Brian J Abraham

Brian J Abraham

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Brian J Abraham

Brian J Abraham

Publications by authors named "Brian J Abraham"

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Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes.

Mol Cell 2019 Sep 19. Epub 2019 Sep 19.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.08.016DOI Listing
September 2019

High MITF Expression Is Associated with Super-Enhancers and Suppressed by CDK7 Inhibition in Melanoma.

J Invest Dermatol 2018 07 8;138(7):1582-1590. Epub 2018 Feb 8.

Wellman Center for Photomedicine and Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2017.09.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019629PMC
July 2018

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.

Cancer Cell 2018 02 18;33(2):202-216.e6. Epub 2018 Jan 18.

Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108173056
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http://dx.doi.org/10.1016/j.ccell.2017.12.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846483PMC
February 2018

YY1 Is a Structural Regulator of Enhancer-Promoter Loops.

Cell 2017 Dec 7;171(7):1573-1588.e28. Epub 2017 Dec 7.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785279PMC
December 2017

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.

Nat Commun 2017 04 5;8:14802. Epub 2017 Apr 5.

Institute for Stem Cell Biology and Regenerative Medicine, and Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.

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http://dx.doi.org/10.1038/ncomms14802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382276PMC
April 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
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http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.

J Biol Chem 2016 Oct 6;291(43):22703-22713. Epub 2016 Sep 6.

From the Transcriptional Regulation and Biochemistry Unit, Metabolism Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 30893,

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http://dx.doi.org/10.1074/jbc.M116.751420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5077205PMC
October 2016

Models of human core transcriptional regulatory circuitries.

Genome Res 2016 Mar 3;26(3):385-96. Epub 2016 Feb 3.

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

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http://dx.doi.org/10.1101/gr.197590.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772020PMC
March 2016

Transcription factor trapping by RNA in gene regulatory elements.

Science 2015 Nov 29;350(6263):978-81. Epub 2015 Oct 29.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1126/science.aad3346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720525PMC
November 2015

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Stem Cell Reports 2013 24;1(5):371-8. Epub 2013 Oct 24.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841252PMC
October 2015

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Cell 2015 Sep;163(1):174-86

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.08.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583659PMC
September 2015

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.

Mol Cell 2015 Apr 19;58(2):362-70. Epub 2015 Mar 19.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2015.02.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402134PMC
April 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions.

Proc Natl Acad Sci U S A 2015 Mar 9;112(12):3841-6. Epub 2015 Mar 9.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139;

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http://dx.doi.org/10.1073/pnas.1502971112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378427PMC
March 2015

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element.

Science 2014 Dec 13;346(6215):1373-7. Epub 2014 Nov 13.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Division of Pediatric Hematology-Oncology, Boston Children's Hospital, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1259037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4720521PMC
December 2014

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Cell 2014 Nov 6;159(5):1126-1139. Epub 2014 Nov 6.

Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243043PMC
November 2014

The developmental potential of iPSCs is greatly influenced by reprogramming factor selection.

Cell Stem Cell 2014 Sep;15(3):295-309

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Skolkovo Institute of Science and Technology (Skoltech), Novaya strazha 100, Skolkovo Moscow Region 143025, Russia. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170792PMC
September 2014

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor.

Nature 2014 Jul 22;511(7511):616-20. Epub 2014 Jun 22.

1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature13393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244910PMC
July 2014

Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver.

J Biol Chem 2014 Jan 27;289(3):1313-28. Epub 2013 Nov 27.

From the Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115.

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http://dx.doi.org/10.1074/jbc.M113.521450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3894317PMC
January 2014

Super-enhancers in the control of cell identity and disease.

Cell 2013 Nov 10;155(4):934-47. Epub 2013 Oct 10.

Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.cell.2013.09.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841062PMC
November 2013

Dynamic regulation of epigenomic landscapes during hematopoiesis.

BMC Genomics 2013 Mar 19;14:193. Epub 2013 Mar 19.

Systems Biology Center, NHLBI, NIH, Rockville Pike, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2164-14-193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636055PMC
March 2013