Brian L Browning

Brian L Browning

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Brian L Browning

Brian L Browning

Publications by authors named "Brian L Browning"

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Estimating the Genome-wide Mutation Rate with Three-Way Identity by Descent.

Am J Hum Genet 2019 Nov 3;105(5):883-893. Epub 2019 Oct 3.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2019.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848988PMC
November 2019

A One-Penny Imputed Genome from Next-Generation Reference Panels.

Am J Hum Genet 2018 09 9;103(3):338-348. Epub 2018 Aug 9.

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6128308PMC
September 2018

POPdemog: visualizing population demographic history from simulation scripts.

Bioinformatics 2018 08;34(16):2854-2855

Department of Biostatistics, University of Washington, WA, USA.

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http://dx.doi.org/10.1093/bioinformatics/bty184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6084562PMC
August 2018

Genotype Imputation from Large Reference Panels.

Annu Rev Genomics Hum Genet 2018 08 23;19:73-96. Epub 2018 May 23.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington 98195-7720, USA; email:

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http://dx.doi.org/10.1146/annurev-genom-083117-021602DOI Listing
August 2018

Ancestry-specific recent effective population size in the Americas.

PLoS Genet 2018 05 24;14(5):e1007385. Epub 2018 May 24.

Department of Biostatistics, University of Washington, Seattle, WA, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967706PMC
May 2018

Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.

Cell 2018 03 15;173(1):53-61.e9. Epub 2018 Mar 15.

Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA; The Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA.

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http://dx.doi.org/10.1016/j.cell.2018.02.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866234PMC
March 2018

Robust Inference of Identity by Descent from Exome-Sequencing Data.

Am J Hum Genet 2016 Nov 13;99(5):1106-1116. Epub 2016 Oct 13.

Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097937PMC
November 2016

ASAFE: ancestry-specific allele frequency estimation.

Bioinformatics 2016 07 3;32(14):2227-9. Epub 2016 May 3.

Department of Biostatistics and.

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http://dx.doi.org/10.1093/bioinformatics/btw220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937201PMC
July 2016

Consideration of Cosegregation in the Pathogenicity Classification of Genomic Variants.

Am J Hum Genet 2016 06 26;98(6):1077-1081. Epub 2016 May 26.

Division of Medical Genetics, Department of Medicine and Department of Genome Sciences, The University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2016.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908147PMC
June 2016

Genotype Imputation with Millions of Reference Samples.

Am J Hum Genet 2016 Jan;98(1):116-26

Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00029297150049
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http://dx.doi.org/10.1016/j.ajhg.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716681PMC
January 2016

Accurate Non-parametric Estimation of Recent Effective Population Size from Segments of Identity by Descent.

Am J Hum Genet 2015 Sep 20;97(3):404-18. Epub 2015 Aug 20.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ajhg.2015.07.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564943PMC
September 2015

Genome-wide haplotypic testing in a Finnish cohort identifies a novel association with low-density lipoprotein cholesterol.

Eur J Hum Genet 2015 May 4;23(5):672-7. Epub 2014 Jun 4.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1038/ejhg.2014.105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402615PMC
May 2015

Large numbers of individuals are required to classify and define risk for rare variants in known cancer risk genes.

Genet Med 2014 Jul 19;16(7):529-34. Epub 2013 Dec 19.

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/gim.2013.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063879PMC
July 2014

Efficient clustering of identity-by-descent between multiple individuals.

Bioinformatics 2014 Apr 19;30(7):915-22. Epub 2013 Dec 19.

Bioinformatics Research Center, Aarhus Universitet, 8000C Aarhus, Denmark, Department of Biostatistics and Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1093/bioinformatics/btt734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967111PMC
April 2014

Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.

Anesthesiology 2013 Nov;119(5):1054-65

* Assistant Professor, Department of Anesthesiology and Pain Medicine, † Professor, ‡ Associate Professor, § Biostatistician, Department of Medicine, Division of Medical Genetics, ‖ Graduate Student, # Research Professor, ** Research Scientist, †† Professor, Department of Genome Sciences, University of Washington, Seattle, Washington. ‡‡ Research Scientist, §§ Professor, Leeds Institute of Molecular Medicine, Leeds, United Kingdom.

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http://dx.doi.org/10.1097/ALN.0b013e3182a8a998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4115638PMC
November 2013

Detecting identity by descent and estimating genotype error rates in sequence data.

Am J Hum Genet 2013 Nov 24;93(5):840-51. Epub 2013 Oct 24.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.09.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824133PMC
November 2013

Improving the accuracy and efficiency of identity-by-descent detection in population data.

Genetics 2013 Jun 27;194(2):459-71. Epub 2013 Mar 27.

Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1534/genetics.113.150029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664855PMC
June 2013

Identity by descent between distant relatives: detection and applications.

Annu Rev Genet 2012 17;46:617-33. Epub 2012 Sep 17.

Department of Statistics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1146/annurev-genet-110711-155534DOI Listing
April 2013

Identity-by-descent-based heritability analysis in the Northern Finland Birth Cohort.

Hum Genet 2013 Feb 29;132(2):129-38. Epub 2012 Sep 29.

