Brian P Ziemba

Brian P Ziemba

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Brian P Ziemba

Brian P Ziemba

Publications by authors named "Brian P Ziemba"

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13Publications

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A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages.

PLoS One 2018 1;13(5):e0196678. Epub 2018 May 1.

Department of Chemistry and Biochemistry, and the Molecular Biophysics Program, University of Colorado at Boulder, Boulder, CO, United States of America.

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July 2018

Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP Signaling.

Biophys J 2017 Dec;113(11):2396-2405

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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December 2017

Regulation of a Coupled MARCKS-PI3K Lipid Kinase Circuit by Calmodulin: Single-Molecule Analysis of a Membrane-Bound Signaling Module.

Biochemistry 2016 Nov 10;55(46):6395-6405. Epub 2016 Nov 10.

Molecular Biophysics Program and Department of Chemistry and Biochemistry, University of Colorado , Boulder, Colorado 80309-0215, United States.

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November 2016

Regulation of PI3K by PKC and MARCKS: Single-Molecule Analysis of a Reconstituted Signaling Pathway.

Biophys J 2016 04;110(8):1811-1825

Molecular Biophysics Program, University of Colorado, Boulder, Colorado; Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado. Electronic address:

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April 2016

Interplay between phosphoinositide lipids and calcium signals at the leading edge of chemotaxing ameboid cells.

Chem Phys Lipids 2014 Sep 19;182:73-9. Epub 2014 Jan 19.

Department of Chemistry and Biochemistry and Molecular Biophysics Program, University of Colorado, Boulder, CO 80309-0596, USA.

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September 2014

Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.

J Am Chem Soc 2014 Aug 11;136(33):11757-66. Epub 2014 Aug 11.

Department of Chemistry, Institute for Biophysical Dynamics, James Franck Institute and Computation Institute, The University of Chicago , 5735 South Ellis Avenue, Chicago, Illinois 60637, United States.

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August 2014

Single-molecule studies reveal a hidden key step in the activation mechanism of membrane-bound protein kinase C-α.

Biochemistry 2014 Mar 7;53(10):1697-713. Epub 2014 Mar 7.

Department of Chemistry and Biochemistry and Molecular Biophysics Program, University of Colorado , Boulder, Colorado 80309-0596, United States.

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March 2014

Lateral diffusion of peripheral membrane proteins on supported lipid bilayers is controlled by the additive frictional drags of (1) bound lipids and (2) protein domains penetrating into the bilayer hydrocarbon core.

Chem Phys Lipids 2013 Jul-Aug;172-173:67-77. Epub 2013 May 20.

Department of Chemistry and Biochemistry and the Molecular Biophysics Program, University of Colorado, Boulder, CO 80309-0596, USA.

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January 2014

The PH domain of phosphoinositide-dependent kinase-1 exhibits a novel, phospho-regulated monomer-dimer equilibrium with important implications for kinase domain activation: single-molecule and ensemble studies.

Biochemistry 2013 Jul 9;52(28):4820-9. Epub 2013 Jul 9.

Department of Chemistry and Biochemistry and Molecular Biophysics Program, University of Colorado , Boulder, Colorado 80309-0596, United States.

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July 2013

A novel mechanism of ligand binding and release in the odorant binding protein 20 from the malaria mosquito Anopheles gambiae.

Protein Sci 2013 Jan 29;22(1):11-21. Epub 2012 Nov 29.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, USA.

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January 2013

Membrane docking geometry of GRP1 PH domain bound to a target lipid bilayer: an EPR site-directed spin-labeling and relaxation study.

PLoS One 2012 30;7(3):e33640. Epub 2012 Mar 30.

Department of Chemistry and Biochemistry and the Molecular Biophysics Program, University of Colorado, Boulder, Colorado, United States of America.

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November 2012

Assembly of membrane-bound protein complexes: detection and analysis by single molecule diffusion.

Biochemistry 2012 Feb 14;51(8):1638-47. Epub 2012 Feb 14.

Department of Chemistry and Biochemistry and the Molecular Biophysics Program, University of Colorado at Boulder, Boulder, Colorado 80309-0215, United States.

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February 2012

1H, 13C and 15N NMR assignments of the C1A and C1B subdomains of PKC-delta.

Biomol NMR Assign 2011 Oct 4;5(2):125-9. Epub 2010 Dec 4.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

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October 2011