Publications by authors named "Brian L West"

59Publications

Sex- and region-biased depletion of microglia/macrophages attenuates CLN1 disease in mice.

J Neuroinflammation 2020 Oct 28;17(1):323. Epub 2020 Oct 28.

Department of Neurology, Section of Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-020-01996-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594417PMC
October 2020

Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments.

Acta Neuropathol Commun 2019 11 21;7(1):186. Epub 2019 Nov 21.

Department of Radiation Oncology, University of California, Medical Sciences I, Room B-149, Irvine, CA, 92697-2695, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40478-019-0838-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868786PMC
November 2019

Targeting microglia attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations.

Glia 2019 02 22;67(2):277-290. Epub 2018 Nov 22.

Department of Neurology, Section of Developmental Neurobiology, University Hospital Wuerzburg, Wuerzburg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/glia.23539
Publisher Site
http://dx.doi.org/10.1002/glia.23539DOI Listing
February 2019

Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.

Endocr Relat Cancer 2019 01;26(1):131-140

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/ERC-18-0284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226051PMC
January 2019

A limited capacity for microglial repopulation in the adult brain.

Glia 2018 11 28;66(11):2385-2396. Epub 2018 Oct 28.

Department of Neurobiology and Behavior Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/glia.23477
Publisher Site
http://dx.doi.org/10.1002/glia.23477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269202PMC
November 2018

Csf1R inhibition attenuates experimental autoimmune encephalomyelitis and promotes recovery.

Exp Neurol 2018 09 24;307:24-36. Epub 2018 May 24.

Programe in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, Stony Brook University, NY 11794-8651, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.expneurol.2018.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380683PMC
September 2018

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.

J Neurosci 2018 05 30;38(19):4610-4620. Epub 2018 Apr 30.

Department of Neurology, Developmental Neurobiology, University Hospital Würzburg, 97080 Würzburg, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.3030-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705935PMC
May 2018

Microglial depletion and activation: A [C]PBR28 PET study in nonhuman primates.

EJNMMI Res 2017 Dec 24;7(1):59. Epub 2017 Jul 24.

Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, 06520, USA.

View Article

Download full-text PDF

Source
http://ejnmmires.springeropen.com/articles/10.1186/s13550-01
Publisher Site
http://dx.doi.org/10.1186/s13550-017-0305-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524658PMC
December 2017

Microglial repopulation resolves inflammation and promotes brain recovery after injury.

Glia 2017 06 2;65(6):931-944. Epub 2017 Mar 2.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, 92697.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/glia.23135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395311PMC
June 2017

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits.

J Neuroinflammation 2016 08 30;13(1):215. Epub 2016 Aug 30.

Brain and Spinal Injury Center, University of California, 1001 Potrero Ave, Bldg. 1, Room 101, San Francisco, CA, 94110, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-016-0671-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006433PMC
August 2016

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

Brain 2016 Apr 26;139(Pt 4):1265-81. Epub 2016 Feb 26.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, 92697-4545, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/brain/aww016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006229PMC
April 2016

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.

Neuro Oncol 2016 06 3;18(6):797-806. Epub 2015 Nov 3.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California (J.H.S., T.H., L.D., S.B.C., K.U., J.M.B.), Department of Radiation Oncology, Juntendo University School of Medicine, Tokyo, Japan (T.H.); Plexxikon Inc., Berkeley, California (B.L.W.).

View Article

Download full-text PDF

Source
https://academic.oup.com/neuro-oncology/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/neuonc/nov272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864255PMC
June 2016

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study.

Neuro Oncol 2016 Apr 8;18(4):557-64. Epub 2015 Oct 8.

University of California at San Francisco, San Francisco, California (N.B., A.P., J.P., A.M.M, M.P.); Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah (H.C.); The University of Texas MD Anderson Cancer Center, Houston, Texas (J.F.D.G.); Department of Neurology, Memorial Sloan Kettering Cancer Hospital, New York, New York (A.M.O.); Center for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts (L.N., P.Y.W., S.H., K.L.L.); UCLA Medical Center, Los Angeles, California (T.F.C.); Plexxikon Inc., Berkeley, California (A.M., B.L.W., K.B.N., H.H.H.); Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts (K.L.L.); Department of Pathology, Memorial Sloan Kettering Cancer Hospital, New York, New York (J.H.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/neuonc/nov245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799682PMC
April 2016

Dynamic microglial modulation of spatial learning and social behavior.

Brain Behav Immun 2016 07 5;55:6-16. Epub 2015 Sep 5.

Program in Molecular and Cellular Pharmacology, Stony Brook University, New York 11794-8651, United States; Department of Pharmacological Sciences, Stony Brook University, New York 11794-8651, United States. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08891591153000
Publisher Site
http://dx.doi.org/10.1016/j.bbi.2015.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779430PMC
July 2016

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice.

Brain 2015 Nov 21;138(Pt 11):3193-205. Epub 2015 Aug 21.

