Brian N Finck

Brian N Finck

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Brian N Finck

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A mutation in Site-1 Protease is associated with a complex phenotype that includes episodic hyperCKemia and focal myoedema.

Mol Genet Genomic Med 2019 Jul 8;7(7):e00733. Epub 2019 May 8.

John T. Milliken Department of Medicine, Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1002/mgg3.733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625134PMC
July 2019

Treating Hepatic Steatosis and Fibrosis by Modulating Mitochondrial Pyruvate Metabolism.

Cell Mol Gastroenterol Hepatol 2019 10;7(2):275-284. Epub 2018 Oct 10.

Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X183014
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http://dx.doi.org/10.1016/j.jcmgh.2018.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352854PMC
May 2019

Fatty Acid Desaturation Gets a NAD Reputation.

Cell Metab 2019 Apr;29(4):790-792

Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.03.007DOI Listing
April 2019

The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

Food Chem Toxicol 2019 Mar 14;125:279-288. Epub 2019 Jan 14.

Dept. of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Dept. of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Center for Dietary Supplement Research, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443093PMC
March 2019

Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice.

Front Cell Dev Biol 2019 22;7:42. Epub 2019 Mar 22.

Department of Pharmacology, Center for Translational Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.

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http://dx.doi.org/10.3389/fcell.2019.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440456PMC
March 2019

Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.

FASEB J 2019 01 20;33(1):652-667. Epub 2018 Jul 20.

Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.1096/fj.201800361RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355067PMC
January 2019

Targeting Metabolism, Insulin Resistance, and Diabetes to Treat Nonalcoholic Steatohepatitis.

Authors:
Brian N Finck

Diabetes 2018 12;67(12):2485-2493

Center for Human Nutrition, Division of Geriatrics and Nutritional Sciences, John T. Milliken Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO

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http://dx.doi.org/10.2337/dbi18-0024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245219PMC
December 2018

High-fat-diet-induced remission of diabetes in a subset of K -GOF insulin-secretory-deficient mice.

Diabetes Obes Metab 2018 11 11;20(11):2574-2584. Epub 2018 Jul 11.

Department of Medicine, Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1111/dom.13423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407888PMC
November 2018

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.

J Lipid Res 2018 09 31;59(9):1630-1639. Epub 2018 May 31.

Medicine, Washington University School of Medicine, St. Louis, MO 63110.

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http://dx.doi.org/10.1194/jlr.M084947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121930PMC
September 2018

Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21.

JCI Insight 2018 07 12;3(13). Epub 2018 Jul 12.

Feinberg Cardiovascular Research Institute (FCVRI), Northwestern University, Chicago, Illinois, USA.

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http://dx.doi.org/10.1172/jci.insight.95948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124529PMC
July 2018

Reply.

Hepatology 2018 05 27;67(5):2055-2056. Epub 2017 May 27.

Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1002/hep.29162DOI Listing
May 2018

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.

Food Chem Toxicol 2018 May 11;115:273-283. Epub 2018 Mar 11.

Dept. of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2018.03.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935563PMC
May 2018

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid.

Endocrinology 2018 02;159(2):609-621

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1210/en.2017-00695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774852PMC
February 2018

Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.

Arterioscler Thromb Vasc Biol 2018 02 7;38(2):324-334. Epub 2017 Dec 7.

From the Department of Microbiology and Immunology (A.E.V., C.M.R.B., M.D.W.), Department of Pathology and Translational Pathobiology (J.M.G., B.H.P., A.W.O.), Department of Cell Biology and Anatomy (A.C.F.), Feist-Weiller Cancer Center (D.T.C.), and Pharmacology, Toxicology, and Neuroscience (R.L.K.), Louisiana State University Health Sciences Center, Shreveport; Department of Pharmacology, University of California San Diego, La Jolla (A.R.N.); Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden (R.C.); and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO (B.N.F.).

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http://dx.doi.org/10.1161/ATVBAHA.117.310455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785462PMC
February 2018

PPARs and nonalcoholic fatty liver disease.

Biochimie 2017 May 2;136:65-74. Epub 2016 Dec 2.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2016.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380579PMC
May 2017

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism.

