Publications by authors named "Brian Leber"

83Publications

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.

N Engl J Med 2020 08;383(7):617-629

From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.); the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California; the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois; the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.); the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.); the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.); Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.); the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.); the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.); the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.); the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.); the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.); the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa); the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.); Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.); the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.); Hadassah Medical Center, Jerusalem (D.L.); the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.); the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.); the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea; the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.); the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.); and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.).

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http://dx.doi.org/10.1056/NEJMoa2012971DOI Listing
August 2020

Allosteric Regulation of BH3 Proteins in Bcl-x Complexes Enables Switch-like Activation of Bax.

Mol Cell 2020 02 27;77(4):901-912.e9. Epub 2020 Jan 27.

Sunnybrook Research Institute, University of Toronto, Toronto, ON M5S 1A1, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada; Departments of Biomedical Sciences and Biochemistry, McMaster University, Hamilton, ON L8S 4L8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.12.025DOI Listing
February 2020

Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove.

Cancer Discov 2018 12;8(12):1511-1514

Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario, Canada.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1167DOI Listing
December 2018

Hand Mirror Cells and Hypercalcemia: A Rare Presentation of Pediatric Acute Lymphoblastic Leukemia.

J Pediatr Hematol Oncol 2020 04;42(3):e181-e184

Division of Pediatric Hematology/Oncology.

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http://dx.doi.org/10.1097/MPH.0000000000001352DOI Listing
April 2020

Identification of Chemotherapy-Induced Leukemic-Regenerating Cells Reveals a Transient Vulnerability of Human AML Recurrence.

Cancer Cell 2018 09;34(3):483-498.e5

McMaster Stem Cell and Cancer Research Institute (SCC-RI), Michael G. DeGroote School of Medicine, McMaster University, 1200 Main Street West, MDCL 5029, Hamilton, Ontario L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.08.007DOI Listing
September 2018

Cyclic thrombocytopenia with statistically significant neutrophil oscillations.

Clin Case Rep 2018 Jul 31;6(7):1347-1352. Epub 2018 May 31.

Departments of Physiology, Physics, and Mathematics McGill University Montreal QC Canada.

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http://dx.doi.org/10.1002/ccr3.1611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028424PMC
July 2018

Sam68 Allows Selective Targeting of Human Cancer Stem Cells.

Cell Chem Biol 2017 Jul 22;24(7):833-844.e9. Epub 2017 Jun 22.

McMaster Stem Cell and Cancer Research Institute, Faculty of Health Sciences, McMaster University, 1280 Main Street West, MDCL 5029, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, Faculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.05.026DOI Listing
July 2017

A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection.

Cell Chem Biol 2017 Apr 6;24(4):493-506.e5. Epub 2017 Apr 6.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4L8, Canada; Biological Sciences, Sunnybrook Research Institute, University of Toronto, Toronto, ON M4N 3M5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6508953PMC
April 2017

Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group.

Am J Clin Pathol 2016 Oct;146(4):408-22

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.1093/ajcp/aqw131DOI Listing
October 2016

High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells.

Blood 2016 08 13;128(7):934-47. Epub 2016 Jun 13.

Biology Platform, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada; Sunnybrook Odette Cancer Center, Toronto, ON, Canada; and Department of Medical Biophysics and Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1182/blood-2015-12-687814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000578PMC
August 2016

Small molecules reveal an alternative mechanism of Bax activation.

Biochem J 2016 Apr 25;473(8):1073-83. Epub 2016 Feb 25.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada, L8S 4L8 Department of Biological Sciences, Sunnybrook Research Institute, University of Toronto, ON, Canada, M4N 3M5

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http://dx.doi.org/10.1042/BCJ20160118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847155PMC
April 2016

Evolving Therapeutic Options for Polycythemia Vera: Perspectives of the Canadian Myeloproliferative Neoplasms Group.

Clin Lymphoma Myeloma Leuk 2015 Dec 7;15(12):715-27. Epub 2015 Aug 7.

Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.clml.2015.07.650DOI Listing
December 2015

Gender and BCR-ABL transcript type are correlated with molecular response to imatinib treatment in patients with chronic myeloid leukemia.

Eur J Haematol 2016 Apr 3;96(4):360-6. Epub 2015 Jul 3.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1111/ejh.12597DOI Listing
April 2016

Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond.

Clin Cancer Res 2015 Jun 2;21(12):2671-6. Epub 2015 Apr 2.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada. Sunnybrook Research Institute, University of Toronto, Toronto, Ontario, Canada. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0959DOI Listing
June 2015

Increased eculizumab requirements during pregnancy in a patient with paroxysmal nocturnal hemoglobinuria: case report and review of the literature.

Clin Case Rep 2015 Feb 15;3(2):88-91. Epub 2014 Oct 15.

Division of Hematology & Thromboembolism, Department of Medicine, Juravinski Hospital and Cancer Centre 711 Concession Street, Hamilton, Ontario, Canada, L8V1C3.

