Brian Fleck

Brian Fleck

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Brian Fleck

Brian Fleck

Publications by authors named "Brian Fleck"

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Ranibizumab versus laser therapy for the treatment of very low birthweight infants with retinopathy of prematurity (RAINBOW): an open-label randomised controlled trial.

Lancet 2019 10 12;394(10208):1551-1559. Epub 2019 Sep 12.

Academic Neonatology, UCL Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01406736193134
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http://dx.doi.org/10.1016/S0140-6736(19)31344-3DOI Listing
October 2019

Effects of magnetic field on the spreading dynamics of an impinging ferrofluid droplet.

J Colloid Interface Sci 2018 Dec 30;532:309-320. Epub 2018 Jul 30.

interfacial Science and Surface Engineering Lab (iSSELab), NINT 6-65, Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta T6G2G8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2018.07.110DOI Listing
December 2018

Drag Reduction Using Polysaccharides in a Taylor⁻Couette Flow.

Polymers (Basel) 2017 Dec 7;9(12). Epub 2017 Dec 7.

Department of Mechanical Engineering, University of Alberta, 9211-116 Street NW, Edmonton, AL T6G 1H9, Canada.

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http://dx.doi.org/10.3390/polym9120683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418573PMC
December 2017

Raised intracranial pressure and retinal haemorrhages in childhood encephalopathies: reply to the commentary by Squier.

Dev Med Child Neurol 2017 09;59(9):981-982

Department of Radiology, New Royal Infirmary, Edinburgh, UK.

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http://dx.doi.org/10.1111/dmcn.13516DOI Listing
September 2017

Raised intracranial pressure and retinal haemorrhages in childhood encephalopathies.

Dev Med Child Neurol 2017 Jun 29;59(6):597-604. Epub 2017 Mar 29.

Department of Radiology, New Royal Infirmary, Edinburgh, UK.

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http://dx.doi.org/10.1111/dmcn.13419DOI Listing
June 2017

Richard Shayle Bartholomew.

BMJ 2016 08 12;354:i4394. Epub 2016 Aug 12.

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http://dx.doi.org/10.1136/bmj.i4394DOI Listing
August 2016

Feasibility, Accuracy, and Repeatability of Suprathreshold Saccadic Vector Optokinetic Perimetry.

Transl Vis Sci Technol 2016 Aug 31;5(4):15. Epub 2016 Aug 31.

University of Edinburgh, Edinburgh, Scotland, UK ; Royal Hospital for Sick Children, Edinburgh, Scotland, UK.

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http://dx.doi.org/10.1167/tvst.5.4.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015923PMC
August 2016

Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

Authors:
Qiao Fan Virginie J M Verhoeven Robert Wojciechowski Veluchamy A Barathi Pirro G Hysi Jeremy A Guggenheim René Höhn Veronique Vitart Anthony P Khawaja Kenji Yamashiro S Mohsen Hosseini Terho Lehtimäki Yi Lu Toomas Haller Jing Xie Cécile Delcourt Mario Pirastu Juho Wedenoja Puya Gharahkhani Cristina Venturini Masahiro Miyake Alex W Hewitt Xiaobo Guo Johanna Mazur Jenifer E Huffman Katie M Williams Ozren Polasek Harry Campbell Igor Rudan Zoran Vatavuk James F Wilson Peter K Joshi George McMahon Beate St Pourcain David M Evans Claire L Simpson Tae-Hwi Schwantes-An Robert P Igo Alireza Mirshahi Audrey Cougnard-Gregoire Céline Bellenguez Maria Blettner Olli Raitakari Mika Kähönen Ilkka Seppala Tanja Zeller Thomas Meitinger Janina S Ried Christian Gieger Laura Portas Elisabeth M van Leeuwen Najaf Amin André G Uitterlinden Fernando Rivadeneira Albert Hofman Johannes R Vingerling Ya Xing Wang Xu Wang Eileen Tai-Hui Boh M Kamran Ikram Charumathi Sabanayagam Preeti Gupta Vincent Tan Lei Zhou Candice E H Ho Wan'e Lim Roger W Beuerman Rosalynn Siantar E-Shyong Tai Eranga Vithana Evelin Mihailov Chiea-Chuen Khor Caroline Hayward Robert N Luben Paul J Foster Barbara E K Klein Ronald Klein Hoi-Suen Wong Paul Mitchell Andres Metspalu Tin Aung Terri L Young Mingguang He Olavi Pärssinen Cornelia M van Duijn Jie Jin Wang Cathy Williams Jost B Jonas Yik-Ying Teo David A Mackey Konrad Oexle Nagahisa Yoshimura Andrew D Paterson Norbert Pfeiffer Tien-Yin Wong Paul N Baird Dwight Stambolian Joan E Bailey Wilson Ching-Yu Cheng Christopher J Hammond Caroline C W Klaver Seang-Mei Saw Jugnoo S Rahi Jean-François Korobelnik John P Kemp Nicholas J Timpson George Davey Smith Jamie E Craig Kathryn P Burdon Rhys D Fogarty Sudha K Iyengar Emily Chew Sarayut Janmahasatian Nicholas G Martin Stuart MacGregor Liang Xu Maria Schache Vinay Nangia Songhomitra Panda-Jonas Alan F Wright Jeremy R Fondran Jonathan H Lass Sheng Feng Jing Hua Zhao Kay-Tee Khaw Nick J Wareham Taina Rantanen Jaakko Kaprio Chi Pui Pang Li Jia Chen Pancy O Tam Vishal Jhanji Alvin L Young Angela Döring Leslie J Raffel Mary-Frances Cotch Xiaohui Li Shea Ping Yip Maurice K H Yap Ginevra Biino Simona Vaccargiu Maurizio Fossarello Brian Fleck Seyhan Yazar Jan Willem L Tideman Milly Tedja Margaret M Deangelis Margaux Morrison Lindsay Farrer Xiangtian Zhou Wei Chen Nobuhisa Mizuki Akira Meguro Kari Matti Mäkelä