Hepatol Commun 2017 05 18;1(3):193-197. Epub 2017 Apr 18.

Department of Medicine Washington University School of Medicine St. Louis MO.

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http://dx.doi.org/10.1002/hep4.1036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721453PMC
May 2017

Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.

Sci Rep 2016 09 26;6:34117. Epub 2016 Sep 26.

Department of Pharmaceutical Sciences, College of Pharmacy, Northeast Ohio Medical University, Rootstown, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036185PMC
http://dx.doi.org/10.1038/srep34117DOI Listing
September 2016

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion.

Mol Metab 2016 Aug 7;5(8):602-614. Epub 2016 Jul 7.

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021712PMC
August 2016

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Biomed Res Int 2015 26;2015:104132. Epub 2015 Jul 26.

Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1155/2015/104132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529893PMC
May 2016

An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis.

PLoS One 2014 7;9(7):e101900. Epub 2014 Jul 7.

Department of Radiology, Washington University in St. Louis, Saint Louis, Missouri, United States of America; Department of Biomedical Engineering, Washington University in St. Louis, Saint Louis, Missouri, United States of America; Division of Biology and Biomedical Sciences, Washington University in St. Louis, Saint Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101900PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085004PMC
December 2015

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.

Cell Metab 2015 Oct 3;22(4):682-94. Epub 2015 Sep 3.

Division of Geriatrics and Nutritional Sciences, Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2015.07.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598280PMC
October 2015

Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.

JIMD Rep 2015 13;23:113-22. Epub 2015 May 13.

Department of Medicine, Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, 660 S. Euclid Ave, Box 8031, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/8904_2015_440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484911PMC
June 2015

Mitochondrial pyruvate transport: a historical perspective and future research directions.

Biochem J 2015 Mar;466(3):443-54

*Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, U.S.A.

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http://dx.doi.org/10.1042/BJ20141171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4464838PMC
March 2015

Head over hepatocytes for FGF21.

Diabetes 2014 Dec;63(12):4013-5

Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO

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http://dx.doi.org/10.2337/db14-1185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237992PMC
December 2014

Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.

Cell Rep 2014 Jun 5;7(6):2042-2053. Epub 2014 Jun 5.

Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.celrep.2014.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074444PMC
June 2014

Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.

Hepatology 2013 Dec 17;58(6):1953-63. Epub 2013 Oct 17.

Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL.

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http://dx.doi.org/10.1002/hep.26589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835749PMC
December 2013

Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice.

Mol Endocrinol 2013 Nov 12;27(11):1887-96. Epub 2013 Sep 12.

MD, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110.

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http://dx.doi.org/10.1210/me.2013-1137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805847PMC
November 2013

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Mol Metab 2013 9;2(3):194-204. Epub 2013 May 9.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, United States ; Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, United States.

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http://dx.doi.org/10.1016/j.molmet.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3773825PMC
September 2013

Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.

Diabetes 2013 Aug 22;62(8):2757-61. Epub 2013 Apr 22.

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine,Washington University School of Medicine, St Louis, Missouri, USA.

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http://dx.doi.org/10.2337/db13-0185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717831PMC
August 2013

Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.

PLoS One 2012 7;7(12):e51320. Epub 2012 Dec 7.

Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051320PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517414PMC
June 2013

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Proc Natl Acad Sci U S A 2013 Jan 24;110(2):642-7. Epub 2012 Dec 24.

Department of Medicine, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1073/pnas.1213493110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545773PMC
January 2013

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Bioorg Med Chem Lett 2012 Oct 9;22(19):6233-6. Epub 2012 Aug 9.

Division of Radiological Sciences, Washington University School of Medicine, 510 S Kingshighway Blvd, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.bmcl.2012.08.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477601PMC
October 2012

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.

Cell Metab 2012 Oct;16(4):473-86

Center for Neuroscience, Aging, and Stem Cell Research, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131120036
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http://dx.doi.org/10.1016/j.cmet.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569089PMC
October 2012

Sexually dimorphic effect of aging on skeletal muscle protein synthesis.

Biol Sex Differ 2012 May 23;3(1):11. Epub 2012 May 23.

Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue; Campus, Box 8031, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1186/2042-6410-3-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467175PMC
May 2012

Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.

Hepatology 2012 Feb 29;55(2):437-46. Epub 2011 Dec 29.

Departments of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, FL, USA.

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http://dx.doi.org/10.1002/hep.24708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253249PMC
February 2012

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Cell 2011 Aug;146(3):408-20

Whitehead Institute for Biomedical Research, Koch Center for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cell.2011.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336367PMC
August 2011

The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium.

PPAR Res 2008 ;2008:253817

Center for Cardiovascular Research, Departments of Pediatrics and Medicine, Washington University School of Medicine, 660 S. Euclid Avenue Campus Box 8031, Saint Louis, MO 63110, USA.

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http://www.hindawi.com/journals/ppar/2008/253817/
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http://dx.doi.org/10.1155/2008/253817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225461PMC
July 2011

PPARs/RXRs in Cardiovascular Physiology and Disease.

PPAR Res 2008 ;2008:173780

Department of Medicine, School of Medicine, Washington University, 660 South Euclid Avenue, Campus Box 8031, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1155/2008/173780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278368PMC
July 2011

Dual function lipin proteins and glycerolipid metabolism.

Trends Endocrinol Metab 2011 Jun 4;22(6):226-33. Epub 2011 Apr 4.

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.tem.2011.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118913PMC
June 2011

Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response.

J Biol Chem 2011 Apr 14;286(13):11155-62. Epub 2011 Feb 14.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.217349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064169PMC
April 2011

Liver regeneration is impaired in lipodystrophic fatty liver dystrophy mice.

Hepatology 2010 Dec 21;52(6):2109-17. Epub 2010 Oct 21.

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/hep.23920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991544PMC
December 2010

Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women.

Diabetes 2010 Aug 3;59(8):1899-905. Epub 2010 Jun 3.

Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.2337/db10-0308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911053PMC
August 2010

Peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) stimulates VLDL assembly through activation of cell death-inducing DFFA-like effector B (CideB).

J Biol Chem 2010 Aug 15;285(34):25996-6004. Epub 2010 Jun 15.

Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1074/jbc.M110.141598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923994PMC
August 2010

Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors.

Mol Cell Biol 2010 Jun 12;30(12):3126-39. Epub 2010 Apr 12.

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1128/MCB.01671-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876672PMC
June 2010

Dynamic and differential regulation of proteins that coat lipid droplets in fatty liver dystrophic mice.

J Lipid Res 2010 Mar 11;51(3):554-63. Epub 2009 Sep 11.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1194/jlr.M000976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2817585PMC
March 2010

Hepatic expression of cell death-inducing DFFA-like effector C in obese subjects is reduced by marked weight loss.

Obesity (Silver Spring) 2010 Feb 6;18(2):417-9. Epub 2009 Aug 6.

Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

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http://doi.wiley.com/10.1038/oby.2009.236
Publisher Site
http://dx.doi.org/10.1038/oby.2009.236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2957480PMC
February 2010

In vivo metabolic phenotyping of myocardial substrate metabolism in rodents: differential efficacy of metformin and rosiglitazone monotherapy.

Circ Cardiovasc Imaging 2009 Sep 21;2(5):373-81. Epub 2009 Jul 21.

Mallinckrodt Institute of Radiology, Division of Radiological Sciences, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1161/CIRCIMAGING.108.843227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760020PMC
September 2009

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

Proc Natl Acad Sci U S A 2009 Jun 16;106(26):10853-8. Epub 2009 Jun 16.

Department of Pharmacology, Howard Hughes Medical Institute, Advanced Imaging Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1073/pnas.0904187106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705613PMC
June 2009

Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction.

Gastroenterology 2009 May 25;136(5):1552-60. Epub 2009 Jan 25.

Center for Human Nutrition and Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850900150
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http://dx.doi.org/10.1053/j.gastro.2009.01.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677125PMC
May 2009

Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion.

Arterioscler Thromb Vasc Biol 2008 Oct 31;28(10):1738-44. Epub 2008 Jul 31.

Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1161/ATVBAHA.108.171538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655237PMC
October 2008

Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons.

