Brian Luke

Brian Luke

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Brian Luke

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Regulatory R-loops as facilitators of gene expression and genome stability.

Nat Rev Mol Cell Biol 2020 Mar 31;21(3):167-178. Epub 2020 Jan 31.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1038/s41580-019-0206-3DOI Listing
March 2020

Npl3 stabilizes R-loops at telomeres to prevent accelerated replicative senescence.

EMBO Rep 2020 Mar 6;21(3):e49087. Epub 2020 Feb 6.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.15252/embr.201949087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054685PMC
March 2020

Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair.

EMBO J 2020 Feb 12;39(3):e102309. Epub 2019 Dec 12.

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.15252/embj.2019102309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996501PMC
February 2020

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Nucleic Acids Res 2020 01;48(1):264-277

DNA Repair Mechanisms and Cancer, German Cancer Research Center (DKFZ), Heidelberg D-69120, Germany.

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http://dx.doi.org/10.1093/nar/gkz1006DOI Listing
January 2020

RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids.

Cell Rep 2019 Nov;29(9):2890-2900.e5

Institute of Developmental Biology and Neurobiology (IDN), Johannes Gutenberg Universität, 55128 Mainz, Germany; Institute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.10.108DOI Listing
November 2019

Electrostatically Driven Guanidinium Interaction Domains that Control Hydrogel-Mediated Protein Delivery In Vivo.

ACS Cent Sci 2019 Nov 18;5(11):1750-1759. Epub 2019 Oct 18.

Chemical Biology Laboratory and Cancer and Inflammation Program, National Cancer Institute, Frederick, Maryland 21702, United States.

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http://dx.doi.org/10.1021/acscentsci.9b00501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6891851PMC
November 2019

A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae.

Sci Rep 2019 02 12;9(1):1845. Epub 2019 Feb 12.

Sorbonne Université, PSL, CNRS, UMR8226, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, F-75005, Paris, France.

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http://dx.doi.org/10.1038/s41598-018-38000-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372760PMC
February 2019

Increased TERRA levels and RNase H sensitivity are conserved hallmarks of post-senescent survivors in budding yeast.

Differentiation 2018 Mar - Apr;100:37-45. Epub 2018 Feb 16.

Institute of Neurobiology and Developmental Biology, JGU Mainz, Ackermannweg 4, 55128 Mainz, Germany; Institute of Molecular Biology (IMB), Ackermannweg 4, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2018.02.002DOI Listing
November 2018

Telomere regulation.

Authors:
Brian Luke

Differentiation 2018 Jul - Aug;102:27-29. Epub 2018 Jun 30.

Institute of Neurobiology and Developmental Biology, Johannes Gutenberg University, IMB-Mainz, Ackermannweg 4, 55128 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.diff.2018.06.002DOI Listing
November 2018

Direct molecular dissection of tumor parenchyma from tumor stroma in tumor xenograft using mass spectrometry-based glycoproteomics.

Oncotarget 2018 May 29;9(41):26431-26452. Epub 2018 May 29.

National Cancer Institute RAS Initiative, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21702, USA.

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http://dx.doi.org/10.18632/oncotarget.25449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995176PMC
May 2018

Ongoing HIV Replication During ART Reconsidered.

Open Forum Infect Dis 2017 19;4(3):ofx173. Epub 2017 Sep 19.

Department of Molecular Biology and Microbiology, Tufts University, Boston, Massachusetts.

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https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofx17
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http://dx.doi.org/10.1093/ofid/ofx173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172598PMC
September 2017

Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle.

Cell 2017 Jun;170(1):72-85.e14

Institute of Molecular Biology (IMB), 55128 Mainz, Germany; Faculty of Biology, Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University Mainz, 55099 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.06.006DOI Listing
June 2017

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir.

PLoS Pathog 2017 03 22;13(3):e1006283. Epub 2017 Mar 22.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378418PMC
March 2017

Ex vivo activation of CD4+ T-cells from donors on suppressive ART can lead to sustained production of infectious HIV-1 from a subset of infected cells.

PLoS Pathog 2017 02 22;13(2):e1006230. Epub 2017 Feb 22.

