Brian Keith

Brian Keith

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Brian Keith

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Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.

Cell Metab 2018 Jun 10;27(6):1263-1280.e6. Epub 2018 May 10.

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5990482PMC
June 2018

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18.

Cell Rep 2017 Sep;20(13):3025-3033

Center for Cellular Immunotherapies, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002762PMC
September 2017

Oxygen availability and metabolic adaptations.

Nat Rev Cancer 2016 09;16(10):663-73

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania.

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http://dx.doi.org/10.1038/nrc.2016.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546320PMC
September 2016

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells.

Immunity 2016 Feb;44(2):380-90

Center for Cellular Immunotherapies, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2016.01.021DOI Listing
February 2016

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma.

Cancer Discov 2015 Jun 31;5(6):652-67. Epub 2015 Mar 31.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania. Howard Hughes Medical Institute, Chevy Chase, Maryland.

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http://dx.doi.org/10.1158/2159-8290.CD-14-1507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456212PMC
June 2015

Feedback circuitry between miR-218 repression and RTK activation in glioblastoma.

Sci Signal 2015 May 5;8(375):ra42. Epub 2015 May 5.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/scisignal.2005978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437515PMC
May 2015

Fructose-1,6-bisphosphatase opposes renal carcinoma progression.

Nature 2014 Sep 20;513(7517):251-5. Epub 2014 Jul 20.

1] Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Howard Hughes Medical Institute, Philadelphia, Pennsylvania 19104, USA [3] Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/doifinder/10.1038/nature13557
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http://dx.doi.org/10.1038/nature13557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162811PMC
September 2014

An archaeal family-B DNA polymerase variant able to replicate past DNA damage: occurrence of replicative and translesion synthesis polymerases within the B family.

Nucleic Acids Res 2014 Sep 24;42(15):9949-63. Epub 2014 Jul 24.

Institute of Cell and Molecular Biosciences, University of Newcastle, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gku683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4150786PMC
September 2014

Human immunodeficiency virus reverse transcriptase displays dramatically higher fidelity under physiological magnesium conditions in vitro.

J Virol 2014 Aug 21;88(15):8514-27. Epub 2014 May 21.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA

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http://dx.doi.org/10.1128/JVI.00752-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135932PMC
August 2014

Restricted expression of miR-30c-2-3p and miR-30a-3p in clear cell renal cell carcinomas enhances HIF2α activity.

Cancer Discov 2014 Jan 4;4(1):53-60. Epub 2013 Nov 4.

1Abramson Family Cancer Research Institute; 2Howard Hughes Medical Institute; 3Department of Cell and Developmental Biology; 4Penn Molecular Profiling Facility, Bioinformatics Group; 5Department of Pathology and Laboratory Medicine; 6Department of Cancer Biology; 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; and 8INSERM U1037, Institut Claudius Regaud, Rue du Pont St Pierre, Toulouse, France.

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http://dx.doi.org/10.1158/2159-8290.CD-13-0291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947282PMC
January 2014

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma.

Proc Natl Acad Sci U S A 2014 Jan 24;111(1):291-6. Epub 2013 Dec 24.

Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, Penn Molecular Profiling Facility - Bioinformatics Group, and Departments of Cell and Developmental Biology, Pathology and Laboratory Medicine, Cancer Biology, and Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104.

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http://dx.doi.org/10.1073/pnas.1314341111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890843PMC
January 2014

Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53.

Cancer Res 2013 Oct 13;73(19):5974-84. Epub 2013 Aug 13.

Authors' Affiliations: Department of Cancer Biology, The Scripps Research Institute, Jupiter; Molecular Oncology Program, DeWitt Daughtry Family Department of Surgery and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida; The Wistar Institute; Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine; Department of Cancer Biology, Abramson Family Cancer Research Institute; and Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; and Ecole Polytechnique Fédérale de Lausanne, EPFL SV ISREC, Lausanne, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3791518PMC
October 2013

A plasmid-based lacZα gene assay for DNA polymerase fidelity measurement.

Anal Biochem 2013 Feb 22;433(2):153-61. Epub 2012 Oct 22.

Institute of Cell and Molecular Biosciences (ICaMB), Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.

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http://dx.doi.org/10.1016/j.ab.2012.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3552156PMC
February 2013

Unwinding of primer-templates by archaeal family-B DNA polymerases in response to template-strand uracil.

Nucleic Acids Res 2013 Feb 8;41(4):2466-78. Epub 2013 Jan 8.

Institute of Cell and Molecular Biosciences (ICaMB), The University of Newcastle, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.1093/nar/gks1364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575838PMC
February 2013

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression.

Nat Rev Cancer 2011 Dec 15;12(1):9-22. Epub 2011 Dec 15.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1038/nrc3183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401912PMC
December 2011

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia.