Nat Commun 2016 Mar 29;7:11008. Epub 2016 Mar 29.

Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ncomms11008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820539PMC
March 2016

A Novel Approach Toward Fabrication of High Performance Thin Film Composite Polyamide Membranes.

Sci Rep 2016 Feb 29;6:22069. Epub 2016 Feb 29.

Department of Mechanical Engineering, 10-367 Donadeo Innovation Center for Engineering, Advanced Water Research Lab (AWRL), University of Alberta, Edmonton, AB, Canada, T6G 1H9.

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http://www.nature.com/articles/srep22069
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http://dx.doi.org/10.1038/srep22069DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770410PMC
February 2016

Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.

Hum Genet 2015 Feb 4;134(2):131-46. Epub 2014 Nov 4.

National Human Genome Research Institute, National Institutes of Health, 333 Cassell Drive Suite 1200, Baltimore, MD, 21224, USA.

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http://dx.doi.org/10.1007/s00439-014-1500-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291519PMC
February 2015

Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.

Nat Genet 2014 Oct 31;46(10):1126-1130. Epub 2014 Aug 31.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

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http://dx.doi.org/10.1038/ng.3087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177225PMC
October 2014

Prediction of severe retinopathy of prematurity using the WINROP algorithm in a birth cohort in South East Scotland.

Arch Dis Child Fetal Neonatal Ed 2014 Jan 28;99(1):F29-33. Epub 2013 Aug 28.

Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, , Edinburgh, UK.

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http://dx.doi.org/10.1136/archdischild-2013-304101DOI Listing
January 2014

Management of retinopathy of prematurity.

Arch Dis Child Fetal Neonatal Ed 2013 Sep 27;98(5):F454-6. Epub 2013 Jun 27.

Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, UK.

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http://dx.doi.org/10.1136/archdischild-2013-303933DOI Listing
September 2013

LTBP2 gene analysis in the GLC3C-linked family and 94 CYP1B1-negative cases with primary congenital glaucoma.

Ophthalmic Genet 2013 Mar-Jun;34(1-2):14-20. Epub 2012 Aug 27.

Molecular Ophthalmic Genetics Laboratory, University of Connecticut Health Center, Farmington, CT 06030, USA.

