Brian H Chen

Brian H Chen

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Brian H Chen

Brian H Chen

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Novel age-associated DNA methylation changes and epigenetic age acceleration in middle-aged African Americans and whites.

Clin Epigenetics 2019 Aug 19;11(1):119. Epub 2019 Aug 19.

Laboratory of Epidemiology and Population Science, National Institute on Aging, NIH Biomedical Research Center, 251 Bayview Boulevard Suite 100 Room 4C-222, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1186/s13148-019-0722-1DOI Listing
August 2019

The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Psychoneuroendocrinology 2019 Jun 6;104:18-24. Epub 2019 Feb 6.

Department of Pathology, Yale School of Medicine, New Haven, CT 06511, USA; Department of Epidemiology, Yale School of Public Health, New Haven, CT 06511, USA. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2019.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6555423PMC
June 2019

Leukocyte telomere length, T cell composition and DNA methylation age.

Aging (Albany NY) 2017 09;9(9):1983-1995

Center of Development and Aging, New Jersey Medical School, Rutgers State University of New Jersey, Newark, NJ 07103, USA.

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http://dx.doi.org/10.18632/aging.101293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636670PMC
September 2017

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases.

Genome Biol 2016 12 12;17(1):255. Epub 2016 Dec 12.

Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13059-016-1119-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5151130PMC
December 2016

Menopause accelerates biological aging.

Proc Natl Acad Sci U S A 2016 08 25;113(33):9327-32. Epub 2016 Jul 25.

Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA 90095

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http://dx.doi.org/10.1073/pnas.1604558113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995944PMC
August 2016

Metabolite Signatures of Metabolic Risk Factors and their Longitudinal Changes.

J Clin Endocrinol Metab 2016 04 23;101(4):1779-89. Epub 2016 Feb 23.

Framingham Heart Study (X.Y., S.S., C.M.W., G.C., P.C., B.H.C., S.-J.H., C.S.F., C.J.O., M.G.L., D.L.), Framingham, Massachusetts 01702; Boston University Department of Mathematics and School of Public Health (X.Y., M.G.L.), Boston, Massachusetts 02118; Population Sciences Branch (S.S., C.M.W., G.C., P.C., B.H.C., S.-J.H., C.S.F., C.J.O., D.L.), Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892; BG Medicine, Inc (P.J., X.L., P.M., N.G., A.A.), Waltham, Massachusetts 02451; Department of Medicine (C.S.F.), Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Medicine (C.J.O.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114; Mount Sinai School of Medicine (V.F.), New York, New York 10029; Centro Nacional de Investigaciones Cardiovasculares (V.F.), 28029 Madrid, Spain; TNO Triskelion BV, Inc (I.B.-P.), 3704 HE Zeist, The Netherlands; Institute of Medical Research A Lanari-IDIM, University of Buenos Aires (S.C.S., C.J.P.), National Scientific and Technical Research Council, Ciudad Autónoma de Buenos Aires C11428, Argentina; and Boston University School of Medicine (D.L.), Boston, Massachusetts 02118.

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http://dx.doi.org/10.1210/jc.2015-2555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4880163PMC
April 2016

Progression of Normal-Tension Glaucoma After Ventriculoperitoneal Shunt to Decrease Cerebrospinal Fluid Pressure.

J Glaucoma 2016 Jan;25(1):e50-2

*Department of Ophthalmology, Morsani College of Medicine, University of South Florida Eye Institute †Department of Neurosurgery, Morsani College of Medicine, University of South Florida, Tampa, FL.

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http://dx.doi.org/10.1097/IJG.0000000000000186DOI Listing
January 2016

Identification of common genetic variants controlling transcript isoform variation in human whole blood.

Nat Genet 2015 Apr 16;47(4):345-52. Epub 2015 Feb 16.

1] Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. [2] National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, Massachusetts, USA. [3] Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3220DOI Listing
April 2015

Integrative network analysis reveals molecular mechanisms of blood pressure regulation.

Mol Syst Biol 2015 Apr 16;11(1):799. Epub 2015 Apr 16.

The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA The Population Sciences Branch and the Division of Intramural Research, National Heart, Lung and Blood Institute, Bethesda, MD, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4422556PMC
http://dx.doi.org/10.15252/msb.20145399DOI Listing
April 2015

A systematic heritability analysis of the human whole blood transcriptome.

Hum Genet 2015 Mar 14;134(3):343-58. Epub 2015 Jan 14.

Framingham Heart Study, Population Sciences Branch, National Heart, Lung and Blood Institute, 73 Mt. Wayte Avenue, Suite 2, Framingham, MA, 01702, USA,

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http://dx.doi.org/10.1007/s00439-014-1524-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339826PMC
March 2015

Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes.

Circulation 2015 Feb 22;131(6):536-49. Epub 2014 Dec 22.

