Brian M Alexander

Brian M Alexander

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Brian M Alexander

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Deviation from the Proportional Hazards Assumption in Randomized Phase 3 Clinical Trials in Oncology: Prevalence, Associated Factors, and Implications.

Clin Cancer Res 2019 Nov 25;25(21):6339-6345. Epub 2019 Jul 25.

Department of Radiation Oncology, Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3999DOI Listing
November 2019

Design and Evaluation of an External Control Arm Using Prior Clinical Trials and Real-World Data.

Clin Cancer Res 2019 Aug 7;25(16):4993-5001. Epub 2019 Jun 7.

Dana-Farber Program in Regulatory Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697596PMC
August 2019

Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases.

Breast Cancer Res Treat 2019 Jul 13;176(1):171-179. Epub 2019 Apr 13.

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://link.springer.com/10.1007/s10549-019-05236-6
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http://dx.doi.org/10.1007/s10549-019-05236-6DOI Listing
July 2019

Association of Neurosurgical Resection With Development of Pachymeningeal Seeding in Patients With Brain Metastases.

JAMA Oncol 2019 May;5(5):703-709

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2018.7204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512273PMC
May 2019

Local control after brain-directed radiation in patients with cystic versus solid brain metastases.

J Neurooncol 2019 Apr 4;142(2):355-363. Epub 2019 Feb 4.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s11060-019-03106-1DOI Listing
April 2019

Bayesian Adaptive Randomization in Dose-Finding Trials.

JAMA Netw Open 2018 12 7;1(8):e186075. Epub 2018 Dec 7.

Dana-Farber Cancer Institute, Department of Biostatistics and Computational Biology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamanetworkopen.2018.6075DOI Listing
December 2018

The FDA NIH Biomarkers, EndpointS, and other Tools (BEST) resource in neuro-oncology.

Neuro Oncol 2018 08;20(9):1162-1172

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071649PMC
August 2018

Immunotherapy and Symptomatic Radiation Necrosis in Patients With Brain Metastases Treated With Stereotactic Radiation.

JAMA Oncol 2018 08;4(8):1123-1124

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2017.3993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885198PMC
August 2018

Neurologic Complications of Radiation Therapy.

Neurol Clin 2018 08 15;36(3):599-625. Epub 2018 Jun 15.

Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, 420 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.ncl.2018.04.012DOI Listing
August 2018

Platform trials arrive on time for glioblastoma.

Neuro Oncol 2018 05;20(6):723-725

UCLA Neuro-Oncology Program and Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.

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http://dx.doi.org/10.1093/neuonc/noy040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5961158PMC
May 2018

Hazards of Hazard Ratios - Deviations from Model Assumptions in Immunotherapy.

N Engl J Med 2018 03;378(12):1158-1159

Dana-Farber Cancer Institute, Boston, MA

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http://dx.doi.org/10.1056/NEJMc1716612DOI Listing
March 2018

Innovation Incentives and Biomarkers.

Clin Pharmacol Ther 2018 Jan 16;103(1):34-36. Epub 2017 Oct 16.

Harvard/MIT Center for Regulatory Science, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cpt.876DOI Listing
January 2018

Quantitative imaging biomarkers for risk stratification of patients with recurrent glioblastoma treated with bevacizumab.

Neuro Oncol 2017 Nov;19(12):1688-1697

Departments of Radiation Oncology and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Product Development, Pharma Division, F. Hoffmann-La Roche Ltd., Basel, Switzerland; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Center for Neuro-Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA; Department of Radiology, Columbia University College of Physicians and Surgeons and New York Presbyterian Hospital, New York, New York, USA.

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http://academic.oup.com/neuro-oncology/article/19/12/1688/38
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http://dx.doi.org/10.1093/neuonc/nox092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716072PMC
November 2017

Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: a population-based study.

Neuro Oncol 2017 Oct;19(11):1511-1521

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Harvard T. H. Chan School of Public Health, and Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; Department of Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1093/neuonc/nox077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737512PMC
October 2017

Designing Clinical Trials That Accept New Arms: An Example in Metastatic Breast Cancer.

J Clin Oncol 2017 Sep 22;35(27):3160-3168. Epub 2017 May 22.