1 Department of Neurology, Developmental Neurobiology, University Hospital Würzburg Josef-Schneider Str. 11, D-97080 Würzburg, Germany

View Article

Download full-text PDF

Source
http://brain.oxfordjournals.org/content/brain/early/2015/08/
Web Search
http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
Publisher Site
http://dx.doi.org/10.1093/brain/awv240DOI Listing
November 2015

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice.

J Neuroinflammation 2015 Aug 1;12:139. Epub 2015 Aug 1.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, 3208 Biological Sciences III, Irvine, CA, 92697-4545, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12974-015-0366-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522109PMC
August 2015

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

N Engl J Med 2015 Jul;373(5):428-37

From Memorial Sloan Kettering Cancer Center (W.D.T., J.H.H.) and Weill Cornell Medical College (W.D.T.) - both in New York; University of California, Los Angeles, Medical Center, Los Angeles (Z.A.W., B.C., A.S.S.), Plexxikon, Berkeley (P.N.I., C.Z., J.Z., G.H., Y.Z., E.A.B., G.V., L.S., P.S., H.N., M.J.K., A.M., G.T., R.S., C.G., B.L.W., P.H., K.N., H.H.H., P.S.L., S.T.-S., G.B.), and Stanford University School of Medicine, Stanford (M.R.) - all in California; Evergreen Hematology and Oncology, Spokane, WA (S.P.A.); University of Pennsylvania School of Medicine, Philadelphia (A.P.S.); Rocky Mountain Cancer Centers, Denver (A.L.C.); Dana-Farber Cancer Institute (G.I.S., A.J.W.) and Massachusetts General Hospital (E.L.K.) - both in Boston; Vanderbilt University Medical Center, Nashville (V.L.K., I.P.); Virginia G. Piper Cancer Center at Scottsdale Healthcare-Translational Genomics Research Institute (TGen), Scottsdale, AZ (D.D.V.H., G.J.W., R.K.R.); and Spire Sciences, Boca Raton, FL (C.P.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1411366DOI Listing
July 2015

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

J Neurosci 2015 Jul;35(27):9977-89

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California 92697, and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.0336-15.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4495246PMC
July 2015

Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.

Pain 2015 Sep;156(9):1692-702

aDepartment of Pharmacology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA bUnidad Académica Multidisciplinaria Reynosa Aztlan Universidad Autónoma de Tamaulipas Reynosa, Tamaulipas, Mexico cTranslational Pharmacology, Plexxikon, Inc., Berkeley, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.pain.0000000000000228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545688PMC
September 2015

Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.

BMC Cancer 2015 May 5;15:356. Epub 2015 May 5.

Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12885-015-1377-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4432503PMC
May 2015

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

Cancer Immunol Res 2015 Sep 17;3(9):1042-51. Epub 2015 Apr 17.

Department of Clinical Oncology, Leiden University Medical Center, Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/2326-6066.CIR-15-0052DOI Listing
September 2015

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

PLoS One 2015 7;10(4):e0122912. Epub 2015 Apr 7.

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders (UCI MIND), University of California, Irvine, Irvine, California, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122912PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388515PMC
January 2016

CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy.

Cancer Res 2015 Mar 3;75(6):950-62. Epub 2015 Mar 3.

Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California. Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/content/early/2015/03/03/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-14-0992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359956PMC
March 2015

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

Cancer Res 2014 Sep 31;74(18):5057-69. Epub 2014 Jul 31.

Department of Medicine, Washington University School of Medicine, St Louis, Missouri. BRIGHT Institute, Washington University School of Medicine, St Louis, Missouri. Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-3723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182950PMC
September 2014

Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

Neuron 2014 Apr;82(2):380-97

Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697-4545, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2014.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161285PMC
April 2014

Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy.

Cancer Res 2014 Jan 18;74(1):153-161. Epub 2013 Nov 18.

Department of Molecular and Medical Pharmacology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 (UCLA).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-1816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947337PMC
January 2014

Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition.

Acta Neuropathol 2013 Jan 26;125(1):159-68. Epub 2012 Oct 26.

Division of Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00401-012-1056-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547628PMC
January 2013

Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression.

J Clin Invest 2006 Nov 12;116(11):2972-84. Epub 2006 Oct 12.

Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI28598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1592548PMC
November 2006

ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus.

Nucl Recept 2003 Jun 28;1(1). Epub 2003 Jun 28.

Metabolic Research Unit and Diabetes Center, University of California, San Francisco, CA 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1478-1336-1-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC179877PMC
June 2003

Two resistance to thyroid hormone mutants with impaired hormone binding.

Mol Endocrinol 2003 Apr 16;17(4):643-52. Epub 2003 Jan 16.

University of California, San Francisco, Department of Biochemistry Biophysics, 513 Parnassus Avenue, San Francisco, California 94143-0448, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/me.2002-0095DOI Listing
April 2003

TR surfaces and conformations required to bind nuclear receptor corepressor.

Mol Endocrinol 2002 Feb;16(2):271-86

Metabolic Research Unit, University of California San Francisco, San Francisco, California 94143, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/mend.16.2.0777DOI Listing
February 2002