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http://dx.doi.org/10.3109/13816810.2012.716486DOI Listing
August 2013

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

Authors:
Ching-Yu Cheng Maria Schache M Kamran Ikram Terri L Young Jeremy A Guggenheim Veronique Vitart Stuart MacGregor Virginie J M Verhoeven Veluchamy A Barathi Jiemin Liao Pirro G Hysi Joan E Bailey-Wilson Beate St Pourcain John P Kemp George McMahon Nicholas J Timpson David M Evans Grant W Montgomery Aniket Mishra Ya Xing Wang Jie Jin Wang Elena Rochtchina Ozren Polasek Alan F Wright Najaf Amin Elisabeth M van Leeuwen James F Wilson Craig E Pennell Cornelia M van Duijn Paulus T V M de Jong Johannes R Vingerling Xin Zhou Peng Chen Ruoying Li Wan-Ting Tay Yingfeng Zheng Merwyn Chew Kathryn P Burdon Jamie E Craig Sudha K Iyengar Robert P Igo Jonathan H Lass Emily Y Chew Toomas Haller Evelin Mihailov Andres Metspalu Juho Wedenoja Claire L Simpson Robert Wojciechowski René Höhn Alireza Mirshahi Tanja Zeller Norbert Pfeiffer Karl J Lackner Thomas Bettecken Thomas Meitinger Konrad Oexle Mario Pirastu Laura Portas Abhishek Nag Katie M Williams Ekaterina Yonova-Doing Ronald Klein Barbara E Klein S Mohsen Hosseini Andrew D Paterson Kari-Matti Makela Terho Lehtimaki Mika Kahonen Olli Raitakari Nagahisa Yoshimura Fumihiko Matsuda Li Jia Chen Chi Pui Pang Shea Ping Yip Maurice K H Yap Akira Meguro Nobuhisa Mizuki Hidetoshi Inoko Paul J Foster Jing Hua Zhao Eranga Vithana E-Shyong Tai Qiao Fan Liang Xu Harry Campbell Brian Fleck Igor Rudan Tin Aung Albert Hofman André G Uitterlinden Goran Bencic Chiea-Chuen Khor Hannah Forward Olavi Pärssinen Paul Mitchell Fernando Rivadeneira Alex W Hewitt Cathy Williams Ben A Oostra Yik-Ying Teo Christopher J Hammond Dwight Stambolian David A Mackey Caroline C W Klaver Tien-Yin Wong Seang-Mei Saw Paul N Baird

Am J Hum Genet 2013 Aug;93(2):264-77

Department of Ophthalmology, National University of Singapore and National University Health System, Singapore 119228, Singapore; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore 117597, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore 168751, Singapore; Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of Singapore Graduate Medical School, Singapore 169857, Singapore.

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http://dx.doi.org/10.1016/j.ajhg.2013.06.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772747PMC
August 2013

Nystagmus and reduced visual acuity secondary to drug exposure in utero: long-term follow-up.

J Pediatr Ophthalmol Strabismus 2012 Jan-Feb;49(1):58-63. Epub 2011 Mar 15.

Royal Victoria Infirmary, Newcastle, United Kingdom.

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http://dx.doi.org/10.3928/01913913-20110308-01DOI Listing
July 2013

Retinopathy of prematurity and the oxygen conundrum: lessons learned from recent randomized trials.

Clin Perinatol 2013 Jun;40(2):229-40

Department of Ophthalmology, Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, EH3 9HA, UK.

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http://dx.doi.org/10.1016/j.clp.2013.02.010DOI Listing
June 2013

Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

Authors:
Virginie J M Verhoeven Pirro G Hysi Robert Wojciechowski Qiao Fan Jeremy A Guggenheim René Höhn Stuart MacGregor Alex W Hewitt Abhishek Nag Ching-Yu Cheng Ekaterina Yonova-Doing Xin Zhou M Kamran Ikram Gabriëlle H S Buitendijk George McMahon John P Kemp Beate St Pourcain Claire L Simpson Kari-Matti Mäkelä Terho Lehtimäki Mika Kähönen Andrew D Paterson S Mohsen Hosseini Hoi Suen Wong Liang Xu Jost B Jonas Olavi Pärssinen Juho Wedenoja Shea Ping Yip Daniel W H Ho Chi Pui Pang Li Jia Chen Kathryn P Burdon Jamie E Craig Barbara E K Klein Ronald Klein Toomas Haller Andres Metspalu Chiea-Chuen Khor E-Shyong Tai Tin Aung Eranga Vithana Wan-Ting Tay Veluchamy A Barathi Peng Chen Ruoying Li Jiemin Liao Yingfeng Zheng Rick T Ong Angela Döring David M Evans Nicholas J Timpson Annemieke J M H Verkerk Thomas Meitinger Olli Raitakari Felicia Hawthorne Tim D Spector Lennart C Karssen Mario Pirastu Federico Murgia Wei Ang Aniket Mishra Grant W Montgomery Craig E Pennell Phillippa M Cumberland Ioana Cotlarciuc Paul Mitchell Jie Jin Wang Maria Schache Sarayut Janmahasatian Sarayut Janmahasathian Robert P Igo Jonathan H Lass Emily Chew Sudha K Iyengar Theo G M F Gorgels Igor Rudan Caroline Hayward Alan F Wright Ozren Polasek Zoran Vatavuk James F Wilson Brian Fleck Tanja Zeller Alireza Mirshahi Christian Müller André G Uitterlinden Fernando Rivadeneira Johannes R Vingerling Albert Hofman Ben A Oostra Najaf Amin Arthur A B Bergen Yik-Ying Teo Jugnoo S Rahi Veronique Vitart Cathy Williams Paul N Baird Tien-Yin Wong Konrad Oexle Norbert Pfeiffer David A Mackey Terri L Young Cornelia M van Duijn Seang-Mei Saw Joan E Bailey-Wilson Dwight Stambolian Caroline C Klaver Christopher J Hammond

