N Engl J Med 2014 Oct 30;371(18):1695-703. Epub 2014 Sep 30.
From the Centre for Infection and Immunity, Queen's University of Belfast (D.F.M., C.M.O.), the Regional Intensive Care Unit (D.F.M., B.M.) and Northern Ireland Clinical Trials Unit (D.F.M., C. McDowell, C. McNally), Royal Victoria Hospital, and the Intensive Care Unit, Ulster Hospital (T.J.T.), Belfast, the Heart of England National Health Service (NHS) Foundation Trust, Birmingham (G.D.P.), Warwick Medical School Clinical Trials Unit, University of Warwick, Warwick (G.D.P.), the Intensive Care Unit, Antrim Area Hospital, Antrim (P.J.), the Critical Care Units, King's Health Partners (King's College Hospital), London (P.A.H.), and the John Farman Intensive Care Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge (A.J.J.) - all in the United Kingdom; the Department of Anaesthesia, School of Medicine, Health Research Board Galway Clinical Research Facility, Clinical Sciences Institute, National University of Ireland, Galway, Ireland (J.G.L.); and the Department of Anesthesia, Centre for Critical Care Research, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, University of Toronto, Toronto (J.G.L.).