Publications by authors named "Brian Long"

92Publications

An η -Bound Allyl Ligand on Magnesium in a Mechanochemically Generated Mg/K Allyl Complex.

Angew Chem Int Ed Engl 2020 Jun 1;59(24):9542-9548. Epub 2020 Apr 1.

Department of Chemistry, Vanderbilt University, Nashville, TN, 37235, USA.

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http://dx.doi.org/10.1002/anie.201916410DOI Listing
June 2020

Structural and Spectroscopic Investigation of Two Plutonium Mellitates.

Inorg Chem 2020 Mar 10;59(5):3085-3090. Epub 2020 Feb 10.

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States.

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http://dx.doi.org/10.1021/acs.inorgchem.9b03432DOI Listing
March 2020

Correction to: Recommendations for the Development of Cell-Based Anti-Viral Vector Neutralizing Antibody Assays.

AAPS J 2020 Feb 4;22(2):42. Epub 2020 Feb 4.

Alzheimer's Drug Discovery Foundation, New York, NY, USA.

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http://dx.doi.org/10.1208/s12248-020-0425-8DOI Listing
February 2020

Recommendations for the Development of Cell-Based Anti-Viral Vector Neutralizing Antibody Assays.

AAPS J 2020 01 6;22(2):24. Epub 2020 Jan 6.

Alzheimer's Drug Discovery Foundation, 57 W 57th St #904, New York, USA.

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http://dx.doi.org/10.1208/s12248-019-0403-1DOI Listing
January 2020

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 - Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62).

Bioanalysis 2019 Dec 10;11(24):2207-2244. Epub 2019 Dec 10.

Janssen R&D, Spring House, PA, USA.

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http://dx.doi.org/10.4155/bio-2019-0271DOI Listing
December 2019

Classification of electrophysiological and morphological neuron types in the mouse visual cortex.

Nat Neurosci 2019 07 17;22(7):1182-1195. Epub 2019 Jun 17.

Allen Institute for Brain Science, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/s41593-019-0417-0DOI Listing
July 2019

The Intrinsic Mechanochemical Reactivity of Vinyl-Addition Polynorbornene.

Angew Chem Int Ed Engl 2019 04 26;58(17):5639-5642. Epub 2019 Mar 26.

Department of Chemistry, University of Washington, Box 351700, Seattle, WA, 98195-1700, USA.

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http://dx.doi.org/10.1002/anie.201900467DOI Listing
April 2019

High Temperature, Living Polymerization of Ethylene by a Sterically-Demanding Nickel(II) α-Diimine Catalyst.

Polymers (Basel) 2018 Jan 2;10(1). Epub 2018 Jan 2.

Department of Chemistry, University of Tennessee, Knoxville, TN 37996, USA.

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http://dx.doi.org/10.3390/polym10010041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415045PMC
January 2018

Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.

Acta Crystallogr D Struct Biol 2017 Dec 10;73(Pt 12):970-984. Epub 2017 Nov 10.

Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA.

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http://scripts.iucr.org/cgi-bin/paper?S2059798317015418
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http://dx.doi.org/10.1107/S2059798317015418DOI Listing
December 2017

Examining the Effects of Video Modeling and Prompts to Teach Activities of Daily Living Skills.

Behav Anal Pract 2016 12 20;9(4):384-388. Epub 2016 May 20.

LMW & Associates Therapy Services, 128 Chestnut Street, Suite 404, Philadelphia, PA 19106 USA.

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http://dx.doi.org/10.1007/s40617-016-0127-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118254PMC
December 2016

A comparison of the neuropsychological profiles of people living in squalor without hoarding to those living in squalor associated with hoarding.

Int J Geriatr Psychiatry 2017 12 2;32(12):1433-1439. Epub 2016 Dec 2.

Aged Psychiatry Service, Caulfield Hospital, Alfred Health, Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1002/gps.4631DOI Listing
December 2017

Enantioselective Syntheses of Lignin Models: An Efficient Synthesis of β-O-4 Dimers and Trimers by Using the Evans Chiral Auxiliary.

Chemistry 2016 Aug 26;22(35):12506-17. Epub 2016 Jul 26.

Center for Renewable Carbon, University of Tennessee, Knoxville, TN, 37996, USA.

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http://dx.doi.org/10.1002/chem.201601592DOI Listing
August 2016

Bioimage Informatics for Big Data.

Adv Anat Embryol Cell Biol 2016 ;219:263-72

Allen Institute for Brain Science, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-3-319-28549-8_10DOI Listing
August 2016

Semi-Crystalline Polar Polyethylene: Ester-Functionalized Linear Polyolefins Enabled by a Functional-Group-Tolerant, Cationic Nickel Catalyst.

Angew Chem Int Ed Engl 2016 06 2;55(25):7106-10. Epub 2016 May 2.

Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, NY, 14853-1301, USA.

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http://dx.doi.org/10.1002/anie.201601703DOI Listing
June 2016

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression.

Cancer Cell 2016 Jan 24;29(1):75-89. Epub 2015 Dec 24.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2015.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816652PMC
January 2016

Redox-Active Ligands: An Advanced Tool To Modulate Polyethylene Microstructure.

J Am Chem Soc 2016 Jan 12;138(3):774-7. Epub 2016 Jan 12.

Department of Chemistry, University of Tennessee , Knoxville, Tennessee 37996, United States.

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http://dx.doi.org/10.1021/jacs.5b12322DOI Listing
January 2016

3D Image-Guided Automatic Pipette Positioning for Single Cell Experiments in vivo.

Sci Rep 2015 Dec 22;5:18426. Epub 2015 Dec 22.

Allen Institute for Brain Science, Seattle, WA, USA.

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http://dx.doi.org/10.1038/srep18426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686883PMC
December 2015

TReMAP: Automatic 3D Neuron Reconstruction Based on Tracing, Reverse Mapping and Assembling of 2D Projections.

Neuroinformatics 2016 Jan;14(1):41-50

Allen Institute for Brain Science, Seattle, WA, USA.

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http://link.springer.com/10.1007/s12021-015-9278-1
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http://dx.doi.org/10.1007/s12021-015-9278-1DOI Listing
January 2016

RELATIONSHIP BETWEEN ISOKINETIC KNEE STRENGTH AND JUMP CHARACTERISTICS FOLLOWING ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION.

Int J Sports Phys Ther 2015 Jun;10(3):272-80

Texas Metroplex Institute for Sports Medicine and Orthopedics, Arlington, TX, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458914PMC
June 2015

A novel minimally-invasive method to sample human endothelial cells for molecular profiling.

PLoS One 2015 13;10(2):e0118081. Epub 2015 Feb 13.

Division of Cardiology and the Center of Excellence in Vascular Research, San Francisco General Hospital, University of California, San Francisco, CA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118081PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332500PMC
December 2015

Synthesis of enantiomerically pure lignin dimer models for catalytic selectivity studies.

J Org Chem 2015 Feb 27;80(3):1771-80. Epub 2015 Jan 27.

Department of Chemistry, University of Tennessee , Knoxville, Tennessee 37996, United States.

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http://dx.doi.org/10.1021/jo502685kDOI Listing
February 2015

A comprehensive thalamocortical projection map at the mesoscopic level.

Nat Neurosci 2014 Sep 3;17(9):1276-85. Epub 2014 Aug 3.

Vollum Institute, Oregon Health and Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1038/nn.3780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4152774PMC
September 2014

Neuropsychological characteristics of people living in squalor.

Int Psychogeriatr 2014 May 4;26(5):837-44. Epub 2014 Feb 4.

Aged Psychiatry Service, Caulfield Hospital, Alfred Health, Victoria, Australia.

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http://dx.doi.org/10.1017/S1041610213002640DOI Listing
May 2014

Subdiffractive microscopy: techniques, applications, and challenges.

Wiley Interdiscip Rev Syst Biol Med 2014 Mar-Apr;6(2):151-68. Epub 2014 Jan 17.

Vollum Institute, Oregon Health & Science University, Portland, OR, USA.

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http://dx.doi.org/10.1002/wsbm.1259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3930153PMC
October 2014

A robust Ni(II) α-diimine catalyst for high temperature ethylene polymerization.

J Am Chem Soc 2013 Nov 28;135(44):16316-9. Epub 2013 Oct 28.

Department of Chemistry, University of Tennessee , Knoxville, Tennessee 37996, United States.

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http://dx.doi.org/10.1021/ja408905tDOI Listing
November 2013

Abbreviated exposure to cuprizone is sufficient to induce demyelination and oligodendrocyte loss.

J Neurosci Res 2013 Mar 26;91(3):363-73. Epub 2012 Dec 26.

UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

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http://dx.doi.org/10.1002/jnr.23174DOI Listing
March 2013

OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice.

Cytometry A 2012 Aug 31;81(8):646-8. Epub 2012 May 31.

Division of Experimental Medicine, University of California, San Francisco, CA 94110, USA.

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http://dx.doi.org/10.1002/cyto.a.22074DOI Listing
August 2012

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity.

Blood 2012 Apr 1;119(16):3734-43. Epub 2012 Mar 1.

Hawaii Center for AIDS, Department of Tropical Medicine, University of Hawaii, John A. Burns School of Medicine, Honolulu, 96813, USA.

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http://dx.doi.org/10.1182/blood-2011-11-392951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335380PMC
April 2012

Alpha interferon and HIV infection cause activation of human T cells in NSG-BLT mice.