Nat Genet 2013 Mar 10;45(3):314-8. Epub 2013 Feb 10.

Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/ng.2554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740568PMC
March 2013

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

Nat Genet 2013 Feb 6;45(2):155-63. Epub 2013 Jan 6.

Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia.

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http://dx.doi.org/10.1038/ng.2506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720123PMC
February 2013

Prediction of inflicted brain injury in infants and children using retinal imaging.

Pediatrics 2012 Nov 8;130(5):e1227-34. Epub 2012 Oct 8.

Department of Child Life and Health, Princess Alexandra Eye Pavilion, Royal Hospital for Sick Children Edinburgh, Edinburgh, Scotland.

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http://pediatrics.aappublications.org/cgi/doi/10.1542/peds.2
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http://dx.doi.org/10.1542/peds.2011-3274DOI Listing
November 2012

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium.

Authors:
Virginie J M Verhoeven Pirro G Hysi Seang-Mei Saw Veronique Vitart Alireza Mirshahi Jeremy A Guggenheim Mary Frances Cotch Kenji Yamashiro Paul N Baird David A Mackey Robert Wojciechowski M Kamran Ikram Alex W Hewitt Priya Duggal Sarayut Janmahasatian Chiea-Chuen Khor Qiao Fan Xin Zhou Terri L Young E-Shyong Tai Liang-Kee Goh Yi-Ju Li Tin Aung Eranga Vithana Yik-Ying Teo Wanting Tay Xueling Sim Igor Rudan Caroline Hayward Alan F Wright Ozren Polasek Harry Campbell James F Wilson Brian W Fleck Isao Nakata Nagahisa Yoshimura Ryo Yamada Fumihiko Matsuda Kyoko Ohno-Matsui Abhishek Nag George McMahon Beate St Pourcain Yi Lu Jugnoo S Rahi Phillippa M Cumberland Shomi Bhattacharya Claire L Simpson Larry D Atwood Xiaohui Li Leslie J Raffel Federico Murgia Laura Portas Dominiek D G Despriet Leonieke M E van Koolwijk Christian Wolfram Karl J Lackner Anke Tönjes Reedik Mägi Terho Lehtimäki Mika Kähönen Tõnu Esko Andres Metspalu Taina Rantanen Olavi Pärssinen Barbara E Klein Thomas Meitinger Timothy D Spector Ben A Oostra Albert V Smith Paulus T V M de Jong Albert Hofman Najaf Amin Lennart C Karssen Fernando Rivadeneira Johannes R Vingerling Guðný Eiríksdóttir Vilmundur Gudnason Angela Döring Thomas Bettecken André G Uitterlinden Cathy Williams Tanja Zeller Raphaële Castagné Konrad Oexle Cornelia M van Duijn Sudha K Iyengar Paul Mitchell Jie Jin Wang René Höhn Norbert Pfeiffer Joan E Bailey-Wilson Dwight Stambolian Tien-Yin Wong Christopher J Hammond Caroline C W Klaver

Hum Genet 2012 Sep 5;131(9):1467-80. Epub 2012 Jun 5.

Department of Ophthalmology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00439-012-1176-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418496PMC
September 2012

The predisposing pathology and clinical characteristics in the Scottish retinal detachment study.

Ophthalmology 2011 Jul 10;118(7):1429-34. Epub 2011 May 10.

Department of Public Health Sciences, University of Edinburgh, Teviot Place, UK.