Steffen Ventz, University of Rhode Island, Kingstown, RI; Brian M. Alexander, Giovanni Parmigiani, Richard D. Gelber, and Lorenzo Trippa, Dana-Farber Cancer Institute; Brian M. Alexander and Richard D. Gelber, Harvard Medical School; Giovanni Parmigiani, Richard D. Gelber, and Lorenzo Trippa, Harvard TH Chan School of Public Health; Richard D. Gelber, Frontier Science Foundation, Boston, MA.

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http://dx.doi.org/10.1200/JCO.2016.70.1169DOI Listing
September 2017

The cost and value of glioblastoma therapy.

Expert Rev Anticancer Ther 2017 08 13;17(8):657-659. Epub 2017 Jul 13.

a Department of Radiation Oncology , Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/14737140.2017.1351355DOI Listing
August 2017

Prophylactic cranial irradiation in patients with extensive-stage small cell lung cancer.

Neuro Oncol 2017 08;19(8):1015-1016

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/nox113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570200PMC
August 2017

Leveraging molecular datasets for biomarker-based clinical trial design in glioblastoma.

Neuro Oncol 2017 Jul;19(7):908-917

Department of Radiation Oncology, Department of Pathology, Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center (DF/BWCC), Harvard Medical School, Boston, Massachusetts; Department of Biostatistics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; Accelerate Brain Cancer Cure (ABC2), Washington, DC; Harvard Program in Therapeutic Science, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1093/neuonc/now312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570228PMC
July 2017

Adult Glioblastoma.

J Clin Oncol 2017 Jul 22;35(21):2402-2409. Epub 2017 Jun 22.

Brian M. Alexander, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, MA; and Timothy F. Cloughesy, University of California Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2017.73.0119DOI Listing
July 2017

Erratum to: Rapid progression of intracranial melanoma metastases controlled with combined BRAF/MEK inhibition after discontinuation of therapy: a clinical challenge.

J Neurooncol 2017 05;133(1):221

Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11060-017-2485-xDOI Listing
May 2017

Whole brain radiotherapy for non-small cell lung cancer.

Lancet 2017 04;389(10077):1394-1395

Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/S0140-6736(17)30895-4DOI Listing
April 2017

Steroid and anticonvulsant prophylaxis for stereotactic radiosurgery: Large variation in physician recommendations.

Pract Radiat Oncol 2016 Jul-Aug;6(4):e89-96. Epub 2015 Nov 10.

Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2015.11.004DOI Listing
March 2017

Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas.

Neuro Oncol 2017 01 26;19(1):109-117. Epub 2016 Jun 26.

Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts (B.Z., K.C., R.Y.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.R., K.L.L.); Department of Pathology, Harvard Medical School, Boston, Massachusetts (S.R., K.L.L.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (S.R., K.L.L.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts(S.R., D.A.R., K.L.L., P.Y.W.); Harvard Radiation Oncology Program, Boston, Massachusetts (S.T.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B.); Center of Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (D.A.R., P.Y.W.); Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (B.M.A.)

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http://dx.doi.org/10.1093/neuonc/now121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5193019PMC
January 2017

The Radiation Oncology Job Market: The Economics and Policy of Workforce Regulation.

Int J Radiat Oncol Biol Phys 2016 11 8;96(3):501-10. Epub 2016 Jun 8.

Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2016.05.029DOI Listing
November 2016

Evaluation of initial setup accuracy and intrafraction motion for spine stereotactic body radiation therapy using stereotactic body frames.

Pract Radiat Oncol 2016 Jan-Feb;6(1):e17-24. Epub 2015 Aug 29.

Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.prro.2015.08.009DOI Listing
October 2016

Genomic landscape of intracranial meningiomas.

J Neurosurg 2016 09 15;125(3):525-35. Epub 2016 Jan 15.

Department of Neurosurgery, Brigham and Women's Hospital;

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http://dx.doi.org/10.3171/2015.6.JNS15591DOI Listing
September 2016

Rapid progression of intracranial melanoma metastases controlled with combined BRAF/MEK inhibition after discontinuation of therapy: a clinical challenge.

J Neurooncol 2016 09 11;129(3):389-393. Epub 2016 Jul 11.

Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11060-016-2196-8DOI Listing
September 2016

Updates in the management of brain metastases.