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http://dx.doi.org/10.1002/ccr3.161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352359PMC
February 2015

Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.

Biochem J 2015 May;467(3):495-505

*Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

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http://www.biochemj.org/content/ppbiochemj/467/3/495.full.pd
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http://biochemj.org/lookup/doi/10.1042/BJ20141291
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http://dx.doi.org/10.1042/BJ20141291DOI Listing
May 2015

Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs.

J Exp Med 2014 Sep 1;211(10):1925-35. Epub 2014 Sep 1.

Stem Cell and Cancer Research Institute; Department of Biochemistry and Biomedical Sciences; Department of Chemistry and Chemical Biology; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada Stem Cell and Cancer Research Institute; Department of Biochemistry and Biomedical Sciences; Department of Chemistry and Chemical Biology; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada Stem Cell and Cancer Research Institute; Department of Biochemistry and Biomedical Sciences; Department of Chemistry and Chemical Biology; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8S 4L8, Canada

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http://dx.doi.org/10.1084/jem.20140131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172227PMC
September 2014

Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy.

Methods Enzymol 2014 ;544:1-23

Department of Biological Sciences, Sunnybrook Research Institute, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-417158-9.00001-7DOI Listing
February 2015

Regulating cell death at, on, and in membranes.

Biochim Biophys Acta 2014 Sep 11;1843(9):2100-13. Epub 2014 Jun 11.

Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada; Biological Sciences, Sunnybrook Research Institute, Toronto, Ontario M4N 3M5, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://www.dwalab.ca/common/pdf/BBA2014_1843_9.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S016748891400205
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http://dx.doi.org/10.1016/j.bbamcr.2014.06.002DOI Listing
September 2014

The sonic hedgehog factor GLI1 imparts drug resistance through inducible glucuronidation.

Nature 2014 Jul 28;511(7507):90-3. Epub 2014 May 28.

Institute for Research in Immunology and Cancer and Department of Pathology and Cell Biology, Université de Montréal, P.O. Box 6128, Downtown Station, Montréal, Québec H3C 3J7, Canada.

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http://dx.doi.org/10.1038/nature13283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138053PMC
July 2014

The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers.

Biophys J 2014 May;106(10):2085-95

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada; Department of Physics and Astronomy, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2014.03.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052270PMC
May 2014

Optimizing the acquisition and analysis of confocal images for quantitative single-mobile-particle detection.

Chemphyschem 2013 Aug 3;14(11):2476-90. Epub 2013 Jul 3.

Department of Physics & Astronomy, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1002/cphc.201201047DOI Listing
August 2013

tBid undergoes multiple conformational changes at the membrane required for Bax activation.

J Biol Chem 2013 Jul 6;288(30):22111-27. Epub 2013 Jun 6.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1074/jbc.M113.482109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3724664PMC
July 2013

Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus.

Am J Blood Res 2013 5;3(2):141-64. Epub 2013 May 5.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre Toronto, Ontario.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649813PMC
May 2013

Mechanisms of action of Bcl-2 family proteins.

Cold Spring Harb Perspect Biol 2013 Apr 1;5(4):a008714. Epub 2013 Apr 1.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S4K1, Canada.

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http://dwalab.ca/common/pdf/a008714full.pdf
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http://cshperspectives.cshlp.org/lookup/doi/10.1101/cshpersp
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http://dx.doi.org/10.1101/cshperspect.a008714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683897PMC
April 2013

Shedding light on apoptosis at subcellular membranes.

Cell 2012 Dec;151(6):1179-84

Department of Biochemistry, McMaster University, Hamilton, Ontario L8S 4L8, Canada.

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http://dx.doi.org/10.1016/j.cell.2012.11.013DOI Listing
December 2012

Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET.

Cell Cycle 2012 Oct 16;11(19):3536-42. Epub 2012 Aug 16.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.4161/cc.21462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478303PMC
October 2012

Differences in the mechanisms of proapoptotic BH3 proteins binding to Bcl-XL and Bcl-2 quantified in live MCF-7 cells.

Mol Cell 2012 Mar;45(6):754-63

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.1016/j.molcel.2012.01.030DOI Listing
March 2012

A review of pneumatosis intestinalis in the setting of systemic cancer treatments, including tyrosine kinase inhibitors.

Can Assoc Radiol J 2012 Nov 7;63(4):312-7. Epub 2012 Mar 7.

The Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.carj.2011.06.004DOI Listing
November 2012

Multiple post-translational modifications regulate E-cadherin transport during apoptosis.

J Cell Sci 2012 Jun 28;125(Pt 11):2615-25. Epub 2012 Feb 28.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1242/jcs.096735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706076PMC
June 2012

Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study.

Biochim Biophys Acta 2012 Mar 15;1818(3):384-401. Epub 2011 Oct 15.

Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbamem.2011.10.007DOI Listing
March 2012

Closing in on the link between apoptosis and autophagy.

F1000 Biol Rep 2010 Dec 17;2:88. Epub 2010 Dec 17.

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http://dx.doi.org/10.3410/B2-88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026626PMC
December 2010

BH3-only proteins: Orchestrators of apoptosis.

Biochim Biophys Acta 2011 Apr 10;1813(4):508-20. Epub 2010 Dec 10.

Department of Biochemistry and Biomedical Sciences and McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1016/j.bbamcr.2010.11.024DOI Listing
April 2011

Mixed variant multicentric Castleman disease treated with rituximab: case report.

J Pediatr Hematol Oncol 2010 Nov;32(8):622

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http://dx.doi.org/10.1097/MPH.0b013e3181f000e2DOI Listing
November 2010

Drugs targeting Bcl-2 family members as an emerging strategy in cancer.

Expert Rev Mol Med 2010 Sep 8;12:e28. Epub 2010 Sep 8.

Departments of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1017/S1462399410001572DOI Listing
September 2010

Apoptosis: embedded in membranes.

Curr Opin Cell Biol 2010 Dec 26;22(6):845-51. Epub 2010 Aug 26.

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Room 4H-41, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.ceb.2010.08.002DOI Listing
December 2010

The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity.

Blood 2010 Sep 4;116(9):1433-42. Epub 2010 Jun 4.

Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada.

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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2009-12-25
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http://dx.doi.org/10.1182/blood-2009-12-258095DOI Listing
September 2010

BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38- cells, through activation of protein kinase Cbeta.

Blood 2009 Nov 8;114(19):4186-96. Epub 2009 Sep 8.

Department of Medicine, Paul O'Gorman Leukaemia Research Centre, Medical Faculty, University of Glasgow, Glasgow, United Kingdom.

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http://dx.doi.org/10.1182/blood-2009-05-219550DOI Listing
November 2009

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.

Cell 2008 Dec;135(6):1074-84

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1016/j.cell.2008.11.010DOI Listing
December 2008

O-GlcNAc-glycosylation of beta-catenin regulates its nuclear localization and transcriptional activity.

Exp Cell Res 2008 Sep 6;314(15):2774-87. Epub 2008 Jun 6.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.yexcr.2008.05.017DOI Listing
September 2008

Bcl-XL inhibits membrane permeabilization by competing with Bax.

PLoS Biol 2008 Jun;6(6):e147

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1371/journal.pbio.0060147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2422857PMC
June 2008

Stem cell transplantation in advanced cutaneous T-cell lymphoma.

J Am Acad Dermatol 2008 Apr 6;58(4):645-9. Epub 2008 Feb 6.

Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.jaad.2007.12.021DOI Listing
April 2008

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes.

Apoptosis 2007 May;12(5):897-911

Departments of Biochemistry and Biomedical Sciences and Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://link.springer.com/10.1007/s10495-007-0746-4
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http://dx.doi.org/10.1007/s10495-007-0746-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868339PMC
May 2007

Circumvention of fluorophore photobleaching in fluorescence fluctuation experiments: a beam scanning approach.

Chemphyschem 2007 Apr;8(6):834-48

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, ON, L8N3Z5, Canada.

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http://dx.doi.org/10.1002/cphc.200600589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891014PMC
April 2007

Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line.

BMC Cancer 2006 Aug 23;6:213. Epub 2006 Aug 23.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1186/1471-2407-6-213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560389PMC
August 2006

Bcl-2 changes conformation to inhibit Bax oligomerization.

EMBO J 2006 Jun 27;25(11):2287-96. Epub 2006 Apr 27.

Department of Biochemistry and Biomedical Sciences, McMaster University Health Sciences Centre, CDN-Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.emboj.7601126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1478188PMC
June 2006

Generation of in vitro B-CLL specific HLA class I restricted CTL responses using autologous dendritic cells pulsed with necrotic tumor lysate.

Leuk Lymphoma 2006 Feb;47(2):297-306

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada, L8N 3Z5.

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http://dx.doi.org/10.1080/10428190500301231DOI Listing
February 2006

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis.

EMBO J 2005 Jun 26;24(12):2096-103. Epub 2005 May 26.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600675
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http://dx.doi.org/10.1038/sj.emboj.7600675DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1150878PMC
June 2005

During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria.

Mol Cell 2004 May;14(4):523-9

Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1016/s1097-2765(04)00263-1DOI Listing
May 2004

There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum.

Biochim Biophys Acta 2004 Mar;1644(2-3):115-23

Department of Biochemistry, McMaster University Medical Centre, McMaster University, 1200 Main St W., Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.bbamcr.2003.07.001DOI Listing
March 2004

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis.

J Biol Chem 2003 Dec 30;278(49):48935-41. Epub 2003 Sep 30.

Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M306289200
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http://dx.doi.org/10.1074/jbc.M306289200DOI Listing
December 2003