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http://dx.doi.org/10.1016/j.ophtha.2010.11.031DOI Listing
July 2011

Population-based estimate of the sibling recurrence risk ratio for rhegmatogenous retinal detachment.

Invest Ophthalmol Vis Sci 2011 Apr 20;52(5):2551-5. Epub 2011 Apr 20.

Department of Public Health Sciences, University of Edinburgh, TeviotPlace, Edinburgh, UK.

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http://dx.doi.org/10.1167/iovs.10-6375DOI Listing
April 2011

Temporal trends in retinal detachment incidence in Scotland between 1987 and 2006.

Br J Ophthalmol 2011 Mar 7;95(3):365-9. Epub 2010 Jul 7.

Clinical Research Fellow, Princess Alexandra Eye Pavilion, Edinburgh EH3 9HA, UK.

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http://dx.doi.org/10.1136/bjo.2009.172296DOI Listing
March 2011

Pathogenesis of rhegmatogenous retinal detachment: predisposing anatomy and cell biology.

Retina 2010 Nov-Dec;30(10):1561-72

Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom.

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http://dx.doi.org/10.1097/IAE.0b013e3181f669e6DOI Listing
February 2011

An inter-observer and intra-observer study of a classification of RetCam images of retinal haemorrhages in children.

Br J Ophthalmol 2011 Jan 3;95(1):99-104. Epub 2010 Jul 3.

Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9HA, UK.

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http://dx.doi.org/10.1136/bjo.2009.168153DOI Listing
January 2011

Feasibility of saccadic vector optokinetic perimetry: a method of automated static perimetry for children using eye tracking.

Ophthalmology 2009 Oct 27;116(10):2017-26. Epub 2009 Jun 27.

University of Edinburgh, Department of Child Life and Health, Edinburgh, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S016164200900279
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http://dx.doi.org/10.1016/j.ophtha.2009.03.015DOI Listing
October 2009

Digital image analysis of plus disease in retinopathy of prematurity.

Acta Ophthalmol 2009 Jun 6;87(4):368-77. Epub 2009 Feb 6.

Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, UK.

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http://doi.wiley.com/10.1111/j.1755-3768.2008.01448.x
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http://dx.doi.org/10.1111/j.1755-3768.2008.01448.xDOI Listing
June 2009

Rhegmatogenous retinal detachment in Scotland: research design and methodology.

BMC Ophthalmol 2009 Mar 24;9. Epub 2009 Mar 24.

Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh, UK.

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http://dx.doi.org/10.1186/1471-2415-9-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666641PMC
March 2009

Pathogenesis of retinopathy of prematurity and possible preventive strategies.

Early Hum Dev 2008 Feb 30;84(2):83-8. Epub 2008 Jan 30.

University of Edinburgh, Department of Ophthalmology, Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9HA UK.

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http://dx.doi.org/10.1016/j.earlhumdev.2007.11.008DOI Listing
February 2008

Amniotic membrane grafting for conjunctival and lid surface disease in the acute phase of toxic epidermal necrolysis.

J AAPOS 2007 Dec 27;11(6):612-3. Epub 2007 Jul 27.

Princess Alexandra Eye Pavilion, Edinburgh, Scotland, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S109185310700308
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http://dx.doi.org/10.1016/j.jaapos.2007.04.020DOI Listing
December 2007

Nystagmus secondary to drug exposure in utero.

Br J Ophthalmol 2007 May 13;91(5):613-5. Epub 2006 Dec 13.

Princess Alexandra Eye Pavilion, Chalmers Street, Edinburgh EH3 9HA, UK.

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http://dx.doi.org/10.1136/bjo.2006.105569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1954747PMC
May 2007

Bilateral fourth-nerve palsy occurring after shaking injury in infancy.

J AAPOS 2004 Jun;8(3):280-1

Princess Alexandra Eye Pavilion, Edinburgh, Scotland, United Kingdom.

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http://dx.doi.org/10.1016/j.jaapos.2004.01.003DOI Listing
June 2004

Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity.

Pediatr Res 2004 Jan 15;55(1):107-13. Epub 2003 Oct 15.

Child Life and Health, Reproductive and Developmental Sciences, University of Edinburgh, Edingurgh, United Kingdom.

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http://www.nature.com/doifinder/10.1203/01.PDR.0000099772.66
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http://dx.doi.org/10.1203/01.PDR.0000099772.66376.02DOI Listing
January 2004