Neuro Oncol 2016 08;18(8):1043-65

St. Luke's Radiation Oncology Associates, St. Luke's Cancer Center, Whiteside Institute for Clinical Research and University of Minnesota Duluth, Duluth, Minnesota (N.D.A.); Center for Neuro-Oncology, Dana-Farber/Brigham & Women's Cancer Center, Boston, Massachusetts (E.Q.L., P.Y.W.); Harvard Medical School, Boston, Massachusetts (E.Q.L., B.M.A., N.U.L., I.F.D., P.Y.W.); Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland (M.P.M.); Department of Medical Oncology, City of Hope, Duarte, California (K.M.); Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Boston, Massachusetts (B.M.A.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (N.U.L.); Department of Medicine, Division of Hematology-Oncology, University of North Carolina, Chapel Hill, North Carolina (C.K.A.); Department of Neurology/Neuro-Oncology, University of Turin, Turin, Italy (R.S.); Division of Medical Oncology, University of Colorado Denver, Denver, Colorado (D.R.C.); Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio (M.A.V.); Department of Neurosurgery, Brigham & Women's Hospital, Boston, Massachusetts (I.F.D.).

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http://dx.doi.org/10.1093/neuonc/now127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933491PMC
August 2016

A randomized, placebo-controlled pilot trial of armodafinil for fatigue in patients with gliomas undergoing radiotherapy.

Neuro Oncol 2016 06 21;18(6):849-54. Epub 2016 Feb 21.

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (E.Q.L., D.A.R., A.D.N., L.N., M.L.R., B.M.A., N.D.A., L.D., J.S., D.L., S.F.R., J.P., K.H.S., S.C.G., S.H., P.Y.W.); Harvard Medical School, Boston, Massachusetts (E.Q.L., E.T.W., D.A.R., A.D.N., L.N., M.L.R., B.M.A., N.D.A., P.Y.W.); Massachusetts General Hospital, Boston, Massachusetts (A.M.); University of Pittsburgh, Pittsburgh, Pennsylvania (J.D.); University of California San Diego, La Jolla, California (S.K.); Beth Israel Deaconess Medical Center, Boston, Massachusetts (E.T.W.); Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire (C.E.F.); Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (C.E.F.).

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http://dx.doi.org/10.1093/neuonc/now007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864265PMC
June 2016

Oncogenic PI3K mutations are as common as AKT1 and SMO mutations in meningioma.

Neuro Oncol 2016 05 28;18(5):649-55. Epub 2016 Jan 28.

Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (M.A., P.H.M., R.B., M.L.L., S.H.R., R.D.F., K.L.L., A.H.L., S.S.); Department of Pathology, King Fahad Medical City, Riyadh, Saudi Arabia (M.A.); King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia (M.A.); Harvard Medical School, Boston, Massachusetts (M.A., A.A.A., D.D.-S., P.K.B., D.A.R., P.Y.W., O.A.-M., S.H.R., R.D.F., K.L.L., A.H.L., B.M.A., I.F.D., R.B., S.S.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., O.A.-M., I.F.D.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A., B.M.A.); Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts (P.K.A.); Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (D.D.-S.); Center for Cancer Genomic Discovery, Dana-Farber Cancer Institute, Boston, Massachusetts (A.R.T., P.V.H.); Department of Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts (P.K.B.); Center of Neuro-Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (D.A.R., P.Y.W, R.B.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (K.L.L., R.B.); Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA (S.S.).

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http://dx.doi.org/10.1093/neuonc/nov316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827048PMC
May 2016

Preclinical Efficacy of the MDM2 Inhibitor RG7112 in MDM2-Amplified and TP53 Wild-type Glioblastomas.

Clin Cancer Res 2016 Mar 19;22(5):1185-96. Epub 2015 Oct 19.

Inserm, U 1127, Paris, France. CNRS, UMR 7225, Paris, France. Sorbonne Universités, UPMC Univ Paris 06, UMR S 1127, Paris, France. Institut du Cerveau et de la Moëlle épinière, ICM, 47, Bd de l'Hôpital, Paris, France. AP-HP, Hôpital universitaire Pitié-Salpêtrière, Service de Neurologie 2-Mazarin, 47, Bd de l'Hôpital, Paris, France. AP-HP, Hôpital de la Pitié-Salpêtrière, Service de Neuropathologie R Escourolle, 47, Bd de l'Hôpital, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4842012PMC
March 2016

A prognostic cytogenetic scoring system to guide the adjuvant management of patients with atypical meningioma.