Blood 2010 Oct 13;116(16):3039-48. Epub 2010 Jul 13.

Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-2372, USA.

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http://dx.doi.org/10.1182/blood-2010-02-270322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974609PMC
October 2010

Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation.

J Clin Invest 2010 Aug 19;120(8):2699-714. Epub 2010 Jul 19.

Abramson Family Cancer Research Institute, Howard Hughes Medical Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6160, USA

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http://www.jci.org/articles/view/39506
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http://dx.doi.org/10.1172/JCI39506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912179PMC
August 2010

HIF-2alpha deletion promotes Kras-driven lung tumor development.

Proc Natl Acad Sci U S A 2010 Aug 21;107(32):14182-7. Epub 2010 Jul 21.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1001296107
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http://dx.doi.org/10.1073/pnas.1001296107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922515PMC
August 2010

Hypoxia-inducible factor 2 regulates hepatic lipid metabolism.

Mol Cell Biol 2009 Aug 15;29(16):4527-38. Epub 2009 Jun 15.

Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1128/MCB.00200-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725738PMC
August 2009

HIF2alpha inhibition promotes p53 pathway activity, tumor cell death, and radiation responses.

Proc Natl Acad Sci U S A 2009 Aug 12;106(34):14391-6. Epub 2009 Aug 12.

Abramson Family Cancer Research Institute, Abramson Cancer Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0907357106
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http://dx.doi.org/10.1073/pnas.0907357106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726037PMC
August 2009

HIF-2alpha, but not HIF-1alpha, promotes iron absorption in mice.

J Clin Invest 2009 May 6;119(5):1159-66. Epub 2009 Apr 6.

Institut Cochin, Université Paris Descartes, CNRS, UMR, France.

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http://dx.doi.org/10.1172/JCI38499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673882PMC
May 2009

Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.

Oncogene 2008 Sep 19;27(40):5354-8. Epub 2008 May 19.

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6144, USA.

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http://dx.doi.org/10.1038/onc.2008.160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575082PMC
September 2008

Effects of 4E-BP1 expression on hypoxic cell cycle inhibition and tumor cell proliferation and survival.

Cancer Biol Ther 2008 Sep 11;7(9):1441-9. Epub 2008 Sep 11.

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575070PMC
http://dx.doi.org/10.4161/cbt.7.9.6426DOI Listing
September 2008

The role of oxygen availability in embryonic development and stem cell function.

Nat Rev Mol Cell Biol 2008 Apr 20;9(4):285-96. Epub 2008 Feb 20.

Howard Hughes Medical Institute, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://www.nature.com/articles/nrm2354
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http://dx.doi.org/10.1038/nrm2354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876333PMC
April 2008

Hypoxia-inducible factors, stem cells, and cancer.

Cell 2007 May;129(3):465-72

Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.cell.2007.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150586PMC
May 2007

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo.

J Clin Invest 2007 Apr;117(4):1068-77

Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6144, USA.

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http://dx.doi.org/10.1172/JCI30117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838939PMC
April 2007

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.

Mol Cell Biol 2007 Feb 4;27(4):1222-35. Epub 2006 Dec 4.

Department of Medicine, Northwestern University Medical School, 240 East Huron Avenue, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1128/MCB.01535-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800715PMC
February 2007

Acute postnatal ablation of Hif-2alpha results in anemia.

Proc Natl Acad Sci U S A 2007 Feb 6;104(7):2301-6. Epub 2007 Feb 6.

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1073/pnas.0608382104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892942PMC
February 2007

HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.

Genes Dev 2006 Mar;20(5):557-70

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1101/gad.1399906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1410808PMC
March 2006

Hypoxia-induced energy stress regulates mRNA translation and cell growth.

Mol Cell 2006 Feb;21(4):521-31

Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S109727650600011
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http://dx.doi.org/10.1016/j.molcel.2006.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153113PMC
February 2006

Targeted replacement of hypoxia-inducible factor-1alpha by a hypoxia-inducible factor-2alpha knock-in allele promotes tumor growth.

Cancer Res 2005 Mar;65(6):2277-86

Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-3246DOI Listing
March 2005

Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species.

J Appl Physiol (1985) 2004 Oct 4;97(4):1358-66. Epub 2004 Jun 4.

Abramson Family Cancer Research Institute, 438 BRB II/III, 421 Curie Blvd, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1152/japplphysiol.00449.2004DOI Listing
October 2004

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation.

Mol Cell Biol 2003 Dec;23(24):9361-74

Abramson Family Cancer Research Institute. Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC309606PMC
http://dx.doi.org/10.1128/mcb.23.24.9361-9374.2003DOI Listing
December 2003

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth.

Cancer Cell 2003 Jan;3(1):75-88

Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120823PMC
January 2003