From the National Heart, Lung, and Blood Institute's Framingham Heart Study, National Institutes of Health, Bethesda, MD (C.Y., B.H.C., R.J., X.Z., C.L., T.H., L.A.C., C.S.F., P.C., C.J.O'D., D.L.); Population Sciences Branch, National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda, MD (C.Y., B.H.C., R.J., X.Z., C.L., T.H., P.C., D.L.); Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, MD (R.J., P.J.M.); Department of Computer Engineering, Middle East Technical University, Ankara, Turkey (B.O.); Department of Computer Engineering, Bilkent University, Ankara, Turkey (O.T.); Department of Biostatistics, Boston University School of Public Health, Boston, MA (L.A.C.); Harvard Medical School, Boston, MA (J.B.M.); Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.S.F.); Department of Medicine, University of Massachusetts Medical School, Worchester (J.E.F.); Division of Cardiology, Massachusetts General Hospital, Boston, MA (C.J.O'D.); and Departments of Statistics and of Biostatistics and Medical Informatics, University of Wisconsin-Madison (S.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.010696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369387PMC
February 2015

Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-lowering Drugs and Diet Network study.

Circulation 2014 Aug 11;130(7):565-72. Epub 2014 Jun 11.

From the Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL (M.R.I., S.A., S.A.C., D.K.A.); Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL (D.Z., H.K.T.); Population Sciences Branch National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Framingham Heart Study, Framingham, MA (R.J., M.M., L.L., B.H.C., C.Y., D.L.); Department of Cardiology, Boston Children's Hospital, Boston, MA (M.M.); Hudson Alpha Institute for Biotechnology, Huntsville, AL (K.S.T, N.P., K.D., L.W.J., D.A.); Departments of Epidemiology and Biostatistics, School of Public Health, Harvard University, Boston, MA (L.L.); and Nutrition and Genomics Laboratory, Jean Mayer-USDA-Human Nutrition Research Center on Aging at Tufts University, Boston, MA (J.M.O.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.114.009158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209699PMC
August 2014

Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.

PLoS Genet 2014 Aug 7;10(8):e1004517. Epub 2014 Aug 7.

Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125087PMC
August 2014

Effects of varying doses of testosterone on atherogenic markers in healthy younger and older men.

Am J Physiol Regul Integr Comp Physiol 2014 Jan 4;306(2):R118-23. Epub 2013 Dec 4.

Exercise and Metabolic Disease Research Laboratory, Translational Sciences Section, School of Nursing, University of California, Los Angeles, California; and.

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http://ajpregu.physiology.org/content/ajpregu/306/2/R118.ful
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http://ajpregu.physiology.org/cgi/doi/10.1152/ajpregu.00372.
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http://dx.doi.org/10.1152/ajpregu.00372.2013DOI Listing
January 2014

A prospective study of leukocyte telomere length and risk of type 2 diabetes in postmenopausal women.

Diabetes 2012 Nov 24;61(11):2998-3004. Epub 2012 Jul 24.

Program on Genomics and Nutrition, Department of Epidemiology, Fielding School of Public Health, and Departments of Medicine and Obstetrics and Gynecology, David Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.2337/db12-0241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478524PMC
November 2012

Severe loss and recovery of vision after glaucoma filtration surgery.

J Glaucoma 2012 Mar;21(3):144-6

Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/IJG.0b013e31820e2cf4DOI Listing
March 2012

Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women.

Diabetes 2011 Jan 28;60(1):269-75. Epub 2010 Oct 28.

Department of Epidemiology, Center for Metabolic Disease Prevention, University of California, Los Angeles, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db10-11
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http://dx.doi.org/10.2337/db10-1193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012180PMC
January 2011

Circulating levels of resistin and risk of type 2 diabetes in men and women: results from two prospective cohorts.

Diabetes Care 2009 Feb 28;32(2):329-34. Epub 2008 Oct 28.

Program on Genomics and Nutrition, Department of Epidemiology, UCLA School of Public Health, Los Angeles, California, USA.

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http://dx.doi.org/10.2337/dc08-1625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628703PMC
February 2009

NTD prevalences in central California before and after folic acid fortification.

Birth Defects Res A Clin Mol Teratol 2008 Aug;82(8):547-52

March of Dimes Foundation, California Research Division, Oakland, California 94609, USA.

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http://dx.doi.org/10.1002/bdra.20466DOI Listing
August 2008

Association between 49 infant gene polymorphisms and preterm delivery.

Am J Med Genet A 2007 Sep;143A(17):1990-6

California Birth Defects Monitoring Program, March of Dimes Foundation, Berkeley, California 94710, USA.

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http://dx.doi.org/10.1002/ajmg.a.31868DOI Listing
September 2007

Novel risk factor in gastroschisis: change of paternity.

Am J Med Genet A 2007 Apr;143A(7):653-9

Division of Dysmorphology and Teratology, Department of Pediatrics, University of California San Diego, La Jolla, CA 92103, USA.

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http://doi.wiley.com/10.1002/ajmg.a.31577
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http://dx.doi.org/10.1002/ajmg.a.31577DOI Listing
April 2007