Brian Lohse

Brian Lohse

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Brian Lohse

Brian Lohse

Publications by authors named "Brian Lohse"

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17Publications

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From Fangs to Pharmacology: The Future of Snakebite Envenoming Therapy.

Curr Pharm Des 2016 ;22(34):5270-5293

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.2174/1381612822666160623073438DOI Listing
December 2017

Synthesis and Characterisation of Substrate-Based Peptides as Inhibitors of Histone Demethylase KDM4C.

Protein Pept Lett 2016 ;23(9):772-6

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.2174/0929866523666160613210831DOI Listing
March 2017

Pitfalls to avoid when using phage display for snake toxins.

Toxicon 2017 Feb 23;126:79-89. Epub 2016 Dec 23.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00410101163063
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http://dx.doi.org/10.1016/j.toxicon.2016.12.010DOI Listing
February 2017

Danger in the reef: Proteome, toxicity, and neutralization of the venom of the olive sea snake, Aipysurus laevis.

Toxicon 2015 Dec 11;107(Pt B):187-96. Epub 2015 Jul 11.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.07.008DOI Listing
December 2015

Selecting key toxins for focused development of elapid snake antivenoms and inhibitors guided by a Toxicity Score.

Toxicon 2015 Sep 31;104:43-5. Epub 2015 Jul 31.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.07.334DOI Listing
September 2015

Snake venomics of monocled cobra (Naja kaouthia) and investigation of human IgG response against venom toxins.

Toxicon 2015 Jun 11;99:23-35. Epub 2015 Mar 11.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.toxicon.2015.03.001DOI Listing
June 2015

A fluorescence resonance energy transfer-based method for histone methyltransferases.

Anal Biochem 2015 May 19;476:78-80. Epub 2015 Feb 19.

Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.ab.2015.02.012DOI Listing
May 2015

Unveiling the nature of black mamba (Dendroaspis polylepis) venom through venomics and antivenom immunoprofiling: Identification of key toxin targets for antivenom development.

J Proteomics 2015 Apr 14;119:126-42. Epub 2015 Feb 14.

Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, San José, Costa Rica. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2015.02.002DOI Listing
April 2015

Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry.

Anal Chem 2014 Dec 11;86(23):11734-41. Epub 2014 Nov 11.

Department of Pharmacy, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ac503137uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4255673PMC
December 2014

Substrate- and cofactor-independent inhibition of histone demethylase KDM4C.

ACS Chem Biol 2014 Sep 17;9(9):2131-8. Epub 2014 Jul 17.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, ‡Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/cb500374fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168794PMC
September 2014

Analogues of the Natural Product Sinefungin as Inhibitors of EHMT1 and EHMT2.

ACS Med Chem Lett 2014 Apr 31;5(4):293-7. Epub 2014 Jan 31.

Department of Drug Design and Pharmacology, University of Copenhagen , Universitetsparken 2, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ml4002503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027773PMC
April 2014

Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C).

Bioorg Med Chem Lett 2012 Sep 2;22(18):5811-3. Epub 2012 Aug 2.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen 2100, Denmark.

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http://dx.doi.org/10.1016/j.bmcl.2012.07.091DOI Listing
September 2012

Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors.

Angew Chem Int Ed Engl 2011 Sep 25;50(39):9100-3. Epub 2011 Aug 25.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1002/anie.201101849DOI Listing
September 2011

Inhibitors of histone demethylases.

Bioorg Med Chem 2011 Jun 1;19(12):3625-36. Epub 2011 Feb 1.

Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2 Universitetsparken, DK-2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.bmc.2011.01.046DOI Listing
June 2011

Encapsulation efficiency measured on single small unilamellar vesicles.

J Am Chem Soc 2008 Nov 9;130(44):14372-3. Epub 2008 Oct 9.

Bio-Nanotechnology Laboratory, Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.

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http://dx.doi.org/10.1021/ja805030wDOI Listing
November 2008

Photodimerization in pyrimidine-substituted dipeptides.

J Pept Sci 2005 Jul;11(8):499-505

Danish Polymer Centre, Risø National Laboratory, Roskilde.

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http://dx.doi.org/10.1002/psc.645DOI Listing
July 2005