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1006230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5338860PMC
February 2017

Ultrasensitive single-genome sequencing: accurate, targeted, next generation sequencing of HIV-1 RNA.

Retrovirology 2016 Dec 20;13(1):87. Epub 2016 Dec 20.

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12977-016-0321-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175307PMC
December 2016

Role of the ESCRT Complexes in Telomere Biology.

mBio 2016 11 8;7(6). Epub 2016 Nov 8.

Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Tel Aviv, Israel

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http://dx.doi.org/10.1128/mBio.01793-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101353PMC
November 2016

Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.

Nucleic Acids Res 2016 06 22;44(10):e93. Epub 2016 Feb 22.

Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, D-07747 Jena, Erlanger Allee 101, Germany Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI) Jena, Beutenbergstrasse 11a, 07745 Jena, Germany Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

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http://dx.doi.org/10.1093/nar/gkw111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889924PMC
June 2016

Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance.

Genes Dev 2016 Mar 10;30(6):700-17. Epub 2016 Mar 10.

Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark; Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

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http://dx.doi.org/10.1101/gad.276204.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803055PMC
March 2016

Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling.

Sci Signal 2016 Mar 15;9(419):ra28. Epub 2016 Mar 15.

Laboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1126/scisignal.aad2357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312101PMC
March 2016

LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes.

Genes Dev 2015 Nov;29(21):2287-97

Section on Eukaryotic Transposable Elements, Program in Cellular Regulation and Metabolism, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA;

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http://dx.doi.org/10.1101/gad.267609.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647561PMC
November 2015

TERRA and the state of the telomere.

Nat Struct Mol Biol 2015 Nov;22(11):853-8

Institute of Molecular Biology (IMB), Mainz, Germany.

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http://dx.doi.org/10.1038/nsmb.3078DOI Listing
November 2015

AVIA v2.0: annotation, visualization and impact analysis of genomic variants and genes.

Bioinformatics 2015 Aug 9;31(16):2748-50. Epub 2015 Apr 9.

Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/bioinformatics/btv200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4528632PMC
August 2015

The somatic autosomal mutation matrix in cancer genomes.

Hum Genet 2015 Aug 23;134(8):851-64. Epub 2015 May 23.

In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., P.O. Box B, Frederick, MD, 21702, USA.

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http://dx.doi.org/10.1007/s00439-015-1566-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495249PMC
August 2015

Erratum to: The somatic autosomal mutation matrix in cancer genomes.

Hum Genet 2015 Aug;134(8):865-7

In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., P.O. Box B, Frederick, MD, 21702, USA.

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http://link.springer.com/10.1007/s00439-015-1576-z
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http://dx.doi.org/10.1007/s00439-015-1576-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643558PMC
August 2015

No DDRama at chromosome ends: TRF2 takes centre stage.

Trends Biochem Sci 2015 May 3;40(5):275-85. Epub 2015 Apr 3.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne 1015, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.03.003DOI Listing
May 2015

Can structural features of kinase receptors provide clues on selectivity and inhibition? A molecular modeling study.

J Mol Graph Model 2015 Apr 12;57:36-48. Epub 2015 Jan 12.

Advanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research (FNLCR), P.O. Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1016/j.jmgm.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361267PMC
April 2015

The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation.

RNA Biol 2014 5;11(2):95-100. Epub 2014 Feb 5.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH); Deutsches Krebsforschungszentrum (DKFZ)-ZMBH Alliance; Heidelberg, Germany.

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http://dx.doi.org/10.4161/rna.27798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3973735PMC
November 2014

High nutrient levels and TORC1 activity reduce cell viability following prolonged telomere dysfunction and cell cycle arrest.

Cell Rep 2014 Oct 26;9(1):324-335. Epub 2014 Sep 26.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.08.053DOI Listing
October 2014

Identification of gene signatures used to recognize biological characteristics of gastric cancer upon gene expression data.

Biomark Insights 2014 14;9:67-76. Epub 2014 Aug 14.

Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, People's Republic of China.

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http://dx.doi.org/10.4137/BMI.S13059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149392PMC
September 2014

Knowledge and theme discovery across very large biological data sets using distributed queries: a prototype combining unstructured and structured data.