Department of Biostatistics, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/s00439-012-1230-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543768PMC
February 2013

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.

Ann Neurol 2011 Dec;70(6):897-912

Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://doi.wiley.com/10.1002/ana.22609
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http://dx.doi.org/10.1002/ana.22609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247076PMC
December 2011

Haplotype phasing: existing methods and new developments.

Nat Rev Genet 2011 Sep 16;12(10):703-14. Epub 2011 Sep 16.

Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nrg3054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217888PMC
September 2011

A fast, powerful method for detecting identity by descent.

Am J Hum Genet 2011 Feb;88(2):173-82

Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98105, USA.

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http://dx.doi.org/10.1016/j.ajhg.2011.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035716PMC
February 2011

High-resolution detection of identity by descent in unrelated individuals.

Am J Hum Genet 2010 Apr 18;86(4):526-39. Epub 2010 Mar 18.

Department of Statistics, University of Auckland, Auckland, New Zealand.

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http://linkinghub.elsevier.com/retrieve/pii/S000292971000103
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http://dx.doi.org/10.1016/j.ajhg.2010.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2850444PMC
April 2010

Genetic analysis of MDR1 and inflammatory bowel disease reveals protective effect of heterozygous variants for ulcerative colitis.

Inflamm Bowel Dis 2009 Dec 14;15(12):1784-93. Epub 2009 Aug 14.

Discipline of Nutrition, FM&HS, University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/ibd.21019DOI Listing
December 2009

A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals.

Am J Hum Genet 2009 Feb 5;84(2):210-23. Epub 2009 Feb 5.

Department of Statistics, University of Auckland, Auckland 1142, New Zealand.

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http://dx.doi.org/10.1016/j.ajhg.2009.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668004PMC
February 2009

PRESTO: rapid calculation of order statistic distributions and multiple-testing adjusted P-values via permutation for one and two-stage genetic association studies.

Authors:
Brian L Browning

BMC Bioinformatics 2008 Jul 13;9:309. Epub 2008 Jul 13.

Department of Statistics, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1186/1471-2105-9-309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483288PMC
July 2008

Haplotypic analysis of Wellcome Trust Case Control Consortium data.

Hum Genet 2008 Apr 26;123(3):273-80. Epub 2008 Jan 26.

Department of Statistics, The University of Auckland, Private Bag 92019, Auckland, New Zealand,

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http://link.springer.com/10.1007/s00439-008-0472-1
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http://dx.doi.org/10.1007/s00439-008-0472-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2384233PMC
April 2008

Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.

Am J Hum Genet 2007 Nov 21;81(5):1084-97. Epub 2007 Sep 21.

Department of Statistics, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1086/521987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265661PMC
November 2007

Association of DLG5 variants with inflammatory bowel disease in the New Zealand Caucasian population and meta-analysis of the DLG5 R30Q variant.

Inflamm Bowel Dis 2007 Sep;13(9):1069-76

Discipline of Nutrition, Department of Statistics, University of Auckland, New Zealand, and Department of Gastroenterology, Box Hill Hospital, Monash, Australia.

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http://dx.doi.org/10.1002/ibd.20157DOI Listing
September 2007

Genes, diet and inflammatory bowel disease.

Mutat Res 2007 Sep 2;622(1-2):70-83. Epub 2007 Jun 2.

Discipline of Nutrition, Faculty of Medical & Health Science, The University of Auckland, Private Bag 92019, Auckland, New Zealand.

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http://linkinghub.elsevier.com/retrieve/pii/S002751070700244
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http://dx.doi.org/10.1016/j.mrfmmm.2007.05.011DOI Listing
September 2007

Efficient multilocus association testing for whole genome association studies using localized haplotype clustering.

Genet Epidemiol 2007 Jul;31(5):365-75

Department of Statistics, The University of Auckland, Auckland, New Zealand.

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http://dx.doi.org/10.1002/gepi.20216DOI Listing
July 2007

Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example.

Cancer Epidemiol Biomarkers Prev 2007 Jun;16(6):1185-92

Discipline of Nutrition, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.

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http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-0
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http://dx.doi.org/10.1158/1055-9965.EPI-06-0759DOI Listing
June 2007

Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia.

Behav Brain Funct 2007 Jun 28;3:31. Epub 2007 Jun 28.

Psychiatry CEDD, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, CM19 5AW Harlow, Essex, UK.

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http://dx.doi.org/10.1186/1744-9081-3-31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934910PMC
June 2007

Evaluation of Nyholt's procedure for multiple testing correction.

Hum Hered 2005 23;60(1):19-25; discussion 61-2. Epub 2005 Aug 23.

Max-Planck Institute of Psychiatry, Munich, Germany.

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http://dx.doi.org/10.1159/000087540DOI Listing
November 2005

On reducing the statespace of hidden Markov models for the identity by descent process.

Theor Popul Biol 2002 Aug;62(1):1-8

Bioinformatics Research Center, North Carolina State University, Campus Box 7566, Raleigh, North Carolina 27695-7566, USA.

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http://dx.doi.org/10.1006/tpbi.2002.1583DOI Listing
August 2002