J Virol 2012 Mar 11;86(6):3327-36. Epub 2012 Jan 11.

Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1128/JVI.06676-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302309PMC
March 2012

Does timing of brain lesion have an impact on children's attention?

Dev Neuropsychol 2011 ;36(3):353-66

Murdoch Childrens Research Institute, Melbourne, Australia.

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http://dx.doi.org/10.1080/87565641.2010.549983DOI Listing
July 2011

Executive function following child stroke: the impact of lesion location.

J Child Neurol 2011 Mar 29;26(3):279-87. Epub 2010 Nov 29.

University of Melbourne, Melbourne, Australia.

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http://dx.doi.org/10.1177/0883073810380049DOI Listing
March 2011

Spatial structure and diffusive dynamics from single-particle trajectories using spline analysis.

Biophys J 2010 Apr;98(8):1712-21

Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.

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http://dx.doi.org/10.1016/j.bpj.2009.12.4299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856136PMC
April 2010

Fundamental optical properties of linear and cyclic alkanes: VUV absorbance and index of refraction.

J Phys Chem A 2009 Aug;113(33):9337-47

Department of Chemical Engineering, The University of Texas at Austin, Austin, Texas, USA.

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http://dx.doi.org/10.1021/jp903435cDOI Listing
August 2009

Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models.

Int J Cancer 2009 Dec;125(11):2711-20

Schering-Plough Research Institute, Biological Research - Oncology, Kenilworth, NJ 07033, USA.

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http://dx.doi.org/10.1002/ijc.24644DOI Listing
December 2009

HIV-1-specific T Cell-dependent natural killer (NK) cell activation: major contribution by NK cells to interferon-gamma production in response to HIV-1 antigens.

AIDS Res Hum Retroviruses 2009 Jun;25(6):603-5

Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA.

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http://www.liebertpub.com/doi/10.1089/aid.2008.0165
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http://dx.doi.org/10.1089/aid.2008.0165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853859PMC
June 2009

Single particle quantum dot imaging achieves ultrasensitive detection capabilities for Western immunoblot analysis.

ACS Nano 2009 Jun;3(6):1318-28

Department of Biomedical Engineering,Oregon Health and Science University, Portland, OR 97239, USA.

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http://dx.doi.org/10.1021/nn9000353DOI Listing
June 2009

Ultra-performance hydrophilic interaction liquid chromatography/tandem mass spectrometry for the determination of everolimus in mouse plasma.

Rapid Commun Mass Spectrom 2009 May;23(10):1461-6

Drug Metabolism and Pharmacokinetics Department, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.

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http://dx.doi.org/10.1002/rcm.4022DOI Listing
May 2009

Realization of a feedback controlled flashing ratchet.

Phys Rev Lett 2008 Nov 25;101(22):220601. Epub 2008 Nov 25.

Department of Physics and Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1274, USA.

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http://dx.doi.org/10.1103/PhysRevLett.101.220601DOI Listing
November 2008

Multidirectional sorting modes in deterministic lateral displacement devices.

Phys Rev E Stat Nonlin Soft Matter Phys 2008 Oct 2;78(4 Pt 2):046304. Epub 2008 Oct 2.

Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1274, USA.

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http://dx.doi.org/10.1103/PhysRevE.78.046304DOI Listing
October 2008

Dying well.

Authors:
R Brian Long

Am J Nurs 2008 Nov;108(11):13; author reply 14

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http://dx.doi.org/10.1097/01.NAJ.0000339137.38834.e5DOI Listing
November 2008

Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection.

J Virol 2008 May 27;82(10):4785-92. Epub 2008 Feb 27.

Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA.

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http://dx.doi.org/10.1128/JVI.02449-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346752PMC
May 2008

Combining the farnesyltransferase inhibitor lonafarnib with paclitaxel results in enhanced growth inhibitory effects on human ovarian cancer models in vitro and in vivo.

Gynecol Oncol 2008 Apr 31;109(1):97-106. Epub 2008 Jan 31.

Schering-Plough Research Institute, Biological Research-Oncology, 2015 Galloping Hill Road, K15-2-2700, Kenilworth, NJ 07033, USA.

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http://dx.doi.org/10.1016/j.ygyno.2007.12.013DOI Listing
April 2008

The role of antiphospholipid syndrome in cardiovascular disease.

Hematol Oncol Clin North Am 2008 Feb;22(1):79-94, vi-vii

Tennessee Heart & Vascular Institute, P.C., Skyline Medical Center, 3443 Dickerson Pike, Nashville, TN 37207, USA.

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http://dx.doi.org/10.1016/j.hoc.2007.10.002DOI Listing
February 2008

Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus.

Clin Vaccine Immunol 2008 Jan 14;15(1):120-30. Epub 2007 Nov 14.

Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 941101, USA.