Neuro Oncol 2016 Feb 30;18(2):269-74. Epub 2015 Aug 30.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (A.A.A., M.C.H., N.D.A., B.M.A.); Department of Pathology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (M.A., K.L.L., A.H.L., S.S.); Department of Neurosurgery, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (W.L.B., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (E.Q.L., L.N., M.L.R., A.D.N., D.A.R., P.Y.W., R.B.).

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https://academic.oup.com/neuro-oncology/article-lookup/doi/1
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http://dx.doi.org/10.1093/neuonc/nov177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724184PMC
February 2016

Somatic mutations associated with MRI-derived volumetric features in glioblastoma.

Neuroradiology 2015 Dec 4;57(12):1227-37. Epub 2015 Sep 4.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/s00234-015-1576-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648958PMC
December 2015

Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma.

Neuro Oncol 2015 Oct 9;17(10):1344-55. Epub 2015 Mar 9.

Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.H.R., L.A.R., S.H., D.K., Y.J.K., K.L.L.); Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (S.E.S., L.B., M.B., D.A.R., E.Q.L., M.L.R., A.D.N., L.N., S.R., L.M.D., D.C.L., P.K., B.J.R., P.Y.W., R.B., K.L.L.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (W.L.B., E.B.C, O.A.-M., M.D.J., A.J.G., I.F.D., E.A.C.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts (M.H., A.A.A., N.D.A., B.M.A.); Harvard Radiation Oncology Program, Boston, Massachusetts (A.R.); Kravis Center for Molecular Oncology & Department of Epidemiology and Biostatistics, Memorial Sloan- Kettering Cancer Center, New York, New York (N.S.); Broad Institute, Cambridge, Massachusetts (R.B.); Department of Pathology, Boston Children's Hospital, Boston, Massachusetts (K.L.L.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., A.D., J.B.C., M.A., S.S., R.D.F., N.I.L., A.H.L., K.L.L.)

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http://dx.doi.org/10.1093/neuonc/nov015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578577PMC
October 2015

Salvage whole brain radiotherapy or stereotactic radiosurgery after initial stereotactic radiosurgery for 1-4 brain metastases.

J Neurooncol 2015 Sep 25;124(3):429-37. Epub 2015 Jun 25.

Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Harvard Medical School, 75 Francis Street, ASB1-L2, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1007/s11060-015-1855-5DOI Listing
September 2015

In Reply to Levra et al.

Int J Radiat Oncol Biol Phys 2015 Sep;93(1):218-9

Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2015.05.007DOI Listing
September 2015

Combining progression-free survival and overall survival as a novel composite endpoint for glioblastoma trials.

Neuro Oncol 2015 Aug 7;17(8):1106-13. Epub 2015 Jan 7.

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T., G.P.); Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T., G.P.); Center for Neuro-Oncology Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, (P.Y.W., B.M.A.); Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas (D.A.B.).

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http://dx.doi.org/10.1093/neuonc/nou345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490868PMC
August 2015

Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients.

Int J Radiat Oncol Biol Phys 2015 Jun 1;92(2):384-9. Epub 2015 Apr 1.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2015.01.017DOI Listing
June 2015

Getting it first versus getting it right: weighing the value of and evidence for progression-free survival as a surrogate endpoint for overall survival in glioblastoma.

Neuro Oncol 2015 May;17(5):765-6

Dana-Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (L.T.); Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T.).

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http://dx.doi.org/10.1093/neuonc/nov024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482865PMC
May 2015

Brain Malignancy Steering Committee clinical trials planning workshop: report from the Targeted Therapies Working Group.

Neuro Oncol 2015 Feb 26;17(2):180-8. Epub 2014 Aug 26.

Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (B.M.A., L.T., K.L.L., P.Y.W.); Mayo Clinic, Rochester, Minnesota (E.G., K.V.B., B.P.O., J.N.S.); The University of Texas M.D. Anderson Cancer Center, Houston, Texas (W.K.A.Y., J.F.D., D.A.B.); St. Jude Children's Research Hospital, Memphis, Tennessee (J.M.B.); University of California, Los Angeles, California (T.F.C.); Memorial Sloan-Kettering Cancer Center, New York, New York (J.T.H., I.K.M.); National Cancer Institute, Bethesda, Maryland (B.M., A.T.-A.); Princess Margaret Cancer Centre, Toronto, Ontario, Canada (W.M.); Henry Ford Hospital, Detroit, Michigan (T.M.); University of California, San Diego, La Jolla, California (P.S.M.); University of California, San Francisco, California (M.D.P.); Johns Hopkins University, Baltimore, Maryland (X.Y.).