PLoS One 2013 2;8(12):e80503. Epub 2013 Dec 2.

Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0080503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846626PMC
August 2014

Breaking new ground: digging into TERRA function.

Biochim Biophys Acta 2014 May 1;1839(5):387-94. Epub 2014 Apr 1.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Deutsches Krebsforschungszentrum (DKFZ)-ZMBH Alliance, Heidelberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2014.03.012DOI Listing
May 2014

Guanine holes are prominent targets for mutation in cancer and inherited disease.

PLoS Genet 2013 26;9(9):e1003816. Epub 2013 Sep 26.

Division of Pharmacology and Toxicology, The University of Texas at Austin, Dell Pediatric Research Institute, Austin, Texas, United States of America ; Advanced Biomedical Computing Center, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1003816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784513PMC
March 2014

Trypsin-mediated ¹⁸O/¹⁶O labeling for biomarker discovery.

Methods Mol Biol 2013 ;1002:133-49

Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-62703-360-2_12DOI Listing
February 2014

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.

Nat Struct Mol Biol 2013 Oct 8;20(10):1199-205. Epub 2013 Sep 8.

1] Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), Deutsches Krebsforschungszentrum (DKFZ)-ZMBH Alliance, Heidelberg, Germany. [2].

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http://dx.doi.org/10.1038/nsmb.2662DOI Listing
October 2013

The Mph1 helicase can promote telomere uncapping and premature senescence in budding yeast.

PLoS One 2012 27;7(7):e42028. Epub 2012 Jul 27.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz, Heidelberg, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042028PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407055PMC
January 2013

Getting in (and out of) the loop: regulating higher order telomere structures.

Front Oncol 2012 30;2:180. Epub 2012 Nov 30.

Zentrum für Molekulare Biologie der Universität Heidelberg (ZMBH), DKFZ-ZMBH Allianz Heidelberg, Germany.

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http://dx.doi.org/10.3389/fonc.2012.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510458PMC
December 2012

High-level theoretical study of the NO dimer and tetramer: has the tetramer been observed?

J Chem Phys 2012 Dec;137(21):214316

Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1063/1.4769226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528699PMC
December 2012

The role of methylation in the intrinsic dynamics of B- and Z-DNA.

PLoS One 2012 17;7(4):e35558. Epub 2012 Apr 17.

In Silico Research Centers of Excellence, Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035558PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328458PMC
November 2012

Post-digestion ¹⁸O exchange/labeling for quantitative shotgun proteomics of membrane proteins.

Methods Mol Biol 2012 ;893:223-40

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.1007/978-1-61779-885-6_15DOI Listing
September 2012

Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast.

PLoS Genet 2012 Sep 20;8(9):e1002960. Epub 2012 Sep 20.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.

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http://dx.doi.org/10.1371/journal.pgen.1002960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3447961PMC
September 2012

Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence.

Nucleic Acids Res 2012 Aug 2;40(14):6649-59. Epub 2012 May 2.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gks358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413150PMC
August 2012

Telomeres and disease: enter TERRA.

RNA Biol 2012 Jun 23;9(6):843-9. Epub 2012 May 23.

Zentrum für Molekulare Biologie der Universität Heidelberg, DKFZ-ZMBH Allianz, Heidelberg, Germany.

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http://dx.doi.org/10.4161/rna.20330DOI Listing
June 2012

Proteomic profiling of H-Ras-G12V induced hypertrophic cardiomyopathy in transgenic mice using comparative LC-MS analysis of thin fresh-frozen tissue sections.

J Proteome Res 2012 Mar 6;11(3):1561-70. Epub 2012 Feb 6.

Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/pr200612yDOI Listing
March 2012

Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast.

EMBO Rep 2011 Jun 28;12(6):587-93. Epub 2011 Apr 28.

Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Frontiers in Genetics National Center of Competence in Research, Ecole Polytechnique Fédérale de Lausanne, Station 19, Lausanne 1015, Switzerland.

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http://embor.embopress.org/cgi/doi/10.1038/embor.2011.73
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http://dx.doi.org/10.1038/embor.2011.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128280PMC
June 2011

The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast.

