.H.); Richmond Pharmacology, St. George's University of London, London (J.T.); and Covance Clinical Research Unit, Leeds, United Kingdom (A. Brooks, C.F.).

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http://dx.doi.org/10.1056/NEJMoa1609243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5778873PMC
January 2017

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study.

Orphanet J Rare Dis 2015 Sep 4;10:109. Epub 2015 Sep 4.

National Reference Center for FAP (NNERF)/ APHP/ INSERM U 1191/ Hôpital de Bicêtre, 78, rue du General Leclerc, 94275, Le Kremlin-Bicêtre, France.

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http://dx.doi.org/10.1186/s13023-015-0326-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559363PMC
September 2015

Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study.

Neurology 2015 Aug 24;85(8):675-82. Epub 2015 Jul 24.

From the National Reference Center for FAP (NNERF) (D.A., Z.M.), APHP, Univ Paris Sud, INSERM Unité 1195, Le Kremlin-Bicêtre, France; Hospital de Santo António (T.C.), Centro Hospitalar do Porto, Portugal; Amyloidosis Research and Treatment Center (L.O., G.M.), Foundation IRCCS Policlinico San Matteo and University of Pavia, Italy; Mayo Clinic (N.S., W.J.L., P.J.D.), Rochester, MN; and Alnylam Pharmaceuticals (B.R.B., J.A.G., P.J.G.), Cambridge, MA.

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http://dx.doi.org/10.1212/WNL.0000000000001870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4553033PMC
August 2015

Natural variation in Drosophila stressed locomotion meets or exceeds variation caused by hsp70 mutation: analysis of behavior and performance.

Behav Genet 2009 May 26;39(3):306-20. Epub 2009 Feb 26.

Department of Biological Sciences, University of Massachusetts Lowell, 1 University Ave, Lowell, MA 01854, USA.

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http://link.springer.com/10.1007/s10519-009-9256-1
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http://dx.doi.org/10.1007/s10519-009-9256-1DOI Listing
May 2009

Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus.

J Mol Evol 2009 Apr 31;68(4):337-50. Epub 2009 Mar 31.

Department of Biological Sciences, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA.

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http://link.springer.com/10.1007/s00239-009-9213-x
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http://dx.doi.org/10.1007/s00239-009-9213-xDOI Listing
April 2009

Polyglutamine expansion in Drosophila: thermal stress and Hsp70 as selective agents.

J Biosci 2007 Apr;32(3):537-47

Department of Biological Sciences, University of Massachusetts Lowell, 1 University Ave., Lowell, MA 01854, USA.

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http://dx.doi.org/10.1007/s12038-007-0053-9DOI Listing
April 2007

Compensated deleterious mutations in insect genomes.

Science 2004 Nov 21;306(5701):1553-4. Epub 2004 Oct 21.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

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http://dx.doi.org/10.1126/science.1100522DOI Listing
November 2004

Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.

Mol Biol Evol 2003 Jan;20(1):135-44

Committee on Evolutionary Biology, The University of Chicago, Chicago, Illinois, USA.

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http://dx.doi.org/10.1093/molbev/msg015DOI Listing
January 2003

Response to natural and laboratory selection at the Drosophila hsp70 genes.

Evolution 2002 Sep;56(9):1796-801

Department of Organismal Biology, University of Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1111/j.0014-3820.2002.tb00193.xDOI Listing
September 2002

Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes.

J Mol Evol 2002 May;54(5):569-86

Department of Organismal Biology and Anatomy, University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1007/s00239-001-0044-7DOI Listing
May 2002

EXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER.

Evolution 1999 Apr;53(2):484-492

Dipartimento di Biologia Evoluzionistica Sperimentale, Università di Bologna, via F. Selmi, 3, 40126, Bologna, Italy.

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http://dx.doi.org/10.1111/j.1558-5646.1999.tb03783.xDOI Listing
April 1999