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http://dx.doi.org/10.1093/neuonc/nou154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288520PMC
February 2015

Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma.

Neuro Oncol 2014 Nov 2;16(11):1547-53. Epub 2014 Jun 2.

Harvard Radiation Oncology Program, Brigham and Women's Hospital, Boston, Massachusetts (A.A.A.); Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (N.D.A., B.M.A.); Department of Biostatistics, Dana-Farber Cancer Institute, Boston, Massachusetts (P.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C., A.J.G., M.D.J., O.A-M., I.F.D.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (P.Y.W., D.A.R., E.Q.L., L.N., M.L.R., R.B.); Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania (S.E.W.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (S.H.R., S.S., M.A.).

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http://dx.doi.org/10.1093/neuonc/nou098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201070PMC
November 2014

Retrospective study of carmustine or lomustine with bevacizumab in recurrent glioblastoma patients who have failed prior bevacizumab.

Neuro Oncol 2014 Nov 23;16(11):1523-9. Epub 2014 Jun 23.

Harvard Medical School, Boston, Massachusetts (R.R., A.D.N., D.A.R., L.N., M.L.R., R.B., B.M.A., R.Y.H., P.Y.W., E.Q.L.); Center of Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (K.H., A.D.N., D.A.R., L.N., M.L.R., R.B., L.D., S.R., J.R., D.L., P.Y.W., E.Q.L.); Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts (A.D.N., D.A.R., L.N., M.L.R., R.B., P.Y.W., E.Q.L.); Department of Radiation Oncology, Brigham and Women's Hospital, Boston, Massachusetts (B.M.A.); Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts (R.Y.H.); Boston University School of Medicine, Boston, Massachusetts (A.R.).

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http://dx.doi.org/10.1093/neuonc/nou118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201074PMC
November 2014

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.

Cancer Discov 2014 Aug 29;4(8):905-13. Epub 2014 May 29.

Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana-Farber Cancer Institute;

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http://dx.doi.org/10.1158/2159-8290.CD-14-0362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125497PMC
August 2014

Cancer-specific outcomes among young adults without health insurance.

J Clin Oncol 2014 Jul 2;32(19):2025-30. Epub 2014 Jun 2.

Ayal A. Aizer and Benjamin Falit, Harvard Radiation Oncology Program; Mallika L. Mendu and Quoc-Dien Trinh, Brigham and Women's Hospital; Toni K. Choueiri, Neil E. Martin, Brian M. Alexander, and Paul L. Nguyen, Brigham and Women's Hospital/Dana-Farber Cancer Institute Boston, MA; Ming-Hui Chen, University of Connecticut, Storrs, CT; Karen E. Hoffman, University of Texas MD Anderson Cancer Center, Houston, TX; and Jim C. Hu, University of California Los Angeles, Los Angeles, CA.

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http://jco.ascopubs.org/content/early/2014/06/02/JCO.2013.54
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2013.54.2555
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http://dx.doi.org/10.1200/JCO.2013.54.2555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879691PMC
July 2014

Progression-free survival: too much risk, not enough reward?

Neuro Oncol 2014 May;16(5):615-6

Dana-Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts (B.M.A.); Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts and Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts (L.T.).

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http://dx.doi.org/10.1093/neuonc/nou041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984564PMC
May 2014

Biomarker-based adaptive trials for patients with glioblastoma--lessons from I-SPY 2.

Neuro Oncol 2013 Aug 14;15(8):972-8. Epub 2013 Jul 14.

Department of Radiation Oncology, Dana-Farber/Brigham and Women’s Cancer Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1093/neuonc/not088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714161PMC
August 2013

Paratesticular liposarcoma: unusual patterns of recurrence and importance of margins.

Ann Surg Oncol 2013 Jul 17;20(7):2148-55. Epub 2013 Apr 17.

Harvard Radiation Oncology Program, Brigham and Women's Hospital, Boston, MA, USA.