J Appl Physiol (1985) 2008 Aug 5;105(2):473-8. Epub 2008 Jun 5.

Department of Internal Medicine, Washington University School of Medicine, Campus Box 8303, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1152/japplphysiol.00006.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519937PMC
August 2008

Hepatic lipin 1beta expression is diminished in insulin-resistant obese subjects and is reactivated by marked weight loss.

Diabetes 2007 Sep 11;56(9):2395-9. Epub 2007 Jun 11.

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.2337/db07-0480DOI Listing
September 2007

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) regulatory cascade in cardiac physiology and disease.

Circulation 2007 May;115(19):2540-8

Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO 63110, USA.

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May 2007

CD36 deficiency rescues lipotoxic cardiomyopathy.

Circ Res 2007 Apr 15;100(8):1208-17. Epub 2007 Mar 15.

Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA.

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https://www.ahajournals.org/doi/10.1161/01.RES.0000264104.25
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http://dx.doi.org/10.1161/01.RES.0000264104.25265.b6DOI Listing
April 2007

Effect of marked weight loss on adiponectin gene expression and plasma concentrations.

Obesity (Silver Spring) 2007 Mar;15(3):640-5

Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/oby.2007.556DOI Listing
March 2007

The PPAR regulatory system in cardiac physiology and disease.

Authors:
Brian N Finck

Cardiovasc Res 2007 Jan 1;73(2):269-77. Epub 2006 Sep 1.

Center for Human Nutrition and Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.cardiores.2006.08.023DOI Listing
January 2007

Synthesis and evaluation of a bromine-76-labeled PPARgamma antagonist 2-bromo-5-nitro-N-phenylbenzamide.

Nucl Med Biol 2006 Oct;33(7):847-54

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.nucmedbio.2006.08.003DOI Listing
October 2006

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

Cell Metab 2006 Sep;4(3):199-210

Center for Cardiovascular Research and Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.cmet.2006.08.005DOI Listing
September 2006

Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle?

Authors:
Brian N Finck

Expert Rev Cardiovasc Ther 2006 Mar;4(2):161-71

Department of Medicine, Washington University School of Medicine, Center for Human Nutrition and Center for Cardiovascular Research, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1586/14779072.4.2.161DOI Listing
March 2006

PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

J Clin Invest 2006 Mar;116(3):615-22

Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1172/JCI27794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1386111PMC
March 2006

Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia.

Am J Physiol Heart Circ Physiol 2006 Jan 9;290(1):H87-95. Epub 2005 Sep 9.

Department of Pediatrics and Pharmacology, Univ. of Alberta, Edmonton, AB, Canada.

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http://dx.doi.org/10.1152/ajpheart.00285.2005DOI Listing
January 2006

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver.

Diabetes 2005 Sep;54(9):2514-24

Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology and Metabolism, The Anlyan Center, S269C, P.O. Box 208020, 300 Cedar St., New Haven, CT 06520-8020, USA.

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http://dx.doi.org/10.2337/diabetes.54.9.2514DOI Listing
September 2005

A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes.

Cell Metab 2005 Feb;1(2):133-44

Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.01.006DOI Listing
February 2005

Mouse models of mitochondrial dysfunction and heart failure.

J Mol Cell Cardiol 2005 Jan 8;38(1):81-91. Epub 2004 Dec 8.

Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8086, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2004.10.010DOI Listing
January 2005

G-protein signaling participates in the development of diabetic cardiomyopathy.

Diabetes 2004 Dec;53(12):3082-90

Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

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http://dx.doi.org/10.2337/diabetes.53.12.3082DOI Listing
December 2004

The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart.

Authors:
Brian N Finck

Curr Opin Clin Nutr Metab Care 2004 Jul;7(4):391-6

Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

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July 2004

Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice.

Nat Med 2003 Aug 6;9(8):1069-75. Epub 2003 Jul 6.

Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110 USA.

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http://www.nature.com/articles/nm898
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August 2003

A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content.

Proc Natl Acad Sci U S A 2003 Feb 27;100(3):1226-31. Epub 2003 Jan 27.

Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0336724100
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http://dx.doi.org/10.1073/pnas.0336724100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298755PMC
February 2003