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http://cvi.asm.org/content/15/1/120.full.pdf
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http://cvi.asm.org/cgi/doi/10.1128/CVI.00357-07
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http://dx.doi.org/10.1128/CVI.00357-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223854PMC
January 2008

Design of reversible cross-linkers for step and flash imprint lithography imprint resists.

ACS Nano 2007 Nov;1(4):307-12

Department of Chemical Engineering,The University of Texas at Austin, Austin, TX 78712, USA.

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http://dx.doi.org/10.1021/nn7001079DOI Listing
November 2007

HIV-1/HSV-2 co-infected adults in early HIV-1 infection have elevated CD4+ T cell counts.

PLoS One 2007 Oct 24;2(10):e1080. Epub 2007 Oct 24.

HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001080PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2031920PMC
October 2007

Enhancement of the antitumor activity of tamoxifen and anastrozole by the farnesyltransferase inhibitor lonafarnib (SCH66336).

Anticancer Drugs 2007 Sep;18(8):923-31

Department of Biological Research - Oncology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033, USA.

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http://dx.doi.org/10.1097/CAD.0b013e3280c1416eDOI Listing
September 2007

Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets.

J Immunol 2007 Feb;178(3):1388-95

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.4049/jimmunol.178.3.1388DOI Listing
February 2007

Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.

Eur J Immunol 2006 Aug;36(8):2003-12

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://dx.doi.org/10.1002/eji.200535717DOI Listing
August 2006

Synthesis and characterization of norbornanediol isomers and their fluorinated analogues.

J Org Chem 2006 Jan;71(1):341-4

Department of Chemistry and Biochemistry, University of Texas, Austin, Texas 78712, USA.

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http://dx.doi.org/10.1021/jo0513156DOI Listing
January 2006

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.

J Biol Chem 2005 Sep 8;280(35):31101-8. Epub 2005 Jul 8.

Department of Tumor Biology, Schering-Plough Research Institute, Kenilwort, New Jersey 07033, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503763200
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http://dx.doi.org/10.1074/jbc.M503763200DOI Listing
September 2005

Model systems: mechanisms involved in the loss of sensitivity to letrozole.

J Steroid Biochem Mol Biol 2005 May;95(1-5):41-8

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facilities 1, Room 580, 685 West Baltimore Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2005.04.026DOI Listing
May 2005

The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation.

Cancer Res 2005 May;65(9):3903-10

Department of Pharmacology and Experimental Therapeutics, University of Maryland Baltimore, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-4092DOI Listing
May 2005

Potent CYP17 inhibitors: improved syntheses, pharmacokinetics and anti-tumor activity in the LNCaP human prostate cancer model.

J Steroid Biochem Mol Biol 2004 Oct;92(3):155-65

Department of Pharmacology and Experimental Therapeutics, School of Medicine, University of Maryland, Baltimore, MD 21201-1559, USA.

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http://dx.doi.org/10.1016/j.jsbmb.2004.07.006DOI Listing
October 2004

Effects of exemestane and tamoxifen in a postmenopausal breast cancer model.

Clin Cancer Res 2004 Nov;10(21):7375-81

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0565DOI Listing
November 2004

Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity.

Blood 2004 Aug 27;104(4):1100-9. Epub 2004 Apr 27.

Department of Microbiology and Immunology, Mary Ellen Jones Bldg, Rm 804, Campus Box 7290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2003-12-43
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http://dx.doi.org/10.1182/blood-2003-12-4302DOI Listing
August 2004

Therapeutic strategies using the aromatase inhibitor letrozole and tamoxifen in a breast cancer model.

J Natl Cancer Inst 2004 Mar;96(6):456-65

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Sciences Facility, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1093/jnci/djh076DOI Listing
March 2004

Signaling pathways of apoptosis activated by aromatase inhibitors and antiestrogens.

Cancer Res 2003 Nov;63(22):8037-50

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Health Science Facility, Room 580G, 685 West Baltimore Street, Baltimore, MD 21201, USA.

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November 2003

The intratumoral aromatase model: studies with aromatase inhibitors and antiestrogens.

J Steroid Biochem Mol Biol 2003 Sep;86(3-5):283-8

Department of Pharmacology & Experimental Therapeutics, School of Medicine, University of Maryland, 655 W Baltimore Street, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1016/s0960-0760(03)00368-6DOI Listing
September 2003

Predictions from a preclinical model: studies of aromatase inhibitors and antiestrogens.

Clin Cancer Res 2003 Jan;9(1 Pt 2):455S-9S

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21202-1559, USA.

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January 2003

The effect of second-line antiestrogen therapy on breast tumor growth after first-line treatment with the aromatase inhibitor letrozole: long-term studies using the intratumoral aromatase postmenopausal breast cancer model.

Clin Cancer Res 2002 Jul;8(7):2378-88

Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.

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July 2002