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http://dx.doi.org/10.1245/s10434-013-2963-0DOI Listing
July 2013

Enhancing radiation therapy for patients with glioblastoma.

Expert Rev Anticancer Ther 2013 May;13(5):569-81

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, 75 Francis Street, ASB1-L2, Boston, MA 02115, USA.

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http://dx.doi.org/10.1586/era.13.44DOI Listing
May 2013

Current and future directions for Phase II trials in high-grade glioma.

Expert Rev Neurother 2013 Apr;13(4):369-87

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, 75 Francis Street, ASB1-L2, Boston, MA 02115, USA.

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http://dx.doi.org/10.1586/ern.12.158DOI Listing
April 2013

A phase II study of conventional radiation therapy and thalidomide for supratentorial, newly-diagnosed glioblastoma (RTOG 9806).

J Neurooncol 2013 Jan 20;111(1):33-9. Epub 2012 Oct 20.

Dana-Farber/Brigham and Women's Cancer Center, 75 Francis Street, ASB1-L2, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s11060-012-0987-0DOI Listing
January 2013

Brain metastases after breast-conserving therapy and systemic therapy: incidence and characteristics by biologic subtype.

Breast Cancer Res Treat 2012 Nov 12;136(1):153-60. Epub 2012 Sep 12.

Department of Radiation Oncology, Dana-Farber/Brigham & Women's Cancer Center, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s10549-012-2243-xDOI Listing
November 2012

Bayesian adaptive randomized trial design for patients with recurrent glioblastoma.

J Clin Oncol 2012 Sep 29;30(26):3258-63. Epub 2012 May 29.

Dana-Farber Cancer Institute, Harvard School of Public Health and Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA 02215, USA.

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http://jco.ascopubs.org/content/early/2012/05/29/JCO.2011.39
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2011.39.8420
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http://dx.doi.org/10.1200/JCO.2011.39.8420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3434985PMC
September 2012

DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer.

Int J Radiat Oncol Biol Phys 2012 May 12;83(1):164-71. Epub 2011 Oct 12.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2011.05.033DOI Listing
May 2012

Targeting DNA repair and the cell cycle in glioblastoma.

J Neurooncol 2012 May 24;107(3):463-77. Epub 2011 Nov 24.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, 75 Francis Street, ASB1-L2, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s11060-011-0765-4DOI Listing
May 2012

Salvage stereotactic radiosurgery for breast cancer brain metastases: outcomes and prognostic factors.

Cancer 2012 Apr 14;118(8):2014-20. Epub 2011 Sep 14.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cncr.26343DOI Listing
April 2012

Stereotactic irradiation of the postoperative resection cavity for brain metastasis: a frameless linear accelerator-based case series and review of the technique.

Int J Radiat Oncol Biol Phys 2012 Jan 17;82(1):95-101. Epub 2010 Dec 17.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2010.10.043DOI Listing
January 2012

Role of isocitrate dehydrogenase in glioma.

Expert Rev Neurother 2011 Oct;11(10):1399-409

Dana-Farber/Brigham and Women's Cancer Center, Department of Radiation Oncology, Boston, MA, USA.

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http://www.tandfonline.com/doi/full/10.1586/ern.11.134
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http://dx.doi.org/10.1586/ern.11.134DOI Listing
October 2011

Tumor volume is a prognostic factor in non-small-cell lung cancer treated with chemoradiotherapy.

Int J Radiat Oncol Biol Phys 2011 Apr 3;79(5):1381-7. Epub 2010 Jun 3.

Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2009.12.060DOI Listing
April 2011

DNA repair protein biomarkers associated with time to recurrence in triple-negative breast cancer.

Clin Cancer Res 2010 Dec;16(23):5796-804

Dana Farber/Brigham and Women's Cancer Center Department of Radiation Oncology, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-10-0292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4220607PMC
December 2010

Incorporating uncertainty into medical decision making: an approach to unexpected test results.

Med Decis Making 2009 Jan-Feb;29(1):116-24. Epub 2008 Sep 23.

Partners Neurology, Massachusetts General Hospital and Brigham and Women's Hospital, Wang Ambulatory Center, Boston, MA, USA.

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http://dx.doi.org/10.1177/0272989X08323620DOI Listing
March 2009