Nat Cell Biol 2011 Jun 12;13(7):867-74. Epub 2011 Jun 12.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/ncb2263DOI Listing
June 2011

Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes.

Nucleic Acids Res 2011 Jan 21;39(Database issue):D383-91. Epub 2010 Nov 21.

Advanced Biomedical Computing Center, Information Systems Program, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1093/nar/gkq1170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013731PMC
January 2011

Optimized method for computing (18)O/(16)O ratios of differentially stable-isotope labeled peptides in the context of postdigestion (18)O exchange/labeling.

Anal Chem 2010 Jul;82(13):5878-86

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1021/ac101284cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3479679PMC
July 2010

FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling.

EMBO J 2010 Feb 10;29(4):795-805. Epub 2009 Dec 10.

Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, Epalinges s/Lausanne, Switzerland.

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.371
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http://dx.doi.org/10.1038/emboj.2009.371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829158PMC
February 2010

Telomerase is essential to alleviate pif1-induced replication stress at telomeres.

Genetics 2009 Nov 24;183(3):779-91. Epub 2009 Aug 24.

Department of Genetics, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1534/genetics.109.107631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2778976PMC
November 2009

TERRA: telomeric repeat-containing RNA.

EMBO J 2009 Sep 23;28(17):2503-10. Epub 2009 Jul 23.

EPFL-Ecole Polytechnique Fédérale de Lausanne, ISREC-Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.

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http://dx.doi.org/10.1038/emboj.2009.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722245PMC
September 2009

Label-free global serum proteomic profiling reveals novel celecoxib-modulated proteins in familial adenomatous polyposis patients.

Cancer Genomics Proteomics 2009 Jan-Feb;6(1):41-9

Molecular Oncology Program, Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi - 7520, Pakistan.

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June 2009

Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control.

EMBO J 2009 May 23;28(10):1429-41. Epub 2009 Apr 23.

Department of Biology, Institute of Biochemistry, ETH Zurich, Zurich, Switzerland. or

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http://emboj.embopress.org/cgi/doi/10.1038/emboj.2009.98
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http://dx.doi.org/10.1038/emboj.2009.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688542PMC
May 2009

18O stable isotope labeling in MS-based proteomics.

Brief Funct Genomic Proteomic 2009 Mar 16;8(2):136-44. Epub 2009 Jan 16.

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick Inc, NCI at Frederick, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1093/bfgp/eln055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722262PMC
March 2009

Examining the significance of fingerprint-based classifiers.

BMC Bioinformatics 2008 Dec 17;9:545. Epub 2008 Dec 17.

Advanced Biomedical Computing Center, Advanced Technology Program, SAIC-Frederick, Inc, NCI-Frederick, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1186/1471-2105-9-545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628908PMC
December 2008

The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae.

Mol Cell 2008 Nov;32(4):465-77

Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research (ISREC), CH-1066 Epalinges, Switzerland.

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http://dx.doi.org/10.1016/j.molcel.2008.10.019DOI Listing
November 2008

Rtt101 and Mms1 in budding yeast form a CUL4(DDB1)-like ubiquitin ligase that promotes replication through damaged DNA.

EMBO Rep 2008 Oct 15;9(10):1034-40. Epub 2008 Aug 15.

Institute of Biochemistry, Swiss Federal Institute of Technology Zurich (ETH), ETH Hoenggerberg, 8093 Zurich, Switzerland.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572122PMC
October 2008

Detection of bladder cancer in human urine by metabolomic profiling using high performance liquid chromatography/mass spectrometry.

J Urol 2008 Jun 23;179(6):2422-6. Epub 2008 Apr 23.

Laboratory of Proteomics and Analytical Technologies, SAIC Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1016/j.juro.2008.01.084DOI Listing
June 2008

A stromal gene signature associated with inflammatory breast cancer.

Int J Cancer 2008 Mar;122(6):1324-32

Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA.

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http://doi.wiley.com/10.1002/ijc.23237
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March 2008

Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions.

BMC Bioinformatics 2008 Mar 6;9:146. Epub 2008 Mar 6.

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2105-9-146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2335300PMC
March 2008

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.

Nucleic Acids Res 2007 4;35(22):7688-97. Epub 2007 Nov 4.

Swiss Institute for Experimental Cancer Research (ISREC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

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http://dx.doi.org/10.1093/nar/gkm912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190716PMC
January 2008

Cambridge Healthtech Institute's 2007 Biomarker Discovery Summit.

Authors:
Brian T Luke

Expert Rev Mol Diagn 2007 Nov;7(6):755-7

SAIC-Frederick, Advanced Biomedical Computing Center, NCI Frederick, PO Box B, Frederick, MD 21702, USA.

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http://dx.doi.org/10.1586/14737159.7.6.755DOI Listing
November 2007

Chronic immune thrombocytopenic purpura in children: a survey of the canadian experience.

J Pediatr Hematol Oncol 2007 Feb;29(2):95-100

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Stollery Children's Hospital, University of Alberta, Alberta, Canada.

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February 2007

Plasma proteomic profiling: search for lung cancer diagnostic and early detection markers.

Oncol Rep 2006 May;15(5):1367-72

Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892, USA.

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May 2006

Exploring SNP-SNP interactions and colon cancer risk using polymorphism interaction analysis.

Int J Cancer 2006 Apr;118(7):1790-7

Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/ijc.21523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1451415PMC
April 2006

The cullin Rtt101p promotes replication fork progression through damaged DNA and natural pause sites.

Curr Biol 2006 Apr;16(8):786-92

Swiss Federal Institute of Technology Zurich (ETH), Institute of Biochemistry, ETH Hoenggerberg HPM G 10.0, Switzerland.

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http://dx.doi.org/10.1016/j.cub.2006.02.071DOI Listing
April 2006

Redefining the common insertion site.

Virology 2006 Jan 4;344(2):292-5. Epub 2005 Nov 4.

Laboratory of Molecular Technology, Scientific Application International Corporation-Frederick, National Cancer Institute at Frederick, NIH, Frederick, MD, USA.

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January 2006

A comprehensive SNP-based genetic analysis of inbred mouse strains.

Mamm Genome 2005 Jul;16(7):476-80

Laboratory of Molecular Technology, SAIC-Frederick, Inc., National Cancer Institute at Frederick, 915 Tollhouse Avenue, Suite 211, Frederick, Maryland 21701, USA.

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July 2005

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.

Nature 2005 Jun;435(7046):1257-61

Institute of Biochemistry, ETH Hönggerberg, 8093 Zürich, Switzerland.

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http://dx.doi.org/10.1038/nature03662DOI Listing
June 2005

Serum proteomic profiles suggest celecoxib-modulated targets and response predictors.

Cancer Res 2004 Apr;64(8):2904-9

Laboratory of Proteomics and Analytical Technologies and Advanced Biomedical Computing Center, SAIC-Frederick Inc., National Cancer Institute at Frederick, Frederick, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.can-03-3754DOI Listing
April 2004

Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.

Science 2003 Nov;302(5648):1208-12

Friedrich Miescher Institut, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1126/science.1088401DOI Listing
November 2003

Tissue Molecular Anatomy Project (TMAP): an expression database for comparative cancer proteomics.

Proteomics 2003 Aug;3(8):1445-53

Laboratory of Molecular Technology, CCR, National Cancer Institute at Frederick, PO Box B, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1002/pmic.200300488DOI Listing
August 2003

The palm subdomain-based active site is internally permuted in viral RNA-dependent RNA polymerases of an ancient lineage.

J Mol Biol 2002 Nov;324(1):47-62

Advanced Biomedical Computing Center, Science Applications International Corporation/National Cancer Institute, P.O. Box B, Frederick, MD 21702-1201, USA.

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http://dx.doi.org/10.1016/s0022-2836(02)01033-1DOI Listing
November 2002

Human topoisomerase I inhibition: docking camptothecin and derivatives into a structure-based active site model.

Biochemistry 2002 Feb;41(5):1428-35

Laboratory of Molecular Pharmacology, Division of Basic Sciences, National Cancer Institute, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

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February 2002